LOCUS       NM_173184                475 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus relaxin 3 (Rln3), mRNA.
ACCESSION   NM_173184
VERSION     NM_173184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Wang,Q., Sun,R.Y., Hu,J.X., Sun,Y.H., Li,C.Y., Huang,H., Wang,H.
            and Li,X.M.
  TITLE     Hypothalamic-hindbrain circuit for consumption-induced fear
            regulation
  JOURNAL   Nat Commun 15 (1), 7728 (2024)
   PUBMED   39231981
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 475)
  AUTHORS   Nasirova,N., Quina,L.A., Morton,G., Walker,A. and Turner,E.E.
  TITLE     Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3
            System of the Nucleus Incertus
  JOURNAL   eNeuro 7 (6) (2020)
   PUBMED   33055197
  REMARK    GeneRIF: Mapping Cell Types and Efferent Pathways in the Ascending
            Relaxin-3 System of the Nucleus Incertus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 475)
  AUTHORS   Haidar,M., Guevremont,G., Zhang,C., Bathgate,R.A.D., Timofeeva,E.,
            Smith,C.M. and Gundlach,A.L.
  TITLE     Relaxin-3 inputs target hippocampal interneurons and deletion of
            hilar relaxin-3 receptors in 'floxed-RXFP3' mice impairs spatial
            memory
  JOURNAL   Hippocampus 27 (5), 529-546 (2017)
   PUBMED   28100033
  REMARK    GeneRIF: Results indicate endogenous RLN3/RXFP3 signaling can
            modulate hippocampal-dependent spatial reference and working memory
            via effects on somatostatin interneurons, and further our knowledge
            of hippocampal cognitive processing
REFERENCE   5  (bases 1 to 475)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 475)
  AUTHORS   Ricci,G., Catizone,A. and Galdieri,M.
  TITLE     Expression and functional role of hepatocyte growth factor and its
            receptor (c-met) during fetal mouse testis development
  JOURNAL   J Endocrinol 191 (3), 559-570 (2006)
   PUBMED   17170214
REFERENCE   7  (bases 1 to 475)
  AUTHORS   Bathgate,R.A., Lin,F., Hanson,N.F., Otvos,L. Jr., Guidolin,A.,
            Giannakis,C., Bastiras,S., Layfield,S.L., Ferraro,T., Ma,S.,
            Zhao,C., Gundlach,A.L., Samuel,C.S., Tregear,G.W. and Wade,J.D.
  TITLE     Relaxin-3: improved synthesis strategy and demonstration of its
            high-affinity interaction with the relaxin receptor LGR7 both in
            vitro and in vivo
  JOURNAL   Biochemistry 45 (3), 1043-1053 (2006)
   PUBMED   16411781
REFERENCE   8  (bases 1 to 475)
  AUTHORS   Kizawa,H., Nishi,K., Ishibashi,Y., Harada,M., Asano,T., Ito,Y.,
            Suzuki,N., Hinuma,S., Fujisawa,Y., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Production of recombinant human relaxin 3 in AtT20 cells
  JOURNAL   Regul Pept 113 (1-3), 79-84 (2003)
   PUBMED   12686464
REFERENCE   9  (bases 1 to 475)
  AUTHORS   Burazin,T.C., Bathgate,R.A., Macris,M., Layfield,S., Gundlach,A.L.
            and Tregear,G.W.
  TITLE     Restricted, but abundant, expression of the novel rat gene-3 (R3)
            relaxin in the dorsal tegmental region of brain
  JOURNAL   J Neurochem 82 (6), 1553-1557 (2002)
   PUBMED   12354304
REFERENCE   10 (bases 1 to 475)
  AUTHORS   Bathgate,R.A., Samuel,C.S., Burazin,T.C., Layfield,S., Claasz,A.A.,
            Reytomas,I.G., Dawson,N.F., Zhao,C., Bond,C., Summers,R.J.,
            Parry,L.J., Wade,J.D. and Tregear,G.W.
  TITLE     Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3)
            gene. Novel members of the relaxin peptide family
  JOURNAL   J Biol Chem 277 (2), 1148-1157 (2002)
   PUBMED   11689565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB076565.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076565.1, CB058792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.26 cM"
     gene            1..475
                     /gene="Rln3"
                     /gene_synonym="insl7; M3"
                     /note="relaxin 3"
                     /db_xref="GeneID:212108"
                     /db_xref="MGI:MGI:2158015"
     exon            1..210
                     /gene="Rln3"
                     /gene_synonym="insl7; M3"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..449
                     /gene="Rln3"
                     /gene_synonym="insl7; M3"
                     /note="insulin-like 7; prorelaxin M3; insulin-like peptide
                     7; insulin-like peptide INSL7"
                     /codon_start=1
                     /product="relaxin-3 precursor"
                     /protein_id="NP_775276.1"
                     /db_xref="CCDS:CCDS22466.1"
                     /db_xref="GeneID:212108"
                     /db_xref="MGI:MGI:2158015"
                     /translation="MAMLGLLLLASWALLGALGLQAEARPAPYGVKLCGREFIRAVIF
                     TCGGSRWRRADILAHESLGDFFADGEANTDHLASELDEAVGSSEWLALTKSPQAFYGG
                     RASWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC"
     exon            211..475
                     /gene="Rln3"
                     /gene_synonym="insl7; M3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgcaggc atctcagctg atcatggcaa tgctcgggct gctgctgctg gcttcctggg
       61 ctctcctcgg ggctctgggg ctgcaggccg aggcgaggcc ggcgccctac ggggtgaagc
      121 tctgcggtcg ggagttcatc cgcgcggtca tcttcacttg cggaggctca cgatggcgcc
      181 gggcggacat cttggcccac gaatctctgg gggacttctt cgctgatgga gaagccaata
      241 cagaccacct ggccagcgag ctggatgaag cggtgggctc cagcgagtgg ctggccctaa
      301 ccaaatcccc ccaggctttc tacggtggtc gagccagctg gcaagggtca cctggagtgg
      361 ttcggggcag cagagatgtg ttggctggcc tttccagcag ttgctgcgag tggggctgta
      421 gcaagagcca aattagcagc ttgtgctagg atcagggttg agcaatggag aagcg
//
