LOCUS       NM_053113                722 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ribonuclease, RNase A family, 2A (liver,
            eosinophil-derived neurotoxin) (Rnase2a), mRNA.
ACCESSION   NM_053113
VERSION     NM_053113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 722)
  AUTHORS   Panova V, Gogoi M, Rodriguez-Rodriguez N, Sivasubramaniam M, Jolin
            HE, Heycock MWD, Walker JA, Rana BMJ, Drynan LF, Hodskinson M,
            Pannell R, King G, Wing M, Easton AJ, Oedekoven CA, Kent DG, Fallon
            PG, Barlow JL and McKenzie ANJ.
  TITLE     Group-2 innate lymphoid cell-dependent regulation of tissue
            neutrophil migration by alternatively activated macrophage-secreted
            Ear11
  JOURNAL   Mucosal Immunol 14 (1), 26-37 (2021)
   PUBMED   32457448
  REMARK    GeneRIF: Group-2 innate lymphoid cell-dependent regulation of
            tissue neutrophil migration by alternatively activated
            macrophage-secreted Ear11.
REFERENCE   2  (bases 1 to 722)
  AUTHORS   Attery A and Batra JK.
  TITLE     Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic,
            antibacterial and antiparasitic activities
  JOURNAL   Int J Biol Macromol 94 (Pt A), 445-450 (2017)
   PUBMED   27765572
  REMARK    GeneRIF: Functional activity of four mouse eosinophil associated
            ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
REFERENCE   3  (bases 1 to 722)
  AUTHORS   Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE,
            Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR,
            Schreiber RD and Borowsky AD.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 722)
  AUTHORS   Yamada KJ, Barker T, Dyer KD, Rice TA, Percopo CM, Garcia-Crespo
            KE, Cho S, Lee JJ, Druey KM and Rosenberg HF.
  TITLE     Eosinophil-associated ribonuclease 11 is a macrophage
            chemoattractant
  JOURNAL   J Biol Chem 290 (14), 8863-8875 (2015)
   PUBMED   25713137
  REMARK    GeneRIF: characterizes a divergent RNase A ribonuclease with a
            unique expression pattern and function, and highlights the
            versatility of this family in promoting innate immunity.
REFERENCE   5  (bases 1 to 722)
  AUTHORS   Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K,
            Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS,
            Gessner A, Schett G, Amling M, McKenzie AN, Horst AK and Schinke T.
  TITLE     Interleukin-33 is expressed in differentiated osteoblasts and
            blocks osteoclast formation from bone marrow precursor cells
  JOURNAL   J Bone Miner Res 26 (4), 704-717 (2011)
   PUBMED   20939024
REFERENCE   6  (bases 1 to 722)
  AUTHORS   Cho S, Beintema JJ and Zhang J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   7  (bases 1 to 722)
  AUTHORS   Dyer KD, Nitto T, Moreau JM, McDevitt AL and Rosenberg HF.
  TITLE     Identification of a purine-rich intronic enhancer element in the
            mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
  JOURNAL   Mamm Genome 15 (2), 126-134 (2004)
   PUBMED   15058383
REFERENCE   8  (bases 1 to 722)
  AUTHORS   Cormier SA, Larson KA, Yuan S, Mitchell TL, Lindenberger K,
            Carrigan P, Lee NA and Lee JJ.
  TITLE     Mouse eosinophil-associated ribonucleases: a unique subfamily
            expressed during hematopoiesis
  JOURNAL   Mamm Genome 12 (5), 352-361 (2001)
   PUBMED   11331942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC027557.1.
            
            On Jun 19, 2003 this sequence version replaced NM_053113.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027557.1, BF158655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.44 cM"
     gene            1..722
                     /gene="Rnase2a"
                     /gene_synonym="Ear11"
                     /note="ribonuclease, RNase A family, 2A (liver,
                     eosinophil-derived neurotoxin)"
                     /db_xref="GeneID:93726"
                     /db_xref="MGI:MGI:1890465"
     exon            1..40
                     /gene="Rnase2a"
                     /gene_synonym="Ear11"
                     /inference="alignment:Splign:2.1.0"
     exon            41..691
                     /gene="Rnase2a"
                     /gene_synonym="Ear11"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..513
                     /gene="Rnase2a"
                     /gene_synonym="Ear11"
                     /EC_number="4.6.1.18"
                     /note="eosinophil-associated ribonuclease 11;
                     eosinophil-associated, ribonuclease A family, member 11"
                     /codon_start=1
                     /product="non-secretory ribonuclease precursor"
                     /protein_id="NP_444343.2"
                     /db_xref="CCDS:CCDS27041.1"
                     /db_xref="GeneID:93726"
                     /db_xref="MGI:MGI:1890465"
                     /translation="MGLEQLESRLCLLLLLGHVLMLASCQPLTPSRWFDIQHIYNRAY
                     PRCDDAMRAVNSYTGVCKDINTFLHTTFANVVRVCHNPRKICKNGISRNCHDSSNRVQ
                     VTICILTTPASHYSNCRYRTTRSMKYYTVACDPRTPQDSPMYPVVPVHLDGIF"
ORIGIN      
        1 agccagcgct cagttccacg ggagccacaa agcagactgg gaaacatggg tctggagcaa
       61 cttgagtctc gactttgtct cctgctgctg ctgggacatg tcctaatgct tgcctcatgc
      121 cagccattga ccccctcccg gtggtttgac atccagcata tctataacag agcctatccc
      181 cgatgtgatg atgcaatgcg ggccgttaac agttacacag gagtgtgtaa agacataaat
      241 acttttcttc atacaacttt tgctaatgtt gtccgtgtgt gtcataatcc acgtaagatc
      301 tgcaaaaatg ggataagtag aaattgtcat gatagttcaa atcgggtaca agtaactatc
      361 tgtatactca caactccggc cagtcattat tccaactgca gataccgaac aacaagatca
      421 atgaagtact acacagttgc ctgtgacccc agaactcctc aggacagtcc catgtatcca
      481 gtggttccag ttcacttgga tgggatattt tagctccagt gccagcactt tgtaccttca
      541 ttcatcggct actgccaaga tcatagttgg gaagaaccga gtcctctgtt tgcactgcat
      601 gtcagcatct gtcctcatga aacctgttgc tgactccctt taatttagct gaacaaaaag
      661 tttctaatca ataaacactt ttgcacacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      721 aa
//
