LOCUS       NM_029096               1586 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus RBPJ interacting and tubulin associated 1 (Rita1),
            transcript variant 2, mRNA.
ACCESSION   NM_029096 XR_106116 XR_107738
VERSION     NM_029096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Tabaja,N., Yuan,Z., Oswald,F. and Kovall,R.A.
  TITLE     Structure-function analysis of RBP-J-interacting and
            tubulin-associated (RITA) reveals regions critical for repression
            of Notch target genes
  JOURNAL   J Biol Chem 292 (25), 10549-10563 (2017)
   PUBMED   28487372
  REMARK    GeneRIF: structural and biophysical studies demonstrate that RITA
            binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain
            of Notch, our biochemical and cellular assays suggest that RITA
            interacts with additional regions in RBP-J.
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Steinhauser,K., Kloble,P., Kreis,N.N., Ritter,A., Friemel,A.,
            Roth,S., Reichel,J.M., Michaelis,J., Rieger,M.A., Louwen,F.,
            Oswald,F. and Yuan,J.
  TITLE     Deficiency of RITA results in multiple mitotic defects by affecting
            microtubule dynamics
  JOURNAL   Oncogene 36 (15), 2146-2159 (2017)
   PUBMED   27721410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125183.4, AK003581.1 and AI850520.1.
            
            On or before Jan 24, 2012 this sequence version replaced
            XR_107738.1, XR_106116.1, NM_029096.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021365.1, AK003581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC125183.4         98677-98696
            21-1568             AK003581.1         2-1549
            1569-1586           AI850520.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.63 cM"
     gene            1..1586
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /note="RBPJ interacting and tubulin associated 1"
                     /db_xref="GeneID:100764"
                     /db_xref="MGI:MGI:1922021"
     exon            1..316
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /inference="alignment:Splign:2.1.0"
     exon            317..668
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1161
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /codon_start=1
                     /product="RBPJ-interacting and tubulin-associated protein
                     1"
                     /protein_id="NP_083372.1"
                     /db_xref="CCDS:CCDS51635.1"
                     /db_xref="GeneID:100764"
                     /db_xref="MGI:MGI:1922021"
                     /translation="MKALHLQHRSPTSYRVKARASYVDETLFGSPARTRPAQPDFDPP
                     WVQNCNRSRGVGPGPPKGSLAKRDCESPSSRGSTPNLTPRKKNKYRLIGHAPSYCDES
                     LFGTSKEGSRMAVGDAAKLRTLFWTPPATPRGSHTPCPRETPLRAIHPAGPSRTEPRV
                     TAGSQMSSQDGLCVPCSLGQRRSHSLTHLTVPSTGHPASSAPQTNGPWSPRPNTSGAT
                     VQSPLVTSKACSGRVSGPAPPRRGACPPKPKPPWK"
     exon            669..1573
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /note="hexamer: AATGAA"
     polyA_site      1573
                     /gene="Rita1"
                     /gene_synonym="1110008J03Rik; Rita"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcaggg gtggggcgtc gcaccggttg cccagcaagg gatgcgggtg ggcgcgtgtc
       61 gctgtggcgc ccttgctgat tctgtgctat gaggctttaa atgtggcgga gacagagctt
      121 tctggccgga ggctccagga gaaaaagcac caggcatgga gatcccgtga cgcctgcgct
      181 ttcagctctg taagctggcc ggtgcgttgc tactctgctg ttgggagcct gagctggact
      241 cggggaaaat gcatttcgta tgagactggt tggcgaggac tggaacgcac cacgtttgca
      301 aagcgctttg cacaagggag ccctggaggc tgagtctgtc aggcacacca cacccactgg
      361 gcaacgtgaa gaccccggtg gcaccggccc agcagcggaa tgaaagccct ccaccttcag
      421 caccgcagtc ccaccagcta cagggtcaag gccagggcat cctatgtgga tgagaccctg
      481 tttggcagcc cagcaagaac cagacctgcc caaccagact ttgacccacc ctgggtgcag
      541 aattgtaacc gatccagagg agtgggccca ggaccaccga agggctctct ggccaagaga
      601 gactgtgagt ccccctcttc caggggcagc accccaaacc tcacaccaag gaagaaaaac
      661 aaatacaggc tgattggcca tgccccatcc tactgcgatg agtcactgtt tggcactagc
      721 aaggaggggt ctcggatggc cgtgggggat gctgcaaagc tccggaccct tttctggacc
      781 ccaccagcca cccctagggg cagccacaca ccttgcccca gggagacccc tctgcgagcc
      841 attcacccag ctggaccctc caggacagag cccagagtga ctgcaggctc ccagatgtca
      901 tcccaggatg ggttgtgtgt tccctgctct ctgggacaga ggcggtccca ttcactcacc
      961 cacctaactg tccccagcac gggtcatcca gcttccagtg ctccccagac caatgggcct
     1021 tggagtcccc ggcctaacac atcaggggcg actgtccaga gtcccctggt cacttccaag
     1081 gcatgctcag gtcgtgtttc ggggccagct ccccctcggc gaggggcctg tcctcccaag
     1141 ccgaagcctc cttggaagtg agattctcgt cagggatgct tttggcccaa agccaggact
     1201 caagctcggg tggggtccta tagagacaac ggtccccagg gcctccagat gctggaaacg
     1261 cctccacggg gtgccacggt gaggatgggc catattgtcc tagtccccac aagctcagga
     1321 tgtccccagc cttctctgaa gggtgtttgg ggtccttgag atgttgtctc tctagcggtg
     1381 tctcagccgc cttctgcatc ggtgccaagc cccacccagc tccctgcaaa ggagtatgtt
     1441 ttttacagtg atctggaggc tctgaggaag tgtcctgggc tgtgcgtgga cccaagtggg
     1501 tgggacatgg gaagacatta ttttagtatt catgtattta ttccatgtat taaatgaatt
     1561 tggatcacta aaaaaaaaaa aaaaaa
//
