LOCUS       NM_001033136            2252 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus regulator of microtubule dynamics 3 (Rmdn3), mRNA.
ACCESSION   NM_001033136 XM_203936 XM_892408 XM_900092 XM_917536 XM_924989
            XM_924991
VERSION     NM_001033136.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Fecher,C., Trovo,L., Muller,S.A., Snaidero,N., Wettmarshausen,J.,
            Heink,S., Ortiz,O., Wagner,I., Kuhn,R., Hartmann,J., Karl,R.M.,
            Konnerth,A., Korn,T., Wurst,W., Merkler,D., Lichtenthaler,S.F.,
            Perocchi,F. and Misgeld,T.
  TITLE     Cell-type-specific profiling of brain mitochondria reveals
            functional and molecular diversity
  JOURNAL   Nat Neurosci 22 (10), 1731-1742 (2019)
   PUBMED   31501572
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Qiao,X., Jia,S., Ye,J., Fang,X., Zhang,C., Cao,Y., Xu,C., Zhao,L.,
            Zhu,Y., Wang,L. and Zheng,M.
  TITLE     PTPIP51 regulates mouse cardiac ischemia/reperfusion through
            mediating the mitochondria-SR junction
  JOURNAL   Sci Rep 7, 45379 (2017)
   PUBMED   28345618
  REMARK    GeneRIF: PTPIP51 as a therapeutic target for ischemic heart
            diseases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Brobeil,A., Viard,M., Petri,M.K., Steger,K., Tag,C. and Wimmer,M.
  TITLE     Memory and PTPIP51--a new protein in hippocampus and cerebellum
  JOURNAL   Mol Cell Neurosci 64, 61-73 (2015)
   PUBMED   25496818
  REMARK    GeneRIF: Protein interaction profile of PTPIP51 suggests a role in
            the memory formation in the hippocampus and cerebellum.
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Bobrich,M.A., Schwabe,S.A., Brobeil,A., Viard,M., Kamm,M.,
            Mooren,F.C., Kruger,K., Tag,C. and Wimmer,M.
  TITLE     PTPIP51: a new interaction partner of the insulin receptor and PKA
            in adipose tissue
  JOURNAL   J Obes 2013, 476240 (2013)
   PUBMED   23533724
  REMARK    GeneRIF: PTPIP51(protein tyrosine phosphatase interacting protein
            51) might serve as a linking protein in adipocyte metabolism by
            connecting the insulin receptor-triggered lipogenesis with the
            protein kinase A-dependent lipolysis.
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Bobrich,M., Brobeil,A., Mooren,F.C., Kruger,K., Steger,K., Tag,C.
            and Wimmer,M.
  TITLE     PTPIP51 interaction with PTP1B and 14-3-3beta in adipose tissue of
            insulin-resistant mice
  JOURNAL   Int J Obes (Lond) 35 (11), 1385-1394 (2011)
   PUBMED   21266951
  REMARK    GeneRIF: The interaction of PTPIP51 with 14-3-3beta, especially in
            trained individuals, hints to an involvement of PTPIP51 in the
            downstream regulation of insulin action.
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Koch,P., Viard,M., Stenzinger,A., Brobeil,A., Tag,C., Steger,K. and
            Wimmer,M.
  TITLE     Expression profile of PTPIP51 in mouse brain
  JOURNAL   J Comp Neurol 517 (6), 892-905 (2009)
   PUBMED   19844996
  REMARK    GeneRIF: The data presented here suggest a role of PTPIP51 in
            neuronal homeostasis, axonal growth, and transport.
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~79%.
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Maerker,D., Stenzinger,A., Schreiner,D., Tag,C. and Wimmer,M.
  TITLE     Expression of PTPIP51 during mouse eye development
  JOURNAL   Histochem Cell Biol 129 (3), 345-356 (2008)
   PUBMED   18084773
  REMARK    GeneRIF: The PTPIP51 was integrated in signaling cascades
            regulating differentiation and apoptosis during eye development.
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   Oishi,K., Okano,H. and Sawa,H.
  TITLE     RMD-1, a novel microtubule-associated protein, functions in
            chromosome segregation in Caenorhabditis elegans
  JOURNAL   J Cell Biol 179 (6), 1149-1162 (2007)
   PUBMED   18070910
  REMARK    Erratum:[J Cell Biol. 2009 Aug 24;186(4):629]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772264.8, AK151090.1 and BY453591.1.
            
            On May 6, 2010 this sequence version replaced NM_001033136.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171770.1, BR000695.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 19372376
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL772264.8         55157-55237
            82-2249             AK151090.1         3-2170
            2250-2252           BY453591.1         435-437
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.94 cM"
     gene            1..2252
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /note="regulator of microtubule dynamics 3"
                     /db_xref="GeneID:67809"
                     /db_xref="MGI:MGI:1915059"
     exon            1..128
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      111..143
                     /regulatory_class="uORF"
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:19372376)"
     exon            129..322
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1548
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /note="tyrosine phosphatase interacting protein 51;
                     microtubule-associated protein; family with sequence
                     similarity 82, member A2; protein tyrosine
                     phosphatase-interacting protein 51"
                     /codon_start=1
                     /product="regulator of microtubule dynamics protein 3"
                     /protein_id="NP_001028308.1"
                     /db_xref="CCDS:CCDS16591.1"
                     /db_xref="GeneID:67809"
                     /db_xref="MGI:MGI:1915059"
                     /translation="MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRS
                     HSLPNSLDYAQASERGRQVTQFRAIPGEAGDAAILPSLSQEGQEKVLDRLDFVLTSLM
                     ALRREVEELQRSLQGLAGEIVGEVRSHIEENQRVARRRRFPFARERSDSTGSSSVYFT
                     ASSGAALTDAESEGGYTTANAESDYERDSDKESGDAEDEVSCETVRMGRKDSLDLDVE
                     AASSPAAAALEEDDSSGREDVQLVLLQADELHQGSKQDKREGFQLLLNNKLAYGSRQD
                     FLWRLARAYSDMSDLTEEESGKKSYALNGKEEAEAALKKGDESAACHLWYAVLCGQLA
                     EHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLNWLEKKTATALF
                     ESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWMKLAQELPD
                     VTNEDSAFQKDLEELEVILG"
     exon            323..515
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..659
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..945
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1048
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1109
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1185
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1263
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1362
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1416
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1497
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..2252
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /note="hexamer: ACTAAA"
     polyA_site      2250
                     /gene="Rmdn3"
                     /gene_synonym="1200015F23Rik; Fam82a2; Ptpip51; RMD-3;
                     Rmd3"
                     /note="major polyA site"
ORIGIN      
        1 agagcctcgt gcgtcatctc cacgcgcgtc tcaccgtgcg cggagcaggt ggcgcggatt
       61 aaggacgtca aaatcattga cagagtgaaa gcgcggtgcc tgctgctgcc atggtggctg
      121 gtggctgggt acactatgtc tagactgggg gccctgggcg gctcccgcgc cgggttggga
      181 ctgttacttg gtactgccgc cggccttgga ttcctgtgcg tcctttacag ccagcgatgg
      241 aaacggaccc agcgccatgg ccggagtcac agtctgccca actccctgga ctatgcgcag
      301 gcttcagagc gtggacgcca ggtgacacag tttcgggcta tcccaggtga agctggagat
      361 gctgccatac tgcccagcct ctcacaggaa gggcaggaga aggtgctgga ccgcctggac
      421 tttgtgctga ccagtcttat ggcgctgcgg cgcgaggtgg aggagcttca gagaagcctg
      481 caaggactag ctggggagat tgttggggag gtccgctctc atatagaaga gaaccagaga
      541 gtggcccggc ggcgcaggtt cccttttgcc agagagagga gtgactccac gggctccagc
      601 tctgtctact tcaccgcctc ctcaggggct gcactcacag acgccgagag cgagggaggt
      661 tatacaacag ccaacgcgga gtctgattac gagcgggact ccgacaagga gagtggagat
      721 gctgaggacg aagtgagctg cgagaccgtg aggatgggga ggaaggactc tctggacctg
      781 gatgtggagg cggcgtccag tccggcggcg gccgccttgg aggaggatga ctcctcaggc
      841 cgagaggatg tgcagctggt cctgctgcag gccgatgagc tgcaccaggg cagcaagcag
      901 gacaagcggg aaggcttcca gctgctgctc aacaataagc tggcgtatgg aagccgacaa
      961 gactttctgt ggcgcctggc ccgggcctac agtgacatgt cagaccttac tgaggaggag
     1021 agcgggaaga agtcctatgc cctaaatgga aaagaagaag cagaggctgc tctgaagaaa
     1081 ggagatgaga gtgctgcgtg ccacctgtgg tatgcagtgc tctgtggtca gctggctgag
     1141 catgagggca tctcgaaacg catccagagt ggctttagct tcaaggaaca tgtggacaaa
     1201 gccattgaac ttcagccaga agaccccagg ggtcactttc ttcttggcag gtggtgctac
     1261 caggtttctc acttgaactg gttggaaaaa aaaacggcta ccgccttgtt tgaaagcccc
     1321 cttagtgcta ctgtgcagga cgctctgcag agtttcctta aggctgagga actacagcca
     1381 ggattttcaa aagctggacg ggtatatatt tctaagtgct atagagaatt aggaaaaaac
     1441 tctgaagcta gaaagtggat gaagctggct caggaactgc cagacgtcac taatgaggat
     1501 tcagctttcc aaaaagacct ggaagaacta gaagtaattt taggataata atcacacttc
     1561 aatgacgtgg gggctactcc ttaaatgtgg aaaagaaatc aagttgcttt tttcctctgt
     1621 gactccccca tggagttcag gaagccaagc aaggtgtcct ggcccctgga gatctgactg
     1681 ctaacaccac catccctcag ctttttatgt tatcagttaa tttattctaa tctcctacct
     1741 taatttaaat tgggggaatt taaattactt gcagctaagg tttctgcttt cttcctctta
     1801 agtgaattct tgaaaaatca agacagtata gccatagggt ttagtgtgga cccagcccag
     1861 aaggccaaga gctgagaatg aagtagcaga actgtcttcc agctgccagt gaggtggatg
     1921 gacttcagag ccacacaaca gagcatagga cttgtaatct tttttgctaa tattcaacat
     1981 gtatttattg tcctttaatg tcacacccta cctacgagga caaaaggagc cagcacagcc
     2041 caggtactgc cctcctacca cccatcatgt atataatacg ctccctgtat tcctgggtga
     2101 gggctggacc atggactgga gacctggcag cttttgggat gacaacgctg gcaaagggtc
     2161 tatgaatcta ttttgaaagt gacttatctg gagaggtgcc tggagtattt ttggtacaaa
     2221 tctgaaataa actaaagttg attacaagga ta
//
