LOCUS       NM_175128               2419 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus RNA 5'-phosphate and 3'-OH ligase 1 (Rlig1), mRNA.
ACCESSION   NM_175128
VERSION     NM_175128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ178338.1, BC082587.1 and AK160693.1.
            
            On Apr 2, 2008 this sequence version replaced NM_175128.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160693.1, SRR1660817.100388.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                CJ178338.1         2-51
            51-2359             BC082587.1         1-2309
            2360-2419           AK160693.1         2344-2403
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.5 cM"
     gene            1..2419
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /note="RNA 5'-phosphate and 3'-OH ligase 1"
                     /db_xref="GeneID:68281"
                     /db_xref="MGI:MGI:1921197"
     exon            1..233
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1127
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /EC_number="6.5.1.3"
                     /note="uncharacterized protein C12orf29 homolog; RNA
                     ligase"
                     /codon_start=1
                     /product="RNA ligase 1"
                     /protein_id="NP_780337.2"
                     /db_xref="CCDS:CCDS24151.1"
                     /db_xref="GeneID:68281"
                     /db_xref="MGI:MGI:1921197"
                     /translation="MKRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKA
                     LDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKESAKE
                     FHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKGSKQYCWHSSVVN
                     YEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTSINGNPYGLGSKKSPLHFL
                     TPHGAFQVRNLPTLKHNDLLSWFEDCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLP
                     DTYMNSKPVIINMNLNLNNYDCAFDNQSLFNQFSKIDKQKFERLKDIILDV"
     exon            234..351
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     exon            352..447
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     exon            448..564
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     exon            565..762
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     exon            763..932
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     exon            933..2419
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /note="hexamer: AATAAA"
     polyA_site      2359
                     /gene="Rlig1"
                     /gene_synonym="4930430F08Rik; 4930571E09Rik;
                     A730088G13Rik; C430008C19Rik; Rnl"
                     /note="major polyA site"
ORIGIN      
        1 ggtagtgagt ccccgcctct ctccggagtg gaccttggtg gtgcagttag gatcttctgg
       61 ctggtgtttg gattctagct catttctgca gacttcctcc gcccggggcc cagcgcagtg
      121 gagacaggtt gcgcgtgggc aacatgaagc gcctgggctc ggtgcagcgg aagatgccgt
      181 gtgtgtttgt gacggaggtg aaagctgagc cttcagccaa gcgggagcat cagccattta
      241 aagttttggc aactgaaact ctaagtgaaa aggcgttaga tgcagacgtg tacaatgcgg
      301 ttgcaacaga aaaagtggat ggaacatgct gctatgttac taactacaaa ggtcagccat
      361 acctttgggc tcgactagat agaaaaccta acaagcaggc tgacaagaga tttaaaaaat
      421 ttctacattc aaaagaaagt gcaaaagagt ttcactggaa cactgaggaa gacttcaagc
      481 ctgtcccaga gtgctggata ccagcaaagg aaatagaaaa acaaaacggg aagccagtgc
      541 ctgatgaaaa cggacacatc cctggttggg taccagtaga gaagggcagc aagcaatatt
      601 gctggcactc gtcggtagtg aattacgagt ttggaattgc cctggtacta aggcaccatc
      661 ctgatgatcc cggggttttg gaaattagtg ctgttcccct gtcagagctt ttagagcaaa
      721 ccctggagct gataggcacg agtatcaatg gaaaccccta tgggctggga agcaagaaat
      781 ccccgttaca ttttctcaca ccacacggag cattccaggt cagaaatctg cccacactga
      841 aacacaatga cctgctgtcc tggtttgaag actgcagaga gggtcaaatt gaagggattg
      901 tgtggcattg cggtgacggc tgtttaatta aggtccatcg tcaccatctt ggtttatgct
      961 ggccacttcc agatacttac atgaattcca aaccagttat tattaacatg aacctgaacc
     1021 tgaacaatta tgactgtgct tttgataacc agtctttgtt taatcagttt tcaaaaatag
     1081 ataaacagaa atttgagaga ctcaaagaca taatacttga tgtataaaat ggaactaatt
     1141 gttgagatta ttgtgatttt ctaagactga atagtttgca tttaattttg ctagctgttt
     1201 ggcaaaacct gtcaacttct aaacatgttt ctaggtattt atagaaatca tcgttaggat
     1261 ttgactatct taacacaaaa ataaatataa aataatcaat tttaaatagt aaattgatat
     1321 aagcttacct ttatgctttt tgaaaattta agttattatg aaaatagtaa tatttatcat
     1381 agctcattgt gcactgtata gtcataaatt aatgaagtct tcaaaaatat acttttctaa
     1441 caagttaaaa ctaaatatga tttttttaaa caaaaaaaat acaatatttt gagctgtaaa
     1501 ttctataaca cagagactgc ttgatttcca gctgaaactt ttttcactca taaaatagtt
     1561 ttaaacctgc agttacacga gggcactaat aaatagggaa actatgagga ctttctccat
     1621 cttccgagtg ttcagaagca gcaagaggac taggcagttc aaatccaaac tgttccgaca
     1681 gtttttttag cttctcttct aataggatat tctttttcac ttcttcctta taattatact
     1741 tcaggtcttc aatttcttca aaaaatgaag gatcaaaatt ttccagttct tttttcagct
     1801 ttttaacttc ctcctaaaag ttacatacag gatacatgtt tttggtttga aattttagat
     1861 ttaattataa acataaaaac tcaaaatctt aaatgtaaat atttttcttt atattttact
     1921 gttcaaggtt ccgttgtacc atgtgaataa tgtagaagct gccatcttta gctaaattat
     1981 aagattaaat ctttaaactg cctcagatat tcccaggcaa gcgaaaggga ctttgctttt
     2041 ttacaacaac attcaagagt tttcagtatt tataatgttc taatttttta tcttttatat
     2101 ataatactta tgatcatggg aaccctggga cttggaaagg ttaagcacct ggtgaagtgc
     2161 atgcttacag catctacaca gaccagtgac gagcagccag accactaaat gatttaaggg
     2221 aaagatccct gaaaataatt tcaaaaggga cttagaaaac actttcccca ccatgaccca
     2281 caaattaaga aaatagttta aaaaaactat taagagatgt gcattggtta caatttaaaa
     2341 ataaatttat tctctagtac tttctgtttg tctgattttt tgctgttgat agttgtttaa
     2401 taaaaagttg tcatgagtc
//
