LOCUS       NM_001360930            2156 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ring finger protein 114 (Rnf114), transcript variant
            3, mRNA.
ACCESSION   NM_001360930 XM_006500439
VERSION     NM_001360930.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Zhou,S., Guo,Y., Sun,H., Liu,L., Yao,L., Liu,C., He,Y., Cao,S.,
            Zhou,C., Li,M., Cao,Y., Wang,C., Lu,Q., Li,W., Guo,X. and Huo,R.
  TITLE     Maternal RNF114-mediated target substrate degradation regulates
            zygotic genome activation in mouse embryos
  JOURNAL   Development 148 (13) (2021)
   PUBMED   34104941
  REMARK    GeneRIF: Maternal RNF114-mediated target substrate degradation
            regulates zygotic genome activation in mouse embryos.
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Wu,Y., Dong,J., Feng,S., Zhao,Q., Duan,P., Xiong,M., Wen,Y., Lv,C.,
            Wang,X. and Yuan,S.
  TITLE     Maternal UHRF1 Is Essential for Transcription Landscapes and
            Repression of Repetitive Elements During the Maternal-to-Zygotic
            Transition
  JOURNAL   Front Cell Dev Biol 8, 610773 (2021)
   PUBMED   33634103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Lin,B., Ke,Q., Li,H., Pheifer,N.S., Velliquette,D.C. and
            Leaman,D.W.
  TITLE     Negative regulation of the RLH signaling by the E3 ubiquitin ligase
            RNF114
  JOURNAL   Cytokine 99, 186-193 (2017)
   PUBMED   28625874
  REMARK    GeneRIF: These data suggested the potential physiological function
            of RNF114 in inflammation and host antiviral responses, but
            demonstrate complexity in the regulation of innate immunity by
            ubiquitin ligases.
REFERENCE   6  (bases 1 to 2156)
  AUTHORS   Yang,Y., Zhou,C., Wang,Y., Liu,W., Liu,C., Wang,L., Liu,Y.,
            Shang,Y., Li,M., Zhou,S., Wang,Y., Zeng,W., Zhou,J., Huo,R. and
            Li,W.
  TITLE     The E3 ubiquitin ligase RNF114 and TAB1 degradation are required
            for maternal-to-zygotic transition
  JOURNAL   EMBO Rep 18 (2), 205-216 (2017)
   PUBMED   28073917
  REMARK    GeneRIF: our study uncovers that RNF114-mediated ubiquitination and
            degradation of TAB1 activate the NF-kappaB pathway during MZT, and
            thus directly link maternal clearance to early embryo development.
REFERENCE   7  (bases 1 to 2156)
  AUTHORS   Han,J., Kim,Y.L., Lee,K.W., Her,N.G., Ha,T.K., Yoon,S., Jeong,S.I.,
            Lee,J.H., Kang,M.J., Lee,M.G., Ryu,B.K., Baik,J.H. and Chi,S.G.
  TITLE     ZNF313 is a novel cell cycle activator with an E3 ligase activity
            inhibiting cellular senescence by destabilizing p21(WAF1.)
  JOURNAL   Cell Death Differ 20 (8), 1055-1067 (2013)
   PUBMED   23645206
  REMARK    GeneRIF: ZNF313 is a novel cell cycle activator with an E3 ligase
            activity inhibiting cellular senescence by destabilizing
            p21(WAF1.).
REFERENCE   8  (bases 1 to 2156)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2156)
  AUTHORS   Li,N., Sun,H., Wu,Q., Tao,D., Zhang,S. and Ma,Y.
  TITLE     Cloning and expression analysis of a novel mouse zinc finger
            protein gene Znf313 abundantly expressed in testis
  JOURNAL   J Biochem Mol Biol 40 (2), 270-276 (2007)
   PUBMED   17394778
  REMARK    GeneRIF: Present data suggests that Znf313 gene might play a
            fundamental role in gene transcription and regulation and relates
            to spermatogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148290.1 and AF502145.1.
            
            On Feb 17, 2018 this sequence version replaced XM_006500439.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282919.2, AF502145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2138              AK148290.1         22-2159
            2139-2156           AF502145.1         2146-2163
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.25 cM"
     gene            1..2156
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /note="ring finger protein 114"
                     /db_xref="GeneID:81018"
                     /db_xref="MGI:MGI:1933159"
     exon            1..159
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..706
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 3; zinc
                     finger protein 313; E3 ubiquitin-protein ligase RNF114;
                     RING-type E3 ubiquitin transferase RNF114"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF114 isoform 1"
                     /protein_id="NP_001347859.1"
                     /db_xref="CCDS:CCDS17101.1"
                     /db_xref="GeneID:81018"
                     /db_xref="MGI:MGI:1933159"
                     /translation="MAAAQPESRDGAAQSAKPASETDPLSRFTCPVCLEVFEKPVQVP
                     CGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESIETSCHGCRKNFILS
                     KIRAHVTSCSKYQNYIMEGVKATTKDASLQPRNIPNRYTFPCPYCPEKNFDQEGLVEH
                     CKLTHSTDTKSVVCPICASMPWGDPSYRSANFMEHIQRRHRFSYDTFVDYDVDEDDMI
                     NQVLQRSIIDQ"
     exon            160..310
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     exon            311..417
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     exon            418..532
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     exon            533..640
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2148
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /note="hexamer: AATAAA"
     polyA_site      2141
                     /gene="Rnf114"
                     /gene_synonym="1110008J21Rik; Zfp228; Zfp313; Znf228"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcagc ggcaagatgg cggcggcgca gccggagtcc cgagatggag ccgcgcagtc
       61 ggcgaagccg gcgtccgaga cggaccccct cagccgcttt acgtgtcccg tgtgcctgga
      121 agtattcgag aagccggtgc aggtgccctg cggacacgtc ttttgctctg catgcctgca
      181 ggaatgtctg aagccgaaga aacctgtctg tggggtgtgt cgcagcgctc tggcacctgg
      241 cgtccgagct gtggagctcg agcggcagat cgagagcata gagacttctt gccatggctg
      301 ccgtaagaat ttcatcctat ctaagatccg ggcccatgtg acgtcatgtt ccaaatacca
      361 gaattacatc atggaaggtg taaaggccac caccaaggat gcatcccttc agccgagaaa
      421 catcccaaac cgatacacct ttccttgtcc ttactgtccc gagaagaact ttgatcagga
      481 aggactcgtg gagcactgca aactcactca cagcaccgat accaagtctg tggtttgtcc
      541 catctgtgcc tcgatgccct ggggagaccc cagctaccgc agtgccaact tcatggagca
      601 tatccaacgc cgtcaccgct tttcctacga cacttttgtg gattacgatg ttgatgaaga
      661 tgacatgata aaccaggtgt tgcagcgctc catcattgac caatgaatcg ggtcctggct
      721 gtccacctca ctctagagct tccattgtgc attaggtgtg agcccttgac tcttgcacct
      781 cacatgtaat gcagatctgg aattgagcca tggcaccaga cagggtcact tcttcaaggg
      841 tgatggggcc ctagggcaga gagagccctg tttcctctgg gctcttgcca gcattgtctt
      901 ccccactggt gaccttgttt gtcccatggt ctgctttcac cacacctcag ctactgcctg
      961 ctttaagaag agcccagctt cttctcctac aggatcttaa tcgcattcat cctgttgccc
     1021 agtgttcatc tctcaggtcc ttctagccag ccaggacctt ccctgggctg tgaatagcac
     1081 aataaagcag ggactccttt ccttggccct gaggtgcctt ggttctgcag tttactgggc
     1141 cagggctctg ctcctctcct cctgggtgac atcgcagtct gatgggggaa gttttggtta
     1201 ctgctgtttc cctacacctg cacatctgta cacctgaggg cttaaatgcc tgatggtgcc
     1261 tttttaggat aaggtatcac catagaattg tagtggaaat gttgggtagc aaagatgggg
     1321 tgtgttcatg tgtaagtagg gagaaggtgt agggtgtgtg gctttttggt ttactttgat
     1381 gctgatgagt gttctcaggt ggctgggtcg tgtgcccctc ttattgagta tatgctgaca
     1441 ttcttgctct gaagagtgtt ggagggaggc accgactgct gggtgctgct tggtaacttg
     1501 atgagcctga gcagtattgc tgcctccttg tgcaagtatg ttttaaaccc tgccttttgt
     1561 tgtggaggca gtggtaaagc cagggtcata cctgggaagt taaagttagg cccctgcaca
     1621 gtcgagggag gcggtctgct gaggctttct tgagcagcag ctataacagc tggaaatgca
     1681 gtcatgttac agagcacaag gaagagcacc tccagtcagt tccacaggac agaccctcta
     1741 ccaggcctgg ggcttgggag tgagtcttct ttctggtcat ggggctctgg tccatctgag
     1801 actgcatgta acattgtact tgtggcacca cgcctccaca gtggtgcctc tgcctgccag
     1861 ggccaagcca gcccagatgc cagcagagtc ggacaggatc attttcccaa cgttactgct
     1921 tcttcactgt accctctgga aaggtttgct caggagatgt gtggagggag gttcaacaag
     1981 acctgccccg agcaactggg aaaggcacag gtgtgccaca gtgcagcagg gacctcttgt
     2041 ccttcatcac actcgctgtt tctaatatga ctttccagaa agtgtggtta tgttctgtct
     2101 tatagaaagt gaaatataaa taaatttcat aatttatcca accagtaaaa aaaaaa
//
