LOCUS       NM_172612               2203 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Rho family GTPase 1 (Rnd1), mRNA.
ACCESSION   NM_172612
VERSION     NM_172612.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Swaminathan,B., Youn,S.W., Naiche,L.A., Du,J., Villa,S.R.,
            Metz,J.B., Feng,H., Zhang,C., Kopan,R., Sims,P.A. and
            Kitajewski,J.K.
  TITLE     Endothelial Notch signaling directly regulates the small GTPase
            RND1 to facilitate Notch suppression of endothelial migration
  JOURNAL   Sci Rep 12 (1), 1655 (2022)
   PUBMED   35102202
  REMARK    GeneRIF: Endothelial Notch signaling directly regulates the small
            GTPase RND1 to facilitate Notch suppression of endothelial
            migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Oinuma,I., Kawada,K., Tsukagoshi,K. and Negishi,M.
  TITLE     Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP
            activation
  JOURNAL   Mol Biol Cell 23 (8), 1593-1604 (2012)
   PUBMED   22357615
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Zhang,N., Liang,J., Tian,Y., Yuan,L., Wu,L., Miao,S., Zong,S. and
            Wang,L.
  TITLE     A novel testis-specific GTPase serves as a link to proteasome
            biogenesis: functional characterization of RhoS/RSA-14-44 in
            spermatogenesis
  JOURNAL   Mol Biol Cell 21 (24), 4312-4324 (2010)
   PUBMED   20980621
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Rohm,B., Rahim,B., Kleiber,B., Hovatta,I. and Puschel,A.W.
  TITLE     The semaphorin 3A receptor may directly regulate the activity of
            small GTPases
  JOURNAL   FEBS Lett 486 (1), 68-72 (2000)
   PUBMED   11108845
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC156543.10.
            
            On May 2, 2007 this sequence version replaced NM_172612.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043639.1, AK161870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC156543.10        76500-76731         c
            233-320             AC156543.10        75757-75844         c
            321-430             AC156543.10        73116-73225         c
            431-565             AC156543.10        71781-71915         c
            566-2203            AC156543.10        68475-70112         c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.65 cM"
     gene            1..2203
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /note="Rho family GTPase 1"
                     /db_xref="GeneID:223881"
                     /db_xref="MGI:MGI:2444878"
     exon            1..232
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..811
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /codon_start=1
                     /product="rho-related GTP-binding protein Rho6"
                     /protein_id="NP_766200.1"
                     /db_xref="CCDS:CCDS27801.1"
                     /db_xref="GeneID:223881"
                     /db_xref="MGI:MGI:2444878"
                     /translation="MKERRAPQPVVVRCKLVLVGDVQCGKTAMLQVLAKDCYPETYVP
                     TVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETMDS
                     ALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLG
                     AEIYLEGSAFTSETSIHSIFRTASMVCLNKSSPVPPKSPVRSLSKRLLHLPSRSELIS
                     TTFKKEKAKSCSIM"
     exon            233..320
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /inference="alignment:Splign:2.1.0"
     exon            321..430
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /inference="alignment:Splign:2.1.0"
     exon            431..565
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /inference="alignment:Splign:2.1.0"
     exon            566..2203
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /note="hexamer: AATATA"
     polyA_site      1633
                     /gene="Rnd1"
                     /gene_synonym="A830014L09Rik; Arhs"
                     /note="major polyA site"
ORIGIN      
        1 ctcagtcgga ggcaggcagg cagggaaccc gcgctagtgt gctagtgcgg acacttgagg
       61 cgcgacctcc tcctccctga acccgagtcc acgtccctcc gaggctgcag ccatgaagga
      121 gagacgggca ccgcagccag tggtggtcag gtgtaagctc gtcctggtgg gagacgtgca
      181 gtgtgggaag acggcgatgt tacaggtgct agcgaaagac tgctatcccg agacctatgt
      241 gcctaccgtg tttgagaatt acacagcctg tttggagaca gaggaacaga gagtggagct
      301 tagtctctgg gacacctcag gttctcctta ctatgacaat gttcgtccac tctgctacag
      361 cgactcagat gcggtattgc tgtgctttga catcagccgt ccagagacca tggacagtgc
      421 actcaagaag tggagaacag aaatcctaga ctactgtccc agcacacgtg ttttgcttat
      481 tggctgcaag acagatcttc gaacagacct gagcactcta atggaactgt cccaccagaa
      541 gcaggcaccc atctcctacg agcagggctg tgcgatagcc aagcagttgg gcgcagaaat
      601 ctacctggag ggctcggctt tcacttccga gacaagcatc cacagcattt tccggacagc
      661 atccatggtg tgtctgaaca agtctagccc agtgcccccg aagagccccg tccgaagcct
      721 ttccaagcga ctcctccacc tccccagtcg ctctgaactc atctcaacta cattcaagaa
      781 ggaaaaggcc aaaagctgtt ccatcatgtg aagtcagagc tggaggcggg ggagacagcc
      841 ccccacttcc tcccttgggg tgcagaggca cggggagagg gaggatgaga cggcttaaga
      901 caccggatgt gacatttttc agatggccac agaggacttt agaaggagac aggaatggaa
      961 ctgaagaaga tgccaggctt ggcaggaggg cctgacatta agcagaaacc atcacacccc
     1021 aagcctggca ctaggctgtg gagggggtcg ttgccccagt gtccccctac tccagaggaa
     1081 ggatgggtac tggggagatg gggacatgct ggcctcacct tcgacatcac gccttttcca
     1141 tacagcgttt ccaggcaggc ttggggtggg cggggtcctt gatcccttct cttctcctta
     1201 aagaagtggc aatggactgg agaccgtgaa aggctggaga cagctccctt cggggcttaa
     1261 cccagacgct ccatcactga aaccaggagg gcgagggctg acctaagagg gaaccctcat
     1321 ttttgcctaa cccatgcatc atggagaggt gatattatac attcacatgc ttcttactga
     1381 agtccccagg gcccaaggga gaagccccag acccccttct cttgcagaat gtgggggtgg
     1441 tggtgctgtg ggggcaggac tgatgggagg ggtcaccaga ctttcctgcc cctggggcgg
     1501 tacagttggc atttgtttta tagactcttg tctttggaac tgggggtggg gtgggggagt
     1561 gtttcaatct gttctatgtt ccgtgtttaa agaagaaaac ctatttatta atgaaatata
     1621 acatatgaag aaattggtgg ggttttgttg ttgttgttct ttggttttta tggcgatcag
     1681 ggaaaagctg aaaagctgtc tttttttttt ttgttttgtt ttgttttgtt ttgttttgtt
     1741 ttttttgaga cagggtttct ctgtatagcc ctggctgtcc tagaactcac tctgtagacc
     1801 aggctggcct ctaactcaga aatctgcctg cctctgcttc ctaagtgctg ggattaaagg
     1861 catggaccac cacaccccgg cggaaaagct gtcttggatc cctttctagg agttacagtg
     1921 gctgtctcca gggtccccta gcatcttgtt ctacttctct gaatcccacc tgcatcctgc
     1981 taagccaaga aagaggtcct tggccctgga gtagggcttc cttctcgtca ggctgctgat
     2041 actgtggaag tgagaatggt ggtttataag gggctgtcct atgtagggta tgatgccctg
     2101 acatcccggt tctagataag agtagcatgt ttcaattgtc acagccaaaa atgtctctag
     2161 atattgctga gtgtcctctg gataaaatca cttcctgctg agg
//
