LOCUS       NM_028810               2827 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus Rho family GTPase 3 (Rnd3), mRNA.
ACCESSION   NM_028810
VERSION     NM_028810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Hu,W., Wang,M., Sun,G., Zhang,L. and Lu,H.
  TITLE     RND3 modulates microglial polarization and alleviates
            neuroinflammation in Parkinson's disease by suppressing NLRP3
            inflammasome activation
  JOURNAL   Exp Cell Res 439 (1), 114088 (2024)
   PUBMED   38744409
  REMARK    GeneRIF: RND3 modulates microglial polarization and alleviates
            neuroinflammation in Parkinson's disease by suppressing NLRP3
            inflammasome activation.
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Abbey,C.A., Duran,C.L., Chen,Z., Chen,Y., Roy,S., Coffell,A.,
            Sveeggen,T.M., Chakraborty,S., Wells,G.B., Chang,J. and
            Bayless,K.J.
  TITLE     Identification of New Markers of Angiogenic Sprouting Using
            Transcriptomics: New Role for RND3
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (5), e145-e167 (2024)
   PUBMED   38482696
  REMARK    GeneRIF: Identification of New Markers of Angiogenic Sprouting
            Using Transcriptomics: New Role for RND3.
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Zhang,Y., Zhu,Z., Cao,Y., Xiong,Z., Duan,Y., Lin,J., Zhang,X.,
            Jiang,M., Liu,Y., Man,W., Jia,T., Feng,J., Chen,Y., Li,C., Guo,B.
            and Sun,D.
  TITLE     Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis
            through regulation of ubiquitination of TRAF6
  JOURNAL   Clin Transl Med 13 (9), e1406 (2023)
   PUBMED   37743632
  REMARK    GeneRIF: Rnd3 suppresses endothelial cell pyroptosis in
            atherosclerosis through regulation of ubiquitination of TRAF6.
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Zhang,Y., Cao,Y., Zheng,R., Xiong,Z., Zhu,Z., Gao,F., Man,W.,
            Duan,Y., Lin,J., Zhang,X., Wu,D., Jiang,M., Zhang,X., Li,C., Gu,X.,
            Fan,Y. and Sun,D.
  TITLE     Fibroblast-specific activation of Rnd3 protects against cardiac
            remodeling in diabetic cardiomyopathy via suppression of Notch and
            TGF-beta signaling
  JOURNAL   Theranostics 12 (17), 7250-7266 (2022)
   PUBMED   36438502
  REMARK    GeneRIF: Fibroblast-specific activation of Rnd3 protects against
            cardiac remodeling in diabetic cardiomyopathy via suppression of
            Notch and TGF-beta signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   8  (bases 1 to 2827)
  AUTHORS   Villalonga,P., Guasch,R.M., Riento,K. and Ridley,A.J.
  TITLE     RhoE inhibits cell cycle progression and Ras-induced transformation
  JOURNAL   Mol Cell Biol 24 (18), 7829-7840 (2004)
   PUBMED   15340047
  REMARK    GeneRIF: RhoE inhibits cell cycle progression upstream of the pRb
            checkpoint.
REFERENCE   9  (bases 1 to 2827)
  AUTHORS   Riento,K., Guasch,R.M., Garg,R., Jin,B. and Ridley,A.J.
  TITLE     RhoE binds to ROCK I and inhibits downstream signaling
  JOURNAL   Mol Cell Biol 23 (12), 4219-4229 (2003)
   PUBMED   12773565
  REMARK    GeneRIF: RhoE induces stress fiber disassembly by directly binding
            ROCK I and inhibiting it from phosphorylating downstream targets
REFERENCE   10 (bases 1 to 2827)
  AUTHORS   Garavini,H., Riento,K., Phelan,J.P., McAlister,M.S., Ridley,A.J.
            and Keep,N.H.
  TITLE     Crystal structure of the core domain of RhoE/Rnd3: a constitutively
            activated small G protein
  JOURNAL   Biochemistry 41 (20), 6303-6310 (2002)
   PUBMED   12009891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL844893.9.
            
            On Nov 17, 2006 this sequence version replaced NM_028810.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011442.1, AK035195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL844893.9         80945-81331         c
            388-475             AL844893.9         80444-80531         c
            476-585             AL844893.9         69356-69465         c
            586-720             AL844893.9         66303-66437         c
            721-2827            AL844893.9         62659-64765         c
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 29.63 cM"
     gene            1..2827
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /note="Rho family GTPase 3"
                     /db_xref="GeneID:74194"
                     /db_xref="MGI:MGI:1921444"
     exon            1..387
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..972
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /note="ras homolog gene family, member E"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoE"
                     /protein_id="NP_083086.1"
                     /db_xref="CCDS:CCDS16028.1"
                     /db_xref="GeneID:74194"
                     /db_xref="MGI:MGI:1921444"
                     /translation="MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFA
                     KDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICF
                     DISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYD
                     QGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRIS
                     HMPSRPELSAVATDLRKDKAKSCTVM"
     exon            388..475
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /inference="alignment:Splign:2.1.0"
     exon            476..585
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /inference="alignment:Splign:2.1.0"
     exon            586..720
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /inference="alignment:Splign:2.1.0"
     exon            721..2827
                     /gene="Rnd3"
                     /gene_synonym="2610017M01Rik; Arhe; Rhoe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagaccg atcggaattg gacttgggaa gagaggcgcg gagtcaggca gaaaacttgt
       61 aggagaggag taaagagccg ctgcctctcc tcctccactc cgctgtgctt aaaggggttc
      121 ccgccggcct tgcgatttat ttttatatct gctttttata gagagaagta tatatatata
      181 tatatttttt cttctaaaga gaaaattcct gttccaagag aaaataaggc aacatcaatg
      241 aaggagagaa gagccagcca gaaattatcc agtaaatcta tcatggatcc taatcagaac
      301 gtgaaatgca agatagtagt agtgggcgac agccagtgtg ggaaaaccgc gctgctccac
      361 gtcttcgcca aggactgctt cccagaaaat tacgtcccta cggtgtttga gaattacact
      421 gccagttttg aaatcgacac acaaagaata gagttgagcc tgtgggacac ttcaggttct
      481 ccttactatg acaacgtccg tccactctct tacccagatt ctgatgcagt gctcatttgc
      541 tttgacatca gtagaccaga gactctggac agtgtcttaa aaaagtggaa aggtgaaatc
      601 caggagtttt gtcccaatac caagatgctg ttggtgggct gcaagtctga tctgcggaca
      661 gatgtcagca cattagtgga actctcaaat cacaggcaga ctcctgtgtc atatgaccag
      721 ggggcaaata tggccaagca gatcggagca gccacttaca tagaatgctc agctttacag
      781 tcagaaaaca gcgtcagaga catttttcac gtcgccacct tggcgtgtgt aaataagaca
      841 aataaaaacg ttaagcggaa caaatcgcag agggccacaa agcggatttc gcacatgcct
      901 agcagaccag aactctcagc agttgctacg gacttacgaa aggacaaagc gaagagctgt
      961 actgtgatgt gaggcttcgc cgtctataag gaggacgcgg gaatatctgg tgttttaaaa
     1021 aattaataat tcaaattaaa aaatgtaaaa agcaggagca aaccggaaag atggagtcaa
     1081 atgaagtgca cagccaaagt cacatagata caggcttagg aggcccttga aaggataccc
     1141 acttttcgga atcctgtcct tagtttcggc atgtagaccg agtggtgaga agcgaatgca
     1201 ttgaagagtt ttgtgtgaca agaagtgtga cttgaaaaat ccgccaaaaa caaagggagc
     1261 tatgaacagg cgagcgctag agaagtgggg gacgccagta cctccaagaa gaacatccac
     1321 gctctgaatg gtgcttgagt attttcggtt ttgtgtttgt ggttttgtta caacctattc
     1381 gtggatctct actttttgat ttcgtttttc aatgttttaa tccctttttc caaaaaatat
     1441 atattagtag accgtcctca ttggggaact cgcactgtga ccttagcgtt tagttttcta
     1501 gaggatgcga tctaatttcc tcctagctca tcattaaaat ggaaattgta ctgggacccg
     1561 ctgggattcg agaggaaaac ttgatgcggc tttgaaatct tgacttcctg aaggtcgctg
     1621 ctgagcaaga tggtttgaaa gcaagcttca gagcccttac aagatgcata gaccagcact
     1681 acagagattg cgtagatcaa ctagaagaga gtgttgcttt ttattctgtc tgatggtttt
     1741 gttcatcctt gtgattgtcc ttaacaagtg gtaaattgtt ccgtgtaata ttttttgtgc
     1801 gctgtttaga agagtgtgtg tggctttgtt tttctttttg ccatcgttga tgaaaacgag
     1861 aagtcaaata aaagatgtga tcgtcagatg tgatagcgtg attaaagaag aggcaggtgg
     1921 ttgccgattt caccaggaga gaccttgaat gaaggagtag tagtagccga gagcacagtt
     1981 ggtgaatggg gctgtctgga acaaaattat acgtcaaata cacagagcaa aagcactcgt
     2041 gtctggggat ggtgccccta gactagcaac agaaagtaag ctgtcgtctg gtgccacttc
     2101 cttcaaagaa atgctgttct ggcaaaaccc ccatttgctc atgctttagt aaaccccagt
     2161 ttgcaaagaa gcctataatg tctgccctgg tatgagccta gggcgtttct caagtgactg
     2221 ctaaacctca cttaaccata catggccagg gccaggttga aaatgttgat cgttgccaga
     2281 gtgataataa gcatttaaaa tagtttacag gtttctcctt ttgagcagtt cctttcagag
     2341 aagaaatcat ttacgatctt tgagagttgg tgcttgttaa aaacaagctt tttttttttt
     2401 ttccccaatg atgacgcttc atttttgaag cgctggagcg gtgtctccct taaaccgcgg
     2461 cagaagggga ggtgaaggta actacaacac ccagctctgt gtcttcacaa gcgctttgtt
     2521 ttgtctctgc aagaaaatgc catctcagtc atttcccatg aaactcagac atcttaccaa
     2581 cataatacgc tctgactggt acagcattat gctttgggca gtattacaaa atcgctggca
     2641 agtgctttct gtatttaaat attgtaaaaa gaaaataagt tataactgtt ataaagcaga
     2701 actttttgtt gctttttttt tttttaatgt tgaagtcact ttgtatgttt gtttggtcag
     2761 tgtttccaca gtatttatta aaacgtatgg gttttttttt ttcttcaaat aaaaaagtaa
     2821 ccatgtc
//
