LOCUS       NM_011882               4758 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ribonuclease L (2', 5'-oligoisoadenylate
            synthetase-dependent) (Rnasel), mRNA.
ACCESSION   NM_011882 NM_001164083 XM_985944
VERSION     NM_011882.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4758)
  AUTHORS   Xi,J., Snieckute,G., Martinez,J.F., Arendrup,F.S.W., Asthana,A.,
            Gaughan,C., Lund,A.H., Bekker-Jensen,S. and Silverman,R.H.
  TITLE     Initiation of a ZAKalpha-dependent ribotoxic stress response by the
            innate immunity endoribonuclease RNase L
  JOURNAL   Cell Rep 43 (4), 113998 (2024)
   PUBMED   38551960
REFERENCE   2  (bases 1 to 4758)
  AUTHORS   Ding,K., Li,H., Tai,F., Duan,J., Wang,Q., Zhai,R., Fu,H., Ge,C. and
            Zheng,X.
  TITLE     Unraveling the Role of RNase L Knockout in Alleviating Immune
            Response Activation in Mice Bone Marrow after Irradiation
  JOURNAL   Int J Mol Sci 25 (5), 2722 (2024)
   PUBMED   38473966
  REMARK    GeneRIF: Unraveling the Role of RNase L Knockout in Alleviating
            Immune Response Activation in Mice Bone Marrow after Irradiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4758)
  AUTHORS   Chen,G., Zhao,X., Dankovskyy,M., Ansah-Zame,A., Alghamdi,U.,
            Liu,D., Wei,R., Zhao,J. and Zhou,A.
  TITLE     A novel role of RNase L in the development of nonalcoholic
            steatohepatitis
  JOURNAL   FASEB J 37 (9), e23158 (2023)
   PUBMED   37615181
  REMARK    GeneRIF: A novel role of RNase L in the development of nonalcoholic
            steatohepatitis.
REFERENCE   4  (bases 1 to 4758)
  AUTHORS   Chen,W., Li,Y., Ruan,G.X., Huang,H., Zhang,R., Wang,J., Ouyang,Y.,
            Li,Y., Xu,S. and Ou,X.
  TITLE     Adenosine deaminase acting on RNA-1 is essential for early B
            lymphopoiesis
  JOURNAL   Cell Rep 41 (8), 111687 (2022)
   PUBMED   36417848
REFERENCE   5  (bases 1 to 4758)
  AUTHORS   Maurano,M., Snyder,J.M., Connelly,C., Henao-Mejia,J., Sidrauski,C.
            and Stetson,D.B.
  TITLE     Protein kinase R and the integrated stress response drive
            immunopathology caused by mutations in the RNA deaminase ADAR1
  JOURNAL   Immunity 54 (9), 1948-1960 (2021)
   PUBMED   34343497
REFERENCE   6  (bases 1 to 4758)
  AUTHORS   Leib,D.A., Machalek,M.A., Williams,B.R., Silverman,R.H. and
            Virgin,H.W.
  TITLE     Specific phenotypic restoration of an attenuated virus by knockout
            of a host resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 97 (11), 6097-6101 (2000)
   PUBMED   10801979
REFERENCE   7  (bases 1 to 4758)
  AUTHORS   Zhou,A., Paranjape,J.M., Der,S.D., Williams,B.R. and Silverman,R.H.
  TITLE     Interferon action in triply deficient mice reveals the existence of
            alternative antiviral pathways
  JOURNAL   Virology 258 (2), 435-440 (1999)
   PUBMED   10366581
REFERENCE   8  (bases 1 to 4758)
  AUTHORS   Zhou,A., Paranjape,J., Brown,T.L., Nie,H., Naik,S., Dong,B.,
            Chang,A., Trapp,B., Fairchild,R., Colmenares,C. and Silverman,R.H.
  TITLE     Interferon action and apoptosis are defective in mice devoid of
            2',5'-oligoadenylate-dependent RNase L
  JOURNAL   EMBO J 16 (21), 6355-6363 (1997)
   PUBMED   9351818
REFERENCE   9  (bases 1 to 4758)
  AUTHORS   Bayard,B., Bette-Bobillo,P. and Aliau,S.
  TITLE     Affinity purification and characterization of
            (2'-5')oligo(adenylate)-dependent RNase from mouse spleen
  JOURNAL   Eur J Biochem 223 (2), 403-410 (1994)
   PUBMED   8055909
REFERENCE   10 (bases 1 to 4758)
  AUTHORS   Zhou,A., Hassel,B.A. and Silverman,R.H.
  TITLE     Expression cloning of 2-5A-dependent RNAase: a uniquely regulated
            mediator of interferon action
  JOURNAL   Cell 72 (5), 753-765 (1993)
   PUBMED   7680958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140815.1, BC138013.1 and AC154140.7.
            
            On or before Aug 14, 2009 this sequence version replaced
            NM_001164083.1, NM_011882.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF281045.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849383, SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AK140815.1         2-584
            584-2857            BC138013.1         1-2274
            2858-4758           AC154140.7         202539-204439
FEATURES             Location/Qualifiers
     source          1..4758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.43 cM"
     gene            1..4758
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /note="ribonuclease L (2', 5'-oligoisoadenylate
                     synthetase-dependent)"
                     /db_xref="GeneID:24014"
                     /db_xref="MGI:MGI:1098272"
     exon            1..182
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            183..383
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..486
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..2093
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2179
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2385
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2518
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2655
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..4758
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4734..4739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4758
                     /gene="Rnasel"
                     /gene_synonym="E230029I04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtgatttc tgctttctgt ggcaaagctc ctctttgttc tgtctggttc ctagaaaaca
       61 acagtgaaag tgtccttcgc ggaatttctc ttgcttccga acagcatcca gttgcgcacg
      121 agtctttgtt tcctcgcacc ccagatcatt cctgccaccc caagcctgtc aggatcacgt
      181 atgggacagc ccttgtcttc ctccaggagg tgaagattgc tcaggctgtg cccggattga
      241 cgctgcaccc atgacttctg ttcttccgtt ttctcactcc tttcttggct cctccctgat
      301 ggctcagcga ctcaccacaa ggaagcattt tctgtagggg ttgttgcagc caaaggaatg
      361 cctgctgaga agaggagtag aagggggacg gagagaacga acagaaagaa cagtgtgtgg
      421 gggtgaccag cctcacctgg gataaagtca gatggaccaa gattaccaga aggtgccaat
      481 tactagctcc cttctttatt cgtgtactga tgagatgtca gaagacagaa cataatcagc
      541 ccaatcccta ctccaagact ctcattgtgt cccaaagaaa cacacgtgtg catttcccaa
      601 ggaaaaggca ttgaggacca tggagacccc ggattataac acacctcagg gtggaacccc
      661 atcagcggga agtcagagga ccgttgtcga agatgattct tcgttgatca aagctgttca
      721 gaagggagat gttgtcaggg tccagcaatt gttagaaaaa ggggctgatg ccaatgcctg
      781 tgaagacacc tggggctgga cacctttgca caacgcagtg caagctggca gggtagacat
      841 tgtgaacctc ctgcttagtc atggtgctga ccctcatcgg aggaagaaga atggggccac
      901 ccccttcatc attgctggga tccagggaga tgtgaaactg ctcgagattc tcctctcttg
      961 tggtgcagac gtcaatgagt gtgacgagaa cggattcacg gctttcatgg aagctgctga
     1021 gcgtggtaac gctgaagcct taagattcct ttttgctaag ggagccaatg tgaatttgcg
     1081 acgacagaca acgaaggaca aaaggcgatt gaagcaagga ggcgccacag ctctcatgag
     1141 cgctgctgag aagggccacc tggaagtcct gagaattctc ctcaatgaca tgaaggcaga
     1201 agtcgatgct cgggacaaca tgggcagaaa tgccctgatc cgtactctgc tgaactggga
     1261 ttgtgaaaat gtggaggaga ttacttcaat cctgattcag cacggggctg atgttaacgt
     1321 gagaggagaa agagggaaaa cacccctcat cgcagcagtg gagaggaagc acacaggctt
     1381 ggtgcagatg ctcctgagtc gggaaggcat aaacatagat gccagggata acgagggcaa
     1441 gacagctctg ctaattgctg ttgataaaca actgaaggaa attgtccagt tgcttcttga
     1501 aaagggagct gataagtgtg acgatcttgt ttggatagcc aggaggaatc atgactatca
     1561 ccttgtaaag cttctcctcc cttatgtagc taatcctgac accgaccctc ctgctggaga
     1621 ctggtcgcct cacagttcac gttgggggac agccttgaaa agcctccaca gtatgactcg
     1681 acccatgatt ggcaaactca agatcttcat tcatgatgac tataaaattg ctggcacttc
     1741 cgaaggggct gtctacctag ggatctatga caatcgagaa gtggctgtga aggtcttccg
     1801 tgagaatagc ccacgtggat gtaaggaagt ctcttgtctg cgggactgcg gtgaccacag
     1861 taacttagtg gctttctatg gaagagagga cgataagggc tgtttatatg tgtgtgtgtc
     1921 cctgtgtgag tggacactgg aagagttcct gaggttgccc agagaggaac ctgtggagaa
     1981 cggggaagat aagtttgccc acagcatcct attatctata tttgagggtg ttcaaaaact
     2041 acacttgcat ggatattccc atcaggacct gcaaccacaa aacatcttaa tagattccaa
     2101 gaaagctgtc cggctggcag attttgatca gagcatccga tggatgggag agtcacagat
     2161 ggtcaggaga gacttggagg atcttggacg gctggttctc tacgtggtaa tgaaaggtga
     2221 gatccccttt gagacactaa agactcagaa tgatgaagtg ctgcttacaa tgtctccaga
     2281 tgaggagact aaggacctca ttcattgcct gttttctcct ggagaaaatg tcaagaactg
     2341 cctggtagac ctgcttggcc atcctttctt ttggacttgg gagaaccgct atagaacact
     2401 ccggaatgtg ggaaatgaat ctgacatcaa agtacggaaa tgtaaaagtg atcttctcag
     2461 actactgcag catcagacac ttgagcctcc cagaagcttt gaccagtgga catctaagat
     2521 cgacaaaaat gttatggatg aaatgaatca tttctacgaa aagagaaaaa aaaaccctta
     2581 tcaggatact gtaggtgatc tgctgaagtt tattcggaat ataggcgaac acatcaatga
     2641 ggaaaaaaag cggggaatga aggagatact tggagatcct tctcgttatt ttcaggagac
     2701 atttccagat cttgtaatct atatctacaa gaaactaaag gaaacagaat acagaaaaca
     2761 cttcccacag cctccaccac gcctcagcgt tccagaggca gtgggaccag ggggcataca
     2821 gagctgagtc ttgcaagctc atgggaccat ttttccaatc agcagagttc ttgggaagtt
     2881 gtacatttct ggtcttttaa gcagcctggt tacttgtgag caatgagtta gacagtcagt
     2941 gtgtcagttt ctgatacagt atgttctaca catttgcatg atcacaaaag cagtatgcta
     3001 caaaactata ctactccatt ttagtggatg gaactgggag agccttctgt taagacttcg
     3061 ttaaagaaaa aacatgtatg tgtgtgtgtg tgtgtgtgtg tgtgtgtatt gtcagataag
     3121 cctcacaaca tgaattcaat ctctggaacc catataaagg ttgcaagaga aaaccaactc
     3181 cacaattgtg tgcccctcct cccccctctc aaacacacac tcaaacacac acatacactc
     3241 tctcacacac acactcaaac acacacacac acacacacac acacacacac acacacacac
     3301 acacacagag catctcttct gtatgaaatt ccagaatagg cttacatatg ccaaaagggc
     3361 tccagaaaag cttcagtatt tgctgggcac tgtataagcc taggtactag ttaaatgaat
     3421 tccattcttt ctggaggcat ctgtaccggt gtctcatgac ttcaagttaa tagctctcac
     3481 ttgaagtcat ttatcagtgt cacgggtggg ggggaggggg tggcactact ggccttgagc
     3541 aaggaggaac cagcggtgcc agcaaacatt ccggggatgc acgaagcagc tacccacaat
     3601 gccacactag gcagatgaca tatcagttgg tgctgaggtg gagaaagact gtctgaaagg
     3661 attggaacac ttcttggccg gccctggact cagggctgtg gagtgcattg aacaccccca
     3721 gaagaacgat gtgggtgtgc tttcttgctg ctggatctga aatgaagcag ctccttttgg
     3781 tgtccacttg agagccctca tttcccccac ttcccatgct ccgtggtgca atgatctatt
     3841 tggggtgctc tctctagctc cctgacacac tgtcacctca gtgcctgctt cattccactt
     3901 tgtccttttg tactccagcc ctccaatcaa agccctgtcc ttagggcctt tgtatcttta
     3961 ttgcttagta aaaatgtttt gttctgtggt gatgcttgac acattttcac tgaataatca
     4021 atggaccctt tttgtatgtg gatgatgatg atgatatgta tggtacttta gaatttacac
     4081 attgtatcta tatattttta aatttaattt tgttttgaaa atagcactgt aagctaagca
     4141 ctgtgatctt tattttgaca atgaagaaag taaggctaga aataatttct atttactcta
     4201 ggcatatggc atgaagttgt cactgtcttg atttagacag actttttggt gtgacatctg
     4261 atgttctttt cacctatcac cacggtggct aaggtggagc ttttggaatg ggaattaaat
     4321 gctatcttag attccttatg aaaggaggca tctggaagca gataggtggc tgtcactgta
     4381 aggagttaaa gcacactgga agaaacaaag taatggctta aaagatggct ttaaactggg
     4441 cagtggcggc acacgccttt aatcccagca cttgggaggc agaggcaggt ggatttctga
     4501 gttcgaggcc agcctggtct acagagtgag ttcaggacag ccaaggctac acagagaaac
     4561 cctgtctcaa aacaaaaaca aaaaaacaaa aaaataaaac aaaaaataaa aataaagtac
     4621 ttaaatatta aaaaagatgg ctttaaaact taatatttaa aagggtttta aaattgagtt
     4681 ttgttgtctg acttggatac gtcaatcaaa atgtctacat gtgaagaata ctcaataaaa
     4741 atttgaatcg tttcatta
//
