LOCUS       NM_026611               1031 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ribonuclease T2B (Rnaset2b), mRNA.
ACCESSION   NM_026611 XM_917595
VERSION     NM_026611.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Kettwig,M., Ternka,K., Wendland,K., Kruger,D.M., Zampar,S.,
            Schob,C., Franz,J., Aich,A., Winkler,A., Sakib,M.S., Kaurani,L.,
            Epple,R., Werner,H.B., Hakroush,S., Kitz,J., Prinz,M., Bartok,E.,
            Hartmann,G., Schroder,S., Rehling,P., Henneke,M., Boretius,S.,
            Alia,A., Wirths,O., Fischer,A., Stadelmann,C., Nessler,S. and
            Gartner,J.
  TITLE     Interferon-driven brain phenotype in a mouse model of RNaseT2
            deficient leukoencephalopathy
  JOURNAL   Nat Commun 12 (1), 6530 (2021)
   PUBMED   34764281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Trubia,M., Sessa,L. and Taramelli,R.
  TITLE     Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning
            of a human member located in a region of chromosome 6 (6q27)
            frequently deleted in human malignancies
  JOURNAL   Genomics 42 (2), 342-344 (1997)
   PUBMED   9192857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY004495.1, BC100330.1 and CD741736.1.
            
            On Feb 3, 2006 this sequence version replaced NM_026611.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084454.1, BC100330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY004495.1         14-88
            76-1010             BC100330.1         1-935
            1011-1031           CD741736.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.57 cM"
     gene            1..1031
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /note="ribonuclease T2B"
                     /db_xref="GeneID:68195"
                     /db_xref="MGI:MGI:3702087"
     exon            1..239
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..918
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /EC_number="4.6.1.19"
                     /note="ribonuclease T2; ribonuclease 6-B; ribonuclease
                     T2-B"
                     /codon_start=1
                     /product="ribonuclease T2-B precursor"
                     /protein_id="NP_080887.1"
                     /db_xref="CCDS:CCDS37429.1"
                     /db_xref="GeneID:68195"
                     /db_xref="MGI:MGI:3702087"
                     /translation="MAPAEARGALPGWISVLGWGLALCSLCGAGPLWSGSHEWKKLIL
                     TQHWPPTVCKEVNSCQDSLDYWTIHGLWPDRAEDCNQSWHFNLDEIKDLLRDMKIYWP
                     DVIHRSSNRSQFWKHEWVKHGTCAAQVDALNSEKKYFGKSLDLYKQIDLNSVLQKFGI
                     KPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGESVQTVGQIELCFTKEDLHLRNCT
                     EPGEQLSSRQEAWLAMEASTHGMMVCEDGPIFYPPPTKTQH"
     exon            240..300
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..353
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..411
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..482
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..596
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..642
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..717
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1013
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /note="hexamer: AAGAAA"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /note="hexamer: ACTAAA"
     polyA_site      1005
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
                     /note="major polyA site"
     polyA_site      1010
                     /gene="Rnaset2b"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; C79750; RNASE6PL; Rnaset2"
ORIGIN      
        1 gggcgtggct taggggttac cctgtggtgc ggcgctggca ggaggaagcc tgcgctgagg
       61 agtcggtgga ggtcggtccg gctgcggagc cggcgtgcgc aaaggccgct gggagccttc
      121 ggagccccgg gcagtgcgat ggcgccggcg gaggctcgcg gcgcgctccc gggctggatc
      181 tccgtgctgg gctggggtct ggcgctgtgc tctctgtgcg gggcgggccc actgtggagt
      241 ggcagccatg agtggaaaaa actaattttg acccagcact ggcccccaac agtatgcaag
      301 gaggttaaca gctgccaaga ctctctggat tactggacaa tacatggact atggcccgat
      361 agagcagaag attgtaacca gtcctggcac tttaacttag atgagattaa ggaccttttg
      421 cgagacatga agatctactg gcccgatgtg attcaccggt cttctaatcg cagccaattc
      481 tggaaacatg agtgggttaa acacggcacc tgtgctgccc aggtagacgc cctcaattcc
      541 gagaagaagt actttgggaa gagcctggat ctgtacaagc agattgacct caacagtgtg
      601 ctacaaaaat ttgggatcaa gccatccatc aactactacc agcttgcaga tttcaaagat
      661 gcacttacca gaatctatgg tgtggtgcct aaaatccagt gccttatgcc agaacaggga
      721 gagagcgtgc agaccgttgg ccagatagag ctgtgcttca ccaaggagga cttacatttg
      781 cggaactgca ctgagccagg ggagcagctg tcctccaggc aggaagcctg gctggccatg
      841 gaggcttcta cacatgggat gatggtctgt gaagacggtc caatcttcta ccctccacct
      901 acaaagaccc aacattgatg ttcacatttt ggaaatattt tgtgtcctac aaagtaagaa
      961 aagttcacaa atcattgctt tctaaaattt tactaaaaag tttcttaaaa tgtaaaaaaa
     1021 aaaaaaaaaa a
//
