LOCUS       NM_133229               1554 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ripply transcriptional repressor 3 (Ripply3), mRNA.
ACCESSION   NM_133229
VERSION     NM_133229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Okubo,T., Hara,K., Azuma,S. and Takada,S.
  TITLE     Effect of retinoic acid signaling on Ripply3 expression and
            pharyngeal arch morphogenesis in mouse embryos
  JOURNAL   Dev Dyn 250 (7), 1036-1050 (2021)
   PUBMED   33452727
  REMARK    GeneRIF: Effect of retinoic acid signaling on Ripply3 expression
            and pharyngeal arch morphogenesis in mouse embryos.
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Hasten,E., McDonald-McGinn,D.M., Crowley,T.B., Zackai,E.,
            Emanuel,B.S., Morrow,B.E. and Racedo,S.E.
  TITLE     Dysregulation of TBX1 dosage in the anterior heart field results in
            congenital heart disease resembling the 22q11.2 duplication
            syndrome
  JOURNAL   Hum Mol Genet 27 (11), 1847-1857 (2018)
   PUBMED   29509905
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Tsuchiya,Y., Mii,Y., Okada,K., Furuse,M., Okubo,T. and Takada,S.
  TITLE     Ripply3 is required for the maintenance of epithelial sheets in the
            morphogenesis of pharyngeal pouches
  JOURNAL   Dev Growth Differ 60 (2), 87-96 (2018)
   PUBMED   29471585
  REMARK    GeneRIF: Ripply3 appears to have been activated to enhance the
            connection between the extracellular matrix and endodermal
            epithelial cells, as a mechanism to resist the mechanical stress
            generated during bending of the epithelial sheets.
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Kawamura,A., Koshida,S. and Takada,S.
  TITLE     Activator-to-repressor conversion of T-box transcription factors by
            the Ripply family of Groucho/TLE-associated mediators
  JOURNAL   Mol Cell Biol 28 (10), 3236-3244 (2008)
   PUBMED   18332117
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Kawamura,A., Koshida,S., Hijikata,H., Ohbayashi,A., Kondoh,H. and
            Takada,S.
  TITLE     Groucho-associated transcriptional repressor ripply1 is required
            for proper transition from the presomitic mesoderm to somites
  JOURNAL   Dev Cell 9 (6), 735-744 (2005)
   PUBMED   16326386
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF170896.1, AK041355.1 and AB063284.1.
            
            On Apr 4, 2008 this sequence version replaced NM_133229.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063284.1, AK041355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CF170896.1         1-12
            13-1523             AK041355.1         3-1513
            1524-1554           AB063284.1         1523-1553
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.17 cM"
     gene            1..1554
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /note="ripply transcriptional repressor 3"
                     /db_xref="GeneID:170765"
                     /db_xref="MGI:MGI:2181192"
     exon            1..176
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..534
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /note="homolog of human Down syndrome critical region gene
                     6 DSCR6; down syndrome critical region protein 6; Down
                     syndrome critical region homolog 6; ripply3 homolog"
                     /codon_start=1
                     /product="protein ripply3"
                     /protein_id="NP_573492.2"
                     /db_xref="CCDS:CCDS28347.1"
                     /db_xref="GeneID:170765"
                     /db_xref="MGI:MGI:2181192"
                     /translation="MRPEAAGVREARGRLCHCPGDDPGRLPLPRGPESSIPAPWRPWM
                     SPPPGDAELTRTERPCESWGDQHTSGSKGAFGFQHPVRLYLPVSKRQEYLQSSGEKVL
                     ASFPVQATIHFYNDDSESGSEEEQEEEAQPNHLQCLEAEVRDSAQEERAE"
     exon            177..252
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /inference="alignment:Splign:2.1.0"
     exon            253..320
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1529
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1510..1515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /note="hexamer: AATAAA"
     polyA_site      1529
                     /gene="Ripply3"
                     /gene_synonym="Dscr6"
                     /note="major polyA site"
ORIGIN      
        1 gagcgggtag gtgagcgcgt tcagccaggg ggaccaggcg ccgtcgggct gagagattcg
       61 cgcgacaccc gcaccatgag accggaggcg gccggagtcc gggaggcgcg gggacgcctc
      121 tgccactgtc cgggggatga tcccgggagg ctaccgctgc cacgcgggcc cgaaagttcc
      181 attccagccc cgtggagacc gtggatgtcg cctccccccg gagatgctga actgaccaga
      241 actgaacgtc cgtgtgagtc ttggggagac caacacacat cgggatcaaa gggagccttt
      301 ggattccagc atcctgtcag actttactta cccgtttcaa agcgtcaaga ataccttcag
      361 agttctgggg aaaaagtgct ggccagcttc ccagtgcaag ccaccattca tttctacaac
      421 gatgactctg agtctggctc tgaggaggaa caagaggagg aggcccagcc caaccacctt
      481 cagtgcctgg aggcagaagt cagggattct gctcaggagg aaagggcaga ataaagctgg
      541 caagcctggg atgaaggagt ggcctccggg aagggtcagc tgcctgcagg tgacactgca
      601 gggggcagcg agagctctag caaatgaagg gagcctctct ctcatgctgg tcactgtgtc
      661 ctggggacag ccttgcctgc caggacccag cctcttctcc agattcctgt gttggaagtt
      721 cagaggttgg actgtgctca gtgcctgctg aggccaggaa ctccactttc ttatttttcc
      781 tgatgtgtgt gtctgactgt atgtctgtct ctgtgtgtct gtctgtgtgt gtgcacacat
      841 gtgctcatgc gtacttttga ggaaaggtgc ctgatgggaa ggtgttctca ggaagaaggc
      901 ctccggatgg agctcactgc tgctctgaaa atgactcctc cctaaacctc accacccctc
      961 tcttgtccag agacccattt tctagtgatt ctcccttcgt aaaaacaatg tagacgttaa
     1021 ctcccatttt aagagttcat ttgcagggct ggagagatgg ctcagcagtt aagagcactg
     1081 actgctcttc cagaggtcct gagttcaatt ctcagcaacc acatggtggc tcccaaccat
     1141 ccgtaatgag atctgatgcc ctcttctggt gtatctgaag acagctacag tgtgcttata
     1201 taaataacat aaataaatct ttggaaaaaa aaaagaagta agaagatatg atctctttag
     1261 gagataaaat agctgtttct gagaactgtg tgtttaagtg tatatgttgt aagggttaat
     1321 tcttattact tggtgaccag cctggtcttg ttatttgcat gaaatgatac tgttaaagtt
     1381 tcttatgtaa gattattttg aattttatta ttttgataac ccaaggactc tgctcctcaa
     1441 acttctccct aattatcttt ctggaatcca tcttcccaca cacaccaccc tgtatgaatt
     1501 tctacttgga ataaaatatt ttgaaagaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
