LOCUS       NM_001364973            5149 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus ring finger protein 125 (Rnf125), transcript variant
            2, mRNA.
ACCESSION   NM_001364973 XM_006526188
VERSION     NM_001364973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Chang,H., Hou,P., Wang,X., Xiang,A., Wu,H., Qi,W., Yang,R.,
            Wang,X., Li,X., He,W., Zhao,G., Sun,W., Wang,T., He,D.C., Wang,H.,
            Gao,Y. and He,H.
  TITLE     CD97 negatively regulates the innate immune response against RNA
            viruses by promoting RNF125-mediated RIG-I degradation
  JOURNAL   Cell Mol Immunol 20 (12), 1457-1471 (2023)
   PUBMED   37978243
  REMARK    GeneRIF: CD97 negatively regulates the innate immune response
            against RNA viruses by promoting RNF125-mediated RIG-I degradation.
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Jiang,C., He,L., Xiao,S., Wu,W., Zhao,Q. and Liu,F.
  TITLE     E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and
            Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression
  JOURNAL   Mol Biotechnol 65 (6), 891-903 (2023)
   PUBMED   36344734
  REMARK    GeneRIF: E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in
            Head and Neck Squamous Cell Carcinoma by Regulating PD-L1
            Expression.
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Pereira,M., Ko,J.H., Logan,J., Protheroe,H., Kim,K.B., Tan,A.L.M.,
            Croucher,P.I., Park,K.S., Rotival,M., Petretto,E., Bassett,J.D.,
            Williams,G.R. and Behmoaras,J.
  TITLE     A trans-eQTL network regulates osteoclast multinucleation and bone
            mass
  JOURNAL   Elife 9, e55549 (2020)
   PUBMED   32553114
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Tang,J., Tu,S., Lin,G., Guo,H., Yan,C., Liu,Q., Huang,L., Tang,N.,
            Xiao,Y., Pope,R.M., Rajaram,M.V.S., Amer,A.O., Ahmer,B.M.,
            Gunn,J.S., Wozniak,D.J., Tao,L., Coppola,V., Zhang,L.,
            Langdon,W.Y., Torrelles,J.B., Lipkowitz,S. and Zhang,J.
  TITLE     Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits
            inflammasome activation and endotoxemia
  JOURNAL   J Exp Med 217 (4) (2020)
   PUBMED   31999304
  REMARK    GeneRIF: Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b
            limits inflammasome activation and endotoxemia.
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Jia,X., Zhou,H., Wu,C., Wu,Q., Ma,S., Wei,C., Cao,Y., Song,J.,
            Zhong,H., Zhou,Z. and Wang,J.
  TITLE     The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein
            TRIM14 for Ubiquitination and Degradation
  JOURNAL   J Immunol 198 (12), 4652-4658 (2017)
   PUBMED   28476934
  REMARK    GeneRIF: study identifies new gene-type zinc finger protein 125
            (RNF125) as a negative regulator of TRIM14 in the innate antiviral
            immune response
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Zhu,B., Ye,J., Nie,Y., Ashraf,U., Zohaib,A., Duan,X., Fu,Z.F.,
            Song,Y., Chen,H. and Cao,S.
  TITLE     MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated
            Inflammation via Targeting RNF125
  JOURNAL   J Immunol 195 (5), 2251-2262 (2015)
   PUBMED   26202983
  REMARK    GeneRIF: Data indicate that brain from Japanese encephalitis virus
            (JEV)-infection showed a reciprocal correlation between microRNA
            miR-15b levels and the expression of ring finger protein 125
            (RNF125).
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Arimoto,K., Takahashi,H., Hishiki,T., Konishi,H., Fujita,T. and
            Shimotohno,K.
  TITLE     Negative regulation of the RIG-I signaling by the ubiquitin ligase
            RNF125
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7500-7505 (2007)
   PUBMED   17460044
  REMARK    GeneRIF: RNF125 is enhanced by IFN, these functions constitute a
            negative regulatory loop circuit for IFN production
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099954.1, AC138611.4, AK016103.1, AK050462.1 and BF148133.1.
            
            On Jul 18, 2018 this sequence version replaced XM_006526188.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016103.1, ERR3363660.169390.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               BY099954.1         51-324
            275-347             AC138611.4         164773-164845       c
            348-1512            AK016103.1         241-1405
            1513-3410           AC138611.4         140863-142760       c
            3411-5044           AK050462.1         1-1634
            5045-5149           BF148133.1         5-109               c
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18"
     gene            1..5149
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="ring finger protein 125"
                     /db_xref="GeneID:67664"
                     /db_xref="MGI:MGI:1914914"
     exon            1..437
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            438..594
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..689
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..780
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..888
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..5149
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1365..1370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1386
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="major polyA site"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="hexamer: AATATA"
     polyA_site      1516
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="major polyA site"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5149
                     /gene="Rnf125"
                     /gene_synonym="4930553F04Rik; C730049O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaactctga gtgcggactc cgagtggagg gttcaggttt caccctccgg ggacctcgag
       61 cctctgcagt gccttgtctc tcgcggaaga gcgtttgtaa gcggcggccg cgcgctccgc
      121 ctgcgctcca ccgagaggcc ccgcggcgcg gctggccgag ccaggaggcg gcgatccggc
      181 ctgggccggg acttccttcc tcccgggcgg gacaacagaa ccacccgcag ccagcaggga
      241 gctcctggca gctcgctgag ctagagcgca gcgatgggct ccctgctgag cagcgacagc
      301 tccaagtccg cgcccgcctc cgccaccccg cggactctgg agcgcagcgg ggactcggag
      361 ctgcccatca cctccttcga ctgctcagtg tgtctggagg tgctacacca gccggtccgg
      421 acccgctgtg gccacgtgtt ctgccgatct tgcattgcga ccagtataaa gaacaataat
      481 aaatggacat gtccatactg ccgggcatac cttccttcag agggagtgcc cgcaactgac
      541 atagccaaga ggatgaagtc agaataccag aactgtgctg agtgtggaac tctggtttgc
      601 ctcagtgaca tgagggcgca cataaggacc tgtgagaagt acatcgataa atatggcccg
      661 ctgctagaac ttggcgacac cacagcaaga tgtgtatgtc cattttgtca gcgggaactg
      721 gatgaagact gcttgctgga tcattgcatt atccaccaca gatcagaaag gaggcccgtg
      781 ttctgtccac tttgccattc acgacctgat gaaagcccaa gtaccttcaa tggcagttta
      841 attagacatt tgcaagtcag tcacactttg ttttatgatg atttcataga ttttgatata
      901 attgaggaag ccattattcg cagagtgcta gaccgctcac ttcttgaata tgtgaatcag
      961 tcaaacacca cataatttta tgactaggaa ggggaccatt cactcgtacc atttaagatg
     1021 ctgcttgaag gactggaggg ggattgtcga cgtttgatgg agaaacatgt actacagtat
     1081 tacctgcttg tctttgttat gttgcattca aaaaccgtgt tcattctggc ttagatctgc
     1141 ccttacattc ttgagtctat tagacattta accacgagac acagcctctc agccattaac
     1201 agatggaaga gacacgacac aggctggcta tgtgatggag cagcttcctg tgtccattag
     1261 tgatgtgtgt ataacgctac atattcccaa ctgtcatcat ggttaggcga gaaagccaat
     1321 ctctgttcca tgctaaaaga cggagaaagg aacaaaatat ggacattaaa ggaaatctga
     1381 aatgtattca aattctcatg ctctaatctc caataaggaa cgtgaataat cttatgaaaa
     1441 ggaggaaagg gaagaatttg aagtcaccaa aatccaattt agccaaatta tagtacataa
     1501 tataatactg caacaacttc tgcgtttgaa gtgtattctt agccaggcat ggaggagcat
     1561 gcctgtaatt caggaggtga gtatagaagg ggcaggagta cgaggccagc cgtggctaat
     1621 gaggtggcta ataagaccat aaaaaaaaaa aattaagctg ggtgtggtgg cgcacgcctt
     1681 taataccagc actcgggagg cagaggcagg tggatttctg agtttgaggc cagcctggtc
     1741 tacaaagtga gttccaggac agccagggct atacagagaa accctgtctc aaaaaaccaa
     1801 aaaaaaaaaa aaaatttttt ttttgataga agatgtttca aatattctta gcttattgct
     1861 tggaagtatt ttataatgta ggtgatttct aggacccctc tgtggatatt tatggtagtt
     1921 ttcacattgg gaaatcccga gctttgtttt ttcattttaa catcttaaaa aagtataaaa
     1981 tgaagtacat gtactaaaag ccagatacaa aatgcatagc ttaacatgtt ataagaaaca
     2041 ttgttaatgg atggttatgc ctgtatgcct aggaggctga gcaggattct agttcaaagc
     2101 cagcctggac tacatagtta gttgcaggcc tgcctgggct atagggtaag accctgtttc
     2161 aaagctgaac aaaagcatta tgaactcatg tattcagtca tgtatgaaca gacttccatc
     2221 cattacaagt gtcactttat tgaggttcaa cttcaattct ctttccattc cttgaaggtt
     2281 ggctgagttc ttaacactct gttactctcc ttgctgtctc ttacagcaag cttccatgtt
     2341 gaatttattt cctgctatga accagagatc agcaactctc taagagttat gcctgcaaag
     2401 aggatctgtt gttcaaggtc tccctcagct acaatgcaag gtcaaagaca acctaggcta
     2461 cacaggactc tgtctcaacc tgcccccatt ttcattccag aaaaaaactt ctaaggtcag
     2521 tgtctgctat tgaggctgcc attgtttgaa ggagagagcc aggaaacagc tctatgcttg
     2581 ttgtaaagat aaaaatggcc aggcagggta gccatggtag tccaggatga ctggtgacta
     2641 gagaccctct tgcttcagcc tcctgtgtgt aagggcacag gtatgtgttg ccatgcctgc
     2701 aattccctat tttcaaaaac agttggatgg tgccaacgtt tttatgctct accctctccc
     2761 ttttatcctc cagttcttca agtaatgtgc atttattatt gctgtcactt ttcacatgtg
     2821 attctttaat gttacattca ggtcacttac taggatttcc atcttggaat taagaaaaag
     2881 taacaaagac tagagacatc aactcctgag ggtaaagtgt tatttgactt aaaaatacct
     2941 tttggaaagg gctggcaata tggctcagta ggtaaaggca cttcctgcca agcctgagag
     3001 tcagagtttg atccctgtga ccacattcgt gaaggagaac taactcccac aagtgcaagc
     3061 ataatgtgta ctccctcctc acacacacac ataagcacaa tacagcttat attgtaattg
     3121 tttataagca tcatctgttg cacatcaaca ttgtcataat catggtgcca tgatttcttc
     3181 cctctttttg agacaggttc tcatatgtat gcctggctgg tctagaactc agtgtgtaaa
     3241 gcagactggc ctggaacttc aagtgatctc cctgcttcta cctcctcgcc ctgggactta
     3301 gatgtgggca ctggcttcta aagttttcct agtgaattat ccgtaactgc tttgatattg
     3361 ctactgtttt ctcctcagga caaggttact atatataaca ccggggaggg acagggcttc
     3421 cgggcagccc ttgcattccc tggattaact taggtgtttg gtcagaccca ggaactgtgg
     3481 tcgctaaggc cagtgctgga ccacatcctt gctttccctt ctgacttcaa agtcgctctt
     3541 catggctgct aacaagtgac agacttttgc aacctctctg cctccagtct gggtggatga
     3601 tacaatatat gaaataagtt gtattaagaa gtgatcatca gcccataaaa tacagtatag
     3661 ttctgattat tggtaactac tgccctgtca gtcaatctag gttaacttag ggcaatatga
     3721 aagtcatgag taagtttaga aacctactgg gggctggagc aatggctcaa cacctaagag
     3781 tactggctgc tcttacagag gacccaggtt cacacctgcc agtagctcca gttccaggga
     3841 atctgacacc ccccacacaa gacacacgca ggcaaaacac cagtacacag aaaataaaca
     3901 ctgacaagac caaaaaacca aaaccaaaaa aacaacaaaa aacaaacaaa catattctgg
     3961 ataaatggaa tggctcagta gataaaaata ccctttgagt aaggctggca cctaagtctg
     4021 tctgaacccc cctccccccc ccccgaactg aaccataaag tttgtccttt cagatctgca
     4081 catgcactgt ggcatgctct tgtctgaatt cacacaaaaa gaattggggg ggtggggtgg
     4141 agagacatga taagtcagca gttagggtcc ttgctactca ctaggattga ggtctcagtc
     4201 ccatgtagga cagcttgctg cagcagccct catctggctc ccactggtac ttggaacaca
     4261 ggcacatgct cacaaatatt taaaaatcat aaaaataatt aagaaaccca acaactgcgt
     4321 aaatggggca aggtgactaa agcctctaat accagcaatt gggaggtaga gacacaatga
     4381 tcaggagcag cttaaggcca gcctcagcta catagcaagt ttggggctgg cctggggttg
     4441 gttacatgtg attctgtgtt ctgagtagta ggttcaagtg aatgaacaga ctgggaatcc
     4501 gacccacagc ttttttcttt gtctgtttta attttgccac ctagaggata agttaggtgc
     4561 tggccacctg agttattttg tattctgaat tgctttgttt tgaaaatgag acgaagatat
     4621 aatttcactg tgcgtttatc ttcttttttt aaaaaaaaaa aaagaattta attcattgct
     4681 ttaaaaagta aaaaccagta ctcaaagttg ttgatcatca gtaagaaact ttcatgtgct
     4741 ttttgtaaat actgcctaat gaaacaactg gaccaggggg gaagatgatg ctgttatttt
     4801 aaaacttaag ttctcctata ctgttggtag aaaacgggtt gattgtggat cagtggtaaa
     4861 gagttggagc tcctaagaac ccctgactct ggtaatgtca gttcctgctg tcactgggga
     4921 ctaggcgtgc tccatttcga agtgagccta ctctagtttt tgaatgtttc tcatgataat
     4981 ttgtatgctt acacattgaa ggtatttttt tgaagtacta acattcattc tttggttcaa
     5041 atgtaaaaag aacttgtgat cagaatttaa agtgtataat tcttcttctt ttgaaaactg
     5101 tattatgaga aataaagagt ggcaggacca ttgctttcat taaaatgtt
//
