LOCUS       NM_028019               1964 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ring finger protein 135 (Rnf135), transcript variant
            1, mRNA.
ACCESSION   NM_028019
VERSION     NM_028019.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Iwamoto,A., Tsukamoto,H., Nakayama,H. and Oshiumi,H.
  TITLE     E3 Ubiquitin Ligase Riplet Is Expressed in T Cells and Suppresses T
            Cell-Mediated Antitumor Immune Responses
  JOURNAL   J Immunol 208 (8), 2067-2076 (2022)
   PUBMED   35365564
  REMARK    GeneRIF: E3 Ubiquitin Ligase Riplet Is Expressed in T Cells and
            Suppresses T Cell-Mediated Antitumor Immune Responses.
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Hayman,T.J., Hsu,A.C., Kolesnik,T.B., Dagley,L.F., Willemsen,J.,
            Tate,M.D., Baker,P.J., Kershaw,N.J., Kedzierski,L., Webb,A.I.,
            Wark,P.A., Kedzierska,K., Masters,S.L., Belz,G.T., Binder,M.,
            Hansbro,P.M., Nicola,N.A. and Nicholson,S.E.
  TITLE     RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent
            antiviral responses
  JOURNAL   Immunol Cell Biol 97 (9), 840-852 (2019)
   PUBMED   31335993
  REMARK    GeneRIF: Riplet, and not TRIM25, is required endogenously for the
            ubiquitination of RIG-I.
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Cadena,C., Ahmad,S., Xavier,A., Willemsen,J., Park,S., Park,J.W.,
            Oh,S.W., Fujita,T., Hou,F., Binder,M. and Hur,S.
  TITLE     Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in
            Innate Immunity
  JOURNAL   Cell 177 (5), 1187-1200 (2019)
   PUBMED   31006531
  REMARK    GeneRIF: Ubiquitin-Dependent and -Independent Roles of E3 Ligase
            RIPLET in Innate Immunity.
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Shi,Y., Yuan,B., Zhu,W., Zhang,R., Li,L., Hao,X., Chen,S. and
            Hou,F.
  TITLE     Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation
            in antiviral innate immunity
  JOURNAL   Nat Commun 8, 15138 (2017)
   PUBMED   28469175
  REMARK    GeneRIF: Together with Riplet, Ube2D3 promotes covalent conjugation
            of polyubiquitin chains to RIG-I, while Ube2N preferentially
            facilitates production of unanchored chains. In the presence of
            these chains, RIG-I induces MAVS aggregation directly on the
            mitochondria. Data thus reveal two essential mechanisms underlying
            the activation of RIG-I and MAVS for triggering innate immune
            signaling in response to viral infection in cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Oshiumi,H., Miyashita,M., Matsumoto,M. and Seya,T.
  TITLE     A distinct role of Riplet-mediated K63-Linked polyubiquitination of
            the RIG-I repressor domain in human antiviral innate immune
            responses
  JOURNAL   PLoS Pathog 9 (8), e1003533 (2013)
   PUBMED   23950712
  REMARK    GeneRIF: Riplet-mediated K63-linked polyubiquitination released
            RIG-I RD autorepression, which allowed the access of positive
            factors to the RIG-I protein.
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Oshiumi,H., Miyashita,M., Inoue,N., Okabe,M., Matsumoto,M. and
            Seya,T.
  TITLE     The ubiquitin ligase Riplet is essential for RIG-I-dependent innate
            immune responses to RNA virus infection
  JOURNAL   Cell Host Microbe 8 (6), 496-509 (2010)
   PUBMED   21147464
  REMARK    GeneRIF: Riplet is essential for regulating RIG-I-mediated innate
            immune response against RNA virus infection in vivo.
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   9  (bases 1 to 1964)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
REFERENCE   10 (bases 1 to 1964)
  AUTHORS   Min,S.H., Simmen,R.C., Alhonen,L., Halmekyto,M., Porter,C.W.,
            Janne,J. and Simmen,F.A.
  TITLE     Altered levels of growth-related and novel gene transcripts in
            reproductive and other tissues of female mice overexpressing
            spermidine/spermine N1-acetyltransferase (SSAT)
  JOURNAL   J Biol Chem 277 (5), 3647-3657 (2002)
   PUBMED   11709547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591426.17.
            
            On Jul 4, 2018 this sequence version replaced NM_028019.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010429.1, AK152096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL591426.17        2796-3182
            388-531             AL591426.17        8151-8294
            532-694             AL591426.17        12813-12975
            695-769             AL591426.17        15800-15874
            770-1964            AL591426.17        17488-18682
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.59 cM"
     gene            1..1964
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /note="ring finger protein 135"
                     /db_xref="GeneID:71956"
                     /db_xref="MGI:MGI:1919206"
     exon            1..387
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1302
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF135"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF135"
                     /protein_id="NP_082295.1"
                     /db_xref="CCDS:CCDS25129.1"
                     /db_xref="GeneID:71956"
                     /db_xref="MGI:MGI:1919206"
                     /translation="MAAVCSGNAVPVWLSEDDLSCIICQGLLDQPTTLPCGHSFCLRC
                     LHDLWVSKRGAVDGCPWACPICRKGPLTKPKLHKNPLLQDLVDKYLQAAREVEAGSEP
                     EPAPAPRSAPQVTVQKSTTNVIQELTDMVRQLVDDVKSLQTQRPNLGSGQDNAQGTPP
                     TDSSSEGEHSLDSPKLVTFSISQKKIQEILHNLEEIQEKLQGSVPGRAPPRERVQEMT
                     SSLCLLPDQRRPAPRKASHLSLWAISPTFDLRTLSYNLEVSNNSRRVTVSRGDLHTYH
                     WSPQRFSISQVFCSQALSSGQKYWEVDTRNCSHWAIGVASWGMKRDGMLGRTMDSWCI
                     EWRGPGQFSAWAKMKKTDLQSDLPEVVGVWLDLESGELAFYAVADHERLLYECEVSSS
                     SPLHPAFWLYGLSPGNYLEIKQLNT"
     exon            388..531
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /inference="alignment:Splign:2.1.0"
     exon            532..694
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /inference="alignment:Splign:2.1.0"
     exon            695..769
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1964
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /note="hexamer: AATAAA"
     polyA_site      1963
                     /gene="Rnf135"
                     /gene_synonym="0610037N03Rik; 2410006N06Rik; Riplet; U
                     2-3-0"
                     /note="major polyA site"
ORIGIN      
        1 agtaggacaa ggcggaacct aagggtgctt cctggctgtc gcctaattat ggcggccgtt
       61 tgttctggca atgcagtccc cgtgtggctg agcgaggacg acctgagctg cattatctgc
      121 caagggctac tagaccagcc caccacgctg ccctgtggcc acagcttctg tctccggtgc
      181 ctccatgacc tgtgggtctc gaagcgtggg gccgtggatg gctgcccttg ggcttgcccc
      241 atatgtcgga agggtccctt gacaaagccc aagctgcaca agaacccgct gctgcaagac
      301 ctggtggaca agtacctcca agcggcgcgg gaggtcgagg ctggctcgga gcctgaaccc
      361 gcccccgcgc cgcgttctgc gccccaggtg acagtacaga aaagtaccac aaacgttatc
      421 caggagctga ctgacatggt gagacagctt gtagacgatg tcaagagcct tcaaacgcaa
      481 agacccaact tgggatctgg acaggacaat gcacaaggca ccccacccac ggattcttcc
      541 tctgaggggg aacattcctt ggattctcca aagctggtga ccttcagtat atctcagaag
      601 aaaattcagg agattctcca taacctggaa gaaattcagg agaaactgca agggagtgtc
      661 ccagggagag cgccccctag agagcgagtt caggaaatga catcttcctt gtgcctgctg
      721 cctgaccaga ggcgtcctgc acccaggaaa gcttctcact tgtccctgtg ggccatcagt
      781 ccaacctttg acctgaggac cctctcctat aacctggagg tttccaacaa tagccggaga
      841 gtgactgtgt ctcgtggtga tctgcacacc tatcactgga gtccccagag attttcaatt
      901 agccaggtct tttgttctca ggccctctct tctggacaga agtactggga agtggacact
      961 aggaactgta gccactgggc catcggggta gcttcttggg gcatgaagcg ggacgggatg
     1021 ctgggaagga ctatggactc ctggtgtata gagtggagag ggcctggcca gttctctgct
     1081 tgggccaaga tgaagaaaac agacttgcag tcggacctcc ctgaggttgt gggcgtgtgg
     1141 ctggacctgg agtcggggga gcttgccttc tacgcagtgg ccgatcacga gaggctcctg
     1201 tatgagtgtg aggtctctag ctcctctcct ctgcatcccg ccttctggct gtatggctta
     1261 agtcctggaa actacctgga aataaagcag ctaaacacat gagcttccct cggggttagg
     1321 acagtggctt cttagcctct ttgtttaggg gccactggag aattccactt agggagactg
     1381 gatatagtag tgcataccta taactccagc acttgggacg tggaggtagg tggatcactg
     1441 caagtttgag gctagcatgg tcaataaaga tagttcaagg ccagcttgga ctatatgata
     1501 tgactgccca attttaaagt tattcttttt gggagtgaga caggattaac taaacaagtt
     1561 tgtgtttttt aaaccttggg catttcagag aaagagctgg tctggagtgt ctcctcacag
     1621 tgacctctga ggcctcagaa tagcctgcct aataagaagg acttcgaacc attccctatg
     1681 gcctcatctg ggactgttgg tttagtaagc ctgtggtcaa caagtcacac ctacatgact
     1741 gaccccccac ccccagttaa aagtctagcc caacagtata gctgggtgaa catctctagc
     1801 tagcatatgc tatatatgtc ctcacatacc tctgctggaa ggacagagcg ctgtcttatg
     1861 actggtaaga gggagtgctc ctggaccctg ctcgtgtgcc tttttctact gttcatttta
     1921 ttctgtggcc tttcagtgta ataaactgaa atcatgactt tcac
//
