LOCUS       NM_001037907            1027 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus ripply transcriptional repressor 2 (Ripply2),
            transcript variant 3, mRNA.
ACCESSION   NM_001037907 XM_918212 XM_985855
VERSION     NM_001037907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1027)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   2  (bases 1 to 1027)
  AUTHORS   Zhao,W., Oginuma,M., Ajima,R., Kiso,M., Okubo,A. and Saga,Y.
  TITLE     Ripply2 recruits proteasome complex for Tbx6 degradation to define
            segment border during murine somitogenesis
  JOURNAL   Elife 7, e33068 (2018)
   PUBMED   29761784
  REMARK    GeneRIF: The authors succeeded in reproducing in vivo events using
            a mouse embryonic stem cell induction system, in which Tbx6
            degradation occurred via Ripply2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1027)
  AUTHORS   Warrier,S., Nuwayhid,S., Sabatino,J.A., Sugrue,K.F. and Zohn,I.E.
  TITLE     Supt20 is required for development of the axial skeleton
  JOURNAL   Dev Biol 421 (2), 245-257 (2017)
   PUBMED   27894818
REFERENCE   4  (bases 1 to 1027)
  AUTHORS   Casaca,A., Novoa,A. and Mallo,M.
  TITLE     Hoxb6 can interfere with somitogenesis in the posterior embryo
            through a mechanism independent of its rib-promoting activity
  JOURNAL   Development 143 (3), 437-448 (2016)
   PUBMED   26718008
REFERENCE   5  (bases 1 to 1027)
  AUTHORS   Zhao,W., Ajima,R., Ninomiya,Y. and Saga,Y.
  TITLE     Segmental border is defined by Ripply2-mediated Tbx6 repression
            independent of Mesp2
  JOURNAL   Dev Biol 400 (1), 105-117 (2015)
   PUBMED   25641698
  REMARK    GeneRIF: Ripply2 represses Tbx6 in a Mesp2-independent manner,
            which contributes to the accurate segmental border formation.
REFERENCE   6  (bases 1 to 1027)
  AUTHORS   Dunty,W.C. Jr., Biris,K.K., Chalamalasetty,R.B., Taketo,M.M.,
            Lewandoski,M. and Yamaguchi,T.P.
  TITLE     Wnt3a/beta-catenin signaling controls posterior body development by
            coordinating mesoderm formation and segmentation
  JOURNAL   Development 135 (1), 85-94 (2008)
   PUBMED   18045842
REFERENCE   7  (bases 1 to 1027)
  AUTHORS   Biris,K.K., Dunty,W.C. Jr. and Yamaguchi,T.P.
  TITLE     Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed
            during somitogenesis
  JOURNAL   Dev Dyn 236 (11), 3167-3172 (2007)
   PUBMED   17937396
  REMARK    GeneRIF: findings show that Ripply2 is expressed in the anterior
            presomitic mesoderm and that it lies downstream of Wnt3a; data are
            consistent with Ripply2 functioning as a segment boundary
            determination gene during mammalian embryogenesis
REFERENCE   8  (bases 1 to 1027)
  AUTHORS   Chan,T., Kondow,A., Hosoya,A., Hitachi,K., Yukita,A.,
            Okabayashi,K., Nakamura,H., Ozawa,H., Kiyonari,H., Michiue,T.,
            Ito,Y. and Asashima,M.
  TITLE     Ripply2 is essential for precise somite formation during mouse
            early development
  JOURNAL   FEBS Lett 581 (14), 2691-2696 (2007)
   PUBMED   17531978
  REMARK    GeneRIF: Defects in segmentation of the axial skeleton were
            observed in the ripply2 homozygous mutant mice.
REFERENCE   9  (bases 1 to 1027)
  AUTHORS   Morimoto,M., Sasaki,N., Oginuma,M., Kiso,M., Igarashi,K.,
            Aizaki,K., Kanno,J. and Saga,Y.
  TITLE     The negative regulation of Mesp2 by mouse Ripply2 is required to
            establish the rostro-caudal patterning within a somite
  JOURNAL   Development 134 (8), 1561-1569 (2007)
   PUBMED   17360776
  REMARK    GeneRIF: Ripply2-Mesp2 negative-feedback loop is essential for the
            periodic generation of the rostro-caudal polarity within a somite.
REFERENCE   10 (bases 1 to 1027)
  AUTHORS   Kawamura,A., Koshida,S., Hijikata,H., Ohbayashi,A., Kondoh,H. and
            Takada,S.
  TITLE     Groucho-associated transcriptional repressor ripply1 is required
            for proper transition from the presomitic mesoderm to somites
  JOURNAL   Dev Cell 9 (6), 735-744 (2005)
   PUBMED   16326386
  REMARK    GeneRIF: Compares Ripply proteins in zebrafish, mouse, human, and
            amphioxus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156793.3.
            
            On Mar 27, 2020 this sequence version replaced NM_001037907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB212223.1, SRR7345562.1007561.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC156793.3         64035-64128         c
            95-173              AC156793.3         63719-63797         c
            174-238             AC156793.3         63331-63395         c
            239-1027            AC156793.3         59224-60012         c
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.69 cM"
     gene            1..1027
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="ripply transcriptional repressor 2"
                     /db_xref="GeneID:382089"
                     /db_xref="MGI:MGI:2685968"
     exon            1..94
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..395
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein ripply2; ripply2 homolog"
                     /codon_start=1
                     /product="protein ripply2 isoform 3"
                     /protein_id="NP_001032996.1"
                     /db_xref="CCDS:CCDS40715.1"
                     /db_xref="GeneID:382089"
                     /db_xref="MGI:MGI:2685968"
                     /translation="MDTTESAESAHNPARPPSRSRCPPSAQPGSEGFWRPWVRTPGEK
                     EKRTGPRAAEALPSGPGMAEASGKLLQYQHPVRLFWPKSKCYDYLYQEAETLLKNFPI
                     QATISFYEDSDSEDEIEGLACENQSN"
     exon            95..173
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /inference="alignment:Splign:2.1.0"
     exon            174..238
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /inference="alignment:Splign:2.1.0"
     exon            239..1027
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /inference="alignment:Splign:2.1.0"
     regulatory      476..481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="hexamer: AATAAA"
     polyA_site      495
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="major polyA site"
     regulatory      1001..1006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="hexamer: ATTAAA"
     polyA_site      1027
                     /gene="Ripply2"
                     /gene_synonym="C030002E08Rik; Gm1122"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgccat ggataccacc gagagcgccg agagcgcgca caacccagca cgtccgccct
       61 cgcgcagccg ctgcccgccg tccgcgcagc ccgggtccga gggcttctgg agaccgtggg
      121 ttcgaactcc tggagagaaa gagaagcgga cggggccccg tgctgcagag gcgttgccca
      181 gtggcccagg aatggcagaa gcttccggga agcttttgca ataccaacac cctgtcaggc
      241 tattctggcc caagtccaag tgttacgact acttatatca agaagcagaa actcttctga
      301 aaaatttccc aattcaagct acaatttcgt tttatgaaga ttctgatagt gaagatgaaa
      361 tagaggggct ggcctgtgaa aatcaatcta attagttact tctgttgaca atttgaattt
      421 tgtatataaa tgtaccataa acttttaaaa ctaatttatt tgtatataca ttattaataa
      481 aacattttgt aataattaca gtatttggaa tcctctttgt ccctacacta gaattaaatg
      541 ttgggatttt aagatagaca tcatgtacaa atgtcctgat tgtgttataa atatttgtga
      601 ttcacaaaga atacttctgg tttttttttt attaaatcac aaatttatct ttagttataa
      661 tttttcaagg aactatttgg tttttttaaa agaccggctc ttgtaatgtc tggtgttttc
      721 tgctgatctc aattggatgt ttagttacag atgatataat cttggcagtt agtgaggaaa
      781 actgggtgct gctactattc tcacggatat tagtatttgt ttgcttgctc atagggaaat
      841 gctttaagta attatagttg agaaagaaaa acaatcttgg gtcacttaaa tcttaaggac
      901 tgtaattaag tatggagtag tgtgactctc actctgatat tctcctgttg tctttaatct
      961 ggtgttcagt actttctgta tatgttgaag gattcctata attaaaaaaa aaaggtttaa
     1021 atttgaa
//
