LOCUS       NM_009543               3247 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ring finger protein 103 (Rnf103), transcript variant
            1, mRNA.
ACCESSION   NM_009543
VERSION     NM_009543.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Hashimoto-Gotoh,T., Iwabe,N., Tsujimura,A., Nakagawa,M. and
            Marunaka,Y.
  TITLE     KF-1 ubiquitin ligase: anxiety suppressor model
  JOURNAL   Cell Biochem Biophys 60 (1-2), 69-75 (2011)
   PUBMED   21455683
  REMARK    GeneRIF: Studies indicate that the kf-1 null mice should be useful
            in elucidating the molecular mechanisms of the anxiety regulation.
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Hashimoto-Gotoh,T., Iwabe,N., Tsujimura,A., Takao,K. and
            Miyakawa,T.
  TITLE     KF-1 Ubiquitin Ligase: An Anxiety Suppressor
  JOURNAL   Front Neurosci 3 (1), 15-24 (2009)
   PUBMED   19753093
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Tsujimura,A., Matsuki,M., Takao,K., Yamanishi,K., Miyakawa,T. and
            Hashimoto-Gotoh,T.
  TITLE     Mice lacking the kf-1 gene exhibit increased anxiety- but not
            despair-like behavior
  JOURNAL   Front Behav Neurosci 2, 4 (2008)
   PUBMED   18958194
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Yamada,M., Yamada,M., Yamazaki,S., Takahashi,K., Nishioka,G.,
            Kudo,K., Ozawa,H., Yamada,S., Kiuchi,Y., Kamijima,K., Higuchi,T.
            and Momose,K.
  TITLE     Identification of a novel gene with RING-H2 finger motif induced
            after chronic antidepressant treatment in rat brain
  JOURNAL   Biochem Biophys Res Commun 278 (1), 150-157 (2000)
   PUBMED   11071867
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Yasojima,K., Tsujimura,A., Mizuno,T., Shigeyoshi,Y., Inazawa,J.,
            Kikuno,R., Kuma,K., Ohkubo,K., Hosokawa,Y., Ibata,Y., Abe,T.,
            Miyata,T., Matsubara,K., Nakajima,K. and Hashimoto-Gotoh,T.
  TITLE     Cloning of human and mouse cDNAs encoding novel zinc finger
            proteins expressed in cerebellum and hippocampus
  JOURNAL   Biochem Biophys Res Commun 231 (2), 481-487 (1997)
   PUBMED   9070305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154001.5.
            
            On Aug 9, 2022 this sequence version replaced NM_009543.3.
            
            Summary: This gene encodes a member of the RING finger family of E3
            ubiquitin-protein ligases. These proteins catalyze the transfer of
            the ubiquitin protein from a ubiquitin E2 enzyme to a protein
            substrate. Homozygous knockout mice for this gene exhibit enhanced
            anxiety-like behavior. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146898.1, D76445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-979               AC154001.5         139747-140725
            980-1119            AC154001.5         142668-142807
            1120-1235           AC154001.5         151571-151686
            1236-3247           AC154001.5         154706-156717
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.16 cM"
     gene            1..3247
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /note="ring finger protein 103"
                     /db_xref="GeneID:22644"
                     /db_xref="MGI:MGI:109483"
     exon            1..979
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1119
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1235
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..3247
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /note="hexamer: AATAAA"
     polyA_site      3247
                     /gene="Rnf103"
                     /gene_synonym="kf-1; Zfp103"
                     /note="major polyA site"
ORIGIN      
        1 agtgctctgg gggcgacggc cgcggcctgc agaggcggca gggacggtgg ccgcggttgg
       61 cgcggcgcgt ccgcacgggg ctgggcaccg cgcggctacg cagctgacag gaagccgccc
      121 gggagagccg cgttggggcc tagcgttatt tgctttttcc tctttttttc ctcccttcac
      181 gactgtcgtc tcgcgctcct cctcagcggg agccgccgcg acgccccctc gcgggccgcg
      241 gggcctgata ggcgccgccc gcgggaacct ggagctgccg ccaggcctgg gcggccgccg
      301 gggcctgaag cctgggcgtt cggcgcggcg ctgcggcggt cactccaacc cgcgctgggc
      361 gcgccgggcc ccgggcctgg cccagccgag taccgcgccc tctggaccac tcagtccggc
      421 cccaaccgcc ctccgctggc ccgcagtccc tcggagctgc ctcccggtca ccccaggtgg
      481 gctcttgccc tcttccagcc gtccgcagct cgatgggtgg ggtgcgtttg aacgtccccc
      541 cttctccctt tctcagctcc tgaccgcaag gccagagccg gggctctcag tcgcacgcac
      601 gccgcgatcc acctgcctcc ccgcggggat ggcccgccgg tgaccgccgc gcgccctcgc
      661 tgccctcgcc caggctgcgc tctgtcgccc cgcactcgat ccccttccct tgtccacggc
      721 gtcccggctc ctggcgacgc caagagggcg aagatgtggc tgaagctgtt tttcttgctc
      781 ctgtatttcc tggtcctgtt cgtcctggcc aggttttttg aggccattgt gtggtacgag
      841 actggcatct ttgctactca gctggtggat ccggtggcat tgagcttcaa gaagctgaag
      901 accattctgg agtgtcgagg gctgggctac tccgggctgc cggagaagaa agatgttcgg
      961 gagctggtgg agaagtcagg tgacttgatg gaaggtgaac tctattctgc tcttaaggaa
     1021 gaagaggcat ctgagtctgt ttctagtacc aatttcagtg gtgaaatgca tttctatgag
     1081 cttgtggaag acacaaaaga tggcatctgg ctggttcagg tcatagcaaa tgacagaagt
     1141 cctttggtgg gtaaaatcca ctgggagaaa atggtgaaaa aagtgtcaag atttggaata
     1201 cggacaggca ctttcaactg ttccagtgat cccaggtact gcagaaggag aggctgggtg
     1261 cgttccacac tcatcatgtc tgtgccacaa acaagtacat ctaaagggaa agtcatgctt
     1321 aaagagtaca gtggacgcaa gattgaagta gagcacattt ttaagtggat aactgcccat
     1381 gcagcttctc ggatcaaaac tatatataat gtggagcatt tgaaggaaga atggaataaa
     1441 agtgatcaat actgggtaaa aatataccta tttgcaaacc ttgaccaacc gccagctttc
     1501 ttctctgcat taagtataaa atttactgga agagttgagt ttatttttgt taatgtggaa
     1561 aattggaaca acaagagtta tatgacagat attggtattt ataacatgcc atcatacata
     1621 cttagaactc ctgaaggaat ttatagatac ggaaaccaca caggtgaatt tatatccctt
     1681 caggccatgg attcatttct gcgctcatta caacctgaag taaatgatct gtttgttttg
     1741 agtttggttc tagttaatct tatggcttgg atggacttat ttattacaca aggagcaacc
     1801 atcaagcgat ttgtggttct cataagcact ttagggacat acaattccct attaattatt
     1861 tcttggctac ctgtgttggg ctttctacag ctcccttact tagatagctt ttatgactat
     1921 agtttaagat tgctgcggta ttctaataca accacactgg cttcgtgggt aagggcagac
     1981 tggatgtttt acacttcaca cccagccctg tttctcagta cataccttgg acatggtttg
     2041 ctaattgatt actttgagaa gaagagacgt cgcagcaaca atgatgaagt taatgcgaat
     2101 aatttagaat ggttatcaag tctgtgggac tggtacacca gctacctctt ccacccgatt
     2161 gcttcttttc agaactttcc tgtagactct gattgggacg aagaccctga cttattcttg
     2221 gaacggttag ctttccctga cctttggctt caccctctga taccaactga ttatattaaa
     2281 aacttaccaa tgtggcgatt taaatgtctt ggggttcagt ctgaagaaga aatgtcagag
     2341 agttctcaag acactgaaaa tgactcggat agtgacaaca tggacacttt tagtagtagt
     2401 aaggatatat ttgaagataa acaaagcgtt gttcacagtt ctccaggaag aacaagtcac
     2461 tgtgatactg aggcttgttc atgtgccaat aaatgtgaga gcagcccatg tgaaaggaag
     2521 aggaggtcgt atggatcaca taatactgat gaagatatgg aaccggactg gttaacttgg
     2581 cctgcgggta cgctgcactg tactgaatgt gttgtttgcc ttgagaattt tgaaaatgga
     2641 tgtttgctaa tggggttgcc ttgtggtcac gtgtttcacc agaattgcat tgttatgtgg
     2701 ttggctgggg gccgacactg ttgccctgtt tgtcgttggc cttcatataa gaaaaagcag
     2761 ccatatgcac aacaacagcc gttgtcaaat gatgttccat cttaaccatg tgcaatgtgt
     2821 ccttaataag ctttgagtat cttacagctt gcctttttaa tgttagtcac aatgtttttg
     2881 tggtttgaag tttagtttaa tgttagtgca gtgacaggaa atacacatta tgctgatgtt
     2941 gatgacagaa tttatttggt tgccttgtgt gtcaattgaa tgcatactaa actgtaaaaa
     3001 aaatttattt acagcattga aaattcagaa gttaatggtt ttttgtaagc acaaaagaag
     3061 tatggtagaa attaatctta acaagacttt atgaggcagg atcaaatcct agtgggcctg
     3121 agcaggtttc ttaccctaag tgttttctcc ctttttacaa tctctgtcca gcacctcttg
     3181 gttaaataat gtatgctctg agacatgaaa ttaaaacaga tctataaaat aaattatttt
     3241 aaaagca
//
