LOCUS       NM_026616                646 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribonuclease H2, subunit C (Rnaseh2c), mRNA.
ACCESSION   NM_026616
VERSION     NM_026616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 646)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 646)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 646)
  AUTHORS   Deasy,S.K., Uehara,R., Vodnala,S.K., Yang,H.H., Dass,R.A., Hu,Y.,
            Lee,M.P., Crouch,R.J. and Hunter,K.W.
  TITLE     Aicardi-Goutieres syndrome gene Rnaseh2c is a metastasis
            susceptibility gene in breast cancer
  JOURNAL   PLoS Genet 15 (5), e1008020 (2019)
   PUBMED   31125342
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 646)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 646)
  AUTHORS   Rabe,B.
  TITLE     Aicardi-Goutieres syndrome: clues from the RNase H2 knock-out mouse
  JOURNAL   J Mol Med (Berl) 91 (11), 1235-1240 (2013)
   PUBMED   23744109
  REMARK    GeneRIF: Recent evidence gathered from ribonuclease H2 knock-out
            mice provides insight into the molecular mechanisms underlying
            Aicardi-Goutieres syndrome development and a potential role of DNA
            damage as a trigger of autoimmunity is discussed. [review]
            Review article
REFERENCE   6  (bases 1 to 646)
  AUTHORS   Hiller,B., Achleitner,M., Glage,S., Naumann,R., Behrendt,R. and
            Roers,A.
  TITLE     Mammalian RNase H2 removes ribonucleotides from DNA to maintain
            genome integrity
  JOURNAL   J Exp Med 209 (8), 1419-1426 (2012)
   PUBMED   22802351
REFERENCE   7  (bases 1 to 646)
  AUTHORS   Reijns,M.A., Rabe,B., Rigby,R.E., Mill,P., Astell,K.R.,
            Lettice,L.A., Boyle,S., Leitch,A., Keighren,M., Kilanowski,F.,
            Devenney,P.S., Sexton,D., Grimes,G., Holt,I.J., Hill,R.E.,
            Taylor,M.S., Lawson,K.A., Dorin,J.R. and Jackson,A.P.
  TITLE     Enzymatic removal of ribonucleotides from DNA is essential for
            mammalian genome integrity and development
  JOURNAL   Cell 149 (5), 1008-1022 (2012)
   PUBMED   22579044
REFERENCE   8  (bases 1 to 646)
  AUTHORS   Shaban,N.M., Harvey,S., Perrino,F.W. and Hollis,T.
  TITLE     The structure of the mammalian RNase H2 complex provides insight
            into RNA.NA hybrid processing to prevent immune dysfunction
  JOURNAL   J Biol Chem 285 (6), 3617-3624 (2010)
   PUBMED   19923215
  REMARK    GeneRIF: Data show that the interwoven architecture of RNase H2B
            and RNase H2C that interface with RNase H2A in a complex ideally
            suited for nucleic acid binding and hydrolysis coupled to
            protein-protein interaction motifs.
REFERENCE   9  (bases 1 to 646)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 646)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126029.3, AK018776.1 and CD553809.1.
            
            On Aug 5, 2005 this sequence version replaced NM_026616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY709643.1, AF346604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC126029.3         42092-42103         c
            13-619              AK018776.1         2-608
            620-646             CD553809.1         111-137
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..646
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /note="ribonuclease H2, subunit C"
                     /db_xref="GeneID:68209"
                     /db_xref="MGI:MGI:1915459"
     exon            1..208
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..537
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /note="RNase H2 subunit C; ribonuclease HI subunit C"
                     /codon_start=1
                     /product="ribonuclease H2 subunit C"
                     /protein_id="NP_080892.1"
                     /db_xref="CCDS:CCDS29471.1"
                     /db_xref="GeneID:68209"
                     /db_xref="MGI:MGI:1915459"
                     /translation="MKNPEEAADGKQRIHLRPGSLRGAAPAKLHLLPCDVLVSRPAPV
                     DRFFTPAVRHDADGLQASFRGRGLRGEEVAVPPGFAGFVMVTEEKGEGLIGKLNFSGD
                     AEDKADEAQEPLERDFDRLIGATGSFSHFTLWGLETVPGPDAKVHRALGWPSLAAAIH
                     AQVPED"
     exon            209..390
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..510
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..646
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      604..609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /note="hexamer: AATAAA"
     polyA_site      623
                     /gene="Rnaseh2c"
                     /gene_synonym="1500026D16Rik; AYP1"
                     /note="major polyA site"
ORIGIN      
        1 ccgccagctt ttgcctgaac cttacaagct tctgagatga agaacccgga ggaagcggca
       61 gacgggaaac agcgtattca cctgcgccct ggctcgctgc gtggtgccgc accggctaag
      121 ctgcacctcc tgccctgcga cgttctagtc agccggccgg ccccggtaga tcgcttcttc
      181 acgcccgccg tccgccacga tgcagacggg ctacaggcgt cgtttcgcgg tcgcggcctg
      241 cggggcgagg aggtagctgt gccgccaggg tttgcgggat tcgtgatggt gacggaggag
      301 aagggagagg ggttgatagg gaaactgaac ttctccgggg acgcggagga caaagcggac
      361 gaggcgcagg agccgctgga gcgggacttc gaccgcctta tcggggccac cggcagcttc
      421 agccatttca ccttgtgggg tctggaaacg gtcccgggtc cagatgccaa agtgcatagg
      481 gccctaggtt ggcccagcct cgcagcagcg attcacgccc aggtccctga ggactgagaa
      541 ccagatcatg agaatgacag tcacagatcc cttctcacca cttggagcga ctgtttctat
      601 cccaataaat gagatcttca caatgcctga gtctgtgggc acctta
//
