LOCUS       NM_026001               1498 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus ribonuclease H2, subunit B (Rnaseh2b), mRNA.
ACCESSION   NM_026001 XM_127746
VERSION     NM_026001.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Dressel,N., Natusch,L., Munz,C.M., Costas Ramon,S., Morcos,M.N.F.,
            Loff,A., Hiller,B., Haase,C., Schulze,L., Muller,P., Lesche,M.,
            Dahl,A., Luksch,H., Rosen-Wolff,A., Roers,A., Behrendt,R. and
            Gerbaulet,A.
  TITLE     Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic
            Cells Does Not Impact Blood Cell Formation or Leukemogenesis
  JOURNAL   Cancer Res 83 (17), 2858-2872 (2023)
   PUBMED   37335136
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Zhao,H., Hartono,S.R., de Vera,K.M.F., Yu,Z., Satchi,K., Zhao,T.,
            Sciammas,R., Sanz,L., Chedin,F. and Barlow,J.
  TITLE     Senataxin and RNase H2 act redundantly to suppress genome
            instability during class switch recombination
  JOURNAL   Elife 11, e78917 (2022)
   PUBMED   36542058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Brown,G.J., Canete,P.F., Wang,H., Medhavy,A., Bones,J., Roco,J.A.,
            He,Y., Qin,Y., Cappello,J., Ellyard,J.I., Bassett,K., Shen,Q.,
            Burgio,G., Zhang,Y., Turnbull,C., Meng,X., Wu,P., Cho,E.,
            Miosge,L.A., Andrews,T.D., Field,M.A., Tvorogov,D., Lopez,A.F.,
            Babon,J.J., Lopez,C.A., Gonzalez-Murillo,A., Garulo,D.C.,
            Pascual,V., Levy,T., Mallack,E.J., Calame,D.G., Lotze,T.,
            Lupski,J.R., Ding,H., Ullah,T.R., Walters,G.D., Koina,M.E.,
            Cook,M.C., Shen,N., de Lucas Collantes,C., Corry,B., Gantier,M.P.,
            Athanasopoulos,V. and Vinuesa,C.G.
  TITLE     TLR7 gain-of-function genetic variation causes human lupus
  JOURNAL   Nature 605 (7909), 349-356 (2022)
   PUBMED   35477763
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Reijns,M.A.M., Parry,D.A., Williams,T.C., Nadeu,F., Hindshaw,R.L.,
            Rios Szwed,D.O., Nicholson,M.D., Carroll,P., Boyle,S., Royo,R.,
            Cornish,A.J., Xiang,H., Ridout,K., Schuh,A., Aden,K., Palles,C.,
            Campo,E., Stankovic,T., Taylor,M.S. and Jackson,A.P.
  CONSRTM   Genomics England Research Consortium; Colorectal Cancer Domain UK
            100,000 Genomes Project
  TITLE     Signatures of TOP1 transcription-associated mutagenesis in cancer
            and germline
  JOURNAL   Nature 602 (7898), 623-631 (2022)
   PUBMED   35140396
  REMARK    Erratum:[Nature. 2022 May;605(7910):E7. doi:
            10.1038/s41586-022-04812-z. PMID: 35504971]
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Rabe,B.
  TITLE     Aicardi-Goutieres syndrome: clues from the RNase H2 knock-out mouse
  JOURNAL   J Mol Med (Berl) 91 (11), 1235-1240 (2013)
   PUBMED   23744109
  REMARK    GeneRIF: Recent evidence gathered from ribonuclease H2 knock-out
            mice provides insight into the molecular mechanisms underlying
            Aicardi-Goutieres syndrome development and a potential role of DNA
            damage as a trigger of autoimmunity is discussed. [review]
            Review article
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Ghodgaonkar,M.M., Lazzaro,F., Olivera-Pimentel,M., Artola-Boran,M.,
            Cejka,P., Reijns,M.A., Jackson,A.P., Plevani,P., Muzi-Falconi,M.
            and Jiricny,J.
  TITLE     Ribonucleotides misincorporated into DNA act as
            strand-discrimination signals in eukaryotic mismatch repair
  JOURNAL   Mol Cell 50 (3), 323-332 (2013)
   PUBMED   23603115
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Hiller,B., Achleitner,M., Glage,S., Naumann,R., Behrendt,R. and
            Roers,A.
  TITLE     Mammalian RNase H2 removes ribonucleotides from DNA to maintain
            genome integrity
  JOURNAL   J Exp Med 209 (8), 1419-1426 (2012)
   PUBMED   22802351
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Reijns,M.A., Rabe,B., Rigby,R.E., Mill,P., Astell,K.R.,
            Lettice,L.A., Boyle,S., Leitch,A., Keighren,M., Kilanowski,F.,
            Devenney,P.S., Sexton,D., Grimes,G., Holt,I.J., Hill,R.E.,
            Taylor,M.S., Lawson,K.A., Dorin,J.R. and Jackson,A.P.
  TITLE     Enzymatic removal of ribonucleotides from DNA is essential for
            mammalian genome integrity and development
  JOURNAL   Cell 149 (5), 1008-1022 (2012)
   PUBMED   22579044
  REMARK    GeneRIF: Study performed targeted mutagenesis of the mouse Rnaseh2b
            gene to gain insight into the in vivo role of the mammalian RNase
            H2 enzyme. Ablation of Rnaseh2b in mice leads to early embryonic
            lethality due to elevated DNA damage and reduced cellular
            proliferation during gastrulation.
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Shaban,N.M., Harvey,S., Perrino,F.W. and Hollis,T.
  TITLE     The structure of the mammalian RNase H2 complex provides insight
            into RNA.NA hybrid processing to prevent immune dysfunction
  JOURNAL   J Biol Chem 285 (6), 3617-3624 (2010)
   PUBMED   19923215
  REMARK    GeneRIF: Data show that the interwoven architecture of RNase H2B
            and RNase H2C that interface with RNase H2A in a complex ideally
            suited for nucleic acid binding and hydrolysis coupled to
            protein-protein interaction motifs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011914.1, AK082752.1 and AC154805.2.
            
            On Apr 17, 2018 this sequence version replaced NM_026001.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011914.1, AK082752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AK011914.1         3-39
            38-1494             AK082752.1         2-1458
            1495-1498           AC154805.2         112039-112042
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.19 cM"
     gene            1..1498
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /note="ribonuclease H2, subunit B"
                     /db_xref="GeneID:67153"
                     /db_xref="MGI:MGI:1914403"
     exon            1..109
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            110..184
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            185..292
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            293..369
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            370..484
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            485..549
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            550..655
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            656..737
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            738..780
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            781..861
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1498
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /note="hexamer: AATAAA"
     polyA_site      1013
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /note="major polyA site"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
                     /note="hexamer: AATAAA"
     polyA_site      1498
                     /gene="Rnaseh2b"
                     /gene_synonym="1110019N06Rik; 2610207P08Rik; Dleu8"
ORIGIN      
        1 ggccccggtt ggcgggcccc tcggcgccac ttccggcagg gcgcgaccat ggccggaggt
       61 cgggaccgcg gggacttggc ggccaggcag ctagtgttcc tacttccaga acatttaaaa
      121 gatgcctcga agaagaagaa gaagagcagc ctcctgttcg taaagctggc caacccgcac
      181 tcaggggaag gagccacata cttaattgat atgtgtcttc aacagctgtt tgaaataaaa
      241 gttttcaagg aaaaacacca ttcttggttt ataaatcaat cagttcaatc agggggcctt
      301 ctccactttg ccacacccat ggatccattg ttcctgctcc ttcactatct cctaaaggct
      361 ggcaaagagg ggaagtatca gcccttggac caagtcgtgg tcgatgacac gtttccagat
      421 tgcaccttgc tgctgagatt tcctgagctt gaaaagtcac ttcggcatgt gacagaggaa
      481 aaagaagtga acagcaagaa gtactataag tacagctcag agaagacatt gaagtggctg
      541 gagaagaagg tcaaccaaac tgtggtggca ctaaaagcta ataatgtcaa tgttggagcc
      601 cgggttcagt catctgcata tttctctggt ggtcaggttt ccagggacaa ggaagaggat
      661 tatgttcgct atgcccatgg tctgatctct gattacatcc ctaaagaact gagtgatgat
      721 ttatccaagt tcttgaagct tccagaacct ccagcttcat tgaccaaccc tccatcaaag
      781 aaactaaagt tatcagatga gcctgtagaa gccaaagaag attacactaa gtttaacact
      841 aaagacttga agaccggcaa gaaaaatagc aaaatgactg cagctcagaa ggctttggct
      901 aaagttgaca aaagtggaat gaaaagtatc gatgcctttt ttggtgcaaa aaataaaaaa
      961 actggaaaga tttgaagcat cgaaaataaa atccagtgaa gcagaaacag aaacttgcct
     1021 cttgcctatt ctgtcttgtc tcttcttgcc gctgccccga cctcccagac cctaagtcac
     1081 tacgctgaga atcaaggtac tttcgcatcc tgcagacact tgctgcgctg tgactttgtg
     1141 tctgacaaac acaaccattg tgggaaagtg attgtgtgaa ctgctgtccg gggactttgg
     1201 gacctttgcc ataatgaaaa gccatcaagt gcatgggtca ccgagtcaca gcttccccag
     1261 ggaggtgtga gcattgccca ggtgttccct gctctgtcct gcatggcttc agctgaaatg
     1321 agctggacaa caaaaccaca cattttggta aattttataa ttagccatat cttcgtatga
     1381 attcatgttc tttgtaaaaa taaaaatcaa taaaacaaaa ttgcaatctt gcccctttcc
     1441 attatgcagg tacaaccagg taattttctt agaataaaaa cattttcaag agctttaa
//
