LOCUS       NM_025346               1946 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus required for meiotic nuclear division 5 homolog B
            (Rmnd5b), mRNA.
ACCESSION   NM_025346
VERSION     NM_025346.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK075599.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075599.1, BC016075.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.15 cM"
     gene            1..1946
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /note="required for meiotic nuclear division 5 homolog B"
                     /db_xref="GeneID:66089"
                     /db_xref="MGI:MGI:1913339"
     exon            1..307
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..493
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1536
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /EC_number="2.3.2.27"
                     /note="protein RMD5 homolog B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein transferase RMND5B"
                     /protein_id="NP_079622.1"
                     /db_xref="CCDS:CCDS24656.1"
                     /db_xref="GeneID:66089"
                     /db_xref="MGI:MGI:1913339"
                     /translation="MEQCACVERELDKVLHKFLTYGQHCEQSLEELLHSVGQLRAELA
                     SAALQGTPLSATLSLVMSQCCRKIRDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEIC
                     GVVSDAVWDSREKQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELN
                     RILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPEKQLEALSY
                     ARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDNSHWAEICETFTRDACSLL
                     GLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWSHKDELPIEIELGMKCWYHS
                     VFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRII
                     F"
     exon            494..639
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..780
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..881
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1048
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1214
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1317
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1472
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1946
                     /gene="Rmnd5b"
                     /gene_synonym="0610039K22Rik; Gid2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgattca ttcggcattc cttgcaaagc cgcgggcgag acacactgtc tccccacgct
       61 ccgcgacacc acgcatgggc gagcccggac ccacccgaga ggcaaccgcc gcgccttccg
      121 gttccgatga cagcggcgcc ggaagcgggc tgagctgcaa gactaggtga cagcctgccg
      181 gctcccggtc ccggggtgcg gggcgccccg accaaagcct ggagcagtcg tcggccacac
      241 cctccaaggg ctggtggagt cgcccggact ccgacgtccc gtcctagtgc acctgactga
      301 gtcagaggat ccacactggc ctgacccagt tgacatcacc aggcagaggc cgccatggag
      361 cagtgtgcct gtgtggagag ggagctggac aaggtcctgc acaagttcct aacctacggg
      421 cagcattgcg agcagagtct ggaggagctg ctgcactccg tgggccagct gagagccgag
      481 ctggccagtg cagctctcca gggcacccct ctctcagcca cgctgtccct tgtgatgtcc
      541 cagtgctgtc ggaagatcag agacacagtc cagaaactgg cttccgacca taaggacatt
      601 cacagcagcg tctctcgagt gggcaaagcc attgacagga acttcgactc tgagatctgc
      661 ggcgtggtct cggatgctgt gtgggactcc cgtgagaagc agcagcagat cctgcagatg
      721 gccatcgtag agcacctgta ccagcaaggc atgctcagtg tagcggagga gctgtgccag
      781 gaatcgacat tgaatgtgga cctggacttc aagcagccct tcttggagtt gaatcggatc
      841 ttggaagctc tgcacgagca agacctagga cctgcgctgg aatgggctgt atctcacagg
      901 cagcgcctgc tggagctcaa cagctcgctg gagttcaagc tgcaccggct gcactttatc
      961 cgcctcctag ctgggggccc cgagaagcag ctggaggccc tcagctatgc tcggcacttc
     1021 cagccttttg ctaggctaca ccagagagag atccaggtga tgatgggcag tctggtgtac
     1081 ctgcggctgg gcttggagaa gtcaccctac tgccacctct tagacaacag ccactgggcg
     1141 gagatctgtg agacctttac tcgggatgca tgctccctcc tgggactttc agtggagtcc
     1201 ccacttagtg tcagcttcgc gtctggctgt gtggcgctgc ccgtgctgat gaacattaaa
     1261 gctgtgatcg aacagaggca gtgcactggg gtgtggagtc acaaggatga gttgccgatt
     1321 gagatagagc tgggcatgaa gtgctggtac cactcagtgt ttgcatgccc tatcctgcga
     1381 cagcagacct cagattccaa cccccccatc aagctcatct gtggccacgt catctccaga
     1441 gatgcactca acaaactcat caatggagga aagctaaagt gtccctactg tcccatggaa
     1501 cagaatccag cagatgggaa acgcatcata ttctgattcc aaggaacatt ctagaaggtg
     1561 taatccaccc atgggccttt gtggagggac tggcttcagc agactgtgat gcctctcaga
     1621 ccagcattac caagagaccc aacctgccta ggcagaggcc agggaaggct gtgaaccagc
     1681 agcctatgct tccttacctt ctagggggac tggctactct gttcctgcat tctgtttaca
     1741 cttgcccctg acggagcagc aaaggtcttg gtcatcaaat gcagacatct ttctactcct
     1801 ggcatcaaag gggtttccag ctgtggccca cttcctactg tacagtctca actgtatcta
     1861 cccattcatt ctccactgta aataacccgt tagaactgaa tgctgtttta taactttgag
     1921 caaatatatt catagccctt ctcctt
//
