LOCUS       NM_001113413            2877 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus ring finger protein 13 (Rnf13), transcript variant 1,
            mRNA.
ACCESSION   NM_001113413
VERSION     NM_001113413.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Guo,S., Zhang,B.B., Gao,L., Yu,X.Y., Shen,J.H., Yang,F.,
            Zhang,W.C., Jin,Y.G., Li,G., Wang,Y.G., Han,Z.Y. and Liu,Y.
  TITLE     RNF13 protects against pathological cardiac hypertrophy through
            p62-NRF2 pathway
  JOURNAL   Free Radic Biol Med 209 (Pt 2), 252-264 (2023)
   PUBMED   37852547
  REMARK    GeneRIF: RNF13 protects against pathological cardiac hypertrophy
            through p62-NRF2 pathway.
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Lin,Z., Yang,P., Hu,Y., Xu,H., Duan,J., He,F., Dou,K. and Wang,L.
  TITLE     RING finger protein 13 protects against nonalcoholic
            steatohepatitis by targeting STING-relayed signaling pathways
  JOURNAL   Nat Commun 14 (1), 6635 (2023)
   PUBMED   37857628
  REMARK    GeneRIF: RING finger protein 13 protects against nonalcoholic
            steatohepatitis by targeting STING-relayed signaling pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Ji,M., Niu,S., Guo,J., Mi,H. and Jiang,P.
  TITLE     Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in
            Mouse Models by Regulating the Endoplasmic Reticulum
            Stress-Mediated IRE1alpha-TRAF2-ASK1-JNK Pathway
  JOURNAL   J Mol Neurosci 70 (12), 1977-1986 (2020)
   PUBMED   32617872
  REMARK    GeneRIF: Silencing RNF13 Alleviates Parkinson's Disease - Like
            Problems in Mouse Models by Regulating the Endoplasmic Reticulum
            Stress-Mediated IRE1alpha-TRAF2-ASK1-JNK Pathway.
            Erratum:[J Mol Neurosci. 2020 Nov 4;:. PMID: 33146809]
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Cheng,H., Wang,A., Meng,J., Zhang,Y. and Zhu,D.
  TITLE     Enhanced metastasis in RNF13 knockout mice is mediated by a
            reduction in GM-CSF levels
  JOURNAL   Protein Cell 6 (10), 746-756 (2015)
   PUBMED   26197965
  REMARK    GeneRIF: host RNF13 affects the concentration of GM-CSF in
            tumor-bearing lungs
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Arshad,M., Ye,Z., Gu,X., Wong,C.K., Liu,Y., Li,D., Zhou,L.,
            Zhang,Y., Bay,W.P., Yu,V.C. and Li,P.
  TITLE     RNF13, a RING finger protein, mediates endoplasmic reticulum
            stress-induced apoptosis through the inositol-requiring enzyme
            (IRE1alpha)/c-Jun NH2-terminal kinase pathway
  JOURNAL   J Biol Chem 288 (12), 8726-8736 (2013)
   PUBMED   23378536
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Zhang,Q., Li,Y., Zhang,L., Yang,N., Meng,J., Zuo,P., Zhang,Y.,
            Chen,J., Wang,L., Gao,X. and Zhu,D.
  TITLE     E3 ubiquitin ligase RNF13 involves spatial learning and assembly of
            the SNARE complex
  JOURNAL   Cell Mol Life Sci 70 (1), 153-165 (2013)
   PUBMED   22890573
  REMARK    GeneRIF: RNF13 is involved in the regulation of the SNARE complex,
            which thereby controls synaptic function.
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Jin,X., Cheng,H., Chen,J. and Zhu,D.
  TITLE     RNF13: an emerging RING finger ubiquitin ligase important in cell
            proliferation
  JOURNAL   FEBS J 278 (1), 78-84 (2011)
   PUBMED   21078127
  REMARK    Review article
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Bocock,J.P., Carmicle,S., Sircar,M. and Erickson,A.H.
  TITLE     Trafficking and proteolytic processing of RNF13, a model PA-TM-RING
            family endosomal membrane ubiquitin ligase
  JOURNAL   FEBS J 278 (1), 69-77 (2011)
   PUBMED   21078126
  REMARK    Review article
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   Bocock,J.P., Carmicle,S., Madamba,E. and Erickson,A.H.
  TITLE     Nuclear targeting of an endosomal E3 ubiquitin ligase
  JOURNAL   Traffic 11 (6), 756-766 (2010)
   PUBMED   20230530
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Bocock,J.P., Carmicle,S., Chhotani,S., Ruffolo,M.R., Chu,H. and
            Erickson,A.H.
  TITLE     The PA-TM-RING protein RING finger protein 13 is an endosomal
            integral membrane E3 ubiquitin ligase whose RING finger domain is
            released to the cytoplasm by proteolysis
  JOURNAL   FEBS J 276 (7), 1860-1877 (2009)
   PUBMED   19292867
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165888.18, AK140682.1 and
            AK158046.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_001113413.4.
            
            On Oct 19, 2017 this sequence version replaced NM_001113413.2.
            
            Summary: This gene encodes a member of the PA-TM-RING family of
            proteins that contain a protease associated (PA) domain and a RING
            finger domain separated by a transmembrane (TM) domain. The encoded
            protein is an E3 ubiquitin ligase localized to the
            endosomal-lysosomal vesicles and inner nuclear membrane. Mice
            lacking the encoded protein have impaired learning abilities
            associated with a decreased synaptic vesicle density and
            dysregulated SNARE complex assembly. Alternative splicing of this
            gene results in multiple transcript variants. A pseudogene for this
            gene has been identified on the X chromosome. [provided by RefSeq,
            Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140682.1, AK167278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC165888.18        142072-142085       c
            15-831              AK140682.1         2-818
            832-832             AK158046.1         805-805
            833-2634            AK140682.1         821-2622
            2635-2635           AC165888.18        42959-42959         c
            2636-2877           AK140682.1         2624-2865
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.04 cM"
     gene            1..2877
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /note="ring finger protein 13"
                     /db_xref="GeneID:24017"
                     /db_xref="MGI:MGI:1346341"
     exon            1..144
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            145..270
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1302
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /EC_number="2.3.2.27"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase RNF13; RING-type E3
                     ubiquitin transferase RNF13"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF13 isoform a
                     precursor"
                     /protein_id="NP_001106884.1"
                     /db_xref="CCDS:CCDS50913.1"
                     /db_xref="GeneID:24017"
                     /db_xref="MGI:MGI:1346341"
                     /translation="MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENA
                     SQTFEDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPLKDNSSGTFIVLIRRLDC
                     NFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDTLKKIDIPSVFIGESSANSLKD
                     EFTYEKGGHIILVPELSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRNRRNRL
                     RKDQLKKLPVHKFKKGDEYDVCAICLEEYEDGDKLRILPCSHAYHCKCVDPWLTKTKK
                     TCPVCKQKVVPSQGDSDSDTDSSQEENQVSEHTPLLPPSASARTQSFGSLSESHSHHN
                     MTESSDYEDDDNEETDSSDADNEITDHSVVVQLQPNGEQDYNIANTV"
     exon            271..351
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            352..477
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            478..565
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            566..656
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            657..762
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            763..856
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            857..937
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
     exon            938..2877
                     /gene="Rnf13"
                     /gene_synonym="2010001H16Rik; Rzf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgggac ttccgcttgc ccgctgttgt ggtcccttct ccgacttgct tgggtagggg
       61 ctcagtgcgg atactcagtc atgaagtccg ggtagcgact tctcttgggt ggccgtgagc
      121 ctaggttccg ggggcggact tcaggtgatt cacaagatgc tgctctccat tgggatgctc
      181 atgctgtccg ccacacaggt ctacaccatc ttgactgtgc agctctttgc attcctaaac
      241 ctgctgcctg tagaagcaga cattttagca tataattttg aaaatgcatc tcagacattt
      301 gaggaccttc cagcaagatt tggttataga ctaccagctg aaggcttaaa gggttttctg
      361 attaactcaa aaccagagaa tgcgtgtgaa cccatagtgc ctccaccact gaaagacaat
      421 tcttccggca cgttcatcgt gctgattaga agacttgatt gcaattttga tataaaggtt
      481 ttaaatgcac agagagcagg atacaaagca gccatagttc acaatgtaga ctctgatgac
      541 ctgattagca tgggatccaa cgacattgat acactaaaga aaattgacat tccgtctgtc
      601 tttattggtg aatcatcagc taattccctg aaagatgaat tcacatatga aaaagggggc
      661 cacattatct tagttccaga actgagtctt cctttggagt actatctgat ccccttcctc
      721 atcatagtgg gcatctgcct catcttaata gtcattttca tgatcacaaa atttgttcag
      781 gacagacata gaaacagaag aaatagactt cgtaaagatc aacttaaaaa acttcccgta
      841 cataaattta aaaagggaga tgagtacgat gtgtgtgcta tctgtctgga ggagtatgaa
      901 gacggagata agctaaggat cctcccctgc tcccatgctt atcattgcaa gtgtgtagat
      961 ccctggctaa ctaaaaccaa aaagacctgt ccagtctgca aacaaaaggt tgttccttcc
     1021 caaggtgact cggactctga cacagacagc agtcaggaag aaaaccaagt gtcagagcac
     1081 acccctttac ttccaccctc agcttctgcc aggacccagt catttgggtc tctgtcagaa
     1141 tcccactcac atcacaacat gacagagtct tcagactacg aggacgacga caatgaagag
     1201 accgacagca gtgacgcaga caacgaaatt accgaccaca gtgttgtggt ccagctgcag
     1261 ccgaacggtg agcaggatta caacatagca aatactgtgt gactttccgg tggttggttg
     1321 acttccctta taatgtttat ttgcgcatat gatttgattt tttgctcctt ttagaagttt
     1381 ctgtagaaat aacttatttt ttagttttct agtgtaatca agttcctgaa acaggctatt
     1441 tgatctctga tacttatctc caatagtata cagccacttc actaacaaag taacagattg
     1501 gtgctgtaac tcaggcatca aattagctct ctggggatga caaaatgtag ccaggacact
     1561 ttaaaaatcc tcagtatagc ttgaaatgaa gacctagatc acagtctgca aatgtcttac
     1621 acatgaagtc tgctatggtc atctagcatg agctaaaaca actctcactt tcataaaagt
     1681 tgcctagtgt ggttgggttg gtacaagtct cttctgatag tccctctatg ttatgattaa
     1741 tgagtggcaa caggcagttt aggatttttc ttcataatac cacagagaaa cttatgtctt
     1801 cttcctttct attcccaagt agtttttcct cataggaaag gtctagtgta gacttcaaat
     1861 actttaaggt tttcaaaacc actatagtgt tatgagtttg attccacggg aatgtctctg
     1921 gaccttactt tccatatttc agtatccttt tgtgttgtga ttttaaaaaa tgttgcataa
     1981 aaataccaaa tttcagcaac tgttaatatt gagatcacat acctcttcat aaagagcatc
     2041 ttatgctaat tagccctgct gaaccatgtg cagaggaaat tgttcaagta ttggatttga
     2101 aaataagtgc ttttgtttaa tagacctaat gtattgaggc aatgtattat gaaaagcaaa
     2161 attatataac tctgtaacta tgtagaaaat atacttaaat ataatcagaa tgctaagact
     2221 ttttatatgg ccttgtatga tgagagcttc aatgttaata aatgttttcc actttaaaag
     2281 ccaccaagta ttgttctggt gaactcttac attaacctta tatgcagggt gctataaagg
     2341 agaatgatgg agtcatacac caccttaaga tgtgatacaa ggttacttac taattactta
     2401 caagcagtca ggtttatcca ccaaagttag cactgtagcc aaaatcatct cctaaatagt
     2461 gtgaattagg gaatttggtt gtaaattgtg acacattctt tacagtagat gcatttagtg
     2521 acttagtgac gtggaaaatt gaataaaatc atgtagtaga ataagtatat cacttatatg
     2581 agcatttcat tatcttttta aaatgctgta ttttaagaga aatataacac taggaaaaga
     2641 aattttaatt ttgaattgtt tcttttaaaa atttatactc agattgtttc tttgttgagt
     2701 tttttgtttg tttgcttgtt tggtttgtca gttggtttgg ttcggtttat tgagccaagg
     2761 tttctctatg tagccctggc tgtcctggaa gtcattctga agaccaggct ggcctcaaac
     2821 tcaagaaatc ctcctgtgtc tgcctcctga gtgctgggat taaagacctg cactacc
//
