LOCUS       NM_023270               2764 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ring finger protein 128 (Rnf128), transcript variant
            1, mRNA.
ACCESSION   NM_023270 XM_003085298 XM_003086854
VERSION     NM_023270.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Yan,C., Kuang,W., Ma,G., Guo,F., Jin,L., Wan,H., Zhu,J., Liao,Y.,
            Tan,H. and Wang,L.
  TITLE     E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and
            type 2 immune response in the murine lung
  JOURNAL   Sci Rep 15 (1), 1193 (2025)
   PUBMED   39774991
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2764)
  AUTHORS   Chuang,K.F., Wang,C.H., Chen,H.K., Lin,Y.Y., Lin,C.H., Lin,Y.C.,
            Shih,C.P., Kuo,C.Y., Chen,Y.C. and Chen,H.C.
  TITLE     GRAIL gene knockout mice protect against aging-related and
            noise-induced hearing loss
  JOURNAL   J Chin Med Assoc 86 (12), 1101-1108 (2023)
   PUBMED   37820291
  REMARK    GeneRIF: GRAIL gene knockout mice protect against aging-related and
            noise-induced hearing loss.
REFERENCE   4  (bases 1 to 2764)
  AUTHORS   Liu,P.Y., Chen,C.Y., Lin,Y.L., Lin,C.M., Tsai,W.C., Tsai,Y.L.,
            Lin,G.J., Chen,Y.G., Wang,S.Y., Sun,R.N., Huang,Y.C., Chang,H. and
            Chen,Y.C.
  TITLE     RNF128 regulates neutrophil infiltration and myeloperoxidase
            functions to prevent acute lung injury
  JOURNAL   Cell Death Dis 14 (6), 369 (2023)
   PUBMED   37344492
  REMARK    GeneRIF: RNF128 regulates neutrophil infiltration and
            myeloperoxidase functions to prevent acute lung injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2764)
  AUTHORS   Fathman,C.G., Yip,L., Gomez-Martin,D., Yu,M., Seroogy,C.M.,
            Hurt,C.R., Lin,J.T., Jenks,J.A., Nadeau,K.C. and Soares,L.
  TITLE     How GRAIL controls Treg function to maintain self-tolerance
  JOURNAL   Front Immunol 13, 1046631 (2022)
   PUBMED   36569931
  REMARK    GeneRIF: How GRAIL controls Treg function to maintain
            self-tolerance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2764)
  AUTHORS   Heissmeyer,V., Macian,F., Im,S.H., Varma,R., Feske,S.,
            Venuprasad,K., Gu,H., Liu,Y.C., Dustin,M.L. and Rao,A.
  TITLE     Calcineurin imposes T cell unresponsiveness through targeted
            proteolysis of signaling proteins
  JOURNAL   Nat Immunol 5 (3), 255-265 (2004)
   PUBMED   14973438
REFERENCE   7  (bases 1 to 2764)
  AUTHORS   Anandasabapathy,N., Ford,G.S., Bloom,D., Holness,C., Paragas,V.,
            Seroogy,C., Skrenta,H., Hollenhorst,M., Fathman,C.G. and Soares,L.
  TITLE     GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene
            transcription is expressed in anergic CD4+ T cells
  JOURNAL   Immunity 18 (4), 535-547 (2003)
   PUBMED   12705856
REFERENCE   8  (bases 1 to 2764)
  AUTHORS   Tanaka,T.S., Kunath,T., Kimber,W.L., Jaradat,S.A., Stagg,C.A.,
            Usuda,M., Yokota,T., Niwa,H., Rossant,J. and Ko,M.S.
  TITLE     Gene expression profiling of embryo-derived stem cells reveals
            candidate genes associated with pluripotency and lineage
            specificity
  JOURNAL   Genome Res 12 (12), 1921-1928 (2002)
   PUBMED   12466296
REFERENCE   9  (bases 1 to 2764)
  AUTHORS   Borchers,A.G., Hufton,A.L., Eldridge,A.G., Jackson,P.K.,
            Harland,R.M. and Baker,J.C.
  TITLE     The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus
            development
  JOURNAL   Dev Biol 251 (2), 395-408 (2002)
   PUBMED   12435366
REFERENCE   10 (bases 1 to 2764)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018582.1, AK004847.1 and CK380647.1.
            
            On or before Dec 16, 2011 this sequence version replaced
            XM_003085298.1, XM_003086854.1, NM_023270.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041548.1, AK004847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1919              AK018582.1         3-1921
            1920-2740           AK004847.1         1921-2741
            2741-2764           CK380647.1         307-330
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..2764
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /note="ring finger protein 128"
                     /db_xref="GeneID:66889"
                     /db_xref="MGI:MGI:1914139"
     exon            1..670
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1473
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase RNF128; RING-type
                     E3 ubiquitin transferase RNF128; gene related to anergy in
                     lymphocytes protein; goliath-related E3 ubiquitin-protein
                     ligase 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF128 isoform 1
                     precursor"
                     /protein_id="NP_075759.3"
                     /db_xref="CCDS:CCDS30435.1"
                     /db_xref="GeneID:66889"
                     /db_xref="MGI:MGI:1914139"
                     /translation="MGPPPGIGVYCRGGCGAARLLAWCFLLALSPHAPGSRGAEAVWT
                     AYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVSGVLVPPDGPGALNACNPHTNF
                     TVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNFPGTRNEVIPMSH
                     PGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFII
                     TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDS
                     CAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDG
                     SVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANENLQLVN
                     HEANSVAVDVVPHVDNPTFEEDETPDQEAAVREIKS"
     exon            671..918
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..990
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1073
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1170
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1339
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..2750
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2596
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /note="major polyA site"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
                     /note="hexamer: AATAAA"
     polyA_site      2743
                     /gene="Rnf128"
                     /gene_synonym="1300002C13Rik; GRAIL; Greul1"
ORIGIN      
        1 agtcgcgagc gagcatccct agcgcttgct tgtaggagct gcgtctgcag tagcctggcc
       61 gctgacgctg cgtgccggct ggcagggcag cctgcgacct cgctggcccc gcgcccgctg
      121 ctagccgccg gctccccacc tggttcgcac ctagtcccag cccgggtcgc ctgccgagtg
      181 cgcgccatgg ggccgccgcc cgggatcggg gtctactgcc gcggcggctg cggagctgcc
      241 cggctactgg cttggtgctt ccttctggct ctgagtccgc acgcgcccgg ttcccgggga
      301 gccgaagccg tgtggaccgc gtacctcaac gtgtcctggc gggttccgca caccggagtg
      361 aaccgcacgg tgtgggagct gagcgaggag ggcgtgtacg gccaggactc gccgctggag
      421 cccgtctccg gggtcctggt accgcccgac gggcccgggg cgctcaacgc ctgtaacccg
      481 cacaccaatt tcacggtgcc cacggtttgg gggagcacgg tgcaagtatc ttggttggcc
      541 ctcatccaac gcggtggagg ctgcaccttc gcggacaaga tccatctggc ttcagagaga
      601 ggggcttctg gagcggtcat ctttaacttc cctgggaccc gcaatgaggt catccccatg
      661 tctcacccgg gtgctgggga cattgttgca atcatgattg gcaatctgaa aggaacaaaa
      721 attctgcagt ctattcaaag aggcatccaa gtcacaatgg tcatcgaagt agggaaaaaa
      781 catggccctt gggtgaatca ttattcaatt ttcttcgttt ctgtgtcctt tttcataatt
      841 acggcagcaa ccgtgggcta tttcatcttt tattctgctc gaagattacg aaatgcaaga
      901 gctcaaagca ggaagcagag gcagttaaag gcagatgcta aaaaagctat tggaaagctt
      961 cagctgcgca ccttgaaaca aggagacaag gaaattggcc ctgatggaga tagctgtgct
     1021 gtgtgcattg agctctataa gccaaatgat ttggtgcgca tcctaacctg caatcatatt
     1081 ttccataaga catgtgtgga cccgtggctt ttagaacaca ggacttgccc catgtgcaag
     1141 tgtgacattc tcaaagctct gggaattgag gtggatgttg aagatggatc agtgtcttta
     1201 caagttcctg tttctaatga agcatctaat actgcctctc cccatgaaga ggacagtcgc
     1261 agtgagactg catcatctgg atatgcttca gtacaaggag cagatgagcc acctctggag
     1321 gaacatgcgc agtcagcaaa tgaaaatcta cagctggtaa accatgaagc aaattctgtg
     1381 gccgtggatg ttgttcccca tgttgacaac ccaacctttg aagaagatga aactcctgat
     1441 caagaggcag ctgttcggga gattaaatct taaaaatctg tgtcaataga aaacttgaac
     1501 cgttagttaa caacaggact gccaatcagg gcctagttta ctatgaatga actgggtaaa
     1561 cgtaaaacaa gaatgatact gaaagtgctg aggtaactta tattatacta tagttaaatg
     1621 gcttaacata tttaccccag taccgttttc cacaaactca ccataacgtt tttcataggc
     1681 aagtttcctc ttggtgatag tgatagcaac atttttaaca ttcagaaccg tctatgagta
     1741 gtcaggtttt tcatttacaa caactttgtt ataaaaaaat atgttgcttt aaaagtgtgg
     1801 agtagctgta atcactttgt tttatgatag tatcataatt aaacaatact actactttag
     1861 cttgggctct gtgtgtcggg gtttgtctcc aggtgcttat attgatctgg aatttgttta
     1921 aaaaaaaaaa gaaaaaaaaa gcaatgcgaa cttaggcatt aagttgatag tacaagatta
     1981 aagcaaaata ttcattttaa ccttttcatt ttaaaattaa gctgtgtatg tatttcatgt
     2041 gagtgttgag catagtttgt cagaaaaata tgaactgaat tggttgatca gtatattagt
     2101 gacaccacac aagattatag acataaaaag tttcttacaa aaacattcta aactatttct
     2161 caagcttgat gttttcaaaa gcacaggata gaaactacca tcaaatttga aaatagtaat
     2221 agctgaacta aatcgtagaa cattggtaac tggttacggt gcagaattca tctgcagaga
     2281 atattctgta aaatgtgtca aatgtggaaa atagtttcca aacaatggtg actttgaaaa
     2341 ctgagtttac atttggcctt gtggtctcta attacatgaa atttaaattc tgtccatcta
     2401 tctataattt tgtgattgca tttgttggtg tttgaaaaag aatcaaggga aggggggatt
     2461 ccaggtgcct taataaaaag tttgaagctt caaccaccaa agttaaatag agctattgaa
     2521 aagacgcact ttatttctac tttgtgtggc ttgtgttttg ttcccagtgc aaattcccac
     2581 aggatttaga caaaaataga acagacgtgt atttttgttt gctgactata taatggatga
     2641 aaccattgca ctcttgtaca ctgatttgaa aatgctgtaa atatgctctg atttgtactg
     2701 attctcttta aatataaaat gtaaataaaa tattccaatg aaagattgta aaaaaaaaaa
     2761 aaaa
//
