LOCUS       NM_009065               1851 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Ras-like without CAAX 2 (Rit2), mRNA.
ACCESSION   NM_009065 NM_019692 XM_356992
VERSION     NM_009065.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Fagan,R.R., Kearney,P.J., Sweeney,C.G., Luethi,D., Schoot
            Uiterkamp,F.E., Schicker,K., Alejandro,B.S., O'Connor,L.C.,
            Sitte,H.H. and Melikian,H.E.
  TITLE     Dopamine transporter trafficking and Rit2 GTPase: Mechanism of
            action and in vivo impact
  JOURNAL   J Biol Chem 295 (16), 5229-5244 (2020)
   PUBMED   32132171
  REMARK    GeneRIF: Dopamine transporter trafficking and Rit2 GTPase:
            Mechanism of action and in vivo impact.
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Sweeney,C.G., Kearney,P.J., Fagan,R.R., Smith,L.A., Bolden,N.C.,
            Zhao-Shea,R., Rivera,I.V., Kolpakova,J., Xie,J., Gao,G.,
            Tapper,A.R., Martin,G.E. and Melikian,H.E.
  TITLE     Conditional, inducible gene silencing in dopamine neurons reveals a
            sex-specific role for Rit2 GTPase in acute cocaine response and
            striatal function
  JOURNAL   Neuropsychopharmacology 45 (2), 384-393 (2020)
   PUBMED   31277075
  REMARK    GeneRIF: Conditional, inducible gene silencing in dopamine neurons
            reveals a sex-specific role for Rit2 GTPase in acute cocaine
            response and striatal function.
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Zhang,L., Wahlin,K., Li,Y., Masuda,T., Yang,Z., Zack,D.J. and
            Esumi,N.
  TITLE     RIT2, a neuron-specific small guanosine triphosphatase, is
            expressed in retinal neuronal cells and its promoter is modulated
            by the POU4 transcription factors
  JOURNAL   Mol Vis 19, 1371-1386 (2013)
   PUBMED   23805044
  REMARK    GeneRIF: These studies confirm the expression of RIT2 in retinal
            neuronal cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Shi,G.X., Jin,L. and Andres,D.A.
  TITLE     Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin
            activation requires Src and contributes to the regulation of HSP27
            signaling during neuronal differentiation
  JOURNAL   Mol Cell Biol 28 (16), 4940-4951 (2008)
   PUBMED   18541665
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Hoshino,M. and Nakamura,S.
  TITLE     The Ras-like small GTP-binding protein Rin is activated by growth
            factor stimulation
  JOURNAL   Biochem Biophys Res Commun 295 (3), 651-656 (2002)
   PUBMED   12099688
  REMARK    GeneRIF: The Ras-like small GTP-binding protein Rin is activated by
            growth factor stimulation
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Spencer,M.L., Shao,H., Tucker,H.M. and Andres,D.A.
  TITLE     Nerve growth factor-dependent activation of the small GTPase Rin
  JOURNAL   J Biol Chem 277 (20), 17605-17615 (2002)
   PUBMED   11877426
  REMARK    GeneRIF: stimulation of PC6 cells with either epidermal growth
            factor or nerve growth factor (NGF) results in rapid activation of
            Rin
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Shao,H. and Andres,D.A.
  TITLE     A novel RalGEF-like protein, RGL3, as a candidate effector for rit
            and Ras
  JOURNAL   J Biol Chem 275 (35), 26914-26924 (2000)
   PUBMED   10869344
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Lee,C.H., Della,N.G., Chew,C.E. and Zack,D.J.
  TITLE     Rin, a neuron-specific and calmodulin-binding small G-protein, and
            Rit define a novel subfamily of ras proteins
  JOURNAL   J Neurosci 16 (21), 6784-6794 (1996)
   PUBMED   8824319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC018267.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_356992.1, NM_009065.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018267.1, AK140726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.69 cM"
     gene            1..1851
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /note="Ras-like without CAAX 2"
                     /db_xref="GeneID:19762"
                     /db_xref="MGI:MGI:108054"
     exon            1..288
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..839
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein Roc2; ras-like without CAAX
                     protein 2; ras-like protein expressed in neurons; RAS-like
                     protein expressed in neuron"
                     /codon_start=1
                     /product="GTP-binding protein Rit2"
                     /protein_id="NP_033091.1"
                     /db_xref="CCDS:CCDS29108.1"
                     /db_xref="GeneID:19762"
                     /db_xref="MGI:MGI:108054"
                     /translation="MEVENEAHCCPGSSSGGSREYKVVMLGAGGVGKSAVTMQFISHQ
                     FPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVT
                     DRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGMNLARDYNCAFF
                     ETSAALRFGIDDAFQGLVREIRRKESMLSLVERKLKRKDSLWKKIKASLKKKRENML"
     exon            289..345
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..419
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..611
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1802
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="Rit2"
                     /gene_synonym="RIBA; Rin; Roc2"
                     /note="major polyA site"
ORIGIN      
        1 caattgcagt ggttgctatg agacccgctc cagcagagga ccagcaggca gcctgtcgct
       61 gatggttctt gtcgtgcacc aaagctttcc tttgacacag ttttagagtt gtttactatc
      121 tgagcaagca cctgacacgg tgactctttt cttccttttt ttcctcctcg ggtcccccga
      181 gtaagatgga agtagaaaac gaagcccact gctgccctgg cagctcatca ggcgggtcca
      241 gagagtacaa ggtggtaatg ctgggcgcag ggggcgttgg taaaagcgca gtcacaatgc
      301 agtttataag ccaccagttc ccggactatc acgaccccac aatcgaagat gcttataaaa
      361 cccaggtgag gattgataat gagcctgctt acttagacat cttggacact gctggtcagg
      421 cagagttcac ggccatgcgg gagcagtaca tgcgtggggg agagggcttc atcatctgct
      481 attctgtcac tgaccgccag tcattccagg aggctgccaa gttcaaggag cttattttcc
      541 aggtccgtca cacctatgaa attccccttg tgctagtggg taacaaaatt gacttggagc
      601 agttccgtca ggtatctaca gaagaaggca tgaatcttgc tcgagactac aactgtgcct
      661 tctttgagac atctgcagcc ctgcgattcg gtatcgatga tgcttttcaa ggcttagtga
      721 gagaaattcg caggaaggaa tccatgctgt ccttggtgga aaggaaattg aagaggaagg
      781 acagcctgtg gaagaagata aaagcctccc tgaagaagaa gagagaaaac atgttgtgag
      841 gctttgcttc cgcatccttc ctgtctctcc ttgtgggttt tatcaaccag acaattgttc
      901 atatctccat ctcactctct ctttctctct ccatctcttt ttctttccct ttccccctct
      961 cttaacacac acacacacac aatctacctg caggcagaaa ttagacttct ataactgtgt
     1021 gtcttgagat agttttattt tgcctttaac agctggatag attttgtcaa tcagctggat
     1081 aatgctttat agattttaca atatattacc aaataaaatt aacattccaa ttgcctcatt
     1141 ttcctgtaaa gtgtagcttc attttgcatg ctgtctggtt ataaagaaaa tctgcaaact
     1201 tgtaactggg atgataaaag gcttagggga tctgcttttg cctgataacc ctggttgttt
     1261 gcatttcaca aatctgtaaa taatgaagag gctggaatag tttagaggaa aaaaaaatgt
     1321 ccttgtcttc tcttaagtgg aagagtcttg gtatttcttc ttgagtcctc tatagatgaa
     1381 cattagagaa attattgata ataggaactg agtttgtgtt attaaaatac taaaattaca
     1441 tgtccccata tttagtgctc agtctgccat atgctttata gaagtaccac agtaaagtta
     1501 ctgtaatgat agtctatgtt atctgttgta ggaagacagc aatactatga actagatgat
     1561 acatgtgccc aagaaaggac cctttgcccc tctcaatgaa tcttcttaga attgcttcac
     1621 ctgcatagta gccatctgtc tgcagcgata tggcctctac atactaagtg ttctcttcat
     1681 attattaaat ttcctctctc attttccaag aagcattaca agaagctgac atcagaaatg
     1741 ttgttgttat ttgtcttgtt atttgttcat tgtgtaaaat aaaatctctc agtcacccat
     1801 ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
