LOCUS       NM_033604               4935 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus ring finger 111 (Rnf111), transcript variant 1, mRNA.
ACCESSION   NM_033604
VERSION     NM_033604.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4935)
  AUTHORS   Song,C., Qin,Y., Li,Y., Yang,B., Guo,T., Ma,W., Xu,D., Xu,K.,
            Fu,F., Jin,L., Wu,Y., Tang,S., Chen,X. and Zhang,F.
  TITLE     Deleterious variants in RNF111 impair female fertility and induce
            premature ovarian insufficiency in humans and mice
  JOURNAL   Sci China Life Sci 67 (7), 1325-1337 (2024)
   PUBMED   38874713
  REMARK    GeneRIF: Deleterious variants in RNF111 impair female fertility and
            induce premature ovarian insufficiency in humans and mice.
REFERENCE   2  (bases 1 to 4935)
  AUTHORS   Xu,H., Wu,L., Nguyen,H.H., Mesa,K.R., Raghavan,V., Episkopou,V. and
            Littman,D.R.
  TITLE     Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34473197
  REMARK    GeneRIF: Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation.
REFERENCE   3  (bases 1 to 4935)
  AUTHORS   Elkouris,M., Kontaki,H., Stavropoulos,A., Antonoglou,A.,
            Nikolaou,K.C., Samiotaki,M., Szantai,E., Saviolaki,D., Brown,P.J.,
            Sideras,P., Panayotou,G. and Talianidis,I.
  TITLE     SET9-Mediated Regulation of TGF-beta Signaling Links Protein
            Methylation to Pulmonary Fibrosis
  JOURNAL   Cell Rep 15 (12), 2733-2744 (2016)
   PUBMED   27292644
REFERENCE   4  (bases 1 to 4935)
  AUTHORS   Tsubakihara,Y., Hikita,A., Yamamoto,S., Matsushita,S.,
            Matsushita,N., Oshima,Y., Miyazawa,K. and Imamura,T.
  TITLE     Arkadia enhances BMP signalling through ubiquitylation and
            degradation of Smad6
  JOURNAL   J Biochem 158 (1), 61-71 (2015)
   PUBMED   25762727
  REMARK    GeneRIF: Arkadia, but not the C937A (CA) mutant lacking E3
            ubiquitin-ligase activity, induced ubiquitylation and
            proteasome-dependent degradation of Smad6.
REFERENCE   5  (bases 1 to 4935)
  AUTHORS   Sun,H., Liu,Y. and Hunter,T.
  TITLE     Multiple Arkadia/RNF111 structures coordinate its Polycomb body
            association and transcriptional control
  JOURNAL   Mol Cell Biol 34 (16), 2981-2995 (2014)
   PUBMED   24912682
REFERENCE   6  (bases 1 to 4935)
  AUTHORS   Koinuma,D., Shinozaki,M., Komuro,A., Goto,K., Saitoh,M., Hanyu,A.,
            Ebina,M., Nukiwa,T., Miyazawa,K., Imamura,T. and Miyazono,K.
  TITLE     Arkadia amplifies TGF-beta superfamily signalling through
            degradation of Smad7
  JOURNAL   EMBO J 22 (24), 6458-6470 (2003)
   PUBMED   14657019
REFERENCE   7  (bases 1 to 4935)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4935)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 4935)
  AUTHORS   Episkopou,V., Arkell,R., Timmons,P.M., Walsh,J.J., Andrew,R.L. and
            Swan,D.
  TITLE     Induction of the mammalian node requires Arkadia function in the
            extraembryonic lineages
  JOURNAL   Nature 410 (6830), 825-830 (2001)
   PUBMED   11298452
REFERENCE   10 (bases 1 to 4935)
  AUTHORS   Hara,Y., Battey,J. and Gainer,H.
  TITLE     Structure of mouse vasopressin and oxytocin genes
  JOURNAL   Brain Res Mol Brain Res 8 (4), 319-324 (1990)
   PUBMED   2176709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158995.2 and AC157086.2.
            
            On Oct 28, 2017 this sequence version replaced NM_033604.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF330197.1, SRR17784647.406250.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC158995.2         95160-95476
            318-380             AC158995.2         95933-95995
            381-1273            AC158995.2         122267-123159
            1274-1400           AC157086.2         1762-1888
            1401-1564           AC157086.2         12090-12253
            1565-1759           AC157086.2         13225-13419
            1760-2076           AC157086.2         17426-17742
            2077-2332           AC157086.2         20702-20957
            2333-2681           AC157086.2         27493-27841
            2682-2807           AC157086.2         28846-28971
            2808-2934           AC157086.2         30362-30488
            2935-3027           AC157086.2         39214-39306
            3028-3123           AC157086.2         40217-40312
            3124-3251           AC157086.2         41564-41691
            3252-4935           AC157086.2         44136-45819
FEATURES             Location/Qualifiers
     source          1..4935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.53 cM"
     gene            1..4935
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /note="ring finger 111"
                     /db_xref="GeneID:93836"
                     /db_xref="MGI:MGI:1934919"
     exon            1..317
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            318..380
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1273
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..3369
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase Arkadia; RING finger protein 111;
                     RING-type E3 ubiquitin transferase Arkadia"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Arkadia isoform 1"
                     /protein_id="NP_291082.1"
                     /db_xref="CCDS:CCDS23321.1"
                     /db_xref="GeneID:93836"
                     /db_xref="MGI:MGI:1934919"
                     /translation="MSQWTPEFNELYTLKVAMKSGTPDAPTTQESLKAVLLHPQPLGA
                     TKSFPAEVEMINSKVGNEFSHLCDDSQKQEKDMTGNQQEQEKSGVVRKKRKSQQAGPS
                     YVQNCVKENQEILGRRQQLETPSDEDNDSSLSECLSSPSSSLHFGGSDTVTSDEDKEV
                     SVRHTQPVLSAKSRSHSARSHKWPRTEADPVPSLLMKRPCFHGSALRRVTCRKRLVKS
                     SSSQRTQKQKERMLVQRKKREALAQRKYALLSSSSSSSENDLSSDSSSSSSTDGEEDL
                     CASASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYR
                     SRSTLGHSRSHWSQGSSSHTGRPQESRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTI
                     VPTTSARMDSQTTSASINNSNPSTSEQASDTTSTVASSQPSTVSETEATLTSNSATGS
                     SVGDDVRRTASSAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQQHGH
                     HFQHHHHHHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDL
                     SNSALRTHGSGGFHGASAFDPCCPVTSSRAAVFGHQAAAAPTQPLSIDGYGSSMVAQP
                     QPQPPPQPSLSSCRHYMPPPYASLTRPLHHQASACHHSHGNAPPQTQPPPQVDYVIPH
                     PVHAFHSQISSHAASHPVAPPPPTHLGSTAAPIPQHLPPAHQPISHHIPAPAPSAQRL
                     HPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAP
                     ERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIR
                     YISSGLDGASFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTDWF
                     SQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNK
                     KCPICRVDIEAQLPSES"
     exon            1274..1400
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1564
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1759
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2076
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2332
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2681
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2807
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2934
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3027
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3123
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3251
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..4935
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /note="hexamer: AATAAA"
     polyA_site      4472
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /note="major polyA site"
     regulatory      4910..4915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /note="hexamer: AATAAA"
     polyA_site      4935
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
ORIGIN      
        1 ggtgtcgcgc tcgcgcagtc ggggagggcc ggcccaggct gcggcggcgg cgacggcgat
       61 ggtggcgggg cgctggtgct gcgcggcgta aggcacgccg gccgttcagg gtcgcgagcg
      121 cgcgtgggcc gcgatcgggt gctcggagcc gggtccagcc gagccaggct cagcctcacg
      181 ctccgcggcg gcggtgttga cagacgccct cctgaggaga gccgcccggc ccgcctcagc
      241 ctcacccggc cgagcgctgt tccccagccc cgcgccagcg agtccgggac ctggccgcac
      301 ggggcctgcg gactcggata attgatcgga gtcagcagtg gtgcggtgga aatatcggtt
      361 tttgttctgg agaaatagag gccttccctg aagtttccca tgtctcaatg gactcctgaa
      421 tttaacgagc tctacaccct aaaagtggct atgaagagtg ggactcctga tgcgcccact
      481 acacaggaga gtctgaaggc ggtccttctg cacccacagc ccctaggggc caccaagagc
      541 ttccctgcag aagtggagat gattaatagc aaagtgggga atgaattctc tcatctgtgt
      601 gatgattctc aaaaacaaga gaaggacatg actggcaacc agcaagaaca agaaaaaagt
      661 ggtgttgtga gaaaaaagcg caaaagccag caggctggcc cctcatatgt gcagaactgt
      721 gtcaaagaaa atcaggaaat cctagggcgc agacaacagc tagagacacc gagtgatgag
      781 gataatgact cttccttaag tgagtgtctg tcttctccct catctagtct ccattttggg
      841 ggctctgata cagtgacttc agatgaggat aaagaagtct cggtgagaca tacccagcct
      901 gttctgagtg ctaaaagtag aagtcacagt gcaaggtctc acaagtggcc tcgaactgag
      961 gcagatcctg tgccaagttt gttaatgaaa agaccttgtt ttcatggcag tgcactaagg
     1021 agagtcacat gcagaaagag gctggtgaag agcagctcct cgcagaggac acagaagcag
     1081 aaggagagga tgctagtgca gaggaagaag cgggaggcgc tagctcagag gaagtatgct
     1141 cttctctcca gctccagtag ctccagtgag aatgacctca gcagcgattc ctcgtccagc
     1201 tcctccaccg atggagaaga ggacctgtgt gcatctgcca gtgagaaccc cagcaacccc
     1261 gctgctccct caggaagtat tgatgaagat gttgtggtga tagaagcctc cttcactccc
     1321 caggtcactg ccaatgaaga aattaatgtt acctcaactg acagtgaagt ggagattgtt
     1381 acagttggag aaagctatcg gtctcgttca acccttggac actccagatc tcattggagc
     1441 caaggttcaa gttcgcatac aggacggcca caggagtctc gaaaccgcag taggatctct
     1501 actgttatac agcccctgag gcagaatgca gcagaagttg tggaccttac tgttgatgaa
     1561 gatgaaccta ctatagtacc aaccacttct gctagaatgg actcacaaac tactagtgct
     1621 tccattaaca attcaaatcc atctacctct gagcaagcct ctgatactac ttcaactgtg
     1681 gccagtagcc agccttccac agtgtcagag actgaagcta ctcttacaag caatagtgca
     1741 actggttctt ctgtgggcga tgacgtgagg agaactgcat ctagtgctgt cccagaaagt
     1801 ggtcctcctg caatgccaag gctaccttct tgctgccccc agcactcacc atgtggaggg
     1861 acatcacaga gccatcatgc attagcacac ccacactcaa gttgttttca gcagcatggc
     1921 caccattttc agcatcacca ccatcaccac catactcccc acccagctgt cccagtttct
     1981 ccttccttca gtgaccctgc ttgcccagtg gaaagacctc aagtacaggc gccttgtgga
     2041 gcaaatagca gctctggttc cagctaccat gaccagcagg cattgccagt cgatctgagc
     2101 aacagtgctc tcaggactca tggaagtggg ggtttccatg gtgcatctgc ttttgacccc
     2161 tgctgccctg tcacatcttc ccgggctgca gtctttggcc atcaggctgc tgctgccccg
     2221 actcagccat tatcaataga tggctatggc tccagcatgg ttgcccagcc ccagccccag
     2281 ccccctccac agccttctct ttcgtcatgt cggcactaca tgccacctcc gtatgcttcc
     2341 ttgacaagac cactgcacca tcaagcctca gcttgccatc actctcatgg aaatgcccct
     2401 ccccagactc agcctccccc tcaagtggat tacgtgattc cgcatcctgt ccatgctttc
     2461 cattctcaga tatcttctca tgcagcatct caccctgtgg caccaccgcc gccaacacat
     2521 ttaggcagta cagcggcacc catccctcag catcttcctc ctgctcacca gccaatttca
     2581 caccatattc cagccccagc accttcagcc cagagactgc accctcatga agtgatgcag
     2641 aggatggaag ttcagaggag gaggatgatg cagcatccaa cgcgggcaca tgaacggccc
     2701 ccgccccatc cacataggat gcacccaaac tatggccatg ggcatcatat tcatgtgcct
     2761 caaaccatgt cttcacatcc tcgccaggct ccagagagaa ctgcctggga actggggatt
     2821 gaagctggag taactgcagc tacctacaca cctggtgctc tgcaccctca cctggcccat
     2881 taccacgccc cgcctcgact tcatcacctc cagttaggag cacttccttt aatggttcct
     2941 gacatggcag gctatcctca catccgttat atttcttcag gattggatgg agcatcattc
     3001 agaggtcctt ttaggggcaa ttttgaggaa ttgattcatc tggaagaaag attaggaaat
     3061 gtcaatcgtg gagcctccca gggaacaatt gaaagatgca catatccaca taaatataaa
     3121 aaggtaacaa ctgattggtt ctcacagagg aaactgcact gcaaacaaga tggggaagaa
     3181 gggactgagg aagacacaga ggaaaaatgt actatctgtt tgtctatttt agaggaaggt
     3241 gaagatgtga ggcgccttcc atgtatgcac cttttccacc aagtgtgtgt tgatcagtgg
     3301 ctgatcacca ataagaagtg ccccatatgc agagtggaca tcgaggccca gctgccaagt
     3361 gaaagttgac attgtgtttc agaactcttg gtgtccctct cattcctatc cttcctggta
     3421 ctgcagtcaa ccaaagatgg catgacttac ctgcgcagat ctggaagcct tgaactcgga
     3481 gtgctgactc tgctacatgg tacagctacc gctagaccta caacttatgt acacagttga
     3541 ttttgatgta tttataaaag cttttttttt ccctagattt gacattactt cctgtatcat
     3601 tttactgtat ttttgcatga ttccttgtat tgcatttctt tgcacatatt atgggcttgt
     3661 gaccctaaac ttgcaggcaa gattagctgc tttagtaagt agtattttgt ggtctttttt
     3721 ttgttttttg ggtttttttg tttttgtttt tgttttgttt ttgttttttg ttttttacat
     3781 agtaccttga aaattatgaa ttttttatcc attactaacc tttaatttaa tcaatcatgt
     3841 actttagttt aatgtataaa gattttctag gaaatgatat tgtgtattaa gacattcctt
     3901 aattaaatta ggacaaaatg gctgctgtat atttacaata tggaattctg agttaagtac
     3961 cgcccttcat actgggaaca gaatgtatgt aacccatgtc aatcagatgc aggtggtacc
     4021 cacacgacca gagtgatcaa taggaatttt cttggtgttc ctttcttcca gcacagtgca
     4081 agatagagtt gctgttgatg ccatatgttt agactgctgt tctgacccta tttatctttc
     4141 tctctgccat ttggaacttt attccctaac ccaggttttg ctgctgtgaa acagcgttga
     4201 tgaacactaa atattaatct gagatagctg gattgtatat acttgcagat ttaaaaatat
     4261 agggaaattg aaaaagacat gtagaatttt gttaggtctt ctgctaagca cgaataagat
     4321 atctgcttac attaattttt ataaagtcat tcagtcagaa tttaggattc agtcattggc
     4381 aggtatctat gcattcgtag aacttctaag ggtcccagga tcacttttaa gggatttttt
     4441 ttttatagtt taaataaagt cagctgaatc tacatgtctc ttgttttatt tctctctaaa
     4501 cttgaaaaca gtaaatctgc agatactgtg aggcacagat tatattgtca agctactgtt
     4561 gctatggtta tagacaccca cttcagacat taccaagagt cgatcactga cttaaaaatt
     4621 ttaatttcta tagttaagat ttacaacata atatagagtg aaagttaaca tactaacatt
     4681 tctcctttgg aggaagtttt aatccacttc aggatgcata ttagcaagat actttcatat
     4741 acaggatagc ctaattttat ttgtttaaat atgcttaata tgcccaagat tgcaaatgca
     4801 tccagtcagt aataccactg tctgtatgtg gaagacatgt tcccatggat catatgtgaa
     4861 gatgtcaata agcttgcatt aagccacctg ctttgtaagt ggattgatta ataaataact
     4921 tatatttcta ttgtc
//
