LOCUS       NM_009548               3098 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ring finger protein 112 (Rnf112), transcript variant
            1, mRNA.
ACCESSION   NM_009548
VERSION     NM_009548.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Kuo,C.J., Lee,K.H., Huang,C.C., Wang,I.F., Hsieh,C.C., Lin,H.C. and
            Lee,Y.C.
  TITLE     Puralpha regulates the induction of Znf179 transcription during
            neuronal differentiation
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1477-1483 (2020)
   PUBMED   33333713
  REMARK    GeneRIF: Puralpha regulates the induction of Znf179 transcription
            during neuronal differentiation.
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Haage,V., Elmadany,N., Roll,L., Faissner,A., Gutmann,D.H.,
            Semtner,M. and Kettenmann,H.
  TITLE     Tenascin C regulates multiple microglial functions involving TLR4
            signaling and HDAC1
  JOURNAL   Brain Behav Immun 81, 470-483 (2019)
   PUBMED   31271872
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Lomash,R.M., Petralia,R.S., Holtzclaw,L.A., Tsuda,M.C., Wang,Y.X.,
            Badger,J.D. 2nd, Cameron,H.A., Youle,R.J. and Roche,K.W.
  TITLE     Neurolastin, a dynamin family GTPase, translocates to mitochondria
            upon neuronal stress and alters mitochondrial morphology in vivo
  JOURNAL   J Biol Chem 294 (30), 11498-11512 (2019)
   PUBMED   31177092
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Tabakoff,B., Bhave,S.V. and Hoffman,P.L.
  TITLE     Selective breeding, quantitative trait locus analysis, and gene
            arrays identify candidate genes for complex drug-related behaviors
  JOURNAL   J Neurosci 23 (11), 4491-4498 (2003)
   PUBMED   12805289
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Probst,F.J., Chen,K.S., Zhao,Q., Wang,A., Friedman,T.B.,
            Lupski,J.R. and Camper,S.A.
  TITLE     A physical map of the mouse shaker-2 region contains many of the
            genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)
  JOURNAL   Genomics 55 (3), 348-352 (1999)
   PUBMED   10049592
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Orimo,A., Inoue,S., Ikeda,K., Sato,M., Kato,A., Tominaga,N.,
            Suzuki,M., Noda,T., Watanabe,M. and Muramatsu,M.
  TITLE     Molecular cloning, localization, and developmental expression of
            mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA
            partially coincides with the affected areas of Smith-Magenis
            syndrome
  JOURNAL   Genomics 54 (1), 59-69 (1998)
   PUBMED   9806830
REFERENCE   9  (bases 1 to 3098)
  AUTHORS   Zhao,Q., Chen,K.S., Bejjani,B.A. and Lupski,J.R.
  TITLE     Cloning, genomic structure, and expression of mouse ring finger
            protein gene Znf179
  JOURNAL   Genomics 49 (3), 394-400 (1998)
   PUBMED   9615224
REFERENCE   10 (bases 1 to 3098)
  AUTHORS   Matsuda,Y., Inoue,S., Seki,N., Hosoi,T., Orimo,A., Muramatsu,M. and
            Hori,T.
  TITLE     Chromosome mapping of human (ZNF179), mouse, and rat genes for
            brain finger protein (bfp), a member of the RING finger family
  JOURNAL   Genomics 33 (2), 325-327 (1996)
   PUBMED   8660987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ148450.1, BC013139.1 and BY599807.1.
            
            On Mar 22, 2014 this sequence version replaced NM_009548.2.
            
            Transcript Variant: This variant (1) uses alternate in-frame splice
            sites in the 5' coding region, compared to variant 3. It encodes
            isoform 1, which lacks an internal segment and is shorter, compared
            to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013139.1, SRR1660815.37877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               CJ148450.1         82-187
            107-3073            BC013139.1         1-2967
            3074-3098           BY599807.1         342-366
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..3098
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /note="ring finger protein 112"
                     /db_xref="GeneID:22671"
                     /db_xref="MGI:MGI:106611"
     exon            1..197
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2108
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; brain
                     finger protein; zinc finger protein 179"
                     /codon_start=1
                     /product="RING finger protein 112 isoform 1"
                     /protein_id="NP_033574.2"
                     /db_xref="CCDS:CCDS24812.1"
                     /db_xref="GeneID:22671"
                     /db_xref="MGI:MGI:106611"
                     /translation="MPRPVLSVTAFCHRLGKRESKRSFMGNSSNSWVLPREEAQGWMG
                     QAVQGGTRTSRSHASFPKLELGLGHRPSPTREPPTCSICLERLREPISLDCGHDFCIR
                     CFSTHRIPGCELPCCPECRKICKQRKGLRSLGERMKLLPQRPLPPALQETCAVRAERL
                     LLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLSGLPS
                     LESGDSGRPRAEGSLPGIRWGANGLTRGIWMWSHPFLLGKEGKKVAVFLVDTGDVMSP
                     ELSKETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQH
                     LDLLVRDSSHHNKSGQGHVGDILQKLSGKYPKVQELLLGKRARCYLLPAPERQWVNKD
                     QASPRGNTEDDFSHHFRAYILDVLSTAPQHAKSRCQGYWSEGRAVARGDRRLLTGQQL
                     AQEIKNLSGWMGKTGPSFNSPDEMAAQLHDLRKVEAAKKEFEEYVRQQDIATKRIFSA
                     LRVLPDTMRNLLSTQKDAILARHGVALLCKEREQTLEALEAELQAEAKAFMDSYTMRF
                     CGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVG
                     AGLAATVGCMEKEEDERVQGGDREPLLQEE"
     exon            198..238
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            239..307
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            308..593
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            594..800
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            801..929
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1034
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1085
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1142
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1217
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1338
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1508
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1562
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1637
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..3098
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
                     /note="hexamer: AATAAA"
     polyA_site      3073
                     /gene="Rnf112"
                     /gene_synonym="bfp; neurolastin; Zfp179; ZNF179"
ORIGIN      
        1 cgctgacagc taggcagagc caccgaggag cccatccccc tgctccaccc tccacctgct
       61 tctctagctg tctgtcctac cgggaaaaag gtctctgtag gtttcctctc tgagcatcgg
      121 accctctgcc attccaacct ctcatgccga ggcccgtcct gtcagtcact gctttttgtc
      181 atcggcttgg caaacgggag agcaaacgaa gcttcatggg aaacagcagc aacagttggg
      241 ttctccccag ggaggaagca caaggctgga tgggccaggc tgtgcaggga gggaccagga
      301 caagcaggtc ccatgcatca ttccccaagc tggagctggg cctgggacac cgtccctccc
      361 caacccggga gccgcccacc tgctccatct gtctggaaag gcttcgagag cccatctcgc
      421 tggactgtgg ccatgacttc tgcatccgat gcttcagcac acaccgcatc ccaggctgtg
      481 agctaccatg ctgtcctgaa tgccggaaga tctgtaagca aaggaagggc ctccgcagtc
      541 taggggaaag gatgaaactc ctaccacagc ggccactgcc ccctgcactg caggagacct
      601 gtgctgtgag ggcagaacgt ctgctgttgg tacgaatcaa tgcctccgga ggcctcatcc
      661 tcaggatggg cgccataaac cgttgcctga agcatccact ggccagggac acacccgtct
      721 gcttattggc tgtcctggga gagcagcact caggaaagtc cttccttttg gaccacttgc
      781 tcagtggctt accaagcctg gaatctggtg acagcggcag gcccagagca gaggggtctc
      841 tgcctgggat cagatggggc gctaacggcc tcacgagggg tatctggatg tggagtcacc
      901 ccttcctgct gggaaaagag gggaagaagg tggctgtgtt cttagtggac acgggggatg
      961 tcatgagccc agaactgagc aaggagacaa gggtcaagct ctgtgctctc accatgatgc
     1021 tcagttccta ccagatcctg aatacctccc aagagctgaa ggataccgat ctgggctatc
     1081 tagagatgtt cgttcacgtg gctgaggtga tgggcaaaca ttatgggatg gtaccaatcc
     1141 agcatctgga tctcttagtc cgagactctt cccatcataa taagtcaggg caagggcacg
     1201 tgggtgacat actccagaag ctgtccggca aataccccaa ggtccaggag ctgctcctcg
     1261 ggaaacgggc ccgctgttac ctcctccctg ctcctgagag gcagtgggta aacaaagacc
     1321 aagccagccc cagaggcaac acagaagatg acttctccca ccatttccgg gcctacatct
     1381 tggacgtgct gagcacagcc cctcagcacg ctaagagccg ctgtcaaggg tactggagtg
     1441 aggggcgtgc cgtggccagg ggagacagac gcctgctcac agggcagcag ctagcacagg
     1501 agatcaagaa tctctctggc tggatgggga agactgggcc cagtttcaac tctcctgatg
     1561 agatggctgc tcagctccat gatctgagga aagtggaagc cgccaagaag gagttcgagg
     1621 agtacgtgag acagcaggac atagccacca agcgcatctt ctctgcacta cgagtcctgc
     1681 ctgacacgat gaggaacctc ctctctaccc agaaggatgc catcttggcc cgccatggtg
     1741 tggccctgtt gtgcaaggag agagagcaga ccttggaggc cctggaagcc gagctgcagg
     1801 cagaagccaa ggccttcatg gactcctaca caatgcgctt ctgtggccac ctggccgcgg
     1861 tagggggcgc tgtaggtgct gggctcatgg gcctggcagg gggtgtggtg ggcgcaggca
     1921 tggcagcagc ggcgttggct gctgaggctg ggatggtagc agctggggcc gcggtggggg
     1981 ccaccggggc tgctgtggtt gggggtggtg tgggtgctgg tctggccgcc actgtgggct
     2041 gcatggagaa agaggaagat gagagagttc aaggagggga ccgagagccc ctactccagg
     2101 aggaatagca gcaagatgtc gaagcgtgaa atacgtgaaa ggcagtagga agggtgcgga
     2161 catcagggac tcagagggga ccacgtatat actggccttg ttgaatgccc catgtcaaac
     2221 actggctgag ctgggggttt acggtgggtc cagaaacctg aggaggcttt ctggccacga
     2281 ggctgtactt ggagtacagc ggatagggtg caaggcctgt ttctggctct ggataattgc
     2341 tactctctgg aacctaggat ctcccaccac ataaggcccc acctcctcta cccagttcca
     2401 gtttatttcc ctggagggcc tgggctggaa atttgcccct ggatccagaa ccccattcgt
     2461 tttacagttg ggataggtcc cagcataact gactttggag ctaggagccc cgctaacagg
     2521 gaagaaaaag gaggggtcac agagcaggga tggggatgat agacagagct ataattctgg
     2581 agtggtgact tgtttccaaa actgctccag aaggccaggc ttggctggcc tccctgctct
     2641 tcagttgggt gtccagatgt gtgtcctgaa ccgccctgta ccccagcctc ctgcagtcct
     2701 cctaagcctg tgccctgtgc caagcccatt tggatggatc aacacagatt acatgccaaa
     2761 gaaccacacc tccgattgca ttctgtgcta aagcagtccg tgccaggttc tgccaaagtg
     2821 tgggaaggga aagtgcagga aacgagctcc gtcttttaac ataagcttga gctgtggggc
     2881 ctctgcgcca cactgtaaga cccccttgat gcagccctct gaacgccaag cctccagaaa
     2941 gcttgtgggc agggggcctc tctcggggga tggagatttc taaagagact tctgggctgt
     3001 taaactataa aagatgttgg gcatatgacc ctttatttta tataaaaata aaatgtgtgc
     3061 gtgtgaatgg taacctctta atacatttct gaaacaag
//
