LOCUS       NM_020012               3056 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 14 (Rnf14), transcript variant 2,
            mRNA.
ACCESSION   NM_020012
VERSION     NM_020012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Ingham,A.B., Osborne,S.A., Menzies,M., Briscoe,S., Chen,W.,
            Kongsuwan,K., Reverter,A., Jeanes,A., Dalrymple,B.P., Wijffels,G.,
            Seymour,R. and Hudson,N.J.
  TITLE     RNF14 is a regulator of mitochondrial and immune function in muscle
  JOURNAL   BMC Syst Biol 8, 10 (2014)
   PUBMED   24472305
  REMARK    GeneRIF: RNF14 influences the expression of both mitochondrial and
            immune related genes
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3056)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 3056)
  AUTHORS   Grimont,A., Bloch-Faure,M., El Abida,B. and Crambert,G.
  TITLE     Mapping of sex hormone receptors and their modulators along the
            nephron of male and female mice
  JOURNAL   FEBS Lett 583 (10), 1644-1648 (2009)
   PUBMED   19401201
REFERENCE   6  (bases 1 to 3056)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3056)
  AUTHORS   Ito,K., Adachi,S., Iwakami,R., Yasuda,H., Muto,Y., Seki,N. and
            Okano,Y.
  TITLE     N-Terminally extended human ubiquitin-conjugating enzymes (E2s)
            mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8
  JOURNAL   Eur J Biochem 268 (9), 2725-2732 (2001)
   PUBMED   11322894
REFERENCE   8  (bases 1 to 3056)
  AUTHORS   van der Reijden,B.A., Erpelinck-Verschueren,C.A., Lowenberg,B. and
            Jansen,J.H.
  TITLE     TRIADs: a new class of proteins with a novel cysteine-rich
            signature
  JOURNAL   Protein Sci 8 (7), 1557-1561 (1999)
   PUBMED   10422847
REFERENCE   9  (bases 1 to 3056)
  AUTHORS   Kang,H.Y., Yeh,S., Fujimoto,N. and Chang,C.
  TITLE     Cloning and characterization of human prostate coactivator ARA54, a
            novel protein that associates with the androgen receptor
  JOURNAL   J Biol Chem 274 (13), 8570-8576 (1999)
   PUBMED   10085091
REFERENCE   10 (bases 1 to 3056)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA315275.1, BC054841.1 and BC094250.1.
            
            On Sep 9, 2009 this sequence version replaced NM_020012.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 4 through 9 encode the same
            isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094250.1, SRR1660817.197684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CA315275.1         1-70
            71-3035             BC054841.1         1-2965
            3036-3056           BC094250.1         2987-3007
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.2 cM"
     gene            1..3056
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /note="ring finger protein 14"
                     /db_xref="GeneID:56736"
                     /db_xref="MGI:MGI:1929668"
     exon            1..164
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            165..337
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..499
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1803
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /EC_number="2.3.2.31"
                     /note="isoform a is encoded by transcript variant 2;
                     TRIAD2 type I; E3 ubiquitin-protein ligase RNF14; protein
                     Triad2; androgen receptor-associated protein 54"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF14 isoform a"
                     /protein_id="NP_064396.2"
                     /db_xref="CCDS:CCDS29200.1"
                     /db_xref="GeneID:56736"
                     /db_xref="MGI:MGI:1929668"
                     /translation="MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQ
                     NFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ
                     LSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATA
                     QASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKL
                     FLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVAT
                     PGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCN
                     FAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEM
                     ESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHFTDS
                     ESPCFNRLFHAVDINGDMWEDEIEEDDDDEDDDDD"
     exon            500..651
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1182
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1411
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1584
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1715
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..3040
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3008..3013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="Rnf14"
                     /gene_synonym="2310075C09Rik; 2610005D23Rik; D18Ertd188e;
                     D7Bwg0165e; Triad2"
                     /note="major polyA site"
ORIGIN      
        1 cctccgctgg catccgcccc tctcagctga cagctctgga gacggaagag gcggtgctca
       61 ggtgctgcgg ctggtctgca ggcctggccg gcaagcgtct gccgaggccc agtcaagggc
      121 atcctgcgga actttagggc ccggctcggc tgagcggccg gaagatggca gactttctgt
      181 agtatatcgg acgcaaatct cacatcttgg tttcttatcc aacttcagtc taacttcact
      241 ggctagaaaa taaatgggat ttgcacaaat tccaagccaa agtgaaatac agattgcagc
      301 agcattaata tccttttctc ctggttgtta ctaacagcaa gttcaatgtc ggcagaagac
      361 ctggaagccc aggaggatga actactggcc ctggcgagta tttatgatgc ggatgaattt
      421 agaaaagctg agtctgtcca aggaggagaa accaggatct atttggatct gccacagaat
      481 tttaagatat tcgtgagcgg caattcaaat gagtctctcc agaatagtgg ctttgaatac
      541 accatttgct ttctgccacc acttgtgctg aactttgaac tgccaccaga ttatccatcc
      601 tcctccccac cttcattcac acttagtggc aaatggctgt caccaactca gctctctgct
      661 ctctgcaagc acctagacaa cctgtgggaa gaacaccgag gcagagtggt gctgtttgcc
      721 tggatgcagt ttcttaagga ggagaccctc acctacctga atattgtctc tccttttgag
      781 ctcaagatgg ggtctcagaa aaaagttcag agaagggcaa cagcccaggc ctcttccagc
      841 acagagcttg gtgtgggagg agctgctgcg gcggatgtag accaagaaga aactgtggat
      901 gagagagctg tacaggatgt agagtcattg tcaagtctga tccaggagat cttggacttc
      961 aatcaagctc ggcagacgaa gtgcttcaat agtaaactgt tcttgtgcag catctgtttc
     1021 tgtgagaagc tgggtagtga ttgcatgtac ttcttggagt gcaagcatgt atactgcaaa
     1081 gcctgtctga aggattactt tgaaatccag atcaaagatg gtcaagttaa atgcctcaac
     1141 tgtccagagc cacagtgccc ttcagtggcg actcctggtc aggtcaaaga gctggtagaa
     1201 gcagacttgt ttgctcgcta tgaccgtctc ctcctgcagt ctaccttgga tctaatggca
     1261 gatgtggtgt attgtccccg tccatgctgc cagctccctg tgatgcaaga gcctggtggt
     1321 accatggcta tctgctccag ctgcaatttt gccttctgta ccttatgcag actgacctat
     1381 cacgggcttt ctccatgtaa ggtaactgca gagaaattaa tagacttacg aaatgaatac
     1441 ctacaagcag atgaagctac taagaggttc ttggaacaga ggtatggcaa gagggtgatt
     1501 cagaaggccc tggaggagat ggaaagtaaa gactggctgg agaagaactc caagagctgc
     1561 ccctgctgtg gcacacccat acagaaatta gacggctgca acaagatgac ttgcactggc
     1621 tgtatgcagt atttctgctg gatttgcatg ggttctctct ctcgagcaaa tccttacaga
     1681 catttcactg attctgagtc tccatgcttt aacaggttgt tccatgccgt ggatattaat
     1741 ggtgatatgt gggaagatga aattgaggag gacgacgatg atgaagacga cgacgacgac
     1801 tagttcattc cttctgctca caatatagaa gtggaatggt ttgccctgat cttctgtcaa
     1861 gtacacaaag agatcttgca ggatatttag gggccgtcta ttcactcttc cagtgtagaa
     1921 ggaagaacag ggttatattt tcctttggtt ctactgatta aggcacatac attttccatg
     1981 taacataatc tgataaaatt atatgccaaa ggatcagaaa tgaaaactat aggagattaa
     2041 atattataat atgcccaaac tgtgaatagt taaaaagtaa atatttattt tctcccccaa
     2101 gctttaggtt agggagaggg tcaagagttt agcttttaga ccatgtccaa gcagcctcac
     2161 gttgttggag cactctcagt tccatccctc agctggggac agtcacagcc ccagccacac
     2221 tgtcctggga gcctgatcca ttctctgtac actgctcact cccatccgtg ctgtggagga
     2281 gcctgtgctc tgtaactgac cagttgtccc agtgtcgttc tgttctagtg cttgccagaa
     2341 tagaagtcta tagtacatta aaagtatttt tagtgccaca atccttgtgg gtcacttgat
     2401 atttatgaat agtgtattga atccactgtt ttagagccaa atgtagaatt taggattctg
     2461 gctcagaatt cctccagata cagagtcaga gctgtgtctg ccccattgtg ttctcaactt
     2521 tctccctttg cctcccacct cttgtgggca aggacagttt taatgttgat cccagcagtg
     2581 tgtgtcttta tttcctcact agagtaggaa aaagcccagt gtattcctca tgaatgctct
     2641 ctaaacctgt gaagagcatc atggctctac cctgaccttc cgaaccctcg ggtcctctct
     2701 agtcacctac agcaactggg cttccttccc tcccttcccc tcccctcgta aacagcagtg
     2761 tctcgagtga taatagtagc ttgatagctg gattcctaat tctgagtttt attggctttt
     2821 tgaaaaactg tcttcttcat gattcggtaa gtggcttggt agttacttgg tggatgtttt
     2881 gaagggacag taattcacct gtagcttgtg aacatgtgtt ttctactttg acactgaaaa
     2941 ttaaggaatt gcttaactgt cagctcagac tgcttctgga ttgtcaatga ggatgcttaa
     3001 tctgaacaat aaagtaattt aagatcatcc tgtaattgaa aaaaaaaaaa aaaaaa
//
