LOCUS       NM_144528               1639 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ring finger protein 126 (Rnf126), transcript variant
            1, mRNA.
ACCESSION   NM_144528 XM_982649
VERSION     NM_144528.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Liu,W., Zheng,M., Zhang,R., Jiang,Q., Du,G., Wu,Y., Yang,C., Li,F.,
            Li,W., Wang,L., Wu,J., Shi,L., Li,W., Zhang,K., Zhou,Z., Liu,R.,
            Gao,Y., Huang,X., Fan,S., Zhi,X., Jiang,D. and Chen,C.
  TITLE     RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage
            Response and Confers Resistance of Triple-Negative Breast Cancer to
            Radiotherapy
  JOURNAL   Adv Sci (Weinh) 10 (5), e2203884 (2023)
   PUBMED   36563124
  REMARK    GeneRIF: RNF126-Mediated MRE11 Ubiquitination Activates the DNA
            Damage Response and Confers Resistance of Triple-Negative Breast
            Cancer to Radiotherapy.
            Erratum:[Adv Sci (Weinh). 2025 Jan 30:e2417701. doi:
            10.1002/advs.202417701.. PMID: 39888281]
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Smith,C.J. and McGlade,C.J.
  TITLE     The ubiquitin ligase RNF126 regulates the retrograde sorting of the
            cation-independent mannose 6-phosphate receptor
  JOURNAL   Exp Cell Res 320 (2), 219-232 (2014)
   PUBMED   24275455
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151828.3.
            
            On Aug 17, 2011 this sequence version replaced NM_144528.2.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes a functional protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154781.1, BC016543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC151828.3         175127-175326       c
            201-259             AC151828.3         171021-171079       c
            260-323             AC151828.3         170856-170919       c
            324-568             AC151828.3         170459-170703       c
            569-637             AC151828.3         169939-170007       c
            638-707             AC151828.3         169804-169873       c
            708-801             AC151828.3         169363-169456       c
            802-917             AC151828.3         169165-169280       c
            918-1639            AC151828.3         166889-167610       c
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1639
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /note="ring finger protein 126"
                     /db_xref="GeneID:70294"
                     /db_xref="MGI:MGI:1917544"
     exon            1..200
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1067
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF126"
                     /protein_id="NP_653111.1"
                     /db_xref="CCDS:CCDS23989.1"
                     /db_xref="GeneID:70294"
                     /db_xref="MGI:MGI:1917544"
                     /translation="MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEET
                     RNTENGSAPSTAPTDQNRQPFENVDQHLFTLPQGYSQFAFGIFDDSFEIPTFPPGAQA
                     DDGRDPESRREREHQSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIISP
                     AAVPSLGLGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADKEKIQALPTV
                     PVTEEHVGSGLECPVCKEDYALGESVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLT
                     GQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS"
     exon            201..259
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            260..323
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..568
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..637
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..707
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..801
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..917
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1639
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1388
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /note="major polyA site"
     regulatory      1592..1597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
                     /note="hexamer: AATACA"
     polyA_site      1615
                     /gene="Rnf126"
                     /gene_synonym="2610010O19Rik"
ORIGIN      
        1 gcctgccgtg cgtgccgtgc gtgccatgcg tgagcgtgcg cgggcgcgtc ggccggcgag
       61 ggagcagcaa acggccggcg gcaggcgccg cgcggggggc gggcggcgcg gaggcggcgg
      121 tggccatggc cgaggcgtcg ccgcagcccg gacggtactt ctgccactgc tgctcggtag
      181 agatcgtgcc gcgcctgccg gattacatct gcccaaggtg cgagtctggc ttcattgagg
      241 agcttccaga agagaccagg aacacagaga atggctcagc cccctccaca gcccccaccg
      301 accagaaccg gcagccattt gagaatgtgg accagcacct gttcacgctg ccacagggat
      361 acagccagtt tgcctttggc atcttcgacg atagctttga gattcccacg ttccctcctg
      421 gagcccaggc cgatgatggc agggaccctg agagccgacg ggagagagag caccagtctc
      481 ggcatcggta cggggcccgg cagccccgtg cccgcctcac tgcccgccgg gccactggcc
      541 ggcatgaagg tgtccctacg ctggaaggga tcatccagca gctcgtgaat ggcatcatct
      601 ctccggctgc tgtgcccagc ctgggccttg gtccctgggg cgtcctgcac tcgaacccaa
      661 tggactacgc ctggggggcc aacggcctgg acaccatcat cacgcagctc ctcaatcagt
      721 ttgagaacac cggcccccca cctgcagaca aggagaagat tcaggctctc cccacggtcc
      781 cagtcacaga ggaacacgtg ggctcagggc ttgagtgccc agtgtgtaaa gaagactatg
      841 cactgggtga gagtgtgcgg cagttgccct gcaaccacct gttccacgac agctgcatcg
      901 tgccctggct ggagcagcat gacagctgcc cggtctgccg taagagcctc actggacaga
      961 acacagccac caatccccca ggcttgaccg gtgtaggttt ctcctcgtcc tcgtcctcat
     1021 cctcctccag ctcgcccagc aatgagaacg ccacaagcaa ctcctgagtc ccacctggcc
     1081 atcccccccg gggtttggtc atcccaccca ccccaggtgc cccagcaccg cccgcctgcc
     1141 cgcccgccat ggctgtggac tagaggtgct gcccgtggcg gccggcagta cctggcgggc
     1201 cccaggctgc gggcaggctt ggacttggcc atggccgctc ctgtttggag gtgtgcacgt
     1261 gggtcccatg tccccagcag gcaggcacct tcagtccgtc ttaacctcac cctccaaatg
     1321 ttcaacggca gaagggtttt tatgatttta aattattact gctttgaaat aaatggacgt
     1381 ttgagccacg tgcggccatg catggtctgt ggagagtcag cagaactgtc gccaggccca
     1441 gcccgccaca cgccctggga ggccgggccc agcacccaac cagcgccggc ctcgggacca
     1501 caagggtgac cagcagaccc aggaacaaac tgctccagca gacaattttt tttttttaag
     1561 ggaaatgtgt gttatctgga aagctattta aaatacacct actcaaaaaa gcagagccca
     1621 tggcttggcg tcttccttc
//
