LOCUS       NM_001302448            3126 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus ring finger protein 10 (Rnf10), transcript variant 1,
            mRNA.
ACCESSION   NM_001302448 XM_006530402
VERSION     NM_001302448.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3126)
  AUTHORS   Tiu GC, Kerr CH, Forester CM, Krishnarao PS, Rosenblatt HD, Raj N,
            Lantz TC, Zhulyn O, Bowen ME, Shokat L, Attardi LD, Ruggero D and
            Barna M.
  TITLE     A p53-dependent translational program directs tissue-selective
            phenotypes in a model of ribosomopathies
  JOURNAL   Dev Cell 56 (14), 2089-2102 (2021)
   PUBMED   34242585
REFERENCE   2  (bases 1 to 3126)
  AUTHORS   van der Weyden L, Swiatkowska A, Iyer V, Speak AO and Adams DJ.
  TITLE     A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators
            of Pulmonary Metastatic Colonisation
  JOURNAL   G3 (Bethesda) 10 (6), 1869-1877 (2020)
   PUBMED   32245826
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3126)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3126)
  AUTHORS   Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim
            SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A,
            Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL,
            Dickinson ME and Samuel MA.
  TITLE     Rapid and Integrative Discovery of Retina Regulatory Molecules
  JOURNAL   Cell Rep 24 (9), 2506-2519 (2018)
   PUBMED   30157441
REFERENCE   5  (bases 1 to 3126)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 3126)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3126)
  AUTHORS   Malik YS, Sheikh MA, Lai M, Cao R and Zhu X.
  TITLE     RING finger protein 10 regulates retinoic acid-induced neuronal
            differentiation and the cell cycle exit of P19 embryonic carcinoma
            cells
  JOURNAL   J Cell Biochem 114 (9), 2007-2015 (2013)
   PUBMED   23526782
  REMARK    GeneRIF: Results showed that increase in Rnf10 expression upon RA
            induction is necessary for the positive regulation of cyclin kinase
            inhibitor p21 expression, which leads to cell cycle arrest and is
            critical for neuronal differentiation.
REFERENCE   8  (bases 1 to 3126)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3126)
  AUTHORS   Dmitriev RI, Korneenko TV, Bessonov AA, Shakhparonov MI, Modyanov
            NN and Pestov NB.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
REFERENCE   10 (bases 1 to 3126)
  AUTHORS   Seki N, Hattori A, Sugano S, Muramatsu M and Saito T.
  TITLE     cDNA cloning, expression profile, and genomic structure of human
            and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein
  JOURNAL   J Hum Genet 45 (1), 38-42 (2000)
   PUBMED   10697961
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146728.1, AK004579.1,
            AC145070.10 and AA792805.1.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_001302448.2.
            
            On Oct 22, 2014 this sequence version replaced XM_006530402.1.
            
            Summary: The protein encoding this gene is a member of the really
            interesting new gene finger protein family. Members of this family
            contain protein motifs similar to zinc finger domains and are
            involved in many processes that include transcriptional regulation,
            DNA repair and signal transduction. Expression of this gene is
            upregulated during neuronal differentiation of cultured cells, and
            inhibition of its expression impairs differentiation and cell cycle
            exit, providing evidence for a function in neuronal
            differentiation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156502.1, AK004579.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK146728.1         2-7
            7-79                AK004579.1         1-73
            80-80               AC145070.10        48772-48772
            81-1349             AK004579.1         75-1343
            1350-1352           AC145070.10        70423-70425
            1353-3112           AK004579.1         1348-3107
            3113-3126           AA792805.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..3126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.01 cM"
     gene            1..3126
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /note="ring finger protein 10"
                     /db_xref="GeneID:50849"
                     /db_xref="MGI:MGI:1859162"
     exon            1..639
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..2900
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; sid
                     2705; E3 ubiquitin-protein ligase RNF10"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF10 isoform 1"
                     /protein_id="NP_001289377.1"
                     /db_xref="CCDS:CCDS80381.1"
                     /db_xref="GeneID:50849"
                     /db_xref="MGI:MGI:1859162"
                     /translation="MPQSSPSAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGP
                     AGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSNQSRRSNSQKSKTFNKMPPQRGGG
                     SSKPFSSSSNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGS
                     GHGGWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRIC
                     SHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLK
                     SVVATESRQYAVGDTITMQLMKREKGVLVALPKSKWVNVDHPINLGDEQLSQYSKLLL
                     ASKEQVLHRVVLEEKGALEQQLAEEKHTPESCFIEAAIQEVKIREEALSGVAGGGGEV
                     TGVVAALEHLVLMAPLATESAFQPRKQGVLEYLSAFDDEAAQVCSLDPPGPLALPLVE
                     EEEAVSEPEACEDAEVADDSLGEGTVGPEMSQEEPITKPGFTQLSSSPCYYFYQAEDG
                     QHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCE
                     FSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEMEENKRQGRYP
                     EVHIPLENLQQFPAFNSYTCPSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLS
                     PTASQGSPSFCVGSLEDDSPFLSFAQMLRVGKAKADGWPKTAPKKDDNSLVPPAPVDS
                     DGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEDRGGKKRKRQKQKLLFS
                     TSVVHTK"
     exon            640..836
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1036
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1127
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1312
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1449
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1610
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1736
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1995
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2129
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2247
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2349
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2505
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2606
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2664
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2823
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3115
                     /gene="Rnf10"
                     /gene_synonym="mKIAA0262; RIE2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgctgttt ggcgactcgt cgccattccc ggagcagctc ggcctcggcc cagaggcgag
       61 tgtcggtcgc tgtgtcggag accccggtcc ccggcaccga gacagccagc cctctctcct
      121 gccccgcggc gggagagcgt gtccggccgg ccggcggggc tcgcgaccct cccgcgcctc
      181 cctttccccc gcagcctctg ccccgccagg cccggcccgg acctccgagc cccggcctcc
      241 tcctcctcct cctcctcgtc ctcgtcctcc tcttcggtca ccgccgcctc tgggccccac
      301 aaccccacct tgccgcttct ccttccattt tgagaagctg aggaaggaaa caaggaaaaa
      361 tgtcgccatg aaggccgaga accgctgccg ccgccgaccc ccgccggccc tgaacgccat
      421 gagcctgggt ccccgccgcg cccgctccgc tccgaccgcc gtcgccgccg aggccccctt
      481 tgatgccgca gagctccccc agcgccgccg ccaccgcctc cgacatggac aagaacagcg
      541 gctccaacag ctcctccgcc tcctcgggca gcagcaaagg gcaacagccg ccccgctccg
      601 cctcggcggg gccggccggc gagtctaaac ccaagagtga tggaaagaac tcaaatggat
      661 ccaagcgtta caatcgcaag cgtgaaccct cctaccccaa aaatgaaaat tttagcaacc
      721 agtcccgtcg ctccaattca cagaaaagca aaacttttaa caagatgcct cctcaaaggg
      781 gcggtggcag cagcaaaccc tttagctctt cttctaatgg tggaagacga gatgaggtag
      841 cagaggctca gcgggcagag tttagccctg cccagttctc tggccctaag aagatcaacc
      901 tgaaccactt gttaaatttc acctttgaac cacgtggcca ggcaggtcac tttgaaggca
      961 gtgggcatgg cggctggggg aagagaaaca agtggggaca caagcctttc aacaaggagc
     1021 tctttctaca ggccaactgc caatttgtgg tgtctgaaga ccaagactac gcagctcact
     1081 ttgctgaccc tgacacctta gtcaactggg actttgtgga acaagtgcgc atctgtagcc
     1141 atgaagtgcc atcttgccca atatgcctct atccacctac tgcggccaag ataacgcgct
     1201 gtggacacat tttctgctgg gcatgcatcc tgcactatct ttcactcagt gagaaaacct
     1261 ggagcaaatg tcccatctgc tacagctctg tgcataagaa ggatctcaag agtgttgttg
     1321 ccacagagtc tcgacagtat gctgtggggg acaccattac catgcagctg atgaagagag
     1381 agaagggagt gttggtggcc ctgcccaaat ccaagtgggt gaatgtagac catcctatta
     1441 acctaggaga tgagcagctc agccagtatt ccaagctgct gctggcctcg aaggagcagg
     1501 tgctgcaccg ggtagttctg gaggagaaag gagcgctgga gcagcagctg gcagaggaga
     1561 agcacactcc tgagtcctgt ttcattgagg ctgctatcca ggaggtcaag attcgggaag
     1621 aagctctgtc aggagtggct ggaggcggag gggaggtcac tggtgttgtg gctgctctgg
     1681 aacacctggt gctgatggct cccctggcca cggagtctgc tttccaaccc aggaagcagg
     1741 gtgtgctgga gtatctgtct gcttttgatg atgaagctgc acaagtttgt tctctggacc
     1801 cccctggtcc tcttgccctc cctttggtag aagaggagga agcagtgtct gagccagaag
     1861 cctgtgagga cgcagaggta gccgatgaca gtctgggaga ggggactgtt ggtcctgaga
     1921 tgagccagga ggagcccatc actaagccag gcttcaccca gctcagcagc tctccgtgtt
     1981 actacttcta ccaggcggaa gatggacagc acatgttcct gcaccctgtc aacgtgcgct
     2041 gccttgtgcg ggagtacggc agcctggagc agagcccaga gaagatctca gcaaccgtgg
     2101 tagagattgc tgggtattcc atgtctgagg atgttcggca gcgtcatagg tatctctctc
     2161 acttgccact cacctgtgag ttcagcatct gtgaactggc tctgcagcct cctgtggtct
     2221 ctaaggaaac cctagagatg ttctcagatg acattgagaa aaggaagcgt cagcgccaaa
     2281 agaaggctcg cgaggagcgt cgccgagagc gcagaattga gatggaggag aacaagagac
     2341 agggcaggta tcccgaggtc cacattcccc tcgagaacct acagcagttt ccggccttca
     2401 attcctatac ctgtccctct gattctgctt tgggtcccac cagcactgag ggccatgggg
     2461 ccctatccct gtctcctctg agcagaagtc caggctccca tgcagacttt ctgctgaccc
     2521 ctctgtcacc cactgccagt cagggcagtc cttccttctg cgttgggagt ctggaagacg
     2581 actctccctt cctttccttt gcccagatgc tgagggttgg caaagcaaaa gcagacgggt
     2641 ggcccaaaac tgctccaaag aaagatgaca atagcttggt tcctcccgcc cctgtggaca
     2701 gtgatgggga gagtgacaat tctgaccgtg ttcctgtgcc cagtttccaa aattccttca
     2761 gccaagctat cgaagcagcc ttcatgaaat tggacacacc agctacttca gaccccctct
     2821 ctgaagacag aggagggaag aaaaggaaga gacagaagca gaagctgctg ttcagcacct
     2881 cggtcgtcca caccaagtga cactattgcc caggcgcctt ctccatcggg tttcctctct
     2941 gtgcttttgt tttgctgctg taatttttaa gtatttgagt ttgaacagat tgattagctt
     3001 ggggcggggg gaggggcttt ccacaaagtg agggggaacc aagaaaattt taaatacagt
     3061 gtattttcca gcttcccctc tttacaccag aataaagtat tgacactcaa cttgaaaaaa
     3121 aaaaaa
//
