LOCUS       NM_009708               1406 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus Rho family GTPase 2 (Rnd2), mRNA.
ACCESSION   NM_009708
VERSION     NM_009708.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Yang,J., Li,Y., Tang,Y., Yang,L., Guo,C. and Peng,C.
  TITLE     Spatial transcriptome reveals the region-specific genes and
            pathways regulated by Satb2 in neocortical development
  JOURNAL   BMC Genomics 25 (1), 757 (2024)
   PUBMED   39095712
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Kerloch,T., Farrugia,F., Bouit,L., Maitre,M., Terral,G., Koehl,M.,
            Mortessagne,P., Heng,J.I., Blanchard,M., Doat,H.,
            Leste-Lasserre,T., Goron,A., Gonzales,D., Perrais,D., Guillemot,F.,
            Abrous,D.N. and Pacary,E.
  TITLE     The atypical Rho GTPase Rnd2 is critical for dentate granule neuron
            development and anxiety-like behavior during adult but not neonatal
            neurogenesis
  JOURNAL   Mol Psychiatry 26 (12), 7280-7295 (2021)
   PUBMED   34561615
  REMARK    GeneRIF: The atypical Rho GTPase Rnd2 is critical for dentate
            granule neuron development and anxiety-like behavior during adult
            but not neonatal neurogenesis.
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Miyamoto,Y., Torii,T., Terao,M., Takada,S., Tanoue,A., Katoh,H. and
            Yamauchi,J.
  TITLE     Rnd2 differentially regulates oligodendrocyte myelination at
            different developmental periods
  JOURNAL   Mol Biol Cell 32 (8), 769-787 (2021)
   PUBMED   33596091
  REMARK    GeneRIF: Rnd2 differentially regulates oligodendrocyte myelination
            at different developmental periods.
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Uesugi,K., Oinuma,I., Katoh,H. and Negishi,M.
  TITLE     Different requirement for Rnd GTPases of R-Ras GAP activity of
            Plexin-C1 and Plexin-D1
  JOURNAL   J Biol Chem 284 (11), 6743-6751 (2009)
   PUBMED   19136556
  REMARK    GeneRIF: Rnd2 bound to Plexin-D1 in cortical neurons, and
            Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical
            neurons required Rnd2 and down-regulation of R-Ras activity.
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Felkl,M. and Leube,R.E.
  TITLE     Interaction assays in yeast and cultured cells confirm known and
            identify novel partners of the synaptic vesicle protein
            synaptophysin
  JOURNAL   Neuroscience 156 (2), 344-352 (2008)
   PUBMED   18706977
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Heng,J.I., Nguyen,L., Castro,D.S., Zimmer,C., Wildner,H.,
            Armant,O., Skowronska-Krawczyk,D., Bedogni,F., Matter,J.M.,
            Hevner,R. and Guillemot,F.
  TITLE     Neurogenin 2 controls cortical neuron migration through regulation
            of Rnd2
  JOURNAL   Nature 455 (7209), 114-118 (2008)
   PUBMED   18690213
  REMARK    GeneRIF: results identify Rnd2 as a novel essential regulator of
            neuronal migration in the cerebral cortex and demonstrate that Rnd2
            is a major effector of Neurog2 function in the promotion of
            migration
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Armentano,M., Filosa,A., Andolfi,G. and Studer,M.
  TITLE     COUP-TFI is required for the formation of commissural projections
            in the forebrain by regulating axonal growth
  JOURNAL   Development 133 (21), 4151-4162 (2006)
   PUBMED   17021036
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Nishi,M., Takeshima,H., Houtani,T., Nakagawara,K., Noda,T. and
            Sugimoto,T.
  TITLE     RhoN, a novel small GTP-binding protein expressed predominantly in
            neurons and hepatic stellate cells
  JOURNAL   Brain Res Mol Brain Res 67 (1), 74-81 (1999)
   PUBMED   10101234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275340.1, BC139331.1 and CD775326.1.
            
            On Feb 13, 2018 this sequence version replaced NM_009708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI410046.1, BI905297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BY275340.1         1-90
            91-906              BC139331.1         1-816
            907-1406            CD775326.1         1-500               c
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.12 cM"
     gene            1..1406
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /note="Rho family GTPase 2"
                     /db_xref="GeneID:11858"
                     /db_xref="MGI:MGI:1338755"
     exon            1..265
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..847
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /note="aplysia ras-related homolog N (RhoN); ras homolog
                     gene family, member N; ras homolog N (RhoN); rho-related
                     GTP-binding protein Rho7"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoN"
                     /protein_id="NP_033838.1"
                     /db_xref="CCDS:CCDS25473.1"
                     /db_xref="GeneID:11858"
                     /db_xref="MGI:MGI:1338755"
                     /translation="MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENY
                     TASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQ
                     GETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVE
                     CSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGLQRSTQLSGRPDRGNEGEMHK
                     DRAKSCNLM"
     exon            266..353
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            354..463
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            464..598
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            599..1394
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1369..1374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="Rnd2"
                     /gene_synonym="Arhn; rho7; Rohn"
                     /note="major polyA site"
ORIGIN      
        1 ggagggggcc cgcagccccg ggcgggggct cggcgcgggc ccgcgagatg ccggtgtcgg
       61 cggcccgaga ggctgcagct gcagcggcgg gggaggaggc ggcagaagcg gcggctgtgc
      121 ccgggagggg ggcggcgtgg ggggccggcg cgtagccggg accatggagg ggcagagtgg
      181 ccgctgcaag atcgtagtgg tgggggacgc ggagtgcggc aagacagcgt tgctgcaggt
      241 gttcgccaag gacgcctacc ccgggagtta tgtccccacg gtgtttgaga actacactgc
      301 cagcttcgag atcgacaagc gccgcattga gctcaacatg tgggatactt caggttcctc
      361 ttactatgac aatgtccggc ctctggccta cccggattct gatgctgtgc ttatctgctt
      421 tgacattagc cggccagaaa cactggacag tgtcctcaag aagtggcaag gagagactca
      481 ggagttttgc cccaatgcca aggtggtgct ggttggctgt aagctggaca tgcggactga
      541 cctggccaca ctgagggagc tatccaagca gagactcatc cctgtcacac atgagcaggg
      601 tactgtgctg gccaagcaag tgggagctgt gtcctacgtt gaatgttcct cccgatcttc
      661 tgagcgcagt gtccgggatg tcttccatgt ggccacagtg gcttctctcg gccgtggcca
      721 taggcagcta cgtcgtactg actctcgccg gggactgcag cgatccactc aactgtcggg
      781 acggccagac cggggaaatg agggcgagat gcataaggat cgagccaaga gctgtaacct
      841 catgtgaggg gttgcagtgg ggcagagagg ggagagggct gggtgagaga cacggttgtt
      901 cccgtgggtg ctcctggact ttttgacctc ctggccctgg ctggaaggtc agggcaggca
      961 gaggagcaat tctggttgga ggagctagag ggtagaaggc tgtcactcct caccccattc
     1021 tctacaccct tatcccttct ctgctgctag ctgagagagc tgacagggta ggcatctggt
     1081 acatgaactt ggatagggca ggtgggggtt tgggaaacca agcaatgact ttggttgagt
     1141 ctcctatgta aagtgtaact tccttgcata ccctggtccc catatcccat ctgccttccc
     1201 taaggaaagt gtccatttga tgaccttctc tgtctctccc ctcaagtcca catctgttct
     1261 gtacatgcta accttcaggc aatgcgcact aaattttaaa gcaagaagct ctttcctccc
     1321 atcaacccac caaccagttc tagcttgccc tttctccatc agcccgcaaa taaagcccat
     1381 gaccatggaa aacaaaaaaa aaaaaa
//
