LOCUS       NM_001418803            4533 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ring finger protein 141 (Rnf141), transcript variant
            12, mRNA.
ACCESSION   NM_001418803 XM_006508123
VERSION     NM_001418803.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Liu,Y., Tao,D., Ma,S., Kuang,Y., Su,D., Zhang,H., Yang,Y., Ma,Y.
            and Zhang,S.
  TITLE     A new mutant transcript generated in Znf230 exon 2 knockout mice
            reveals a potential exon structure in the targeting vector sequence
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (2), 123-128 (2013)
   PUBMED   23196134
  REMARK    GeneRIF: In summary, a potential exon structure in the targeting
            vector sequence involved in the expression of targeting Znf230 gene
            and disturbed the strategy of this gene-targeting experiment.
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Song,H., Su,D., Lu,P., Yang,J., Zhang,W., Yang,Y., Liu,Y. and
            Zhang,S.
  TITLE     Expression and localization of the spermatogenesis-related gene,
            Znf230, in mouse testis and spermatozoa during postnatal
            development
  JOURNAL   BMB Rep 41 (9), 664-669 (2008)
   PUBMED   18823591
  REMARK    GeneRIF: The results indicate that Znf230 may play an important
            role in mouse spermatogenesis, including spermatogenic cell
            proliferation and sperm maturation, as well as motility and
            fertilization.
REFERENCE   4  (bases 1 to 4533)
  AUTHORS   Qiu,W., Zhang,S., Xiao,C., Xu,W., Ma,Y., Liu,Y. and Wu,Q.
  TITLE     Molecular cloning and characterization of a mouse
            spermatogenesis-related ring finger gene znf230
  JOURNAL   Biochem Biophys Res Commun 306 (2), 347-353 (2003)
   PUBMED   12804569
  REMARK    GeneRIF: may function as a testis specific transcription factor
            during mouse spermatogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC184052.2 and AC122844.4.
            
            On Mar 23, 2023 this sequence version replaced XM_006508123.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.14032.1,
                                           SRR17253011.7634878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN02415137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               AC184052.2         109148-109767       c
            621-814             AC122844.4         187874-188067       c
            815-923             AC122844.4         184534-184642       c
            924-1105            AC122844.4         176014-176195       c
            1106-1213           AC122844.4         172051-172158       c
            1214-4533           AC122844.4         164328-167647       c
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.87 cM"
     gene            1..4533
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /note="ring finger protein 141"
                     /db_xref="GeneID:67150"
                     /db_xref="MGI:MGI:1914400"
     exon            1..620
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            621..814
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     CDS             672..1364
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /note="isoform 1 is encoded by transcript variant 12; zinc
                     finger protein 230"
                     /codon_start=1
                     /product="RING finger protein 141 isoform 1"
                     /protein_id="NP_001405732.1"
                     /db_xref="GeneID:67150"
                     /db_xref="MGI:MGI:1914400"
                     /translation="MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAE
                     LNDVTAKVAAGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQ
                     FIQLYKDITSQAAGVLAQSSTSEEPDENPSSVTSCQASLWMGRVKQLTDEEECCICMD
                     GRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYIL
                     NMADEAGQPHRP"
     exon            815..923
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1105
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1213
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..4533
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /note="hexamer: ATTAAA"
     polyA_site      4533
                     /gene="Rnf141"
                     /gene_synonym="2610110L04Rik; ZFP36; ZNF230"
                     /note="major polyA site"
ORIGIN      
        1 gccgctgccg cctagcgggt ttagctaagc agcagccgag gcggtgtccc tggtgcgagg
       61 agagcgatgc cttgaactgg gtgagccttg cagcgccgcc ccttcgctgt gtcccttccc
      121 agccactcca cggtcctgga gtagggagtg gaggcccggg cagcaccagg gtgtgaaacc
      181 gggcttcaga ggagctaggg ccccttgtca gggcctcggc tgcgggcttt gggcaccgat
      241 tcctgggcgg gtggagactc tgggtccgcc ttctcggtgg cggtggagac tctgggtccg
      301 ccttcgcggt ggtgctgagg agagctttca gagatcagct cgagcggttt tgaatcttgg
      361 cgctggcgca ctgagcagtt tagctgttgg ttagcagagc aggtgcgcca aggaggggct
      421 gaggggcggg tgctggggcc agggcggcag ggtggccaca gggcaaggct tctgagggag
      481 agcctgggcc cgtggtgtcg gccagccctc ctactaaacc cgccccggca gtgcacccgg
      541 gcccttgctt gtcaagctaa ttgctacctt ttgaggaccg acattaaaaa aaaagtttcc
      601 ttgctaatca taattgtagg aaactatggg aagcaaaact ctttctgaat tctgaaagac
      661 atcatttcac catgggacag caaatttcgg atcagacgca gttggttatt aacaagttac
      721 cagaaaaggt agcaaagcac gtcaccttgg ttcgagaaag tggctcctta acttacgaag
      781 agtttcttgg gagagtagct gaactcaatg atgtaactgc taaggtggct gctggccagg
      841 aaaagcatct tctctttgag gtacaacctg ggtctgactc ctctgccttc tggaaagtag
      901 ttgtacgggt ggtctgtacc aagattaaca aaagcagtgg cattgtggaa gcatcgcgga
      961 tcatgaattt gtaccagttt attcagctct ataaagacat cacaagccaa gctgctggag
     1021 tgctggctca gagctccacc tctgaagagc ctgatgagaa cccatcctcg gtcacatctt
     1081 gccaggctag tctatggatg ggcagggtga agcagctgac tgatgaggag gagtgttgta
     1141 tctgcatgga cgggcgagct gacctcatcc tgccctgtgc tcacagcttc tgtcagaagt
     1201 gcattgataa atggagtgat cgacacagga actgccccat ttgtcgccta cagatgactg
     1261 gagcaaatga atcatgggtg gtgtcagatg cacccactga agatgacatg gctaactata
     1321 ttcttaacat ggctgatgag gcaggccagc cccacaggcc atgacttggg gaagactttc
     1381 tgttgttatt ctgaactaca aatacactgt tgtcgtagag gagaaggggg ggatattgtg
     1441 gcacacacag aaatatcagt tttcccaccc tcttattttt gctattctgg tatgtcccgt
     1501 tcttaaataa actcccatgt cttccatgta tggtgggcta cagtttgcta ctgtttagcc
     1561 atatttccca cagtccacct attctatgtt gctcttgagc cctttgctac agatagcagc
     1621 aatacttgac actactgctt ttcagggagg gagggactgt tctggcatct ttttagtagg
     1681 tttaagtttt agagtgttga cagttgtagc catctgagat aaatgactga aactaatgtc
     1741 tcagttggaa cctgaggtgt gtgtgctctg cccccttgtg gttcattatg gatccttcag
     1801 tactgtggcc caattgcttc ctgatgttat gtcacttttg gccttgggtt ctggaactac
     1861 ttattcttta tgttgccatg atgcagcaca cggattagga ctgtctggtt ggaactttgt
     1921 ctcgaaaatg gactgtaccg gagggatctt catggctgct ttagaaaggc atccccggac
     1981 ctggataggt gcccgttgga ttttttcata atgcccatga agcttgagtt ttcagaagga
     2041 tttttttctt ttatagaaac acacatttta tatttccaga ttccacagag gcatccagtc
     2101 ctgagccaga cagcgtttat tttaggtaaa gacgcctttc tgaggcttcg gtttcctcaa
     2161 atttctcaga ttaaaagaag aggacgatca ggtaaacctc ctcaccaagc agttgtaaaa
     2221 ccctaaactc cagaccttga ttggctttct tcccatttct ctgcactatt caggcatcta
     2281 gagagagaac cgtgacagga gtgcggcctc agtgacagcc acagtggctt atggaggaag
     2341 aacgttaatg ctaacagtgc agcctataaa agtgctagtg catgaaataa gtcccctgta
     2401 agaaatgtta gcgttccata gaagtcttct cacagatttt tggcaagttt caactgtccc
     2461 tgttttccta agtatagatg tacacaattg aagttactgc ttattgattt ttgattcaga
     2521 ttttaatgaa tatttaaata aaatcccttt caaagaaaaa gatctgactt gattcagatt
     2581 ttaatgaata ttcaaataaa atccctctcg ggggaaaaaa aggtctgact tgattctgcc
     2641 cccaaatact gaagacatca atagtccatt cactgtaagg acagggcagt gacaccaaat
     2701 ggctaagcag tctgccgagc atgcgggcaa gcacagtgct gttgtctgtc ataccttagc
     2761 tgagatggtt tcacaacccc gagaaagtct tactctgttg taggttctta ttgagaaact
     2821 cagattgtat ttgtggtttt caaacattag catttcaagt aagttctgag agcctattca
     2881 cactgagtgc acacacacac atgctacccc gttatagaga agctacatat tattaataca
     2941 agtttcctta cacaaacctt agtgtgatcg agtttaagtc agtatatgaa aatgtgaaaa
     3001 tgtattggtg atacagttac attagaattt gtaaatgaaa aaacctctgt tttgtaaaaa
     3061 taataacaat tcagggctag aggtgtaact cagttggtag agtgcttacc taatatatat
     3121 aaagcctggg ttccatccca gcactgcgta aaaacagtga tgctggtgca cccctcctac
     3181 cccagcactt gagaggagga agcaggaaga ccagaaggcc caggtcatcc tccatcacag
     3241 agtgagttca aggatagcct gggctacatt gaaatgctgt ttcaaaaaca attgggatgg
     3301 ctaggctaga gagctaactc agtggttaag agcacttact gttcttgcag aggaccagag
     3361 tttaatcccc agcacccaca ttagtggttt acaaccacct gtatctctcc aagggctcca
     3421 acaccctcat ctgaccacct agggcaccca catgcatgtt acacacagag agacacacta
     3481 gcaaaacaac tttaaaacat tttaaaattc atattctgtc atattctgtc aactttcaag
     3541 tgctccatag aacacattct ctaagccttg gaatgagtga tcttctgaga tgctttctag
     3601 ccctaaaatt gtccttttgg attttgactt gctgggttta attcaaattg tctaatctta
     3661 aagtgtttca gaaattaata acatagcttt aggggttggg gatatttcca gcaatagcca
     3721 atacctctat tccccagaat ccttcatttt tgaaagaata gaaagtgagt ccagtgactt
     3781 gatcttgccc actgcccttt atttaaagtg tgatctctgg gatactaact ggtctactgt
     3841 gaagcgtcag tgtctccaac tgccttatca agtagtaagc agagttctct atgcattcca
     3901 ttgaactggg tggtgactcc agatgtcaat agtaggtagg gttcaccata ggatctaatc
     3961 ataaatttgt ctcatgagta aaatgtatac tttttctatt ctgtacagct ttgcctttat
     4021 aaaataagaa ctacataaat acatttacca tggtaggaaa ttgtgtgcct tcagtgatgt
     4081 gcaaattgcc tcctgcttta gggaattgtt gtaaattgta tgttagtgct gtgctcactc
     4141 agtaacagca ggttggctca aatgctggaa acgttgggtt tcagaaagag tttgactatg
     4201 tattgatgta aaggctgaca acagcaaagc ctgttttatt cttaggaaaa actgatacaa
     4261 tgtgcaataa gtaaactttg caagtgaaca ttagctaact aaaaacgttt gcttatgtaa
     4321 tttcacattc ttatatacta aatatttata tttattagag gactgttttg tattgtgctc
     4381 tgggggttgt gttgtttgtg tgctgttttg aggtgatttt cttgtattaa tatacaactg
     4441 ggtaataagg ctgcttggaa accttttttt ggttccctga ttttttaaca ctgggaagtt
     4501 ggattcatta aaagatagtc tgaataactt gca
//
