LOCUS       NM_011272                697 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus relaxin 1 (Rln1), mRNA.
ACCESSION   NM_011272 XM_129225
VERSION     NM_011272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 697)
  AUTHORS   Wingert,J., Meinhardt,E., Sasipong,N., Pott,M., Lederer,C., de la
            Torre,C., Sticht,C., Most,P., Katus,H.A., Frey,N., Raake,P.W.J. and
            Schlegel,P.
  TITLE     Cardiomyocyte-specific RXFP1 overexpression protects against
            pressure overload-induced cardiac dysfunction independently of
            relaxin
  JOURNAL   Biochem Pharmacol 225, 116305 (2024)
   PUBMED   38768763
REFERENCE   2  (bases 1 to 697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 697)
  AUTHORS   Feiteng,C., Lei,C., Deng,L., Chaoliang,X., Zijie,X., Yi,S. and
            Minglei,S.
  TITLE     Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal
            transition via the Wnt/beta-catenin signaling pathway
  JOURNAL   Ren Fail 44 (1), 513-524 (2022)
   PUBMED   35311469
  REMARK    GeneRIF: Relaxin inhibits renal fibrosis and the
            epithelial-to-mesenchymal transition via the Wnt/beta-catenin
            signaling pathway.
REFERENCE   4  (bases 1 to 697)
  AUTHORS   Hu,M., Wang,Y., Liu,Z., Yu,Z., Guan,K., Liu,M., Wang,M., Tan,J. and
            Huang,L.
  TITLE     Hepatic macrophages act as a central hub for relaxin-mediated
            alleviation of liver fibrosis
  JOURNAL   Nat Nanotechnol 16 (4), 466-477 (2021)
   PUBMED   33495618
  REMARK    GeneRIF: Hepatic macrophages act as a central hub for
            relaxin-mediated alleviation of liver fibrosis.
REFERENCE   5  (bases 1 to 697)
  AUTHORS   Bai,M., Han,Y., Wu,Y., Liao,J., Li,L., Wang,L., Li,Q., Xing,W.,
            Chen,L., Zou,W. and Li,J.
  TITLE     Targeted genetic screening in mice through haploid embryonic stem
            cells identifies critical genes in bone development
  JOURNAL   PLoS Biol 17 (7), e3000350 (2019)
   PUBMED   31265461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 697)
  AUTHORS   Gough,N.M., Rakar,S., Harpur,A. and Wilks,A.F.
  TITLE     Localization of genes for two members of the JAK family of protein
            tyrosine kinases to murine chromosomes 4 and 19
  JOURNAL   Mamm Genome 6 (4), 247-248 (1995)
   PUBMED   7613027
REFERENCE   7  (bases 1 to 697)
  AUTHORS   White,R.A., Dowler,L.L., Adkison,L.R., Ezekowitz,R.A. and
            Sastry,K.N.
  TITLE     The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize
            to chromosomes 14 and 19
  JOURNAL   Mamm Genome 5 (12), 807-809 (1994)
   PUBMED   7894166
REFERENCE   8  (bases 1 to 697)
  AUTHORS   Bullesbach,E.E. and Schwabe,C.
  TITLE     Mouse relaxin: synthesis and biological activity of the first
            relaxin with an unusual crosslinking pattern
  JOURNAL   Biochem Biophys Res Commun 196 (1), 311-319 (1993)
   PUBMED   8216305
REFERENCE   9  (bases 1 to 697)
  AUTHORS   Evans,B.A., John,M., Fowler,K.J., Summers,R.J., Cronk,M., Shine,J.
            and Tregear,G.W.
  TITLE     The mouse relaxin gene: nucleotide sequence and expression
  JOURNAL   J Mol Endocrinol 10 (1), 15-23 (1993)
   PUBMED   8452637
REFERENCE   10 (bases 1 to 697)
  AUTHORS   Fowler,K.J., Clouston,W.M., Fournier,R.E. and Evans,B.A.
  TITLE     The relaxin gene is located on chromosome 19 in the mouse
  JOURNAL   FEBS Lett 292 (1-2), 183-186 (1991)
   PUBMED   1959604
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC132656.1.
            
            On Mar 17, 2009 this sequence version replaced NM_011272.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132654.1, AA833286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.83 cM"
     gene            1..697
                     /gene="Rln1"
                     /gene_synonym="Rln; rlx"
                     /note="relaxin 1"
                     /db_xref="GeneID:19773"
                     /db_xref="MGI:MGI:97931"
     exon            1..285
                     /gene="Rln1"
                     /gene_synonym="Rln; rlx"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..632
                     /gene="Rln1"
                     /gene_synonym="Rln; rlx"
                     /note="prorelaxin 1"
                     /codon_start=1
                     /product="prorelaxin 1 precursor"
                     /protein_id="NP_035402.2"
                     /db_xref="CCDS:CCDS29733.1"
                     /db_xref="GeneID:19773"
                     /db_xref="MGI:MGI:97931"
                     /translation="MSSRFLLQLLGFWLLLSQPCRTRVSEEWMDGFIRMCGREYAREL
                     IKICGASVGRLALSQEEPALLARQATEVVPSFINKDAEPFDTTLKCLPNLSEELKAVL
                     SEAQASLPELQHAPVLSDSVVSLEGFKKTLHDKLGEAEDGSPPGLKYLQSDTHSRKKR
                     ESGGLMSQQCCHVGCSRRSIAKLYC"
     exon            286..697
                     /gene="Rln1"
                     /gene_synonym="Rln; rlx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattgagca ctggggaagc agcaggagcc cagtcccgcc aaggctgagc cgcccagaag
       61 cagcccagac cggaatgtcc agcagatttt tgctccagct cctggggttc tggctattgc
      121 tgagccagcc ttgcaggacg cgagtctcgg aggagtggat ggacggattc attcggatgt
      181 gcggccgtga atatgcccgt gaattgatca aaatctgcgg ggcctccgtg ggaagattgg
      241 ctttgagcca ggaggagcca gctctgcttg ccaggcaagc cactgaagtt gtgccatcct
      301 tcatcaacaa agatgcagag cctttcgata cgacgctgaa atgccttcca aatttgtctg
      361 aagagctcaa ggcagtactg tctgaggctc aggcctcgct cccagagcta caacacgcac
      421 ctgtgttgag cgattctgtt gttagcttgg aaggctttaa gaaaactctc catgataaac
      481 tgggtgaagc agaagacggc agtcctccag ggcttaaata cttgcaatca gatacccatt
      541 cacggaaaaa gagggagtct ggtggattga tgagccagca atgttgccac gtcggttgta
      601 gcagaagatc tattgctaaa ctctattgct gatacggagc taattgtgta ccaccagtcc
      661 agtgttcaca tgcattcttg ctacctggtt gatggcc
//
