LOCUS       NM_001357494            4741 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus ring finger 111 (Rnf111), transcript variant 2, mRNA.
ACCESSION   NM_001357494 XM_006511586
VERSION     NM_001357494.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Xu H, Wu L, Nguyen HH, Mesa KR, Raghavan V, Episkopou V and Littman
            DR.
  TITLE     Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34473197
  REMARK    GeneRIF: Arkadia-SKI/SnoN signaling differentially regulates
            TGF-beta-induced iTreg and Th17 cell differentiation.
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou KC,
            Samiotaki M, Szantai E, Saviolaki D, Brown PJ, Sideras P, Panayotou
            G and Talianidis I.
  TITLE     SET9-Mediated Regulation of TGF-beta Signaling Links Protein
            Methylation to Pulmonary Fibrosis
  JOURNAL   Cell Rep 15 (12), 2733-2744 (2016)
   PUBMED   27292644
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Tsubakihara Y, Hikita A, Yamamoto S, Matsushita S, Matsushita N,
            Oshima Y, Miyazawa K and Imamura T.
  TITLE     Arkadia enhances BMP signalling through ubiquitylation and
            degradation of Smad6
  JOURNAL   J Biochem 158 (1), 61-71 (2015)
   PUBMED   25762727
  REMARK    GeneRIF: Arkadia, but not the C937A (CA) mutant lacking E3
            ubiquitin-ligase activity, induced ubiquitylation and
            proteasome-dependent degradation of Smad6.
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Sun H, Liu Y and Hunter T.
  TITLE     Multiple Arkadia/RNF111 structures coordinate its Polycomb body
            association and transcriptional control
  JOURNAL   Mol Cell Biol 34 (16), 2981-2995 (2014)
   PUBMED   24912682
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ,
            Streicher W, Wikstrom M, Choudhary C, Houtsmuller AB, Marteijn JA,
            Bekker-Jensen S and Mailand N.
  TITLE     RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates
            the DNA damage response
  JOURNAL   J Cell Biol 201 (6), 797-807 (2013)
   PUBMED   23751493
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina
            M, Nukiwa T, Miyazawa K, Imamura T and Miyazono K.
  TITLE     Arkadia amplifies TGF-beta superfamily signalling through
            degradation of Smad7
  JOURNAL   EMBO J 22 (24), 6458-6470 (2003)
   PUBMED   14657019
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4741)
  AUTHORS   Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire
            G, Caceres JF and Bickmore WA.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 4741)
  AUTHORS   Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL and Swan D.
  TITLE     Induction of the mammalian node requires Arkadia function in the
            extraembryonic lineages
  JOURNAL   Nature 410 (6830), 825-830 (2001)
   PUBMED   11298452
REFERENCE   10 (bases 1 to 4741)
  AUTHORS   Hara Y, Battey J and Gainer H.
  TITLE     Structure of mouse vasopressin and oxytocin genes
  JOURNAL   Brain Res Mol Brain Res 8 (4), 319-324 (1990)
   PUBMED   2176709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158995.2 and AC157086.2.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_001357494.2.
            
            On Oct 28, 2017 this sequence version replaced XM_006511586.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice junction compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC158995.2         95557-95703
            148-210             AC158995.2         95933-95995
            211-1103            AC158995.2         122267-123159
            1104-1230           AC157086.2         1762-1888
            1231-1394           AC157086.2         12090-12253
            1395-1589           AC157086.2         13225-13419
            1590-1906           AC157086.2         17426-17742
            1907-2162           AC157086.2         20702-20957
            2163-2511           AC157086.2         27493-27841
            2512-2637           AC157086.2         28846-28971
            2638-2764           AC157086.2         30362-30488
            2765-2857           AC157086.2         39214-39306
            2858-2953           AC157086.2         40217-40312
            2954-3057           AC157086.2         41588-41691
            3058-4741           AC157086.2         44136-45819
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.53 cM"
     gene            1..4741
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /note="ring finger 111"
                     /db_xref="GeneID:93836"
                     /db_xref="MGI:MGI:1934919"
     exon            1..147
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            148..210
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1103
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..3175
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase Arkadia; RING finger protein 111;
                     RING-type E3 ubiquitin transferase Arkadia"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Arkadia isoform 2"
                     /protein_id="NP_001344423.1"
                     /db_xref="CCDS:CCDS90614.1"
                     /db_xref="GeneID:93836"
                     /db_xref="MGI:MGI:1934919"
                     /translation="MSQWTPEFNELYTLKVAMKSGTPDAPTTQESLKAVLLHPQPLGA
                     TKSFPAEVEMINSKVGNEFSHLCDDSQKQEKDMTGNQQEQEKSGVVRKKRKSQQAGPS
                     YVQNCVKENQEILGRRQQLETPSDEDNDSSLSECLSSPSSSLHFGGSDTVTSDEDKEV
                     SVRHTQPVLSAKSRSHSARSHKWPRTEADPVPSLLMKRPCFHGSALRRVTCRKRLVKS
                     SSSQRTQKQKERMLVQRKKREALAQRKYALLSSSSSSSENDLSSDSSSSSSTDGEEDL
                     CASASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYR
                     SRSTLGHSRSHWSQGSSSHTGRPQESRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTI
                     VPTTSARMDSQTTSASINNSNPSTSEQASDTTSTVASSQPSTVSETEATLTSNSATGS
                     SVGDDVRRTASSAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQQHGH
                     HFQHHHHHHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDL
                     SNSALRTHGSGGFHGASAFDPCCPVTSSRAAVFGHQAAAAPTQPLSIDGYGSSMVAQP
                     QPQPPPQPSLSSCRHYMPPPYASLTRPLHHQASACHHSHGNAPPQTQPPPQVDYVIPH
                     PVHAFHSQISSHAASHPVAPPPPTHLGSTAAPIPQHLPPAHQPISHHIPAPAPSAQRL
                     HPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAP
                     ERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIR
                     YISSGLDGASFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKRKLHCK
                     QDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVD
                     IEAQLPSES"
     exon            1104..1230
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1394
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1589
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1906
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2162
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2511
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2637
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2764
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2857
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2953
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3057
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..4741
                     /gene="Rnf111"
                     /gene_synonym="ARK; Arkadia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaggagg gagaaagagg aagggccgcg gcggccggcc cgggtcggcg acaggggaat
       61 gaccgcgggt cccggacggc gcggagtggc tcattgtgtc cgggcaagag tccgcccgcg
      121 gacacaccca cggcctcttg ggaggggata attgatcgga gtcagcagtg gtgcggtgga
      181 aatatcggtt tttgttctgg agaaatagag gccttccctg aagtttccca tgtctcaatg
      241 gactcctgaa tttaacgagc tctacaccct aaaagtggct atgaagagtg ggactcctga
      301 tgcgcccact acacaggaga gtctgaaggc ggtccttctg cacccacagc ccctaggggc
      361 caccaagagc ttccctgcag aagtggagat gattaatagc aaagtgggga atgaattctc
      421 tcatctgtgt gatgattctc aaaaacaaga gaaggacatg actggcaacc agcaagaaca
      481 agaaaaaagt ggtgttgtga gaaaaaagcg caaaagccag caggctggcc cctcatatgt
      541 gcagaactgt gtcaaagaaa atcaggaaat cctagggcgc agacaacagc tagagacacc
      601 gagtgatgag gataatgact cttccttaag tgagtgtctg tcttctccct catctagtct
      661 ccattttggg ggctctgata cagtgacttc agatgaggat aaagaagtct cggtgagaca
      721 tacccagcct gttctgagtg ctaaaagtag aagtcacagt gcaaggtctc acaagtggcc
      781 tcgaactgag gcagatcctg tgccaagttt gttaatgaaa agaccttgtt ttcatggcag
      841 tgcactaagg agagtcacat gcagaaagag gctggtgaag agcagctcct cgcagaggac
      901 acagaagcag aaggagagga tgctagtgca gaggaagaag cgggaggcgc tagctcagag
      961 gaagtatgct cttctctcca gctccagtag ctccagtgag aatgacctca gcagcgattc
     1021 ctcgtccagc tcctccaccg atggagaaga ggacctgtgt gcatctgcca gtgagaaccc
     1081 cagcaacccc gctgctccct caggaagtat tgatgaagat gttgtggtga tagaagcctc
     1141 cttcactccc caggtcactg ccaatgaaga aattaatgtt acctcaactg acagtgaagt
     1201 ggagattgtt acagttggag aaagctatcg gtctcgttca acccttggac actccagatc
     1261 tcattggagc caaggttcaa gttcgcatac aggacggcca caggagtctc gaaaccgcag
     1321 taggatctct actgttatac agcccctgag gcagaatgca gcagaagttg tggaccttac
     1381 tgttgatgaa gatgaaccta ctatagtacc aaccacttct gctagaatgg actcacaaac
     1441 tactagtgct tccattaaca attcaaatcc atctacctct gagcaagcct ctgatactac
     1501 ttcaactgtg gccagtagcc agccttccac agtgtcagag actgaagcta ctcttacaag
     1561 caatagtgca actggttctt ctgtgggcga tgacgtgagg agaactgcat ctagtgctgt
     1621 cccagaaagt ggtcctcctg caatgccaag gctaccttct tgctgccccc agcactcacc
     1681 atgtggaggg acatcacaga gccatcatgc attagcacac ccacactcaa gttgttttca
     1741 gcagcatggc caccattttc agcatcacca ccatcaccac catactcccc acccagctgt
     1801 cccagtttct ccttccttca gtgaccctgc ttgcccagtg gaaagacctc aagtacaggc
     1861 gccttgtgga gcaaatagca gctctggttc cagctaccat gaccagcagg cattgccagt
     1921 cgatctgagc aacagtgctc tcaggactca tggaagtggg ggtttccatg gtgcatctgc
     1981 ttttgacccc tgctgccctg tcacatcttc ccgggctgca gtctttggcc atcaggctgc
     2041 tgctgccccg actcagccat tatcaataga tggctatggc tccagcatgg ttgcccagcc
     2101 ccagccccag ccccctccac agccttctct ttcgtcatgt cggcactaca tgccacctcc
     2161 gtatgcttcc ttgacaagac cactgcacca tcaagcctca gcttgccatc actctcatgg
     2221 aaatgcccct ccccagactc agcctccccc tcaagtggat tacgtgattc cgcatcctgt
     2281 ccatgctttc cattctcaga tatcttctca tgcagcatct caccctgtgg caccaccgcc
     2341 gccaacacat ttaggcagta cagcggcacc catccctcag catcttcctc ctgctcacca
     2401 gccaatttca caccatattc cagccccagc accttcagcc cagagactgc accctcatga
     2461 agtgatgcag aggatggaag ttcagaggag gaggatgatg cagcatccaa cgcgggcaca
     2521 tgaacggccc ccgccccatc cacataggat gcacccaaac tatggccatg ggcatcatat
     2581 tcatgtgcct caaaccatgt cttcacatcc tcgccaggct ccagagagaa ctgcctggga
     2641 actggggatt gaagctggag taactgcagc tacctacaca cctggtgctc tgcaccctca
     2701 cctggcccat taccacgccc cgcctcgact tcatcacctc cagttaggag cacttccttt
     2761 aatggttcct gacatggcag gctatcctca catccgttat atttcttcag gattggatgg
     2821 agcatcattc agaggtcctt ttaggggcaa ttttgaggaa ttgattcatc tggaagaaag
     2881 attaggaaat gtcaatcgtg gagcctccca gggaacaatt gaaagatgca catatccaca
     2941 taaatataaa aagaggaaac tgcactgcaa acaagatggg gaagaaggga ctgaggaaga
     3001 cacagaggaa aaatgtacta tctgtttgtc tattttagag gaaggtgaag atgtgaggcg
     3061 ccttccatgt atgcaccttt tccaccaagt gtgtgttgat cagtggctga tcaccaataa
     3121 gaagtgcccc atatgcagag tggacatcga ggcccagctg ccaagtgaaa gttgacattg
     3181 tgtttcagaa ctcttggtgt ccctctcatt cctatccttc ctggtactgc agtcaaccaa
     3241 agatggcatg acttacctgc gcagatctgg aagccttgaa ctcggagtgc tgactctgct
     3301 acatggtaca gctaccgcta gacctacaac ttatgtacac agttgatttt gatgtattta
     3361 taaaagcttt ttttttccct agatttgaca ttacttcctg tatcatttta ctgtattttt
     3421 gcatgattcc ttgtattgca tttctttgca catattatgg gcttgtgacc ctaaacttgc
     3481 aggcaagatt agctgcttta gtaagtagta ttttgtggtc ttttttttgt tttttgggtt
     3541 tttttgtttt tgtttttgtt ttgtttttgt tttttgtttt ttacatagta ccttgaaaat
     3601 tatgaatttt ttatccatta ctaaccttta atttaatcaa tcatgtactt tagtttaatg
     3661 tataaagatt ttctaggaaa tgatattgtg tattaagaca ttccttaatt aaattaggac
     3721 aaaatggctg ctgtatattt acaatatgga attctgagtt aagtaccgcc cttcatactg
     3781 ggaacagaat gtatgtaacc catgtcaatc agatgcaggt ggtacccaca cgaccagagt
     3841 gatcaatagg aattttcttg gtgttccttt cttccagcac agtgcaagat agagttgctg
     3901 ttgatgccat atgtttagac tgctgttctg accctattta tctttctctc tgccatttgg
     3961 aactttattc cctaacccag gttttgctgc tgtgaaacag cgttgatgaa cactaaatat
     4021 taatctgaga tagctggatt gtatatactt gcagatttaa aaatataggg aaattgaaaa
     4081 agacatgtag aattttgtta ggtcttctgc taagcacgaa taagatatct gcttacatta
     4141 atttttataa agtcattcag tcagaattta ggattcagtc attggcaggt atctatgcat
     4201 tcgtagaact tctaagggtc ccaggatcac ttttaaggga tttttttttt atagtttaaa
     4261 taaagtcagc tgaatctaca tgtctcttgt tttatttctc tctaaacttg aaaacagtaa
     4321 atctgcagat actgtgaggc acagattata ttgtcaagct actgttgcta tggttataga
     4381 cacccacttc agacattacc aagagtcgat cactgactta aaaattttaa tttctatagt
     4441 taagatttac aacataatat agagtgaaag ttaacatact aacatttctc ctttggagga
     4501 agttttaatc cacttcagga tgcatattag caagatactt tcatatacag gatagcctaa
     4561 ttttatttgt ttaaatatgc ttaatatgcc caagattgca aatgcatcca gtcagtaata
     4621 ccactgtctg tatgtggaag acatgttccc atggatcata tgtgaagatg tcaataagct
     4681 tgcattaagc cacctgcttt gtaagtggat tgattaataa ataacttata tttctattgt
     4741 c
//
