LOCUS       NM_001311152            4745 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus ring finger protein 123 (Rnf123), transcript variant
            1, mRNA.
ACCESSION   NM_001311152 XM_006511880
VERSION     NM_001311152.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Miyasaka Y, Niwa S, Masuya T, Ishii R, Kobayashi M, Horio F and
            Ohno T.
  TITLE     E3 ubiquitin ligase RNF123-deficient mice exhibit reduced
            parasitemia and mortality in rodent malaria (Plasmodium yoelii
            17XL) infection
  JOURNAL   Parasitol Int 88, 102542 (2022)
   PUBMED   35063657
  REMARK    GeneRIF: E3 ubiquitin ligase RNF123-deficient mice exhibit reduced
            parasitemia and mortality in rodent malaria (Plasmodium yoelii
            17XL) infection.
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A,
            Fujimura M, Kure S, Ishii N and Tominaga T.
  TITLE     Dysregulation of Rnf 213 gene contributes to T cell response via
            antigen uptake, processing, and presentation
  JOURNAL   J Cell Physiol 236 (11), 7554-7564 (2021)
   PUBMED   33973242
  REMARK    GeneRIF: Dysregulation of Rnf 213 gene contributes to T cell
            response via antigen uptake, processing, and presentation.
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Horiuchi K, Perez-Cerezales S, Papasaikas P, Ramos-Ibeas P,
            Lopez-Cardona AP, Laguna-Barraza R, Fonseca Balvis N, Pericuesta E,
            Fernandez-Gonzalez R, Planells B, Viera A, Suja JA, Ross PJ, Alen
            F, Orio L, Rodriguez de Fonseca F, Pintado B, Valcarcel J and
            Gutierrez-Adan A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Susaki E, Nakayama K, Yamasaki L and Nakayama KI.
  TITLE     Common and specific roles of the related CDK inhibitors p27 and p57
            revealed by a knock-in mouse model
  JOURNAL   Proc Natl Acad Sci U S A 106 (13), 5192-5197 (2009)
   PUBMED   19276117
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Lu Y, Adegoke OA, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J
            and Wing SS.
  TITLE     USP19 deubiquitinating enzyme supports cell proliferation by
            stabilizing KPC1, a ubiquitin ligase for p27Kip1
  JOURNAL   Mol Cell Biol 29 (2), 547-558 (2009)
   PUBMED   19015242
  REMARK    Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241]
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S,
            Yoshida M, Nakayama K and Nakayama KI.
  TITLE     Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1)
            at G1 phase
  JOURNAL   Nat Cell Biol 6 (12), 1229-1235 (2004)
   PUBMED   15531880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057082.1.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_001311152.2.
            
            On Jul 25, 2015 this sequence version replaced XM_006511880.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057082.1, SRR1660815.266383.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4745              BC057082.1         1-4745
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..4745
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /note="ring finger protein 123"
                     /db_xref="GeneID:84585"
                     /db_xref="MGI:MGI:2148796"
     exon            1..502
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..678
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..4559
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF123; ubiquitin ligase; kip1
                     ubiquitination-promoting complex protein 1; RING-type E3
                     ubiquitin transferase RNF123"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF123 isoform 1"
                     /protein_id="NP_001298081.1"
                     /db_xref="CCDS:CCDS81072.1"
                     /db_xref="GeneID:84585"
                     /db_xref="MGI:MGI:2148796"
                     /translation="MASKGTGMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFS
                     PPDRGPAAATSRKPLNFHNLPEHVDQLLQVDSEDNESQGQVEGRLGPSTVVLDHTGGF
                     EGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQ
                     EEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSL
                     GTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQ
                     RLLGCFQAVLSVELDPVEGRLVETESSEWQLQGQPTVLLTLAHIFHHFAPLLRKVYLV
                     EAVLMSFLLGVVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFS
                     PIVPDLGLQIHYLRLTMSILRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLK
                     ELIPTTWWPHRSSRESRDGKEAREETTEERQRRRAYERGCQRLKKRIEVVEELQVQIL
                     KLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALR
                     FYWDEYKASNPRASFSEEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKA
                     NIVIDPLELQAATMDDLDEDEEPAPSAAQVWQEGQRPMQALAIGGALPLPRPGWLSSP
                     TLGRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRP
                     PEEPEQPLTENSLLEVLDGTVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRR
                     CPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIE
                     HGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHF
                     ADPRIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQT
                     NWILVRLWRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSD
                     VAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLL
                     RVLEMTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGL
                     ESVDHYPILVAVTGILVRLLVHGPTSETEQATSVLLADPCFQLRSICYLLGQPEPLAP
                     GTTLPAPDRKRFSLQSYTDYISAEELAQVEQMLAHLTAASAQAAAASLPTNEEDLCPI
                     CYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAANTSAMSSAA
                     "
     exon            679..763
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..843
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..938
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..993
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1079
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1166
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1234
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1360
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1475
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1580
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1706
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1799
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1873
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1991
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2091
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2153
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2225
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2346
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2448
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2573
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2772
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2918
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3002
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3110
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3288
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3363
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3451
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3539
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3624
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3764
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3953
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4029
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4114
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4257
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4352
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4438
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4727
                     /gene="Rnf123"
                     /gene_synonym="Kpc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtgagcc ggtcgcggag gctgaggccg ggggtgagtg agaggcggcc tggctatgag
       61 ccgggcgggt tcggtgactc ccctcgaggc ccctggccga tccagtgcga cagtgccgcg
      121 gcctgcggta taggagtccc agcgggagct ggcctgacag gtcctatgga ccttggggcc
      181 aagcaggggc gacctggggg agcatgcgct gcccttgaca tccttggcca cccagtctta
      241 gtcggttcgg ttctgagcct ggatctctta gaagggctgg gcaataatgg agtggcaggg
      301 agctctgggg caggcgcagg ttccgcctct aaatcctcta cacctgacac tcagagtgtg
      361 tgtctggaag gttggcttcc aggtcttact aactgtgtcc aataagtcct gcaattgttc
      421 caatataaga gggactggtt gtggatgttc atcgagggcc cccggagggc ggcacagcgg
      481 cagaatcacc ttcctgagcc tggactgagg tctgtgtgag cctttgacta gcctggagta
      541 gacacctgca tctggctcag cctccaggac cattgactgc ccatgagtaa tgagggatgg
      601 cgtccaaggg gactggcatg tcgttctccc gaaagagcta taggctgacc tcagatgctg
      661 agaagtccag ggtcacaggc atcgtgcaag agaaactact gagcgactat ctgtaccgca
      721 tcttttcccc tcctgaccgt ggacccgccg cagccaccag caggaaaccg ctaaacttcc
      781 ataacctgcc tgagcacgtg gaccagctgc tacaggtgga cagtgaagac aacgagagcc
      841 agggacaagt tgaaggtcga cttggcccat ctactgtggt cctagaccac acaggaggct
      901 ttgaggggct tctccttgtg gatgatgacc tcctgggggt gattggacac agcaactttg
      961 gcactatccg ttctaccaca tgtgtgtaca aagggaagtg ggtctacgag gtgctcatct
     1021 cctcccaggg cctcatgcag atcggctggt gcaccatcaa ctgccgcttt aatcaggagg
     1081 aaggggttgg agacacacat aactcctatg cctatgacgg caaccgagtg cgcaagtgga
     1141 atgttaccac cacgaattat ggcaaggcgt gggctgcggg ggacattgtc agctgcctaa
     1201 ttgatctgga tgatgggact ctgtccttct gcctgaatgg cgtgtcactg ggcactgcct
     1261 tcgagaacct ttccaggggc ctaggaatgg cgtacttccc agccatcagc ctgtcattca
     1321 aggagtctgt ggcattcaac tttggcagcc gtcctttgcg ctacccagtt gcgggcttcc
     1381 ggcccctgca ggaccctccg tttgctgacc tggtccgggc acagaggttg ctgggctgct
     1441 tccaggcagt gctaagtgtg gagctggacc ctgtggaagg gcggctggtg gagacggaga
     1501 gctctgagtg gcagctgcaa gggcagccca ctgtcctcct cacgctggcc cacatcttcc
     1561 atcactttgc accactgctg cgcaaggtat acctggtgga ggctgtgcta atgagcttcc
     1621 tgctgggcgt tgtggagaag ggcacaccag agcaggcgca gtctgtggta caccagatct
     1681 tggacctctt gtggctcttc atggaggact atgaggtaca ggattgcctg aagcagttga
     1741 tgatgtcact tctacgtctc taccgattct cgcctattgt cccagacctg ggtctacaga
     1801 tccactacct gcgcctcact atgtccatcc tgagacacga gaagtcccgc aagttcctgc
     1861 ttagcaatgt cctttttgac atgctccggt ccgtggtctt cttttatatt aagagtcccc
     1921 tgcgtgtgga ggaagctggc ctgaaggaac tcattcccac cacctggtgg ccccatcgct
     1981 ccagcaggga gagcagagac ggtaaggaag caagggagga gaccaccgaa gagcggcagc
     2041 ggaggcgagc ctatgagcgt ggctgccaaa gactcaagaa acgcattgaa gtggtggaag
     2101 aactgcaggt ccagatcctg aagctgctgt tggacaataa agatgacaat gggggtgaag
     2161 cttctaggta catctttctg acaaaattcc gaaagttcct gcaggagaat gccagcggcc
     2221 gggggaacac acccgtgctc tgcccccctg agtacatggt ctgcttccta caccggctgg
     2281 tgtctgcctt gcgcttctat tgggatgaat acaaagcttc caacccccgt gcttccttca
     2341 gtgaggaggc ttacatcccg ccccagatct tctataatgg caaggtggac tactttgacc
     2401 ttcagcgcct tgggggcctc ctctcacacc ttcgaaagac ccttaaagat gaccttgctt
     2461 ccaaagccaa catcgtgatc gaccccctgg agctccaggc agccaccatg gatgacctgg
     2521 atgaggatga agagcctgcc ccctcagcgg cccaggtgtg gcaggaggga cagcgtccga
     2581 tgcaagccct ggccatcgga ggggcactgc ccctgccccg gccaggctgg ctcagttctc
     2641 caaccctggg cagagccaac cgcttcctca gcacggcagc tgtgagcctc atgaccccac
     2701 ggcggcttct gagcaccatg gagaaagtca aagttcgctc actgaatgtg gaacagagga
     2761 cccgtgagga cattgagggc agccactgga atgagggcct gctgttgggg aggccccctg
     2821 aagagcctga gcagccgctt accgagaact cgctgttgga agtcctggat ggcacagtca
     2881 tgatgtataa cctcagcgtt caccagcagc tgggcaagat ggtgggtgtg tctgatgatg
     2941 tcaacgagta tgcaatggcc ctaagagaca cagaggacaa gctccgtcgg tgccctaaga
     3001 ggaggaagga tatccttgca gagttgacca agagccagaa ggttttctca gaaaagctgg
     3061 accacctgag ccgcaggctt gcctgggtcc acgccacagt ctactcacag gagaaaatgc
     3121 tggatatcta ctggttactg cgtgtctgcc tacggaccat tgagcatggg gaccgcacgg
     3181 ggtctctctt tgccttcatg cctgagttct acctaagtgt ggctatcaac agctacagtg
     3241 ccctgaagaa ctattttggc cctgtgcaca gcatggagga actcccaggc tatgaagaga
     3301 ccctgacacg cttagctgcc atcctcgcca aacactttgc tgaccctcga atagtaggca
     3361 ctgatattcg agactcactg atgcaggccc tggccagcta tgtgtgctac ccacactccc
     3421 tgcgggctgt ggaacggatt cctgaggaac agcgcatcgc catggtgagg aaccttttgg
     3481 caccctatga gcaacggccc tgggcccaga ccaactggat cctggtgcgg ctttggaggg
     3541 gctgtgggtt tgggtaccgc tatacacggc tgccacatct gctgaaaacc aagccagagg
     3601 atgccaattt gcccagcctc caaaagccct gcccttcgac cttgctacag cagcacatgg
     3661 cggacctgct gcgacaaggg tctgatgtgg caccgagctt cctcaacagt gtccttaacc
     3721 agctcaactg ggccttctct gagttcatcg gcatgatcca ggagattcaa caggctgctg
     3781 aacgcctgga gcggaacttt gtggacagcc gacagctcaa ggtctgtgcc acctgctttg
     3841 acctgtcggt cagcttgttg cgcgtcttgg aaatgaccat cacgctggta cctgaaatat
     3901 tccttgactg gtcccgccct acctctgaga tgctgcttcg gcgtctggca cagctgctga
     3961 accaggtgct gaaccgggtg acagctgaga ggaacctgtt tgaccgtgta gttaccctac
     4021 ggctacctgg gctggagagt gtggaccact accctatcct ggtggcagtg actggcatcc
     4081 tggtacgcct cctggtgcac ggcccaacct cagagacaga gcaagccacc tctgtgctcc
     4141 tggctgatcc ctgcttccag cttcgttcca tatgctatct cctggggcag ccagagcccc
     4201 tagcacctgg cactaccttg cctgcccctg accggaaacg cttctctcta cagagttata
     4261 cagattatat cagcgctgag gagctggccc aggtggaaca gatgctggct cacctgaccg
     4321 ctgcatctgc ccaggcggcc gccgcctccc tgcccaccaa tgaagaggac ctctgcccaa
     4381 tctgctacgc ccaccccatc tctgctgtgt tccagccttg tggtcacaaa tcctgcaaag
     4441 cctgcatcaa ccagcacctg atgaacaaca aggactgctt cttctgcaaa gccaccattg
     4501 tatctgtaga ggactgggac aaggcagcca acacaagcgc catgtcctca gctgcctagg
     4561 ccatcctgga agctccgcca tcagccgcag accgggccct gtttacccat caccctcact
     4621 cttaccactt ccacccaccc atctgcctgt gtgtagcctc gctggtggga gcctgagctt
     4681 gacttccagt ccaggctaca gtgagcatta aattattatt ccaaacaaaa aaaaaaaaaa
     4741 aaaaa
//
