LOCUS       NM_029145               1630 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ribonuclease, RNase A family, 10 (non-active)
            (Rnase10), transcript variant 1, mRNA.
ACCESSION   NM_029145 XM_127683
VERSION     NM_029145.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Jun,H.J., Ali,Z.A. and Charest,A.
  TITLE     Male sterility in ROS1 receptor tyrosine kinase conditionally
            deleted in epididymal epithelial
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (3), 119413 (2023)
   PUBMED   36535370
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Xu,B., Turner,S.D. and Hinton,B.T.
  TITLE     Alteration of transporter activities in the epididymides of
            infertile initial segment-specific Pten knockout mice
  JOURNAL   Biol Reprod 99 (3), 536-545 (2018)
   PUBMED   29590317
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Xu,B., Washington,A.M., Domeniconi,R.F., Ferreira Souza,A.C.,
            Lu,X., Sutherland,A. and Hinton,B.T.
  TITLE     Protein tyrosine kinase 7 is essential for tubular morphogenesis of
            the Wolffian duct
  JOURNAL   Dev Biol 412 (2), 219-233 (2016)
   PUBMED   26944093
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Xu,B., Washington,A.M. and Hinton,B.T.
  TITLE     PTEN signaling through RAF1 proto-oncogene serine/threonine kinase
            (RAF1)/ERK in the epididymis is essential for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 111 (52), 18643-18648 (2014)
   PUBMED   25512490
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Xu,B., Yang,L. and Hinton,B.T.
  TITLE     The Role of fibroblast growth factor receptor substrate 2 (FRS2) in
            the regulation of two activity levels of the components of the
            extracellular signal-regulated kinase (ERK) pathway in the mouse
            epididymis
  JOURNAL   Biol Reprod 89 (2), 48 (2013)
   PUBMED   23782834
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Krutskikh,A., Poliandri,A., Cabrera-Sharp,V., Dacheux,J.L.,
            Poutanen,M. and Huhtaniemi,I.
  TITLE     Epididymal protein Rnase10 is required for post-testicular sperm
            maturation and male fertility
  JOURNAL   FASEB J 26 (10), 4198-4209 (2012)
   PUBMED   22750516
  REMARK    GeneRIF: Epididymal protein Rnase10 is required for post-testicular
            sperm maturation and male fertility.
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Krutskikh,A., De Gendt,K., Sharp,V., Verhoeven,G., Poutanen,M. and
            Huhtaniemi,I.
  TITLE     Targeted inactivation of the androgen receptor gene in murine
            proximal epididymis causes epithelial hypotrophy and obstructive
            azoospermia
  JOURNAL   Endocrinology 152 (2), 689-696 (2011)
   PUBMED   21084446
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Castella,S., Fouchecourt,S., Teixeira-Gomes,A.P., Vinh,J.,
            Belghazi,M., Dacheux,F. and Dacheux,J.L.
  TITLE     Identification of a member of a new RNase a family specifically
            secreted by epididymal caput epithelium
  JOURNAL   Biol Reprod 70 (2), 319-328 (2004)
   PUBMED   14561640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136376.3.
            
            On Jul 2, 2009 this sequence version replaced NM_029145.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY226990.1, BC141116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC136376.3         69427-69570         c
            145-1630            AC136376.3         66741-68226         c
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.34 cM"
     gene            1..1630
                     /gene="Rnase10"
                     /gene_synonym="4930474F22Rik; Rah1"
                     /note="ribonuclease, RNase A family, 10 (non-active)"
                     /db_xref="GeneID:75019"
                     /db_xref="MGI:MGI:1922269"
     exon            1..144
                     /gene="Rnase10"
                     /gene_synonym="4930474F22Rik; Rah1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..776
                     /gene="Rnase10"
                     /gene_synonym="4930474F22Rik; Rah1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribonuclease A family, member 10; RNase 10;
                     ribonuclease-like protein 10; protein train A; inactive
                     ribonuclease-like protein 10; ribonuclease A h1"
                     /codon_start=1
                     /product="inactive ribonuclease-like protein 10 isoform 1"
                     /protein_id="NP_083421.2"
                     /db_xref="CCDS:CCDS27030.1"
                     /db_xref="GeneID:75019"
                     /db_xref="MGI:MGI:1922269"
                     /translation="MESSFWVQLTEKDALGEQNWGHRKSQDYLKLLTSVGKMKVTLVH
                     LLFMMLLLLLGLGLGLGLGLHMAAAVLEDQPLNEFWPSDSQNTEEGEGIWTTEGLALG
                     YKEMAQPVWPEEAVLSEDEVGGSRMLRAEPRFQSKQDYLKFDLSVRDCNTMMAHKIKE
                     PNQSCINQYTFIHEDPNTVKAVCNGSLVDCDLKGGKCYKSPRPFDLTLCKLAKPGQVT
                     PNCHYLTYITEKVIFMTCNDKKQLETK"
     exon            145..1630
                     /gene="Rnase10"
                     /gene_synonym="4930474F22Rik; Rah1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaaaagcc ctcagcacac aaggagatag ctacttgtat ggagagcagt ttctgggtac
       61 agctcacaga gaaggacgct ctaggagagc agaactgggg acataggaag agccaagact
      121 atctaaagct gcttacaagt gtaggcaaaa tgaaggtgac actggtgcat ctgttgttca
      181 tgatgttgct gctgttgcta ggcctagggc tggggctggg cctgggcctt cacatggcag
      241 ctgccgtcct ggaggatcag ccactgaatg aattttggcc cagtgactcc cagaatactg
      301 aagagggaga gggcatctgg accacagaag gtctggcact tggctacaaa gaaatggcac
      361 aacctgtctg gccagaagag gctgtcctca gtgaagatga agtgggggga agcaggatgc
      421 tgagggctga gccccgcttt cagagcaaac aagactacct taagtttgac ttgagtgtca
      481 gggactgtaa taccatgatg gcacacaaga taaaggagcc taatcagagc tgcataaacc
      541 agtacacgtt catccatgag gacccaaaca cagtcaaagc tgtctgtaac ggttccctgg
      601 ttgactgtga cctcaagggg ggcaaatgtt acaaaagtcc ccggcctttt gatctgacat
      661 tgtgcaaatt ggccaaacca ggccaagtca ctcccaactg tcactatctg acttacataa
      721 ccgaaaaggt cattttcatg acatgcaatg acaagaaaca actggagact aaatgaagca
      781 ccttgtgcct ttcccttctc ttcggcccgt tgcctctctt ctcttggatt tccattcact
      841 gatgcttctg tcccctcctt gggtttgcta actatagaga agatcctggg aggagagaat
      901 ggaccatctc tgatttttga cttctgaaaa tataattatt ctttgtattg gggtggggag
      961 gtgtcattca acttgcattt ttgttctggg ggtctgaaat ggcaaagaat aatgcttagt
     1021 ttctcctaga tatctctcac cttcaatccc tgtcctacaa aggccaaact ctagacccta
     1081 ccttagccat ggtcatcagc ttgatccctg gattgagtac accttgggtg tagactagaa
     1141 gagtttaatg cctcctttat ctacctcctt ccctgctact tacataggga ctctacatgc
     1201 tacctacttg tggtaatcac agacttctgg gccctataca atgcaacaca cttctctgct
     1261 gcagatgcaa ctaaagccat tcaatctagg actgtgtctg gaaagccacg tggctaggct
     1321 tcttttcctg agcctggaaa atcatagagc ctgctgtgag ttggtgtagg gcataggcct
     1381 gaagatcaaa catgcccttc tcccagcctt gagcagtcta aatagacctt aagtgtttgc
     1441 cacagttgga ccttaatgac ccaggtggag tcaatttcct acaggaatac tgctggctga
     1501 gcttgcttta caatataatc cagctgaaac aaaacaactc aatccagctg aaacaaagga
     1561 tgggtctgtt ggcttttcct atataaatgc agtgtgctgt gctgactatt aaactttgag
     1621 tcttgatcag
//
