LOCUS       NM_011276               7440 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus ring finger protein, LIM domain interacting (Rlim),
            transcript variant 1, mRNA.
ACCESSION   NM_011276 NM_013916
VERSION     NM_011276.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7440)
  AUTHORS   Segarra-Fas A, Espejo-Serrano C, Bustos F, Zhou H, Wang F, Toth R,
            Macartney T, Bach I, Nardocci G and Findlay GM.
  TITLE     An RNF12-USP26 amplification loop drives germ cell specification
            and is disrupted by disease-associated mutations
  JOURNAL   Sci Signal 15 (742), eabm5995 (2022)
   PUBMED   35857630
  REMARK    GeneRIF: An RNF12-USP26 amplification loop drives germ cell
            specification and is disrupted by disease-associated mutations.
REFERENCE   2  (bases 1 to 7440)
  AUTHORS   Wang F, Gervasi MG, Boskovic A, Sun F, Rinaldi VD, Yu J,
            Wallingford MC, Tourzani DA, Mager J, Zhu LJ, Rando OJ, Visconti
            PE, Strittmatter L and Bach I.
  TITLE     Deficient spermiogenesis in mice lacking Rlim
  JOURNAL   Elife 10, e63556 (2021)
   PUBMED   33620316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7440)
  AUTHORS   Harris C, Cloutier M, Trotter M, Hinten M, Gayen S, Du Z, Xie W and
            Kalantry S.
  TITLE     Conversion of random X-inactivation to imprinted X-inactivation by
            maternal PRC2
  JOURNAL   Elife 8, e44258 (2019)
   PUBMED   30938678
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7440)
  AUTHORS   Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS,
            Rentmeester E, Demmers J and Gribnau J.
  TITLE     REX1 is the critical target of RNF12 in imprinted X chromosome
            inactivation in mice
  JOURNAL   Nat Commun 9 (1), 4752 (2018)
   PUBMED   30420655
  REMARK    GeneRIF: RNF12 targets pluripotency protein REX1 for degradation to
            initiate random X chromosome inactivation in embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7440)
  AUTHORS   Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E,
            Toth R, Macartney T, Knebel A, Hay RT, Walden H and Findlay GM.
  TITLE     RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase
            Activity and Neural Differentiation
  JOURNAL   Cell Rep 23 (6), 1599-1611 (2018)
   PUBMED   29742418
  REMARK    GeneRIF: These data uncover a key function for RNF12 E3 ubiquitin
            ligase activity in stem cell and neural development.
REFERENCE   6  (bases 1 to 7440)
  AUTHORS   Loebel DA, O'Rourke MP, Steiner KA, Banyer J and Tam PP.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   7  (bases 1 to 7440)
  AUTHORS   Ostendorff HP, Peirano RI, Peters MA, Schluter A, Bossenz M,
            Scheffner M and Bach I.
  TITLE     Ubiquitination-dependent cofactor exchange on LIM homeodomain
            transcription factors
  JOURNAL   Nature 416 (6876), 99-103 (2002)
   PUBMED   11882901
REFERENCE   8  (bases 1 to 7440)
  AUTHORS   Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ,
            Jenkins NA, Lichter P and Bach I.
  TITLE     Functional characterization of the gene encoding RLIM, the
            corepressor of LIM homeodomain factors
  JOURNAL   Genomics 69 (1), 120-130 (2000)
   PUBMED   11013082
REFERENCE   9  (bases 1 to 7440)
  AUTHORS   Shen J and Gudas LJ.
  TITLE     Molecular cloning of a novel retinoic acid-responsive gene,
            HA1R-62, which is also up-regulated in Hoxa-1-overexpressing cells
  JOURNAL   Cell Growth Differ 11 (1), 11-17 (2000)
   PUBMED   10672899
REFERENCE   10 (bases 1 to 7440)
  AUTHORS   Bach I, Rodriguez-Esteban C, Carriere C, Bhushan A, Krones A, Rose
            DW, Glass CK, Andersen B, Izpisua Belmonte JC and Rosenfeld MG.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY321640.1, AK029295.1, AK013207.1, BB024661.2, CF163533.1,
            BY713511.1, AK052543.1, CB237411.1 and AU043143.1.
            
            [WARNING] On Nov 30, 2023 this sequence was replaced by
            NM_011276.5.
            
            On Nov 23, 2017 this sequence version replaced NM_011276.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029295.1, SRR1660811.176712.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY321640.1         1-10
            11-745              AK029295.1         4-738
            746-1392            AK013207.1         717-1363
            1393-1925           AK029295.1         1386-1918
            1926-2222           AK013207.1         1897-2193
            2223-3143           AK029295.1         2216-3136
            3144-3702           BB024661.2         120-678
            3703-3725           CF163533.1         369-391
            3726-4280           BY713511.1         4-558
            4281-5393           AK052543.1         560-1672
            5394-5403           CB237411.1         166-175
            5404-7436           AK052543.1         1683-3715
            7437-7440           AU043143.1         1-4                 c
FEATURES             Location/Qualifiers
     source          1..7440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.42 cM"
     gene            1..7440
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /note="ring finger protein, LIM domain interacting"
                     /db_xref="GeneID:19820"
                     /db_xref="MGI:MGI:1342291"
     exon            1..223
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            224..285
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            286..475
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2112
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /EC_number="2.3.2.27"
                     /note="Hoxa1 regulated; RING finger LIM domain-binding
                     protein; LIM domain-interacting RING finger protein; ring
                     finger protein 12; RING-type E3 ubiquitin transferase
                     RLIM"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RLIM"
                     /protein_id="NP_035406.3"
                     /db_xref="CCDS:CCDS30331.1"
                     /db_xref="GeneID:19820"
                     /db_xref="MGI:MGI:1342291"
                     /translation="MENSDSNDKGSDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYR
                     LMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQSPDENRAGESSDDVTNSDSIIDWLN
                     SVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQTSENESEPSTR
                     RLSVENMESSSQRQMENSASESASARPSRAERNSAEAVTEVPTTRAQRRARSRSPEHR
                     RTRARAERSRSPLQPTSEIPRRAPTLEQSSENEPEGSSRTRHHVTLRQQISGPELLGR
                     GLFAASGSRNPSQGTSSSDTGSNSESSGSGQRPPTIVLDLQVRRVRPGEYRQRDSIAS
                     RTRSRSQAPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS
                     VAIQTMLRQIMTGFGELSYFMYSDSDSEPSASVSSRNVERVESRNGRGSSGGGNSSGS
                     SSSSSPSPSSSGESSESSSEMFEGSSEGGSSGPSRRDGRHRAPVTFDESGSLPFLSLA
                     QFFLLNEDDEDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSH
                     EYHVHCIDRWLSENSTCPICRRAVLSSGNRESVV"
     exon            476..559
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
     exon            560..7440
                     /gene="Rlim"
                     /gene_synonym="Ha1r; Rlim1; Rnf12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggcagtca tttcctgtca gtgctaggta acaatgggga agataatggc tgattgagct
       61 acgtctccga gctggcgctg ttctagaggc gggtctcttg cccgggttta gaggcgggtt
      121 agaacgcggc ggcagcggca gcacagtagc gcagcggagg tcccagtggc ggcggcggag
      181 cccagttgag ttccctcctg gccgaaacac cgtgtaagtg aagagctgag tgaagaagac
      241 taaaatccag tttattggat ttcaatacta tgtcctaaaa gacagataat tttccacttg
      301 atcaccaaga tggagaactc agattctaac gataaaggaa gtgaccagtc tgcagctcag
      361 cgcagaagtc aaatggatcg cttggatcgg gaagaggctt tctatcaatt tgtgaataat
      421 ctcagtgaag aagattatag acttatgaga gacaacaatt tgctgggcac cccaggtgaa
      481 agtactgagg aagagttgct cagaagacta caacaaatta aagagggtcc accaccacag
      541 agccccgatg aaaatagagc tggagagtct tcagatgatg tgaccaacag tgattctata
      601 atagattggc ttaactcagt cagacagact ggaaatacaa caagaagtgg tcagagagga
      661 aaccagtcct ggagagcagt gagccggact aatccaaaca gcggtgattt cagattcagt
      721 ttagagataa atgttaaccg taacaatgga agccaaactt ccgagaatga aagtgaacca
      781 tccactaggc gtcttagtgt agaaaacatg gagagcagca gccaaaggca aatggaaaat
      841 tctgcatctg aatcagcatc ggccagacct tctcgagcgg agcgcaattc agctgaagca
      901 gtaacagaag tgccgaccac cagagctcag aggagggcaa gaagccggag cccagagcat
      961 cggagaacca gagcaagagc tgaaagaagc aggtcccctc tgcagccaac aagtgaaatt
     1021 ccacgaagag ctccgacctt ggagcagtct tcggaaaacg agcctgaagg aagttctaga
     1081 acccggcacc atgtgaccct gagacagcag atatctggac cggagttgtt aggtagaggt
     1141 ctttttgcag cttctggatc aagaaacccc tctcagggga caagctcttc agacacaggt
     1201 agcaatagtg aatcctcagg atctggccaa agacctccaa ccatagttct tgatcttcaa
     1261 gtaagaagag ttcgtcctgg agaataccgg cagagagata gtatagctag cagaactcga
     1321 tcaagatctc aggctccgaa caacacagtt acttatgaaa gtgaacgtgg aggttttagg
     1381 cgtacctttt cccgttctga acgtgcaggt gtgagaacct atgtgagtac tatcaggatt
     1441 cctattcgca gaatcttaaa tactggatta agtgaaacta catctgttgc aattcaaacc
     1501 atgttaaggc agataatgac aggctttggt gagctaagct actttatgta cagtgacagt
     1561 gattcagagc ctagtgcctc agtctccagc cgaaatgtgg agagagtaga gtcacggaat
     1621 ggaagaggga gctctggtgg cggtaacagc tctggttcca gttccagctc aagtcctagc
     1681 cccagttcaa gtggtgaaag ttccgagagt agctcagaga tgttcgaagg cagtagtgaa
     1741 ggaggctcgt ctggcccatc cagaagagat ggtcgacata gggccccagt cacatttgat
     1801 gaaagtggct ctctgccatt ccttagtctg gctcagtttt ttcttttaaa tgaagatgat
     1861 gaagaccaac ctagaggact cactaaagaa cagatcgata acttggcaat gagaagcttt
     1921 ggtgaaaatg atgcattgaa aacgtgtagt gtttgcatta cagaatacac agaaggcaac
     1981 aaacttcgta aactaccttg ctcccatgag taccacgtcc actgcatcga ccgctggttg
     2041 tctgagaatt ccacctgtcc catttgtcgc agggcagtct tatcttctgg gaacagagaa
     2101 agtgttgtgt gatgagacca gaactctgag ctgtgtagct ggaatagtga tgggcaaaca
     2161 aatcacctgc tttatgtcca cttttttttt tgagtggtgc ttaaaatata aagtcacaag
     2221 ctgaattgag tcattgcttt cttagggtat catgcctttt ctctagtttc tctttcagga
     2281 tggaaagaat attttaaaaa caacatttta ggacttaaac atttgatttc ggtaccagat
     2341 gaattgctaa cctgttactg ataatttacc catgtccact tgtcagtttt tcctttgttg
     2401 tcttaagggc cgccttagca gtggctcctt tctatattct atatcccatt gacctctttt
     2461 gaaagtttcc caggccataa gagaggcatg aagaaagtcc ccactcaaga ctaagttcca
     2521 ttctttgttt tgaaagtgat taactaaaac tataccattc ccagttattg acacaaattc
     2581 attcacattc tgaatattgt ttgttcacct tccagagtag gtgatgatgg acatatcagt
     2641 gtaaataaca ctaaacagtt aggatctttt aaatgtatta actgtcctaa gcccatcact
     2701 gtggcacaca atagagcgaa tttagagttt aattgagata tttatcttgt ggaaatatta
     2761 aaaagcctat gcttgtgtaa gtgaaaaaaa tcacattcat ttgtttaaaa atgtaaagct
     2821 attttgtaga ggctcagtac ttttccaatg cactgttgta ttaatgcatt caaaattgta
     2881 aagtaccatg cttagaaatg agaactgctt ttttgtgagc cagcatagta aaacaaacac
     2941 accaaacaaa gtacgaagct gcttttgtaa gtgtgtagat gtcaagagca gaacatatct
     3001 atatttagtg tatttgtgaa cagctactgt gacatgaaaa ggaaaggacc gtgcagaacc
     3061 cagctgcatt gaagaccaat ggagagcatg tattttaact tggatttagg caggaagtga
     3121 tacatgatgg tgaagaaaac ggccctgaag aatggaccat attcatgaag acagtaagta
     3181 atacagacgt gaactggatt cctacagtga gagccacagc agcccgaccc actgttctgt
     3241 ttgaatagat gaagcagaag atgagtacat ttggcagagc tttcttgggt gtttgaaaaa
     3301 gaagccacta ctacctagta caagttaaat tgatgtcttt acaatctgct cctcaaaaac
     3361 aagtagagga aagagactta agccaatttt aaagtaaggt tttcagttgg tacagatgtg
     3421 tgtgctattg gaaatgtctc ggatttgctt gtttgagacc ttctaaggta ccagtgcaca
     3481 cttagttgct tatttcactc ttatgtctag cagatctaat gggccacaaa gacctgttgt
     3541 gaattaagag atttttattt tttattgaaa ggaagtcatg ttgggttatt tgagattcaa
     3601 attttaattg tgttgccgta tttgaagata aggtggctgt ctcatatctg tgaacacgca
     3661 ctttattgtt gttttgtagg aagaatagat tgtgataacc ccagtactct tgcctcaggt
     3721 gggttttttt tttttttttg aggctgattg gggttaagat tagtttggct gtggagcaga
     3781 tctgtaaaat gtttctctct ggggaaagct aacaggccag aagagacctg gattgagcat
     3841 atacaatctt ggtctttaac caaatgagct aactacccag gttagtccag tactctagaa
     3901 aatgttttac acaaatctgc tttaggaatt acctgcttac cctcactgat attgccttag
     3961 cagtaaagat tatttcaaag tacattcttt catgttttct tctggctttc agtcctacct
     4021 aagtattaag gaaagtaaat tgtaaatatc gtagttgttt acaaaggata tgtactgctc
     4081 ttgcaaggaa ataatgtcca aacaaagctt cacttatttt ttttaataga agcatatttc
     4141 actgtttatg gcgcttatgt aatacatttt tatcttttta aaaagaattg tccatgtaaa
     4201 agtcagggtt cctttatatt tgtgagcctc cttgtcacct ttccctggtt ttcggatctg
     4261 caggatagtc ctggttaagt aaaaatacat cccgttttcc tcttgataaa atgttccatt
     4321 gtagagggat tcattttcta tagctcaaaa acagctgcag cacattctaa acacagtgat
     4381 ggacagcagg cacctcccta acctccccaa atgtattact catctctgaa gtattgaagt
     4441 tagagggaac tcaatcagga tactggttat gaatgtagat gttgaagcta ttcaaaaaca
     4501 ctggaagtca gtctttacat ttctagcctt gtttgatctg catgtggact atttcaagaa
     4561 gcactcgtag acattgggct gtctagaatg gatacaagta tttttagtgg gagttgcttt
     4621 ttttattttg gtgtccacag ctattctata ttactagttg cagctgttaa agatgaggtt
     4681 gttggtgtag gtgtcaggtg tgcaatgaag aacaggaatc ttggtttcct caccagtgtc
     4741 caaatgccta ttcttgaggg aacattttct tgcgaaagac tttacatttc gttttggatc
     4801 ttcgcacttt ttctttatta cagaaaggtt ctgtgtttaa gacctacttt gaacttcatg
     4861 cagtaatgtt gggggattac attgttcaaa gcatagggga aagtactaaa gcctgatttt
     4921 ccttgaattt ttaattgttt taatccactt actagtgtaa aggtttgcag tgttttattt
     4981 tattccacac agcttacaat gttgagattt attagtgctg aaaacaaaat ttaacatgtt
     5041 aagaatggca ggctgtttgt agtaaccatg cagaataagc tgtggtggga atttggaaca
     5101 ttttctctga aaaagaacat gttagttgca ctgccctgac ctccatataa atggaggtgg
     5161 ctttggtggg gagagggaga aggctcacat gctagtgttg gaacaggtaa ttgtcagttt
     5221 gataacaaaa ggttagtgcc aggagatgct cggtctctag ggcacagttg ttagactcca
     5281 tccaagctag ggaactggtt tgctctgtta ccttaagcaa tattttgctt tgtttttgtt
     5341 tttgtttttt tttctcctgg gaaaactttg tttctgttcc aagtattctc tgcttttatc
     5401 aatgtcttat agttatgaag ggttagcatt tagcacattt tgtatttaac cacctgcttc
     5461 tatgaatgag tctccagata accatgtgat aaagaggtct atgttacaaa atgactgtta
     5521 aaggccattt ctgacagttt gctagaatac agtggcacct tgtggttgac ttttttttta
     5581 acagatggag gatagttctt ttgtgaaagg aaataatttg taatctgcct tagctgattt
     5641 aatgtttttt cttactggct tccgtgtcac acgtcttaac caaaaatata cagtacctgg
     5701 aagccatgtt gcagggcact tagattcttg gctaatctaa gatttttcac tctctggaag
     5761 tattctttct atacctgtgt aacgaggtgg agaaggcaca tgtgaaggtg tttctttttc
     5821 ccctttagta cagttcaata tgtctaatgc acagtaacag tgttgttatt gagttaacta
     5881 gtaaatggtt cttctaaaaa atttttttaa gtgtatgttg atgtatcatg ggaagttaaa
     5941 gtgcaagatc tggggaaaga atatttttaa gttcagttta ataaaaacag ttgtgagctc
     6001 aatcaatagc caccctttaa attttttagc attgagttac ctttcttgag gtaagatctt
     6061 gctgtgtgct cacagctggc ctggaactct gtggaccagg ctggctttag atttgtggca
     6121 gtccttgtgc ctctgcctct ttcttgaatg ttaggaatgc aggtacttag cactcaaatt
     6181 caccttcatt ggaacatttc taaaatacta tccaacactc caggaagtgg cctcctgtaa
     6241 gtcgccatag tttgtatcta aaagcccaca gcttagaata gaactaccgg ggtttttgtt
     6301 ttttgttttt ttttaagtat caggtttatg attttttttt catgtccatg tagatgtctg
     6361 gattcaaatc ttaaaaaggt taccaaccac tcaaaattac agtgagatac atgggacaat
     6421 ttgctttggg tattttgaga gggtcttgtt ttgtagccca ggctggcctg gaattagtga
     6481 tcctcctgat gactgggatt atagttatgt gtcaccccaa cccagcaagg atttgtttac
     6541 tgaagtccca cagctgcttt ataatcattt gggaaagcag ctagagatgc gcagtgaaag
     6601 tgaaccctgt catacatacc actgtgcctt gtttcaaggt ctgtcttagt tctcattctc
     6661 aagattgttt ccagttgcaa gttagaggca agccagctag ctgcccagcc ttaactctgt
     6721 tcagtgccct gttactaaca ttttttaaca gattggtttc tacatgttta aagtatccag
     6781 cgttggattt tacctcttgc tagttccatt tgtccctggt gctgctttta aaggtatagg
     6841 gccctgtgaa gtgtccagtg gagtaggtac gcagttggcc tggttatatg gaaaagctgc
     6901 tttggaatag atgtttactt gggttcctgt gcagaactgg gcagcaatcc tggaaagctc
     6961 tgtaaagccc ataagaaagg atttgaagag ggctgcgctt aagtctttga acatgaagca
     7021 catgtgtgca tgctgtcaaa agactggagt gattgtcata ccagggcctg acctccagga
     7081 gacactttga aaaggcaaca gaggagcacc aagggaagtg aatttgcttg gcttgctttg
     7141 tctgctttct cgtttcctta ccatttgcac ctgaaagaaa cacccttctc cggtatctga
     7201 tccagcaaac ttggttggga aaccctgtgt tgaattttga gaatgtaccc aactttttgt
     7261 acagcgcttt acacctgcta aaatttacct tgtttaatgc agaaagagac cttgaaaggt
     7321 cagtcatgaa atctggtttg attattaata gctatctttt aggaagaagc tttttcccta
     7381 tgtacgatgt catactgcag acttaaaata tagactatca ataaaatgca tgaagtgatc
//
