LOCUS       NM_021540               1542 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ring finger protein 130 (Rnf130), transcript variant
            1, mRNA.
ACCESSION   NM_021540 XM_909426
VERSION     NM_021540.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Hao,S., Zhang,S., Ye,J., Chen,L., Wang,Y., Pei,S., Zhu,Q., Xu,J.,
            Tao,Y., Zhou,N., Yin,H., Duan,C.W., Mao,C., Zheng,M. and Xiao,Y.
  TITLE     Goliath induces inflammation in obese mice by linking fatty acid
            beta-oxidation to glycolysis
  JOURNAL   EMBO Rep 24 (4), e56932 (2023)
   PUBMED   36862324
  REMARK    GeneRIF: Goliath induces inflammation in obese mice by linking
            fatty acid beta-oxidation to glycolysis.
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Zhang,J., Chen,W., Du,J., Chu,L., Zhou,Z., Zhong,W., Liu,D.,
            Huang,H., Huang,Y., Qiao,Y., Meng,X., Zou,F., Cai,S. and Dong,H.
  TITLE     RNF130 protects against pulmonary fibrosis through suppressing
            aerobic glycolysis by mediating c-myc ubiquitination
  JOURNAL   Int Immunopharmacol 117, 109985 (2023)
   PUBMED   36893517
  REMARK    GeneRIF: RNF130 protects against pulmonary fibrosis through
            suppressing aerobic glycolysis by mediating c-myc ubiquitination.
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Clifford,B.L., Jarrett,K.E., Cheng,J., Cheng,A., Seldin,M.,
            Morand,P., Lee,R., Chen,M., Baldan,A., de Aguiar Vallim,T.Q. and
            Tarling,E.J.
  TITLE     RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol
            Levels
  JOURNAL   Circ Res 132 (7), 849-863 (2023)
   PUBMED   36876496
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Sebastiani,G., Krzywkowski,P., Dudal,S., Yu,M., Paquette,J.,
            Malo,D., Gervais,F. and Tremblay,P.
  TITLE     Mapping genetic modulators of amyloid plaque deposition in TgCRND8
            transgenic mice
  JOURNAL   Hum Mol Genet 15 (15), 2313-2323 (2006)
   PUBMED   16785251
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Borchers,A.G., Hufton,A.L., Eldridge,A.G., Jackson,P.K.,
            Harland,R.M. and Baker,J.C.
  TITLE     The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus
            development
  JOURNAL   Dev Biol 251 (2), 395-408 (2002)
   PUBMED   12435366
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Baker,S.J. and Reddy,E.P.
  TITLE     Cloning of murine G1RP, a novel gene related to Drosophila
            melanogaster g1
  JOURNAL   Gene 248 (1-2), 33-40 (2000)
   PUBMED   10806348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645913.12, BC048901.1 and AI852677.1.
            
            On Apr 18, 2014 this sequence version replaced NM_021540.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018199.1, AF171875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL645913.12        111525-111541
            18-1496             BC048901.1         1-1479
            1497-1542           AI852677.1         1-46                c
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.16 cM"
     gene            1..1542
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /note="ring finger protein 130"
                     /db_xref="GeneID:59044"
                     /db_xref="MGI:MGI:1891717"
     exon            1..317
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1330
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; goliath homolog; E3 ubiquitin-protein ligase
                     RNF130; g1-related zinc finger protein; RING-type E3
                     ubiquitin transferase RNF130"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF130 isoform 1
                     precursor"
                     /protein_id="NP_067515.2"
                     /db_xref="CCDS:CCDS24626.1"
                     /db_xref="GeneID:59044"
                     /db_xref="MGI:MGI:1891717"
                     /translation="MSGAARAGPARLAALALLTCSLWPTRADNASQEYYTALINVTVQ
                     EPGRGTPLTFRIDRGRYGLDSPKAEVRGQVLAPLPIHGVADHLGCDPQTRFFVPPNIK
                     QWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITEL
                     RGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFI
                     QKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDV
                     VRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNLPCTDNVAFDMERLTRT
                     QAVNRRAALGDLAGDSSLGLEPLRTSGISPLPQDGELTPRTGEINIAVTKEWFIIASF
                     GLLSALTLCYMIIRATASLNANEVEWF"
     exon            318..512
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            513..763
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            764..835
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            836..918
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1015
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1220
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1314
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1525
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1490..1495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /note="hexamer: AATAAA"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /note="hexamer: AATAAA"
     polyA_site      1501
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /note="major polyA site"
     polyA_site      1519
                     /gene="Rnf130"
                     /gene_synonym="2510042A13Rik; G1rp; G1RZFP; GOLIATH; GP"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcctc tcagcaccgg ccccggagcc cggtccgcga gcggcggcgg cggcggcggc
       61 cggagggacc atgagcggcg cggcgcgagc gggcccggcc cggctcgcgg cgctggccct
      121 gctgacttgc agcctgtggc cgacgcgagc ggacaacgcg agccaggagt actacacggc
      181 gctcatcaac gtgacggtgc aggagcccgg ccgcggcacc ccgctcacgt tccgcatcga
      241 ccgcgggcgc tacgggctcg actcacccaa ggccgaggtc cgcggccagg tgctggcacc
      301 gctgcccatc cacggagttg ctgatcatct gggctgtgat cctcaaacac ggttctttgt
      361 ccctcctaat atcaaacagt ggatcgcctt gctacaaaga ggaaattgca cctttaaaga
      421 gaaaatatca cgggctgctt ttcacaatgc ggttgctgta gtcatctaca ataataaatc
      481 caaagaggag ccggtcacca tgactcatcc aggcacggga gatattattg ctgtcatgat
      541 aacagaattg aggggtaagg atattttgag ttatctggag aaaaacatct ctgtacaaat
      601 gacaatagct gttggaactc gaatgccgcc aaagaacttc agccgtggct ctctagtctt
      661 cgtgtcaatc tcctttattg ttttgatgat tatttcttca gcgtggctca tattctactt
      721 cattcagaag atcaggtaca caaatgctcg ggacaggaac cagcgtcgtc ttggagacgc
      781 agccaagaaa gccatcagta aattgacaac tagaacggtg aaaaagggcg ataaggaaac
      841 agacccagac ttcgatcact gtgcagtctg catagaaagc tataagcaga atgatgttgt
      901 tcgggttctc ccctgcaagc atgttttcca caaatcctgt gtggatccct ggctcagtga
      961 acactgtacc tgtcctatgt gcaaacttaa tattttgaaa gccctaggaa ttgtgccaaa
     1021 tctgccatgt actgataatg tagcctttga tatggaaagg ctgaccagaa cccaagcggt
     1081 taaccggaga gcagcccttg gtgaccttgc cggtgacagt tcccttggcc ttgagccact
     1141 gagaacttcg gggatatcgc ctcttcctca agatggggag ctcactcctc gcacgggtga
     1201 aatcaacatt gcagtaacaa aagaatggtt tattattgcc agttttggcc tcctcagtgc
     1261 tctcacactc tgctacatga tcatcagagc cacagctagc ttgaatgcta atgaggtaga
     1321 atggttttga agaaggaaaa cactgctttc tgactgattg ccttgaagga aaaaagaacc
     1381 tatttttgtg catcatttac caatcatgcc acacaagcgt ttatttttag tacattttat
     1441 tttttcataa aattgctaat gccaaagctt tgtattaaaa taaataaata ataaaataaa
     1501 agtaccgtgt tgctaagtat ccttcaaaaa aaaaaaaaaa aa
//
