LOCUS       NM_011271                970 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ribonuclease, RNase A family, 1 (pancreatic) (Rnase1),
            mRNA.
ACCESSION   NM_011271
VERSION     NM_011271.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Garnett,E.R., Lomax,J.E., Mohammed,B.M., Gailani,D., Sheehan,J.P.
            and Raines,R.T.
  TITLE     Phenotype of ribonuclease 1 deficiency in mice
  JOURNAL   RNA 25 (8), 921-934 (2019)
   PUBMED   31053653
  REMARK    GeneRIF: Findings suggest that one of the physiological functions
            of RNase 1 is to degrade extracellular RNA in blood plasma. Loss of
            this function facilitates FXII and FXI activation, which could have
            effects on inflammation and blood coagulation.
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Fischer,S., Nishio,M., Dadkhahi,S., Gansler,J., Saffarzadeh,M.,
            Shibamiyama,A., Kral,N., Baal,N., Koyama,T., Deindl,E. and
            Preissner,K.T.
  TITLE     Expression and localisation of vascular ribonucleases in
            endothelial cells
  JOURNAL   Thromb Haemost 105 (2), 345-355 (2011)
   PUBMED   21103661
  REMARK    GeneRIF: Vascular RNase1 and RNase5 are mainly produced by vascular
            endothelial cells and can serve, depending on the vascular bed,
            different functions in vascular homeostasis and endothelial cell
            responses.
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Schein,C.H., Boix,E., Haugg,M., Holliger,K.P., Hemmi,S., Frank,G.
            and Schwalbe,H.
  TITLE     Secretion of mammalian ribonucleases from Escherichia coli using
            the signal sequence of murine spleen ribonuclease
  JOURNAL   Biochem J 283 (Pt 1) (Pt 1), 137-144 (1992)
   PUBMED   1567361
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Nadeau,J.H., Compton,J.G., Giguere,V., Rossant,J. and Varmuza,S.
  TITLE     Close linkage of retinoic acid receptor genes with homeobox- and
            keratin-encoding genes on paralogous segments of mouse chromosomes
            11 and 15
  JOURNAL   Mamm Genome 3 (4), 202-208 (1992)
   PUBMED   1377062
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Gleditsch,L. and Bogen,B.
  TITLE     A Tcra congenic mouse: V alpha epitope expression is influenced by
            both Tcra haplotypes and background genes
  JOURNAL   Immunogenetics 35 (3), 153-160 (1992)
   PUBMED   1371498
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Lenstra,J.A. and Beintema,J.J.
  TITLE     The amino acid sequence of mouse pancreatic ribonuclease. Extremely
            rapid evolutionary rates of the myomorph rodent ribonucleases
  JOURNAL   Eur J Biochem 98 (2), 399-408 (1979)
   PUBMED   556267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163664.3.
            
            On Aug 21, 2018 this sequence version replaced NM_011271.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075775.1, AV049860.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC163664.3         84331-84382
            53-970              AC163664.3         85179-86096
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.4 cM"
     gene            1..970
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /note="ribonuclease, RNase A family, 1 (pancreatic)"
                     /db_xref="GeneID:19752"
                     /db_xref="MGI:MGI:97919"
     exon            1..52
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..970
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..526
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /EC_number="4.6.1.18"
                     /note="ribonuclease pancreatic; RNase 1; RNase A;
                     ribonuclease 1, pancreatic"
                     /codon_start=1
                     /product="ribonuclease pancreatic precursor"
                     /protein_id="NP_035401.2"
                     /db_xref="CCDS:CCDS27038.1"
                     /db_xref="GeneID:19752"
                     /db_xref="MGI:MGI:97919"
                     /translation="MGLEKSLILFPLFVLLLGWVQPSLGRESAAQKFQRQHMDPDGSS
                     INSPTYCNQMMKRRDMTNGSCKPVNTFVHEPLADVQAVCSQENVTCKNRKSNCYKSSS
                     ALHITDCHLKGNSKYPNCDYKTTQYQKHIIVACEGNPYVPVHFDATV"
     regulatory      773..778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /note="hexamer: AATAAA"
     polyA_site      795
                     /gene="Rnase1"
                     /gene_synonym="Rib-1; Rib1"
                     /note="major polyA site"
ORIGIN      
        1 gactgaagaa actgacttcc aattcgtctt ggagttcaaa ctaaaatttt aggcttttcc
       61 gagcagccaa gccaccatgg gtctggagaa gtccctcatt ctgtttccat tgtttgtcct
      121 gctgcttgga tgggtccagc cttccctggg cagggaatct gcagcacaga agtttcagcg
      181 gcagcacatg gatccagatg gttcctccat caacagcccc acctactgca accaaatgat
      241 gaaacgccgg gatatgacaa atgggtcatg caagcccgtg aacaccttcg tgcatgagcc
      301 cttggcagat gtccaggctg tctgctccca ggaaaatgtc acctgcaaga acaggaagag
      361 caactgctac aagagcagct ctgccctgca catcactgac tgccacctga agggcaactc
      421 caagtatccc aactgtgact acaagaccac tcaataccag aagcacatca ttgtggcctg
      481 tgaagggaac ccctacgtac cagtccactt tgatgctact gtgtagggct ccacataggc
      541 caaaccagtg agatgtctat gtctcccaac ctcatcacct gtctcccctc tgtctaccat
      601 tctttctctg aaagaagtaa gtcatgttag gacttccata tgacaaaaca tgcgttcctg
      661 tcctgtgtca tgctcccaga tccctctctt gctgtagaca aatgaagcaa gatggccctc
      721 accagaacat gtcccttcaa ccttagactt tcttgacttt agaaaacaac caaataaaat
      781 tctgttcatc ataaattgtg catttagggc agttcgaagt ggagtaagga caatgggcaa
      841 gtcacctcat tcattggtcc agaatttcct cactcctgac tactttaact acactattga
      901 aactagactt ttctgcctct ctgctgatca ttcattcttc gcatatacaa taaagtctaa
      961 catctatttc
//
