LOCUS       NM_019398                759 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus ribonuclease, RNase A family, 2B (liver,
            eosinophil-derived neurotoxin) (Rnase2b), mRNA.
ACCESSION   NM_019398
VERSION     NM_019398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Attery,A. and Batra,J.K.
  TITLE     Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic,
            antibacterial and antiparasitic activities
  JOURNAL   Int J Biol Macromol 94 (Pt A), 445-450 (2017)
   PUBMED   27765572
  REMARK    GeneRIF: Functional activity of four mouse eosinophil associated
            ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Pastori,C., Peschansky,V.J., Barbouth,D., Mehta,A., Silva,J.P. and
            Wahlestedt,C.
  TITLE     Comprehensive analysis of the transcriptional landscape of the
            human FMR1 gene reveals two new long noncoding RNAs differentially
            expressed in Fragile X syndrome and Fragile X-associated
            tremor/ataxia syndrome
  JOURNAL   Hum Genet 133 (1), 59-67 (2014)
   PUBMED   24005575
  REMARK    GeneRIF: two novel lncRNAs, FMR5 and FMR6, are differentially
            expressed in Fragile X syndrome and Fragile X-associated
            tremor/ataxia syndrome
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Dyer,K.D., Nitto,T., Moreau,J.M., McDevitt,A.L. and Rosenberg,H.F.
  TITLE     Identification of a purine-rich intronic enhancer element in the
            mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
  JOURNAL   Mamm Genome 15 (2), 126-134 (2004)
   PUBMED   15058383
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Singhania,N.A., Dyer,K.D., Zhang,J., Deming,M.S., Bonville,C.A.,
            Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Rapid evolution of the ribonuclease A superfamily: adaptive
            expansion of independent gene clusters in rats and mice
  JOURNAL   J Mol Evol 49 (6), 721-728 (1999)
   PUBMED   10594173
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Batten,D., Dyer,K.D., Domachowske,J.B. and Rosenberg,H.F.
  TITLE     Molecular cloning of four novel murine ribonuclease genes: unusual
            expansion within the ribonuclease A gene family
  JOURNAL   Nucleic Acids Res 25 (21), 4235-4239 (1997)
   PUBMED   9336452
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Larson,K.A., Olson,E.V., Madden,B.J., Gleich,G.J., Lee,N.A. and
            Lee,J.J.
  TITLE     Two highly homologous ribonuclease genes expressed in mouse
            eosinophils identify a larger subgroup of the mammalian
            ribonuclease superfamily
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12370-12375 (1996)
   PUBMED   8901588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163664.3.
            
            On Aug 21, 2009 this sequence version replaced NM_019398.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117776.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               AC163664.3         68080-68838         c
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.4 cM"
     gene            1..759
                     /gene="Rnase2b"
                     /gene_synonym="Ear5; mR5; Raf4"
                     /note="ribonuclease, RNase A family, 2B (liver,
                     eosinophil-derived neurotoxin)"
                     /db_xref="GeneID:54159"
                     /db_xref="MGI:MGI:1858598"
     exon            1..759
                     /gene="Rnase2b"
                     /gene_synonym="Ear5; mR5; Raf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..672
                     /gene="Rnase2b"
                     /gene_synonym="Ear5; mR5; Raf4"
                     /EC_number="4.6.1.18"
                     /note="eosinophil-associated ribonuclease 5; eosinophil
                     cationic-type ribonuclease 5; MR-5; murine ribonuclease 5;
                     ribonuclease A f4; eosinophil-associated, ribonuclease A
                     family, member 5; ribonuclease 2B"
                     /codon_start=1
                     /product="ribonuclease 2B precursor"
                     /protein_id="NP_062271.2"
                     /db_xref="CCDS:CCDS27039.1"
                     /db_xref="GeneID:54159"
                     /db_xref="MGI:MGI:1858598"
                     /translation="MGLKLLESRLCLLLLLGLVLTLVSCQRPTPSQKFDIQHIYKKSS
                     PKCDDAMRVVNKYTGKCKDLNTFLHTTFADVVRVCHNPPKTCKDGTSPNCHDSSSKVS
                     VTICKLTKRARNYTHCRYKTTGAKKSYTVACNPRTPKDRPTYPVVPVHLDRLF"
ORIGIN      
        1 cagcgctcag ttccacggga gccacaaagc agactgggta agacactgac tgtctgggcc
       61 tgggacagga ggggcagtga tgggacagtg tccaggagaa gtcccaccgt ggacccacag
      121 tgacagcaga gggccttcag gaagagatat ggaaaactga ggtagggtgg aagtagtcac
      181 ttctcttctg tcctcacagg aaacatgggt ctgaagctgc ttgaatccag actttgtctc
      241 ctgctgctgc tgggacttgt cctaacgctt gtctcatgcc agcgaccaac cccttcccag
      301 aagtttgaca tccagcatat ctataagaaa tcctctccca aatgtgatga tgcaatgcgg
      361 gtcgttaaca agtatacagg aaaatgtaag gacttgaata cttttcttca tacaactttt
      421 gctgatgttg tccgtgtgtg tcacaatcca cccaagactt gcaaagacgg gacaagtcca
      481 aattgtcatg atagttcatc taaggtatct gtaactatct gtaaactcac aaaacgggca
      541 aggaattata cccactgcag atacaaaaca acaggagcaa agaagtccta cacagttgcc
      601 tgtaacccca gaactccaaa ggaccgtccc acctatccag tagttccggt tcacttggat
      661 cggctatttt agctccagtg ccagcacttt gtaccttccc tcatctgcta ctgccgagat
      721 catagtagtg aagaacgaat tcctctgtct gcgctgcat
//
