LOCUS       NM_030098               2168 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ribonuclease, RNase A family, 6 (Rnase6), transcript
            variant 1, mRNA.
ACCESSION   NM_030098 XM_127690
VERSION     NM_030098.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2168)
  AUTHORS   Cortado,H., Kercsmar,M., Li,B., Vasquez-Martinez,G., Gupta,S.,
            Ching,C., Ballash,G., Cotzomi-Ortega,I., Sanchez-Zamora,Y.I.,
            Boix,E., Zepeda-Orozco,D., Jackson,A.R., Spencer,J.D.,
            Ruiz-Rosado,J.D. and Becknell,B.
  TITLE     Murine Ribonuclease 6 Limits Bacterial Dissemination during
            Experimental Urinary Tract Infection
  JOURNAL   J Innate Immun 16 (1), 283-294 (2024)
   PUBMED   38744252
  REMARK    GeneRIF: Murine Ribonuclease 6 Limits Bacterial Dissemination
            during Experimental Urinary Tract Infection.
REFERENCE   3  (bases 1 to 2168)
  AUTHORS   Becknell,B., Eichler,T.E., Beceiro,S., Li,B., Easterling,R.S.,
            Carpenter,A.R., James,C.L., McHugh,K.M., Hains,D.S.,
            Partida-Sanchez,S. and Spencer,J.D.
  TITLE     Ribonucleases 6 and 7 have antimicrobial function in the human and
            murine urinary tract
  JOURNAL   Kidney Int 87 (1), 151-161 (2015)
   PUBMED   25075772
REFERENCE   4  (bases 1 to 2168)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   5  (bases 1 to 2168)
  AUTHORS   Dyer,K.D., Rosenberg,H.F. and Zhang,J.
  TITLE     Isolation, characterization, and evolutionary divergence of mouse
            RNase 6: evidence for unusual evolution in rodents
  JOURNAL   J Mol Evol 59 (5), 657-665 (2004)
   PUBMED   15693621
  REMARK    GeneRIF: the ancestral rodent RNase 6 was subject to accelerated
            evolution
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA182060.1, AK020595.1, AK038708.1 and BG091045.1.
            
            On Jan 27, 2018 this sequence version replaced NM_030098.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA182060.1, AY545655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AA182060.1         1-310
            311-727             AK020595.1         224-640
            728-2163            AK038708.1         1013-2448
            2164-2168           BG091045.1         374-378
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.39 cM"
     gene            1..2168
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="ribonuclease, RNase A family, 6"
                     /db_xref="GeneID:78416"
                     /db_xref="MGI:MGI:1925666"
     exon            1..128
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            129..2168
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..595
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="ribonuclease A family, member 6; RNase K6"
                     /codon_start=1
                     /product="ribonuclease K6"
                     /protein_id="NP_084374.2"
                     /db_xref="CCDS:CCDS27037.1"
                     /db_xref="GeneID:78416"
                     /db_xref="MGI:MGI:1925666"
                     /translation="MVVDLPRYLPLLLLLELWEPMYLLCSQPKGLSRAHWFEIQHVQT
                     SRQPCNTAMRGVNNYTQHCKQINTFLHESFQNVAATCSLHNITCKNGRKNCHESAEPV
                     KMTDCSHTGGAYPNCRYSSDKQYKFFIVACEHPKKEDPPYQLVPVHLDKIV"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1121
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="major polyA site"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2168
                     /gene="Rnase6"
                     /gene_synonym="9530043P15Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaataagcct tcctgtgccc cacctaggca gctgtgaccg gcttgaagaa gagaaacaaa
       61 caaaatattc tgagcctggg acggatcatc tggccctgtt caccatagga gcccagcaca
      121 accagcagaa aacatggtgg tagaccttcc caggtacctt cctctcctat tgctgcttga
      181 gctgtgggag ccgatgtatc tactttgctc tcagcctaag ggtctctcca gggcacactg
      241 gtttgaaatt cagcacgtac agacaagtcg tcaaccatgc aacacagcca tgcgcggtgt
      301 caacaattat acccaacact gtaaacagat aaacaccttt ctgcatgaat ctttccagaa
      361 tgtggctgct acctgcagtt tgcacaatat cacctgcaag aacggtcgga agaactgcca
      421 cgagagcgca gaacctgtca agatgactga ctgctcacac actggaggag cctatcctaa
      481 ctgccgctat agtagtgata agcaatacaa gttcttcatt gtggcctgtg aacacccaaa
      541 gaaggaagac cctccctacc aactagtgcc tgtgcactta gataagattg tgtgaggcta
      601 ggccttttct tctgtttgat acaggttctc ttacagttta ttccactttg ccttctgttc
      661 ccacagaaaa gggaaggtgt tggaagaatt aagatgccta cgctatcaaa acggagctta
      721 aaaaaaaaga gtgcatgggt tatgatggag ctccgtcaat gagcacttgc ttagtgcaca
      781 gaggtccctg ggttctatca tcatactacc ccccaccaaa atagaaagaa agaagattat
      841 tttctgctct ggggttacct ttgttgaagg aggaatataa gaaaagtata aagaaggacc
      901 aagccgctga acaatttatc ctgcaatttt ttgggtcaag ctttattgta caatgctcat
      961 aggcagaaaa aaatttcttt ttttaataga atgagtgtta tttttctggg ttgtttgttt
     1021 gttgtttttt gacagggtct gatttggtca gggtgggctc agcgtcgcta tgtaaccaag
     1081 agtggttatc aactcttatt aaatcctgtt atcatctctt acacttccat tcttgctcag
     1141 tccctagctt ccctaccctc ctactgtgtg aggttcatgt tcccaaagca ggaaaggggg
     1201 agggtcactg ggggccagga ggctggagag attttgagga ctcacaatca tctttcactc
     1261 cagcctaaag ccaccaggca agcagccacc agcaggcacc aggcacatac tggctacaca
     1321 caagccacgt ggagataggc atgttgggaa caagcaaaag aaacttagat tctaagtatt
     1381 actgtttcat ttttacactc catttaatca cagagaaaaa agaaattcat gatcccaagc
     1441 cctaagggag ctggggactt cccaatagac gagtaggtct tactataagg aaacagttgt
     1501 ctgaatccca acatctcagg gacaacttgg aaaggagtgt agccgcccac agctgtacga
     1561 accaggttcc cgaaagggag gctggggctg catgggagaa aatatccaga gaaataacga
     1621 gaccaagaca aagataatga tcaaggccca aagtttactt aagagtctga gcttataaag
     1681 ggggaaggct catccctggc cacgccaggc tcttgttgct ttgtcaccag gctgttgctt
     1741 acttaggaat gtctcaggtt caggttcagc ctctcagcca gtggctgtgt cttggagaaa
     1801 acccgcagag gtggcagaac aatagaccta tctaggtcag aaggctccac tctaggtggt
     1861 cttgctcaca gtggcagaac aggtctgagc cggctgctca aggctggggg agactacaga
     1921 ggagcagttg tctgagtaga gacagcttct ccatcttgct ggaagggttg aaccaggatc
     1981 ctgtttccag gcccaggaac ctactcctaa catgattggt gaaaactccc tggctcacat
     2041 cccttttacc aaaatatgat tggagagtgc aatacagccc accctgaagt tcagttccca
     2101 agtctgttct gtggccctaa tcaatcagta gcagcttgat tgcaataaaa ttttgtcatt
     2161 tgcattga
//
