LOCUS       NM_001083938             999 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ribonuclease T2A (Rnaset2a), transcript variant 1,
            mRNA.
ACCESSION   NM_001083938 XM_001476345 XM_001476365 XM_001480967
VERSION     NM_001083938.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Zhang,T., Wu,S., Xu,R., Zhang,S., Wang,M. and Li,J.
  TITLE     Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and
            chemokine signaling pathway during vascular smooth muscle cell
            phenotypic switch in atherosclerosis
  JOURNAL   Cell Signal 111, 110869 (2023)
   PUBMED   37633478
  REMARK    GeneRIF: Musashi-2 binds with Fbxo6 to induce Rnaset2
            ubiquitination and chemokine signaling pathway during vascular
            smooth muscle cell phenotypic switch in atherosclerosis.
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Kettwig,M., Ternka,K., Wendland,K., Kruger,D.M., Zampar,S.,
            Schob,C., Franz,J., Aich,A., Winkler,A., Sakib,M.S., Kaurani,L.,
            Epple,R., Werner,H.B., Hakroush,S., Kitz,J., Prinz,M., Bartok,E.,
            Hartmann,G., Schroder,S., Rehling,P., Henneke,M., Boretius,S.,
            Alia,A., Wirths,O., Fischer,A., Stadelmann,C., Nessler,S. and
            Gartner,J.
  TITLE     Interferon-driven brain phenotype in a mouse model of RNaseT2
            deficient leukoencephalopathy
  JOURNAL   Nat Commun 12 (1), 6530 (2021)
   PUBMED   34764281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 999)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Trubia,M., Sessa,L. and Taramelli,R.
  TITLE     Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning
            of a human member located in a region of chromosome 6 (6q27)
            frequently deleted in human malignancies
  JOURNAL   Genomics 42 (2), 342-344 (1997)
   PUBMED   9192857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018722.1 and CJ214477.1.
            
            On Jul 17, 2018 this sequence version replaced NM_001083938.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018722.1, BC089534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-961               AK018722.1         2-962
            962-999             CJ214477.1         345-382
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.87 cM"
     gene            1..999
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /note="ribonuclease T2A"
                     /db_xref="GeneID:100037283"
                     /db_xref="MGI:MGI:1915445"
     exon            1..194
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..873
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /EC_number="4.6.1.19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ribonuclease T2; ribonuclease 6; ribonuclease
                     6-A; ribonuclease T2-A"
                     /codon_start=1
                     /product="ribonuclease T2-A isoform 1 precursor"
                     /protein_id="NP_001077407.1"
                     /db_xref="CCDS:CCDS37433.1"
                     /db_xref="GeneID:100037283"
                     /db_xref="MGI:MGI:1915445"
                     /translation="MAPAEARGALPGWISVLGWGLALCSLCGAGPLWSGSHEWKKLIL
                     TQHWPPTVCKEVNSCQDSLDYWTIHGLWPDRAEDCNQSWHFNLDEIKDLLRDMKIYWP
                     DVIHRSSNRSQFWKHEWVKHGTCAAQVDALNSEKKYFGKSLDLYKQIDLNSVLQKFGI
                     KPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGESVQTVGQIELCFTKEDLHLRNCT
                     EPGEQLSSRQEAWLAMEASTHGMMVCEDGPIFYPPPTKTQH"
     exon            195..255
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..308
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..366
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..437
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..551
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..597
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..672
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..979
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /note="hexamer: AAGAAA"
     regulatory      947..952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /note="hexamer: ACTAAA"
     polyA_site      960
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /note="major polyA site"
     polyA_site      965
                     /gene="Rnaset2a"
                     /gene_synonym="0610007O07Rik; 4833423A10Rik;
                     4930532K22Rik; RNASE6PL; Rnaset2"
                     /note="major polyA site"
ORIGIN      
        1 aagcctgcgc tgaggagtcg gtggaggtcg gtccggctgc ggagccggcg tgcgcaaagg
       61 ccgctgggag ccttcggagc ccggggcagt gcgatggcgc cggcggaggc tcgcggcgcg
      121 ctcccgggct ggatctccgt gctgggctgg ggtctggcgc tgtgctctct gtgcggggcg
      181 ggcccactgt ggagtggcag ccatgagtgg aaaaaactaa ttttgaccca gcactggccc
      241 ccaacagtat gcaaggaggt taacagctgc caagactctc tggattactg gacaatacat
      301 ggactatggc ccgatagagc agaagattgt aaccagtcct ggcactttaa cttagatgag
      361 attaaggacc ttttgcgaga catgaagatc tactggcccg atgtgattca ccggtcttct
      421 aatcgcagcc aattctggaa acatgagtgg gttaaacacg gcacctgtgc tgcccaggta
      481 gacgccctca attccgagaa gaagtacttt gggaagagcc tggatctgta caagcagatt
      541 gacctcaaca gtgtgctaca aaaatttggg atcaagccat ccatcaacta ctaccagctt
      601 gcagatttca aagatgcact taccagaatc tatggtgtgg tgcctaaaat ccagtgcctt
      661 atgccagaac agggagagag cgtgcagacc gttggccaga tagagctgtg cttcaccaag
      721 gaggacttac atttgcggaa ctgcactgag ccaggggagc agctgtcctc caggcaggaa
      781 gcctggctgg ccatggaggc ttctacacat gggatgatgg tctgtgaaga cggtccaatc
      841 ttctaccctc cacctacaaa gacccaacat tgatgttcac attttggaaa tattttgtgt
      901 cccacaaagt aagaaaagtt cacaaatcat tgctttctaa aattttacta aaaagtttct
      961 taaaatgtgt ttggctttta aaaaaaaaaa aaaaaaaaa
//
