LOCUS       NM_175226               4348 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ring finger protein 139 (Rnf139), mRNA.
ACCESSION   NM_175226
VERSION     NM_175226.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4348)
  AUTHORS   Chang,P.C., Tsai,H.W., Chiang,M.T., Huang,P.L., Shyue,S.K. and
            Chau,L.Y.
  TITLE     TRC8 downregulation contributes to the development of non-alcoholic
            steatohepatitis by exacerbating hepatic endoplasmic reticulum
            stress
  JOURNAL   Biochim Biophys Acta 1852 (11), 2339-2351 (2015)
   PUBMED   26319415
REFERENCE   2  (bases 1 to 4348)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ180442.1, AK033506.1 and AK029069.1.
            
            On Oct 22, 2009 this sequence version replaced NM_175226.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029069.1, AK033506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                CJ180442.1         236-304
            70-2512             AK033506.1         4-2446
            2513-4348           AK029069.1         2516-4351
FEATURES             Location/Qualifiers
     source          1..4348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 25.09 cM"
     gene            1..4348
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /note="ring finger protein 139"
                     /db_xref="GeneID:75841"
                     /db_xref="MGI:MGI:1923091"
     exon            1..266
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2092
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /EC_number="2.3.2.27"
                     /note="translocation in renal carcinoma on chromosome 8
                     protein; RING-type E3 ubiquitin transferase RNF139"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF139"
                     /protein_id="NP_780435.1"
                     /db_xref="CCDS:CCDS27494.1"
                     /db_xref="GeneID:75841"
                     /db_xref="MGI:MGI:1923091"
                     /translation="MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDS
                     SQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALH
                     IDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNIL
                     VPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRI
                     YGLQLLMEDTWKRIRFPDILRVFWLTRITAQATVLMYILRMANETESFFISWDDFWDV
                     ICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFIL
                     ALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPV
                     LFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYY
                     NVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNI
                     YLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHY
                     FHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDA
                     AGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD"
     exon            267..4348
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2343
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /note="major polyA site"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2904
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3536
                     /gene="Rnf139"
                     /gene_synonym="4930555P18Rik"
ORIGIN      
        1 ggcgcccgcc ccggccgcgg ccccgggcct cccccgcgcc gccctgcctg gcccggcccg
       61 cccagccccg gtgtggcagc ggctcatggc ggcggtgggg cccccgcagc agcaggtgcg
      121 gatggcccag cagcaggtct gggcggcgct cgaagtggcg ctccgggtgc cctgcctcta
      181 catcatcgac gccatcttca actcctacta cgattccagc caaagccggt tctgcatcgg
      241 gcttcagatc tttctccggc tccttggtat agttgtatcc agtattgttc tgatcttgtc
      301 acagcgatca cttttcaagt tttacatgta cagctcagcc tttctattag ctgcaacttc
      361 agtgttggtg aattactatg ctgctttgca cattgacttc tatggtgcct acaacacgtc
      421 agcgtttgga atcgagttgc ttcctcggaa agggccctca ctgtggatgg cactcatcgt
      481 tctgcagcta acctttggaa ttggatatgt cacattactg cagattcagt ccatctattc
      541 acagttaatg attttaaata tcttggttcc tataattggc ttaatcacag agctgccatt
      601 acacatcaga gagacagtag tgctcatgtc gtccttgatt ctcatattta acacagtgct
      661 tgtcttggca gtgaaactta agtggtttta ctactctact cggtatgtgt acttgttagt
      721 gaggcatatg taccgaattt atggattaca gttactgatg gaggacacat ggaagaggat
      781 tcgtttccca gacatacttc gggtcttctg gctaacaaga attacagctc aggctacagt
      841 gttaatgtac attttaagga tggcaaatga aactgagtcc ttctttattt cttgggatga
      901 tttctgggac gtcatttgca atctaataat tagtgggtgt gattctacac taactgtact
      961 aggcatgagt gctgtaattt cttcaatagc ccattatttg ggccttggaa tattggcctt
     1021 tattggatca actgaagaag atgacaggcg gcttggcttt gtagctcctg ttttattttt
     1081 cattttggct cttcagactg gtttaagtgg gctaagacct gaagagagac ttattcgctt
     1141 aagtagaaac atgtgccttt tattaactgc agtcctgcat ttcatccatg ggatgacaga
     1201 ccctgtatta atgtcgctca gtgcctccca tgtgtcatct ttccatagac actttcctgt
     1261 gctgtttgtc tctgcttgcc tgttcattct ccctgtctta ctcagttatg tcctttggca
     1321 tcactatgca ctaaatacat ggctgtttgc agttacagcc ttttgtgtgg aactctgctt
     1381 gaaggtaatc gtctccctca ctgtctacac gctgttcatg attgatggct actataacgt
     1441 cctctgggaa aagcttgatg actatgtcta ctttgttcgc tccacgggca atattatcga
     1501 atttatattt ggagtagtaa tgtttgggaa tggggcctat accatgatgt ttgagtcagg
     1561 aagtaaaatt cgggcttgta tgatgtgcct acatgcatat tttaacatct acttacaagt
     1621 aaaaaatggc tggaagacat tcatgaatcg tagaactgct gttaagaaaa ttaattcact
     1681 tcctgagata aaagggagcc acttgcaaga aatagatgat gtctgtgcaa tctgctatca
     1741 tgagttcaca acatctgctc gtataacacc gtgtaaccat tatttccatg cactctgcct
     1801 tcggaaatgg ctgtacattc aagatacttg tccaatgtgc catcagaaag tgtacatcga
     1861 agatgagatc aaggataact caaatgcatc taacaacaac ggatttattg cacccaatga
     1921 aaatccaaac ccagaggagg ctttaagaga ggatgctgct ggatctgacc gagaactgaa
     1981 cgaggatgac agtacagact gtgatgatga tgctcaaaga gaaagaaacg gggggattca
     2041 gcacacaggc gcagcagcag cagccgcaga atttaatgat gacactgatt aaagtagcat
     2101 ttactaatca ttgaggtatt tgtttaaaat tcagttcatc caaaatggag taatatgctt
     2161 cacgtcagtg tgtaaccaag cacaaaaaca gtatggatgt tgaaactgtg aatgctttcc
     2221 gtttactgtg atgtgctact gtaaatatac ctctttaatt acttctggtc tctttggtga
     2281 cctgtttaaa tttgtgtaca ttattgtaca tagaataaaa gttttcacgt ttttatgaca
     2341 aaatttgaac aaatagcttc ttaatagaga taatgatcat atggtgcgtc aattgtgcca
     2401 aagattcctc catgaaattg gaatatatct aatgctggac tctagctttt ccttaaaatg
     2461 agtgggaaaa tgaaaatgca gaataaagga actttagtat aagagacgag aagaaaaata
     2521 atcttgagta gaaaggctat aaaatgtctt ctaaaactaa ggcaagataa cctgctagaa
     2581 gcaactaaaa aacttgaaac ctgagctgca gcttagagct aggttcaaaa gtcaaaaaac
     2641 agggacagaa ttgagaaata ggcttgttat caactaaact ttgatataat ccaggatgtg
     2701 ctgtctaagt cttagtagaa gcatcactgt gtttgcagtg agagcataaa actgtccttt
     2761 cagacttctg atgagattac acaataaaaa ggtggacatt gttaactaaa gcagcctaaa
     2821 cagtgctgac ctgactcttc gaggtgtaat gtacagtgct actggaaaaa attcctcaat
     2881 aaagttcaca gttttacaat gaaattccac atcataaaaa ggaaacacaa atcaggaaaa
     2941 aaacacttta atggtgttgt tatagagcgt gttggccaat tccagtgggt cttcttctct
     3001 gactgctgac attatctcca atatttgact aaaacaaaaa acaagggatc aacttactca
     3061 gaatatattg ttagaggtat gtaatcacct ttttctatgt aaacatgaga agatcttaca
     3121 ctagcacctc ttctaaggaa gtttatgagt tactaaagtt gtcagtaatg tctgtaggaa
     3181 agcatcacca attactgtca actagaagac tctggagcta actggaatat aaagttacag
     3241 ggtcacgtaa gggcaccact aatggaatta tcctataggg gaggcgtcct ttaaaactct
     3301 aggtcctagc acttttgttc ccggatcatg agcatcttaa aagtaaaatg aagtctgcac
     3361 agtaaaacag gctaagtagg caccttccta ctttggattt agtttttttt tttatatttg
     3421 ttttactatt actagtataa ctattttata tttataaata aaatatatat gcgtatgtat
     3481 atatatattt atatgtaata tgaataaaat ggtattgaag agaatagggc caaaaatttg
     3541 aaaggcactg cttattcata tagtctctaa caggcagcaa ggaatgtttg tgtgcatgct
     3601 aaatccttga caagtggact ggagagatgg ctcagcagtt aagagcactg actggtattc
     3661 cagaggtcct gagttcaaat cccagcaacc acatggtggt tcacaaccat ctgtaatgag
     3721 atctcttgca ctctgctggg tgtcttaaaa cagctacagt gtactcacat gcattaaata
     3781 aaacaaacaa atatgacagg ttaggtgtgg ctgtgggagg ggctctaggc ttgtacttag
     3841 agcagagaga agagctcaga gactcatttc tttgctcaaa atgagcagtg ggttcctagt
     3901 aatactatct gtttttatat atgcattagg ttatatacag gttgtagttc gaattaaacc
     3961 tttaaatatt cctggtcacg agctttttct cccattctga ggaccctaag tgtgaacact
     4021 caaaagaact aggaatgagg atttacagtt agctggacct ttacaggttg tggtcagcgt
     4081 gacacagaca ttcacatgca gtctgtgcag tgaactcaga ctgcatctgt aagtagtgct
     4141 gctgctggcg gacggtggcc aagggcacgg ctgctctgct gagacttggg cagcagagcc
     4201 atttactgct catgtttgtt aacgtcaccg gtgcttggta aagcactgtt tagtaagcca
     4261 gtaagccagc aacctgaaca gtaccttttt attcagtgca tttttctgta ctttgaggaa
     4321 taaagctgca gttattttta agaatagc
//
