LOCUS       NM_026406               2265 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 115 (Rnf115), mRNA.
ACCESSION   NM_026406 XM_906605
VERSION     NM_026406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Feng,J., Ye,S., Hai,B., Lou,Y., Duan,M., Guo,P., Lv,P., Lu,W. and
            Chen,Y.
  TITLE     RNF115/BCA2 deficiency alleviated acute liver injury in mice by
            promoting autophagy and inhibiting inflammatory response
  JOURNAL   Cell Death Dis 14 (12), 855 (2023)
   PUBMED   38129372
  REMARK    GeneRIF: RNF115/BCA2 deficiency alleviated acute liver injury in
            mice by promoting autophagy and inhibiting inflammatory response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Bilkei-Gorzo,O., Heunis,T., Marin-Rubio,J.L., Cianfanelli,F.R.,
            Raymond,B.B.A., Inns,J., Fabrikova,D., Peltier,J., Oakley,F.,
            Schmid,R., Hartlova,A. and Trost,M.
  TITLE     The E3 ubiquitin ligase RNF115 regulates phagosome maturation and
            host response to bacterial infection
  JOURNAL   EMBO J 41 (23), e108970 (2022)
   PUBMED   36281581
  REMARK    GeneRIF: The E3 ubiquitin ligase RNF115 regulates phagosome
            maturation and host response to bacterial infection.
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Zhang,Z.D., Xiong,T.C., Yao,S.Q., Wei,M.C., Chen,M., Lin,D. and
            Zhong,B.
  TITLE     RNF115 plays dual roles in innate antiviral responses by catalyzing
            distinct ubiquitination of MAVS and MITA
  JOURNAL   Nat Commun 11 (1), 5536 (2020)
   PUBMED   33139700
  REMARK    GeneRIF: RNF115 plays dual roles in innate antiviral responses by
            catalyzing distinct ubiquitination of MAVS and MITA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Li,R., Gu,Z., Zhang,X., Yu,J., Feng,J., Lou,Y., Lv,P. and Chen,Y.
  TITLE     RNF115 deletion inhibits autophagosome maturation and growth of
            gastric cancer
  JOURNAL   Cell Death Dis 11 (9), 810 (2020)
   PUBMED   32980859
  REMARK    GeneRIF: RNF115 deletion inhibits autophagosome maturation and
            growth of gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Mizuno,K., Kitamura,A. and Sasaki,T.
  TITLE     Rabring7, a novel Rab7 target protein with a RING finger motif
  JOURNAL   Mol Biol Cell 14 (9), 3741-3752 (2003)
   PUBMED   12972561
  REMARK    GeneRIF: Rabring7 plays crucial roles as a Rab7 target protein in
            vesicle traffic to late endosome/lysosome and lysosome biogenesis
            (rabring7)
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112261.4 and AC127297.4.
            
            On Mar 18, 2008 this sequence version replaced NM_026406.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.45761.1, BC023113.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC112261.4         52682-52981         c
            301-359             AC112261.4         26199-26257         c
            360-417             AC112261.4         22558-22615         c
            418-629             AC112261.4         4751-4962           c
            630-701             AC127297.4         167361-167432       c
            702-774             AC127297.4         166015-166087       c
            775-868             AC127297.4         165056-165149       c
            869-984             AC127297.4         162395-162510       c
            985-2265            AC127297.4         159925-161205       c
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.96 cM"
     gene            1..2265
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /note="ring finger protein 115"
                     /db_xref="GeneID:67845"
                     /db_xref="MGI:MGI:1915095"
     exon            1..300
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1116
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /EC_number="2.3.2.27"
                     /note="zinc finger protein 364; Rabring7; Rab7-interacting
                     RING finger protein; rabring 7; RING-type E3 ubiquitin
                     transferase RNF115"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF115"
                     /protein_id="NP_080682.3"
                     /db_xref="CCDS:CCDS17647.1"
                     /db_xref="GeneID:67845"
                     /db_xref="MGI:MGI:1915095"
                     /translation="MAEASAAGADAGSAVAAHRFFCHFCKGEVNPKLPEYICPRCDSG
                     FIEEVTDDSSFLGGGGSRTDNSTATHFAELWDHLDHTMFLQDFRPFLSSNPLDQDNRA
                     NERGHQTHTDFWGPSRPPRLPMTRRYRSRGSTRPDRSPAIEGIIQQIFAGFFANSAIP
                     GSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTV
                     TQEQVNTGLECPVCKEDYTVEEKVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGE
                     DSTRQTQSSEASASNRFSNDSQLHDRWTF"
     exon            301..359
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            360..417
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            418..629
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            630..701
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            702..774
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            775..868
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            869..984
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2265
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /note="hexamer: ATTAAA"
     polyA_site      2061
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /note="major polyA site"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="Rnf115"
                     /gene_synonym="2610028E05Rik; Zfp364"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcgggc ctcgggtcgc gtggccgctg gcgggcgggc ctctcggggc cgggcggact
       61 cacgtgaccc ttgcgggcct cggagcggcg ggccgcccag aggaggcggc gacggcggtg
      121 gcgaccgcag cacgggaggt agcggcctgg ggagggaccg ccggccgccc tttcggacat
      181 cctcggcgga ggcgaaacat ggcggaggcc tcggcggcgg gggcggacgc gggctccgct
      241 gtcgccgcac accgtttctt ctgccacttt tgtaagggcg aggtcaatcc caaactaccg
      301 gaatatatat gtcccagatg tgactcaggc tttattgagg aagtgacaga tgattccagt
      361 tttttaggtg gtggtggaag ccggacagac aatagcacag cgacacattt tgcagagctt
      421 tgggaccatc tggatcacac aatgttttta caagatttta gaccatttct aagtagcaat
      481 ccactggacc aagataatag agccaatgag agaggtcacc aaactcacac tgacttttgg
      541 ggaccaagtc ggcctccaag gttgccaatg acaagaagat acaggtctcg cggaagtact
      601 cgtcccgaca ggtcgccagc tatcgaagga ataatacaac agatctttgc aggattcttt
      661 gcaaattctg ccattcctgg atccccacac cccttttctt ggagcgggat gctgcactcc
      721 aaccctgggg actatgcctg gggtcagaca ggccttgatg ccattgtaac ccagcttcta
      781 ggacagctgg aaaacacggg tccccctcca gccgacaagg agaagatcac atctctccca
      841 acagttacag taactcagga acaagtcaat acgggtttag aatgtccagt atgcaaagaa
      901 gattacacag ttgaggagaa agtccggcag ttaccctgca accacttctt tcacagcagc
      961 tgcatcgtgc cctggttaga actgcatgac acatgcccag tatgtaggaa gagcttaaat
     1021 ggtgaggact ctactcggca aacccagagc tctgaggcct ctgcaagcaa cagatttagc
     1081 aatgacagcc agctacatga ccgatggact ttctgaaact aaagaccaca cctgaaccag
     1141 ggctgcctgc gttagtcctg ttatcatagc tgtaaattgt atcaaaacta aacaaacaaa
     1201 atagtagatg gatttaggaa tcatgtaaga aacccccaac ccataatatt aatgcaaacg
     1261 agtgtatttc ttctctaaat ttaaagttag gacttacagg tggaattgta tcgacaacca
     1321 aatgcctctt gttcctgaat tgagtgatag ttttataagt gtgaaactta attatgtcag
     1381 ttttctcctg cttgagtaga atcaattcct taaagtctag gtagggttct actgttatgt
     1441 tgtcttgtaa tggatgtctc tacctcctcc ttcaatctct atcctaccat tagtggattt
     1501 cacagcaaat agagaagaag ccagagccct aaggtctttt ttttcttaat tgtataagag
     1561 tacaagtatc tgctcctggc cccattagca aggtaagact aattcagggg tctgagactc
     1621 taacgctgtt ctgtcttgat gatcagagag caaatcaaga aaattacagt gggaaggaaa
     1681 aatgccgtgt cactatatac tttgattttc ttattttagt tcaggaagca cagtttccct
     1741 aaacatcacc atggcatgtc ttacttagcc ttgggttggt agaaatctga ttttggttcc
     1801 tctgtgacat taaattgagc agcatataga cgggagatgt gggagatttt actactgaaa
     1861 tgttcttaat gactgtcaac tcattgttta ttgtctttca tactagaaac cttacaataa
     1921 ttttcttcat aaaataattt ccttcaaaaa tacaattcct tcattaaaaa taggattatt
     1981 ttattactgc ttctatacca gtttacagtt ttggtaattc attgtttatt taggaattaa
     2041 agttgtatgt ttcttgtttt agtttgtaaa gctcattttt catgtctgaa acttttcctg
     2101 ttctgttcac ttctagctat acttggaatc aatctgatca atgtaatcat ggccaaaaca
     2161 acttagtttg ggaaggtaga ttgtgtttta cattctagcg atgctcatac acatactctg
     2221 tacgtgtttg aaatggaata aatggagatt gtggagcatg tcatt
//
