LOCUS       NM_201239               1837 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus ribonuclease, RNase A family 4 (Rnase4), transcript
            variant 2, mRNA.
ACCESSION   NM_201239
VERSION     NM_201239.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Sun,J., Chen,M., Hu,Z., Xu,N., Wang,W., Ping,Z., Zhu,J., Sun,D.,
            Zhu,Z., Li,H., Ge,X., Luo,L., Zhou,W., Bai,R., Xu,Z. and Sheng,J.
  TITLE     Ribonuclease 4 functions as an intestinal antimicrobial protein to
            maintain gut microbiota and metabolite homeostasis
  JOURNAL   Nat Commun 15 (1), 5778 (2024)
   PUBMED   38987259
  REMARK    GeneRIF: Ribonuclease 4 functions as an intestinal antimicrobial
            protein to maintain gut microbiota and metabolite homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Murtha,M.J., Eichler,T., Bender,K., Metheny,J., Li,B.,
            Schwaderer,A.L., Mosquera,C., James,C., Schwartz,L., Becknell,B.
            and Spencer,J.D.
  TITLE     Insulin receptor signaling regulates renal collecting duct and
            intercalated cell antibacterial defenses
  JOURNAL   J Clin Invest 128 (12), 5634-5646 (2018)
   PUBMED   30418175
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   5  (bases 1 to 1837)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 1837)
  AUTHORS   Hsieh,Y.C., Hsu,C., Yang,R.C., Lee,P.Y., Hsu,H.K. and Sun,Y.M.
  TITLE     Isolation of bona fide differentially expressed genes in the
            18-hour sepsis liver by suppression subtractive hybridization
  JOURNAL   Shock 21 (6), 549-555 (2004)
   PUBMED   15167684
REFERENCE   7  (bases 1 to 1837)
  AUTHORS   Koshizuka,Y., Ikegawa,S., Sano,M., Nakamura,K. and Nakamura,Y.
  TITLE     Isolation of novel mouse genes associated with ectopic ossification
            by differential display method using ttw, a mouse model for ectopic
            ossification
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 163-168 (2001)
   PUBMED   11856874
REFERENCE   8  (bases 1 to 1837)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 1837)
  AUTHORS   Hofsteenge,J., Vicentini,A. and Zelenko,O.
  TITLE     Ribonuclease 4, an evolutionarily highly conserved member of the
            superfamily
  JOURNAL   Cell Mol Life Sci 54 (8), 804-810 (1998)
   PUBMED   9760989
  REMARK    Review article
REFERENCE   10 (bases 1 to 1837)
  AUTHORS   Batten,D., Dyer,K.D., Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Molecular cloning of four novel murine ribonuclease genes: unusual
            expansion within the ribonuclease A gene family
  JOURNAL   Nucleic Acids Res 25 (21), 4235-4239 (1997)
   PUBMED   9336452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163664.3, AK050451.1 and
            CD742377.1.
            
            On Jun 20, 2009 this sequence version replaced NM_201239.2.
            
            Summary: This gene encodes a member of the pancreatic ribonuclease
            A superfamily. The encoded enzyme is sereted and has unique uridine
            specificity. This gene resides in a cluster of highly related
            genes. It shares dual promoters and 5' exons with the angiogenin,
            ribonuclease, RNase A family, 5 gene. Each gene splices to a unique
            downstream exon that contains its complete coding region. Two
            alternatively spliced variants, with different 5' exons but the
            same coding exon, have been identified. [provided by RefSeq, Jun
            2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY762362.1, AK050451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AC163664.3         134698-135098       c
            402-1808            AK050451.1         2-1408
            1809-1837           CD742377.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.37 cM"
     gene            1..1837
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /note="ribonuclease, RNase A family 4"
                     /db_xref="GeneID:58809"
                     /db_xref="MGI:MGI:1926217"
     exon            1..474
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1819
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..935
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /note="ribonuclease 4; RNase 4; ribonuclease A b1"
                     /codon_start=1
                     /product="ribonuclease 4 precursor"
                     /protein_id="NP_957691.1"
                     /db_xref="CCDS:CCDS27035.1"
                     /db_xref="GeneID:58809"
                     /db_xref="MGI:MGI:1926217"
                     /translation="MMDLQRTQSLLLLLVLTLLGLGLVQPSYGQDRMYQRFLRQHVDP
                     QVTGGNDNYCNVMMQRRKMTSVQCKRFNTFIHEDIWNIRGICSTTNILCKNGQMNCHE
                     GVVKVTDCRETGNSKAPNCRYRARTSTRRVVIACEGDPEVPVHFDR"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="Rnase4"
                     /gene_synonym="C730049F20Rik; Rab1"
                     /note="major polyA site"
ORIGIN      
        1 acagttgcct cactccttcc tttagacttc tttcaaagta gttcctgaag ttggcctgaa
       61 cgtcagggat aatatgtttt tggatctatg gcatatgcac agtgaaactt cagtcctacc
      121 ctgagcaagg ataaggacca tacacataag gaaagaggca gcttaggaac aaaaggccgt
      181 gcttagcaaa cattatcatt gctgaaagag atgtgtggtc caccaggtgg ttaatatttg
      241 acccaggcat gctcagggga aaggtgaatg actccttgtt tgcccatgat tagtggcctt
      301 ggtttacaag tcgctgccaa agtaaagatc cttagatagg ttctccccac cccgtcacat
      361 gagcactgta tattaccagc ctgtgaggag cctctagctt cacaccgcag gaccctgtct
      421 ccaggagcac gcagctggac acattcccag tcggaggaaa gctggccagc tttggcactt
      481 tctaggtaat gatggatcta cagaggactc agtccttgct tctgctcttg gtgctgaccc
      541 tgctggggtt agggcttgta cagccctcct atggccagga tcgaatgtac caacggttcc
      601 ttcgacagca tgtggaccct caggtgacag gtggcaatga caactactgc aacgtgatga
      661 tgcagagacg gaagatgact tctgtccagt gcaaacgctt caacaccttc atccacgaag
      721 acatctggaa cattcgtggc atctgcagta ccaccaatat cctgtgcaag aacggccaga
      781 tgaactgtca cgaaggtgta gtgaaggtca cggactgcag agagacaggg aactccaagg
      841 cccccaactg tagatacagg gcaagaacca gcactaggcg agttgtcatt gcctgtgagg
      901 gtgacccaga ggtcccagtg cactttgaca gatagatgct gtcctgcagc tgttacagct
      961 gatagttgac ctctgagtca gtgagaccaa caatgagtgg tggccccagg ctttgtttcc
     1021 tttgctcgtg ccttatactc acatatatcc aatataaccc atggtgttaa gcgcatccca
     1081 tccaagggaa gaaagaaccc actgctcaca gcactgatgg cttggttctc ccagattcta
     1141 tcccctggaa cttatgcatt acatgtattc agatagtatc tcaacgatta tagagagcct
     1201 tttctgtcca agctgtctca ttccagtcct ctaacacccc ttgagaccaa ttctgccact
     1261 gtatttagaa gctttgagtt aaaggatttg acgaccacaa aaaaccaaaa ccaaaaccaa
     1321 aaacaaaaac ccagtggaag atctcagaca aaaatccaac tggacgggct actcacaaaa
     1381 ggtgttaccc acttcgttat atatactttc tgttattcca aaatgtcatc attagggaag
     1441 ccactaagag tttggaaata ggggctggag agatgcctct gtggttaaga gcattggctg
     1501 ctcctctaga ggacccaggt tcaattccca gcgcccacac atcagctcac aactgtctgt
     1561 aacccagttc taggtgattt gataccctca cacagacata catgtagaca gatcaccaat
     1621 gcatataaaa ttaaaataaa gattttggaa acaacatatt gccaaaatga gaattacttg
     1681 gtattatttt ggtctgtggc ttctaagatt ttttaaaata catgaaaaat gtagtaaatc
     1741 actaaaattc atttatcctt ctcctttgaa agattttcaa tattttagta taataaagag
     1801 ctgtatgttg agccatctga aaaaaaaaaa aaaaaaa
//
