LOCUS       NM_001404022            2699 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus Ras-like without CAAX 1 (Rit1), transcript variant 4,
            mRNA.
ACCESSION   NM_001404022 XM_006501160
VERSION     NM_001404022.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Egami,Y., Kawai,K. and Araki,N.
  TITLE     Rit1-TBC1D10B signaling modulates FcgammaR-mediated phagosome
            formation in RAW264 macrophages
  JOURNAL   Life Sci Alliance 7 (10), e202402651 (2024)
   PUBMED   39084876
  REMARK    GeneRIF: Rit1-TBC1D10B signaling modulates FcgammaR-mediated
            phagosome formation in RAW264 macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Riley,A.K., Grant,M., Snell,A., Cromwell,E., Vichas,A., Moorthi,S.,
            Rominger,C., Modukuri,S.P., Urisman,A., Castel,P., Wan,L. and
            Berger,A.H.
  TITLE     The deubiquitinase USP9X regulates RIT1 protein abundance and
            oncogenic phenotypes
  JOURNAL   iScience 27 (8), 110499 (2024)
   PUBMED   39161959
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Chen,S., Vedula,R.S., Cuevas-Navarro,A., Lu,B., Hogg,S.J., Wang,E.,
            Benbarche,S., Knorr,K., Kim,W.J., Stanley,R.F., Cho,H.,
            Erickson,C., Singer,M., Cui,D., Tittley,S., Durham,B.H.,
            Pavletich,T.S., Fiala,E., Walsh,M.F., Inoue,D., Monette,S.,
            Taylor,J., Rosen,N., McCormick,F., Lindsley,R.C., Castel,P. and
            Abdel-Wahab,O.
  TITLE     Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal
            Hematopoietic Transformation
  JOURNAL   Cancer Discov 12 (10), 2434-2453 (2022)
   PUBMED   35904492
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Cuevas-Navarro,A., Rodriguez-Munoz,L., Grego-Bessa,J., Cheng,A.,
            Rauen,K.A., Urisman,A., McCormick,F., Jimenez,G. and Castel,P.
  TITLE     Cross-species analysis of LZTR1 loss-of-function mutants
            demonstrates dependency to RIT1 orthologs
  JOURNAL   Elife 11, e76495 (2022)
   PUBMED   35467524
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Cai,W., Carlson,S.W., Brelsfoard,J.M., Mannon,C.E., Moncman,C.L.,
            Saatman,K.E. and Andres,D.A.
  TITLE     Rit GTPase signaling promotes immature hippocampal neuronal
            survival
  JOURNAL   J Neurosci 32 (29), 9887-9897 (2012)
   PUBMED   22815504
  REMARK    GeneRIF: these data identify a new and unexpected role for Rit in
            injury-induced neurogenesis, functioning as a selective survival
            mechanism for immature hippocampal neurons within the subgranular
            zone of the dentate gyrus following TBI.
REFERENCE   7  (bases 1 to 2699)
  AUTHORS   Cai,W., Rudolph,J.L., Harrison,S.M., Jin,L., Frantz,A.L.,
            Harrison,D.A. and Andres,D.A.
  TITLE     An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway
            mediates oxidative stress resistance
  JOURNAL   Mol Biol Cell 22 (17), 3231-3241 (2011)
   PUBMED   21737674
  REMARK    GeneRIF: our studies establish the Rit GTPases as critical
            regulators of an evolutionarily conserved, p38 MAPK-dependent
            signaling cascade
REFERENCE   8  (bases 1 to 2699)
  AUTHORS   Hoshino,M., Yoshimori,T. and Nakamura,S.
  TITLE     Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and
            regulate cell transformation
  JOURNAL   J Biol Chem 280 (24), 22868-22874 (2005)
   PUBMED   15831491
  REMARK    GeneRIF: Rin and Rit Bind to PAR6 GTP-dependently and regulate cell
            transformation
REFERENCE   9  (bases 1 to 2699)
  AUTHORS   Shao,H. and Andres,D.A.
  TITLE     A novel RalGEF-like protein, RGL3, as a candidate effector for rit
            and Ras
  JOURNAL   J Biol Chem 275 (35), 26914-26924 (2000)
   PUBMED   10869344
REFERENCE   10 (bases 1 to 2699)
  AUTHORS   Lee,C.H., Della,N.G., Chew,C.E. and Zack,D.J.
  TITLE     Rin, a neuron-specific and calmodulin-binding small G-protein, and
            Rit define a novel subfamily of ras proteins
  JOURNAL   J Neurosci 16 (21), 6784-6794 (1996)
   PUBMED   8824319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134246.4.
            
            On Apr 7, 2022 this sequence version replaced XM_006501160.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1138859.1,
                                           SRR14777535.869949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC134246.4         121937-122231
            296-440             AC134246.4         122416-122560
            441-497             AC134246.4         122692-122748
            498-571             AC134246.4         131085-131158
            572-763             AC134246.4         131370-131561
            764-2699            AC134246.4         134202-136137
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.95 cM"
     gene            1..2699
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /note="Ras-like without CAAX 1"
                     /db_xref="GeneID:19769"
                     /db_xref="MGI:MGI:108053"
     exon            1..295
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..440
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..994
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     GTP-binding protein Rit1; ras-like without CAAX protein 1;
                     RAS-like protein expressed in many tissues"
                     /codon_start=1
                     /product="GTP-binding protein Rit1 isoform 1"
                     /protein_id="NP_001390951.1"
                     /db_xref="GeneID:19769"
                     /db_xref="MGI:MGI:108053"
                     /translation="MESGARPIGSSCSSPAALSREYKLVMLGAGGVGKSAMTMQFISH
                     RFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSI
                     TDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVSKEEGLSLAREFSCPF
                     FETSAAYRYYIDDVFHALVREIRKKEKELVLAMEKKAKPKNSVWKRLKSPFRRKKDSV
                     T"
     exon            441..497
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..571
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..763
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2699
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1317
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /note="major polyA site"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
                     /note="hexamer: AATACA"
     polyA_site      2699
                     /gene="Rit1"
                     /gene_synonym="RIBB; Rit; ROC1"
ORIGIN      
        1 atgccccgcc caccggcgcc atcttccagg acccgggcgg ggccctgggc tgtggggcgc
       61 agctgggaaa ggaacgcggg ttaccacccg gcctcaaagc tggtttcaga ggtacaggct
      121 caggtgaaca gggcgggggg gtgacggtgg cgggaaaggt ggtgaagtgg gggagccacg
      181 gccaccgtga aagaacgtga cagtgtcagg cagcgctctg cactcatccg gctccttcct
      241 actggcacgc tgcctcaatc tgaagtttta agttcttttt agttttctgg aaaaagaggc
      301 ctttcccagg ggcccaggac tgccccggag gacaatggag tccggagctc gccccattgg
      361 tagcagctgt agcagccctg cagcactctc ccgggaatac aaactagtga tgctgggtgc
      421 cggtggagtt gggaagagtg ccatgacaat gcagttcatc agccaccgat tcccagaaga
      481 ccatgacccc accattgaag atgcttataa gatccggatc cgcattgatg atgaacctgc
      541 caatctggac atcctggaca cagcaggaca ggcagagttt acagccatgc gggatcagta
      601 tatgagggca ggagaaggat tcatcatctg ttactccatc acggatcgtc gaagtttcca
      661 cgaagttcgg gagtttaaac aactgattta ccgggtccga cgcaccgatg atacaccggt
      721 ggttcttgtg gggaacaagt ctgacctaaa gcagctgagg caggtctcca aggaagaggg
      781 attgtctctg gctcgagaat tcagttgtcc cttttttgag acctcagctg cctaccgtta
      841 ctacatcgac gacgttttcc acgccctcgt ccgggagatc cgtaagaaag agaaggagct
      901 agtactggcc atggagaaga aggccaaacc caagaacagc gtatggaaga ggctgaagtc
      961 accgttcagg aggaagaaag actcggtcac ctgagtgaag tgggctgtgc tcctgtgaac
     1021 tgcagtgctc cttgtgcctg ctgtgaactg cagtgctccc cagtgcagtc ctgtaatctg
     1081 cagcagggag cacgtcctct gctctctgct atgtggttat tctaaacgtc actggccagg
     1141 ggactcgcct actgagagct gtcattgact tactgtctaa agccctgtgc tccgtgactc
     1201 ccacgcatga actcatcagg gccgtgtcta ctccttaatt gtcacattag aatttggtcg
     1261 gccattgttt tggttatgtt gctgatgtaa atttgtgtaa atggtttcta ccctggagag
     1321 tgtgtgtacc gtgtgcactt gactaaggtc acaacagaac gttgtgttgt attctcccca
     1381 ccacccttca acctgaactt cctgctactg tctcacagaa ggacatctgc gttgtgtagc
     1441 cacactgtgc gtcctggaga cagagcagag attgagtagg gaaactggcg tgaaaggtga
     1501 gcaggcgtct gcggagcgga ttcctgtggt ggaccgtgga gtgcagaggt ttagggagat
     1561 cctgccattg ctcacacaag aagacagagc cggaaacatg cagggtcaga ccagtgttcc
     1621 tacagtgagc cccagaactg cacatttgac ccaaaggcac tcaggtggtg aaaagagaca
     1681 gaagcgtatt tctctctgaa catgcttggc tccccccccc ccccagtgtc tgcctttctt
     1741 tacctgtgag gcctggttct ggatctggga ccattgctgg atgacttgaa tcttagtgaa
     1801 gtcctttgtt gggctatggg ctagcatgtg gctcactgct gtaatgctag tatttcaaag
     1861 tctgaagcag gaggactccc atgaggttga ggttaccctg gcttatggag cgacagcctg
     1921 tctcagagaa acaagagcac aagtaaatga acacaaatcc ttccttagga ccactgcacc
     1981 acaggccttg tccagtgttc tatcccctct gaagagtcag gcgaggcctg atggctttta
     2041 ggcctttcat tcaaccaatg tcattgtcca aacagaagag actcaggagt ctgagtaaaa
     2101 ttgtgttccc ttgccctgag cagtccttag actcagggct tgaaggtctg tggtgtctct
     2161 gtccgatgga gcagtcttaa agctttagtc agcacaggcc tagcaaggcc ctgacagcca
     2221 catcgactga agattgtcaa ggcgatagaa aaccactgcc agaaagacct gtaagaaggg
     2281 atttgttcta tacgaggcaa ctgcagtgag tgcttttaag gctatccctg tcgcacgttg
     2341 gatcctggat aagctagtcc cttcgtttgc gttgagaatt ggcatgcagt gtgtgtgagc
     2401 cgagggcctc ctcagtgttc cacaagcttc aggtcatcag gtcggtccaa ctgaaggcat
     2461 gaaaatcaag tgttccctgg agttttgaag cgaagattca gggacaagtt gaaaggcact
     2521 gaaactgtgt tgaagccaga tgagtaatta taagtaactg taatcggtag ggagacatgt
     2581 tttaacctgg atatgttaga aaagtatcac gtgccacctg ggaagaagtt cttttctggc
     2641 aactgtcaca ctcacacatg aaggcaatcc gtgcagcaca atacaagatg tttaaacaa
//
