LOCUS       NM_001346660            6242 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus rearranged L-myc fusion sequence (Rlf), mRNA.
ACCESSION   NM_001346660 XM_006502656
VERSION     NM_001346660.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6242)
  AUTHORS   Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva
            G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams
            RH, Harten SK, Tzahor E, Zhou B and Harvey RP.
  TITLE     Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the
            building plan for trabeculation
  JOURNAL   Nature 557 (7705), 439-445 (2018)
   PUBMED   29743679
REFERENCE   2  (bases 1 to 6242)
  AUTHORS   Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM,
            Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R,
            Suter CM, Harvey RP and Harten SK.
  TITLE     Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart
            development in the mouse
  JOURNAL   Differentiation 94, 8-20 (2017)
   PUBMED   27930960
  REMARK    GeneRIF: Our study highlights the importance of RLF-dependent
            epigenetic modifications to DNA for maintaining correct gene
            regulatory network and intercellular signalling interactions during
            heart chamber and septal development.
REFERENCE   3  (bases 1 to 6242)
  AUTHORS   Harten,S.K., Oey,H., Bourke,L.M., Bharti,V., Isbel,L., Daxinger,L.,
            Faou,P., Robertson,N., Matthews,J.M. and Whitelaw,E.
  TITLE     The recently identified modifier of murine metastable epialleles,
            Rearranged L-Myc Fusion, is involved in maintaining epigenetic
            marks at CpG island shores and enhancers
  JOURNAL   BMC Biol 13, 21 (2015)
   PUBMED   25857663
  REMARK    GeneRIF: This study provides the first evidence that the epigenetic
            modifier Rlf is involved in the maintenance of DNA methylation at
            enhancers and CpG island shores across the genome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6242)
  AUTHORS   Daxinger,L., Harten,S.K., Oey,H., Epp,T., Isbel,L., Huang,E.,
            Whitelaw,N., Apedaile,A., Sorolla,A., Yong,J., Bharti,V.,
            Sutton,J., Ashe,A., Pang,Z., Wallace,N., Gerhardt,D.J.,
            Blewitt,M.E., Jeddeloh,J.A. and Whitelaw,E.
  TITLE     An ENU mutagenesis screen identifies novel and known genes involved
            in epigenetic processes in the mouse
  JOURNAL   Genome Biol 14 (9), R96 (2013)
   PUBMED   24025402
REFERENCE   5  (bases 1 to 6242)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6242)
  AUTHORS   Ashe A, Morgan DK, Whitelaw NC, Bruxner TJ, Vickaryous NK, Cox LL,
            Butterfield NC, Wicking C, Blewitt ME, Wilkins SJ, Anderson GJ, Cox
            TC and Whitelaw E.
  TITLE     A genome-wide screen for modifiers of transgene variegation
            identifies genes with critical roles in development
  JOURNAL   Genome Biol 9 (12), R182 (2008)
   PUBMED   19099580
REFERENCE   7  (bases 1 to 6242)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606927.12.
            
            On Oct 25, 2016 this sequence version replaced XM_006502656.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.30884.1,
                                           SRR1660815.107745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AL606927.12        73503-73752         c
            251-405             AL606927.12        48772-48926         c
            406-487             AL606927.12        46883-46964         c
            488-620             AL606927.12        41274-41406         c
            621-823             AL606927.12        29286-29488         c
            824-960             AL606927.12        17860-17996         c
            961-1102            AL606927.12        13524-13665         c
            1103-6242           AL606927.12        4551-9690           c
FEATURES             Location/Qualifiers
     source          1..6242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.8 cM"
     gene            1..6242
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /note="rearranged L-myc fusion sequence"
                     /db_xref="GeneID:109263"
                     /db_xref="MGI:MGI:1924705"
     exon            1..250
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            251..405
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            406..487
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            488..620
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            621..823
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            824..960
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1102
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..6242
                     /gene="Rlf"
                     /gene_synonym="9230110M18Rik; MommeD8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccgtggg aagatggcgg acggaaaggg agacgccacg gccgccgccg gggccggggc
       61 tggggctgag gctccggcgg tggcgggagc cgaagtcgag actgagtcca tggctcgggg
      121 tcatcgccct gcatctccgg cgtcgggagc gccgggccta cgaccgtgtc tctggcagct
      181 ggagaccgag ctgagggagc aggaggtgtc cgaggtctca tctttgagct actgccggag
      241 cttctgccag accttattgc aatatgcaag caacaagaat gcatcagaac acattgtgta
      301 tcttctggag gtataccgcc tcgctatcca aagctttgcc agcgcacgtc catttctaac
      361 tactgaatgt gaagatgttc tcttagtgct tggcagatta gtcctgagtt gttttgaatt
      421 actgctttca gtgtctgaaa gtgaactgcc ctgtgaagtc tgggtaccat tccttcagtc
      481 tctacaggag tcacatgatg cattgttgga atttggaaat aataatttac aaatactggt
      541 tcatgttaca aaagaaggag tgtggaaaaa ccccattctt cttaaaattc tgtcacaaca
      601 gccagtagag acagaggaag ttaacaaatt gattgcacaa gaaggacctt cctttctaca
      661 aatgagaatc aagcatttgt tgaagtctaa ctgcatcccc caagctactg ctttatcaaa
      721 actgtgtgca gagtctaaag aacttgccca ggtgtcgtgt tttcagcaag cctatatcac
      781 atgtttatgt tccatgcttc ccagcgaaga ggctattcag gagattgcaa aggtggactg
      841 caaggacgtg ttagacatca tatgtaatct ggaatctgag ggtcaggata acacagcatt
      901 tgttctttgt acaacttacc ttacccagca gctccaaacg gccagtgtat attgttcttg
      961 ggagctgact ctcttttgga gtaaactgca aagaagaatt gacccatctt tggagacatt
     1021 tttggagcgt tgtcggcagt ttggtgtcat agctaaaaca caacagcatt tattttgcct
     1081 gattagagtc atacagactg aagcacaaga tgctggcatt ggggtatcaa ttttattatg
     1141 tgtcagagct cttcaactca gatcaagtga agatgaggaa atgaaagctt cggtctgtaa
     1201 aacaatttcc tgtcttttac cagaagattt ggaagtcaga cgagcctgtc agcttacaga
     1261 attcttaatt gaacccagtt tggatggatt caatatgctg gaagaactgt atttgcagcc
     1321 agatcaaaaa tttgatgaag aaaacgcacc agttccaaat tccctgcggt gtgagctttt
     1381 actagcttta aaagcccatt ggccctttga tcctgaattt tgggactgga aaactttgaa
     1441 gcgacactgc caccaactcc tgggacaaga agcctcagat tccgatgatg acctaagtgg
     1501 ctatgaaatg tctattaatg atacagatgt cttagagtca tttctcagtg actatgatga
     1561 tggaaaagaa gataagcaat atagaagaag tctaacagat cagaataagg agaaaagaga
     1621 caaaaagccc attggttcct ctgagagata ccagaggtgg cttcagtata agtttttctg
     1681 tttgttgtgt aagcgggaat gcatagaggc caggattctc catcattcca agatgcacat
     1741 ggaagatgga atatatacct gtccagtttg tattaaaaaa ttcaagagaa aagagctatt
     1801 tgttcctcac gtaatggaac atgttaaaat gccaccaagc agaagccacc gttctagaaa
     1861 gaaattacta ttgaaaagcg ctcaaagggg tatttatccc aagagtccta ctggaagtct
     1921 ggaacaaaat ccagagcaag ccaggggaga gtctcatgaa tatgtcacat ttagcaagtt
     1981 agaagaccgc cgcctgcaag acagagactt gtacccgtgt ccgggtacag attgttcccg
     2041 tgtgttcaaa cagtttaaat atttaagcgt gcatcttaaa gctgaacacc aaaataatga
     2101 cgaaaacgcc aagcactact tggatatgaa aaataggaga gagaagtgta cttattgccg
     2161 gcggcatttc atgtcagctt ttcacctccg agaacatgag caggtgcatt gtggtcctca
     2221 gccttacatg tgtgtctcta tagattgcta tgcaaggttt gggtcagtga atgaactcct
     2281 taaccacaag cagaagcatg atgacctccg ttacaaatgt gagttgaatg gctgcaatat
     2341 tgtgttcagt gacttgggcc agctttacca ccatgaagca caacacttca gggatgcatc
     2401 ctacacatgc aatgtccttg gctgtaaaaa gttctattat tctaaaattg aataccagaa
     2461 ccacctctcc atgcataatg ttgaaagtcc agatggagaa ttaaagaaat cagtgaaact
     2521 tgaggaacct ggagcaggtg ggaagcaaga ttgtgtggac cagtcccatc tacttgatga
     2581 aactgagaag tcccattctc ttgaagatca ccatctctgt ccagggtcag ctagtgctca
     2641 tatagacacc acagagaccc tgaaggacaa cagcgacagc aattctagtg atcagttaag
     2701 tcacagctct tccacgtcaa taactgagga gttaattgac accctagacc actctgaaac
     2761 catgcaggac ctgttactgt ctcatgagaa agtctttgtt ccctccagtt taaaagacaa
     2821 gtgctccaat gtggctgttt gttttgatgg aactaaattc acctgtggtt ttgacggctg
     2881 tggctccacc tacaaaaacg caagagggat gcagaaacat ctgcggaagg tgcatccgta
     2941 ccactgcaag ccaagaaaaa taaagacaaa agacctcttt aactgcctgg atgacaaaca
     3001 taatgaagct gacaagtttg atgcagaacc taaacctagc tctgatacaa atagtgactc
     3061 cccagatgaa ggtccagatc acagtatcca cacaaaatgc aaacgagaac atcaaggtta
     3121 ttcccctgaa ccttccattt gtgcttctaa aaggccatgt acagaggata caatgttgga
     3181 acttctgtta cgtttgaaac atttaagctt gaagaactca atagcacatg gctctttctc
     3241 agggtcattg caagggtgcc catctagtgg tgctaagtct cttcagtcag tcccatcttc
     3301 catttcagac gttaatcttc agaatcagga tgaaaatatg ccaagtcagt accttgcaca
     3361 gttggcggca aagcctttct tctgtgagct tcaaggatgc aaatatgagt ttgtgaccag
     3421 agaagctttg ttaatgcatt atcttaaaaa gcataactat tcaaaagaga aggtccttca
     3481 gttaaccatg tttcagcacc gatattcccc attccggtgt cacatctgcc aaaggtcatt
     3541 tacaagaaaa acacatctta ggattcatta taaaaacaaa catcaaattg gcagtgacag
     3601 ggcaactcac agactgttag acagtgaaaa atgtgatcat gaagggccat gctcagtaga
     3661 cagactgaaa ggtgactgct ctacagaact tggtcccaac agtaattcag agaccacgca
     3721 atgtcattct aaaaaagatg aatgcagctc agaaacagac ttggagtcct cttgtgagga
     3781 aacagaaagt aagatctctg gtatctcatc accaataggt agccatagag aagagggaga
     3841 ggagaaagag gggagaggaa gtaggcggac tgttgctaaa ggaaatctgt gctatatttt
     3901 gaataagtac cacaaaccat tccattgtat ccacaaaact tgcaattctt catttaccaa
     3961 tctaaaaggc ctgattcgcc attacagaac tgtgcatcag tacaacaaag agcagttatg
     4021 cttagagaag gacaaagcaa gaaccaaaag ggagcttgta aaatgtaaaa agctatttgc
     4081 ttgcaaatat aaagactgta acaagcgctt cctgtgctcc aaggccctgg ctaagcactg
     4141 tagtgactct cataacctag accacattga agagtctaaa gtgctttctg agacggagtc
     4201 tgcagcgagg ttttcttgta accagcctca gtgccctgct gttttttatt cattcagtaa
     4261 gttgaaacac cacctgttgg aacagcataa tattgaagga gaaatccatt cggattatga
     4321 gatccattgt actcttaatg gctgtggcca gattttcagc catcgaagta attacttcca
     4381 gcatgtctac taccgacata aggactatta tgacaacctg ttcagcagcc agaaagtagc
     4441 aaatgagcgg cttctaagga gtgaaaaggt gtgtcagaca actcaggcac aaggactgac
     4501 gcagacgcag gggcagacac agggacagac gcagggacag gaacagcagg ctgccaaaag
     4561 gccatttaat actaaagcta aaaaatgtgg cttactcaaa gataaaaaag ctccaattac
     4621 ctttaaaaca agagcagaag cgatccatat gtgtgttgag cattctgagc acacacagta
     4681 cccgtgcatg gttcagggat gcttgtctgt ggtgaagctg gaaagcagca ttgtgagaca
     4741 ttacaaacgt acccaccaga tgaatagtgc ctatttagag cagcagttgg agaaccttgt
     4801 ggtttgtgtt aagtatggta ccaaaattaa agacgagccc ccttcagaag tagagccctg
     4861 tgtaaagaaa gaggaaagta ctagctgtga atcggtgcac acagagaatg gagccccagg
     4921 agacagcagt gtgcccctcc caaacactga ttctacttgc ccagctgaac aagatgtcgg
     4981 tcagaaaggg tgttcagaaa gaaacccagt ttttgacaca cacagtctgc tctacagggg
     5041 aactttgaaa tgcaaccatt cttcagaaac cacttctttg gaacagtgta atatagctca
     5101 gtcttctccc tgtaaaatag aaagccccat acctaatccc agtgggacag aaagtggtac
     5161 ttatttcacg gacttccagc tgccattacc aaggatcaaa gaagaacctg ggcagcatag
     5221 ttcagggcaa gaaaacactg taaagaatgc aacccaggtc ccaaaagaga atattagaaa
     5281 gcattctcag cccaggtcat ttgatctgaa gacttacaaa cctatgggat ttgagtcttc
     5341 ctttctgaaa tttattcagg aaagtgaaga gaaggatgat gattttgatg actgggagcc
     5401 ttcagagcac ttaacattga ataactcctc tcaccccagt aatgacttga cagggaatgt
     5461 tgtggcagat accatagtga atgagagtgc ccctcaagtt gacatacctc attcttccag
     5521 tgaccctcca gtttcagaga acctgactgc agtcccacca ttagtagtag ctgaagcaac
     5581 agcagttcct tccttggaaa acctgagggt tgtgctggac aaagcattaa cagactgtgg
     5641 agaacttgcc ttaaaacagc ttcattacct tcggcctgtg gttgtccttg aaagatctaa
     5701 gttctctaca ccaattttag acttgtttcc aactaagaag acagatgagc tttgtgtagg
     5761 aagttcctga atcactgttg tttttgaagc acctagctcc agcactgcaa catggggaca
     5821 cttgctaacg tgaacaaagg ctgggaatca gccacacttg cttaggatag aataggctgt
     5881 gtatgtacat gaatgtacaa tatctgtgtc agcagtattg gcggcgtcca gtagctttcc
     5941 agttggttta ttgattggga tttttgtttg tttgtttgtt tgtttattaa aaaaatggaa
     6001 ctgtactctt gtttggtgct aattaataca tcaaatatac tggggcttcc tttttccaat
     6061 taagtgtgca tgattgtata tggaacatat attaaagtcc cagggtggga gggctaggga
     6121 aagggtagga agttcttact tgacttgaat gtgcacccaa gggtgctttg tgtaatatat
     6181 tgtacactac agcatcttat attttttgag ttgagtttca ataaattaca atttttcacc
     6241 ca
//
