LOCUS       NM_001168248            3637 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus RecQ mediated genome instability 1 (Rmi1), transcript
            variant 1, mRNA.
ACCESSION   NM_001168248
VERSION     NM_001168248.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3637)
  AUTHORS   Guiraldelli,M.F., Eyster,C. and Pezza,R.J.
  TITLE     Genome instability and embryonic developmental defects in RMI1
            deficient mice
  JOURNAL   DNA Repair (Amst) 12 (10), 835-843 (2013)
   PUBMED   23900276
  REMARK    GeneRIF: results demonstrate the importance of RMI1 in maintaining
            genome integrity and normal embryonic development
REFERENCE   2  (bases 1 to 3637)
  AUTHORS   Xue,X., Raynard,S., Busygina,V., Singh,A.K. and Sung,P.
  TITLE     Role of replication protein A in double holliday junction
            dissolution mediated by the BLM-Topo IIIalpha-RMI1-RMI2 protein
            complex
  JOURNAL   J Biol Chem 288 (20), 14221-14227 (2013)
   PUBMED   23543748
REFERENCE   3  (bases 1 to 3637)
  AUTHORS   Suwa,A., Yoshino,M., Kurama,T., Shimokawa,T. and Aramori,I.
  TITLE     Glucose regulates RMI1 expression through the E2F pathways in
            adipose cells
  JOURNAL   Endocrine 40 (1), 56-61 (2011)
   PUBMED   21432623
  REMARK    GeneRIF: Glucose regulates RMI1 expression through the E2F pathways
            in adipose cells.
REFERENCE   4  (bases 1 to 3637)
  AUTHORS   Chen,H., You,M.J., Jiang,Y., Wang,W. and Li,L.
  TITLE     RMI1 attenuates tumor development and is essential for early
            embryonic survival
  JOURNAL   Mol Carcinog 50 (2), 80-88 (2011)
   PUBMED   21229605
  REMARK    GeneRIF: These results demonstrated a dual-role of RMI1 in
            embryonic development and tumor suppression.
REFERENCE   5  (bases 1 to 3637)
  AUTHORS   Suwa,A., Yoshino,M., Yamazaki,C., Naitou,M., Fujikawa,R.,
            Matsumoto,S., Kurama,T., Shimokawa,T. and Aramori,I.
  TITLE     RMI1 deficiency in mice protects from diet and genetic-induced
            obesity
  JOURNAL   FEBS J 277 (3), 677-686 (2010)
   PUBMED   20050919
  REMARK    GeneRIF: results suggest that the regulation of energy balance by
            RMI1 is attributable to the regulation of food intake and E2F8
            expression in adipose tissue.
REFERENCE   6  (bases 1 to 3637)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154437.2.
            
            On Jan 26, 2022 this sequence version replaced NM_001168248.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR10662772.506465.1, SRR11927937.5699866.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC154437.2         143779-144002
            225-309             AC154437.2         145784-145868
            310-398             AC154437.2         148215-148303
            399-3637            AC154437.2         149123-152361
FEATURES             Location/Qualifiers
     source          1..3637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.05 cM"
     gene            1..3637
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="RecQ mediated genome instability 1"
                     /db_xref="GeneID:74386"
                     /db_xref="MGI:MGI:1921636"
     exon            1..224
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..309
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..398
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            399..3637
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2278
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="RMI1, RecQ mediated genome instability 1, homolog"
                     /codon_start=1
                     /product="recQ-mediated genome instability protein 1"
                     /protein_id="NP_001161720.1"
                     /db_xref="CCDS:CCDS26571.1"
                     /db_xref="GeneID:74386"
                     /db_xref="MGI:MGI:1921636"
                     /translation="MSVASAVLRVETWLLATWHVKVPPMWLEACVNWIQEENNNATLS
                     QAQINKQVLEQWLLTDLRDLEHPLLPDDILELPKGELNGFYALQINSLVDVSQPAYSQ
                     IQKLRGKNTTNDLVSAETQSTPKPWEVRPSRMLMLQLTDGVTHIQGMEYQSIPALHSG
                     LPPGTKILVRGCILFRLGVLLLKPENVKVLGGEVDGLSEENAQEKVLARLIGELDPTV
                     PVIPNNSIHNVPKVSGGLDAVLGPSDEELLASLDESEESAANNDVAMERSCFSTGTSS
                     NTTPTNPSGFEPGCNISSRPKEKPPNQPTHFTDGEFDDFSLEEALLLEETVQKEQMET
                     KASQPLTLKENTGKCMEIFSHKPSSLNHTALIHKQGNSNFDEKTSEQMIHEDKFFDCA
                     STRNHHKRFSAHDFTNDSKISEVDDAAQQTLSSSNVHCLRNKILNRKLDLSEKSSQIS
                     KENGHPFQACSSRSFENNTYLSIGMDLHSPPFIYLSVLMARKPKEVTTVTVKAFIVTL
                     TGNLSSSGGFWGVTAKVSDGTAYLDVDFIDEILTSMIGYSVPEMKQLRKDPLKYKTFL
                     EGLQKCQRDLIDLCCLMTISYDPSSCKGVVLELQDVGMEHVENLKKRLNK"
     regulatory      2548..2553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="hexamer: AATAAA"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="major polyA site"
     polyA_site      2585
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="major polyA site"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3637
                     /gene="Rmi1"
                     /gene_synonym="4932432N11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcacg tgtgccggga ggggcgactg cggggggatt ttcgagcccc gagggagttt
       61 ggcgcgattg gaggagggac ggtcgccccg tgagcgcccg attgggcggg aagaagtgaa
      121 agagggaaaa gagaacccag ctgggaacgg gagagggaga gcggcgcgcg gccctgggat
      181 cacgctgcgg tgcgaggcga ggcgaggcga ggcgggaagg ccagctggga agcagagatg
      241 tgaatctgtg agttctaggt cagccagagc tacatagtca aactgtctca agaaacaaac
      301 aaaactaagg gtcatttctc tgcagaggag gctctgagta ctgtactgac catctagctt
      361 gaaatccctc gttagctcac aggctggcct gctaagtggt agatgtggat cctcttactt
      421 aaaagaaatg agtgtagcta gtgctgtatt aagagttgaa acctggcttt tggcaacatg
      481 gcatgttaag gtacctccaa tgtggctgga agcttgtgtt aactggatcc aagaagaaaa
      541 taataatgct actttgagtc aggcacaaat aaataaacaa gtgttggagc aatggcttct
      601 tactgacctg agagacttgg aacatcctct cttacctgat gacattttag aactgccaaa
      661 gggagaactg aatgggtttt atgctctaca gatcaattct ttggttgatg tgagtcagcc
      721 tgcttattca cagatacaga agctgagagg aaagaataca accaatgatc tcgtctcagc
      781 tgaaacgcag agtactccaa aaccatggga agtgaggcct tctcggatgc tgatgctaca
      841 gctcactgat ggtgtcacac acattcaggg aatggagtat cagtctatcc cagctctcca
      901 tagtggtctt cctccaggta caaaaatttt agttcgtgga tgcattttgt tccgtcttgg
      961 tgttctctta ctgaaaccag aaaatgtgaa ggtgctaggg ggtgaggtag atggtctttc
     1021 agaagaaaat gcccaagaaa aagtacttgc aagattaatt ggggaacttg atcctacagt
     1081 tccagtcatt ccaaataatt ccattcacaa cgtgcccaaa gtttcagggg gcttagatgc
     1141 tgttttgggg ccctcggatg aagaactctt ggcaagtctt gatgaaagtg aagagtctgc
     1201 agcaaataat gacgtggcta tggaaagaag ctgtttcagc acaggcactt cctcaaatac
     1261 tactccgaca aatccgtctg gttttgagcc aggatgtaac atttcttcaa ggccaaagga
     1321 gaaaccacca aaccagccca cgcatttcac tgatggagaa tttgatgact tttcactgga
     1381 agaggccttg cttttggaag agactgtcca gaaagaacag atggaaacaa aagcatcgca
     1441 gccactaact ttgaaggaaa acactggtaa atgtatggag attttttcac ataaacctag
     1501 tagtctgaac cacacagctt tgattcataa acaaggaaac agcaattttg atgaaaaaac
     1561 atctgaacaa atgattcatg aagacaaatt ttttgattgt gcatctacta gaaaccatca
     1621 taagagattc tcagctcatg attttacaaa tgacagtaag atttcagaag tagatgatgc
     1681 agcacaacag accctcagca gttcaaatgt acattgctta cgtaataaaa tattaaacag
     1741 aaagctggac ctatcagaaa agagttcaca aatttctaaa gaaaatggcc accctttcca
     1801 ggcttgttct tcaagatcat ttgagaataa tacttatcta tctattggca tggacttaca
     1861 ttctccaccc tttatctatt tgtctgttct aatggccaga aagccaaagg aagttactac
     1921 tgtgacagtc aaagcgttta ttgtcacttt aactggaaat ctctcaagtt ctggtggctt
     1981 ttggggtgta actgcaaaag tttctgatgg tactgcatat ctagatgtag attttataga
     2041 cgaaatactt accagtatga tagggtattc agtaccagaa atgaaacaat taagaaagga
     2101 ccctcttaaa tataaaacat tcctagaagg gttacagaaa tgtcagcgag atctgatcga
     2161 tttgtgttgc ctgatgacta tttcatacga tccttcttca tgtaaagggg tggtgctgga
     2221 attgcaagat gttggtatgg aacacgtgga gaacctaaag aaacggttga ataaataatt
     2281 tgccagaatg ctattggagc acactttaaa acaggcaaat atttggaatc aaatttgtgt
     2341 attctcagtt ttggaattct gtaagaaaaa gcttcagagc ttaaagctgg ggcagctccg
     2401 cggttgacag acacagtgtc tgccaagtgt ggtaactgga gtttaaccat ctggtctctc
     2461 gaggcaaaag gcgagaccct gcttccagaa tccgttggta gtcctctaca caggtggcag
     2521 aggacacaca cacacacaca cgtactaaat aaatgacatt taaaaataaa gatatttaat
     2581 caaaatatgt gaaagaatgt ttatattttg gtgatactgg cccagagtct tgtaatgcta
     2641 gcaagtttct accatagtta catctctaga tccttgggat gtttgtttgt tttgtttatt
     2701 tttttgtttt ccctccctgg aaactggatc tcatacacag gctgtcctca aactctcttg
     2761 tatagctgag agtgacctcg agtttctggt ctcttgcctt caccacccaa gtgctagatt
     2821 tagggttgta catttttacc tgtgcgtgct aggcaaatgc tctaccaact gagccatatc
     2881 cccagtcctt gttgaagggt ttagctgacc cactctggct gagaaacttg ttttccactt
     2941 gtcattggat aaacctaaaa ttgataaaga atagtgatgg actgacagca gtttgttggg
     3001 taaaggtgct tgctgctgag cctgacaacc tgatgctatt cctggtacca catgctggaa
     3061 agcgaaaact ctcccacaag atggcctctg atttccacct gcatgccaaa acgtgtgtgc
     3121 tccctcccat acataaaggt acacacaatg aaataaaatt taataaagag ttgatgttcc
     3181 ccagtgagat attactgaaa gttaggaatt gaaaattagt aattttacct ctaataagtt
     3241 gaatattaaa aaaaattgta ctgtgattta gatatcttcc atttactgtg tgtataggtc
     3301 agagggcagc ctgggacact tggctttctc ctgctgtgtg gattcatggg gtaaaatcct
     3361 caggctctgc acgcaccttg tacctgctga gctgtgagga tggctctggc ttttgagata
     3421 gtatcctgat acgtttccag gatcctgcga attggctttg catatgagtt atttgtgtta
     3481 ttgttttaaa gagactagac tatttccttt tgctgtacta gattatgttt gggagatgta
     3541 cttttaaaat tgtaaaagtg tgtgtgtgtg tagagattga tgaatggaat gaacctctga
     3601 acctgtaagc catccccaat taaatgtcct tagaaga
//
