LOCUS       NM_023663               3583 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus receptor-interacting serine-threonine kinase 4
            (Ripk4), mRNA.
ACCESSION   NM_023663
VERSION     NM_023663.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Wronski,N., Madej,E., Grabacka,M., Brozyna,A.A. and
            Wolnicka-Glubisz,A.
  TITLE     RIPK4 downregulation impairs Wnt3A-stimulated invasiveness via
            Wnt/beta-catenin signaling in melanoma cells and tumor growth in
            vivo
  JOURNAL   Cell Signal 113, 110938 (2024)
   PUBMED   37871667
  REMARK    GeneRIF: RIPK4 downregulation impairs Wnt3A-stimulated invasiveness
            via Wnt/beta-catenin signaling in melanoma cells and tumor growth
            in vivo.
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Yan,Y., Gauthier,M.A., Malik,A., Fotiadou,I., Ostrovski,M.,
            Dervovic,D., Ghadban,L., Tsai,R., Gish,G., Loganathan,S.K. and
            Schramek,D.
  TITLE     The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma
  JOURNAL   Cancers (Basel) 15 (3), 737 (2023)
   PUBMED   36765696
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Loganathan,S.K., Schleicher,K., Malik,A., Quevedo,R., Langille,E.,
            Teng,K., Oh,R.H., Rathod,B., Tsai,R., Samavarchi-Tehrani,P.,
            Pugh,T.J., Gingras,A.C. and Schramek,D.
  TITLE     Rare driver mutations in head and neck squamous cell carcinomas
            converge on NOTCH signaling
  JOURNAL   Science 367 (6483), 1264-1269 (2020)
   PUBMED   32165588
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Oberbeck,N., Pham,V.C., Webster,J.D., Reja,R., Huang,C.S.,
            Zhang,Y., Roose-Girma,M., Warming,S., Li,Q., Birnberg,A., Wong,W.,
            Sandoval,W., Komuves,L.G., Yu,K., Dugger,D.L., Maltzman,A.,
            Newton,K. and Dixit,V.M.
  TITLE     The RIPK4-IRF6 signalling axis safeguards epidermal differentiation
            and barrier function
  JOURNAL   Nature 574 (7777), 249-253 (2019)
   PUBMED   31578523
  REMARK    GeneRIF: results explain how RIPK4 and IRF6 function to ensure the
            integrity of the epidermis and provide mechanistic insights into
            why developmental syndromes that are characterized by orofacial,
            skin and genital abnormalities result when this axis goes awry
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Muto,A., Ruland,J., McAllister-Lucas,L.M., Lucas,P.C., Yamaoka,S.,
            Chen,F.F., Lin,A., Mak,T.W., Nunez,G. and Inohara,N.
  TITLE     Protein kinase C-associated kinase (PKK) mediates Bcl10-independent
            NF-kappa B activation induced by phorbol ester
  JOURNAL   J Biol Chem 277 (35), 31871-31876 (2002)
   PUBMED   12091384
  REMARK    GeneRIF: a member of the RICK/RIP family of kinases, which is
            involved in a PKC-activated NF-kappa B signaling pathway that is
            independent of Bcl10 and IKK gamma
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Holland,P., Willis,C., Kanaly,S., Glaccum,M., Warren,A.,
            Charrier,K., Murison,J., Derry,J., Virca,G., Bird,T. and Peschon,J.
  TITLE     RIP4 is an ankyrin repeat-containing kinase essential for
            keratinocyte differentiation
  JOURNAL   Curr Biol 12 (16), 1424-1428 (2002)
   PUBMED   12194825
  REMARK    GeneRIF: Data show that RIP4 is a critical component of a novel
            pathway that controls keratinocyte differentiation.
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Chen,L., Haider,K., Ponda,M., Cariappa,A., Rowitch,D. and Pillai,S.
  TITLE     Protein kinase C-associated kinase (PKK), a novel
            membrane-associated, ankyrin repeat-containing protein kinase
  JOURNAL   J Biol Chem 276 (24), 21737-21744 (2001)
   PUBMED   11278382
REFERENCE   10 (bases 1 to 3583)
  AUTHORS   Akeson,E.C., Lambert,J.P., Narayanswami,S., Gardiner,K.,
            Bechtel,L.J. and Davisson,M.T.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121560.17.
            
            On Apr 20, 2018 this sequence version replaced NM_023663.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057871.1, AK145203.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC121560.17        68999-69250         c
            253-544             AC121560.17        60539-60830         c
            545-693             AC121560.17        56965-57113         c
            694-743             AC121560.17        55564-55613         c
            744-902             AC121560.17        53494-53652         c
            903-1006            AC121560.17        52764-52867         c
            1007-1271           AC121560.17        51331-51595         c
            1272-3583           AC121560.17        47404-49715         c
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.63 cM"
     gene            1..3583
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /note="receptor-interacting serine-threonine kinase 4"
                     /db_xref="GeneID:72388"
                     /db_xref="MGI:MGI:1919638"
     exon            1..252
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2431
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /EC_number="2.7.11.1"
                     /note="PKC-regulated protein kinase; PKC-associated
                     protein kinase; ankyrin repeat domain-containing protein
                     3"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 4"
                     /protein_id="NP_076152.2"
                     /db_xref="CCDS:CCDS28360.1"
                     /db_xref="GeneID:72388"
                     /db_xref="MGI:MGI:1919638"
                     /translation="MEGEGRGRWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHW
                     KTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETG
                     SLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKIS
                     DFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLT
                     QKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTF
                     QEITSETEDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLKRASAPPFDNDCSL
                     SELLSQLDSGISQTLEGPEELSRSSSECKLPSSSSGKRLSGVSSVDSAFSSRGSLSLS
                     FEREASTGDLGPTDIQKKKLVDAIISGDTSRLMKILQPQDVDLVLDSSASLLHLAVEA
                     GQEECVKWLLLNNANPNLTNRKGSTPLHMAVERKGRGIVELLLARKTSVNAKDEDQWT
                     ALHFAAQNGDEASTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRTLLRRGVDVG
                     LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI
                     LIDLCSDVNICSLQAQTPLHVAAETGHTSTARLLLHRGAGKEALTSEGYTALHLAAQN
                     GHLATVKLLIEEKADVMARGPLNQTALHLAAARGHSEVVEELVSADLIDLSDEQGLSA
                     LHLAAQGRHSQTVETLLKHGAHINLQSLKFQGGQSSAATLLRRSKT"
     exon            253..544
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..693
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..743
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..902
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1006
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1271
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..3583
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /note="hexamer: AATAAA"
     polyA_site      3583
                     /gene="Ripk4"
                     /gene_synonym="2310069J12Rik; ANKK2; Ankrd3; DIk; PKK;
                     RIP4"
                     /note="major polyA site"
ORIGIN      
        1 agcgggcggg gcatgcacct gagcacctgg gcggacacgg ttgagccagg ctgcttgcga
       61 tacgcacgcg atggagggcg agggccgggg ccggtgggct ctggggctgc tgcgcacctt
      121 cgacgccggc gaattcgcag gctgggagaa ggtgggctcg ggcggcttcg ggcaggtgta
      181 caaggtgcgc catgtgcact ggaagacgtg gctcgcgatc aagtgctcgc ccagtctgca
      241 cgtcgacgac agggaacgaa tggagctcct ggaggaagct aagaagatgg agatggccaa
      301 gttccgatac attctacctg tgtacggcat atgccaggaa cctgtcggct tggtcatgga
      361 gtacatggag acaggctccc tggagaagct gctggcctca gagccattgc cttgggacct
      421 gcgctttcgc atcgtgcacg agacagccgt gggcatgaac ttcctgcatt gcatgtctcc
      481 gccactgctg cacctagacc tgaagccagc gaacatcctg ctggatgccc actaccatgt
      541 caagatttct gactttgggc tggccaagtg caatggcatg tcccactctc atgacctcag
      601 catggatggc ctgtttggta caatcgctta cctccctcca gagcgaattc gtgagaagag
      661 ccgcttgttt gacaccaaac atgatgtata cagcttcgcc attgtgatct ggggtgtgct
      721 tacacagaag aagccatttg cagatgaaaa gaacatccta cacatcatga tgaaagtggt
      781 aaagggccac cgcccagagc tgccacccat ctgcagaccc cggccgcgtg cctgtgccag
      841 cctgataggg ctcatgcaac ggtgctggca tgcagaccca caggtgcggc ccaccttcca
      901 agaaattacc tctgaaacag aagacctttg tgagaagcct gatgaggagg tgaaagacct
      961 ggctcatgag ccaggcgaga aaagctctct agagtccaag agtgaggcca ggcccgagtc
     1021 ctcacgcctc aagcgcgcct ctgctccccc cttcgataac gactgcagtc tctccgagtt
     1081 gctgtcacag ttggactctg ggatctccca gactcttgaa ggccccgaag agctcagccg
     1141 aagttcctct gaatgcaagc tcccatcgtc cagcagtggc aagaggctct cgggggtgtc
     1201 ctcagtggac tcagcctttt cctccagagg atcgctgtca ctgtcttttg agcgggaagc
     1261 ttcaacaggc gacctgggcc ccacagacat ccagaagaag aagctagtgg atgccatcat
     1321 atcaggggac accagcaggc tgatgaagat cctacagccc caagatgtgg acttggttct
     1381 agacagcagt gccagcctgc tgcacctggc tgtggaggcc ggacaggagg agtgtgtcaa
     1441 gtggctgctg cttaacaatg ccaaccccaa cctgaccaac aggaagggct ctacaccact
     1501 gcatatggct gtggagcgga agggacgtgg aattgtggag ctactgctag cccggaagac
     1561 cagtgtcaat gccaaggatg aagaccagtg gactgccctg cactttgcag cccagaatgg
     1621 ggatgaggcc agcacaaggc tgctgctaga gaagaatgct tctgtcaatg aggtggactt
     1681 tgagggccga acacccatgc atgtagcctg ccagcatgga caggagaaca ttgtgcgcac
     1741 cctgctccgc cgtggtgtgg atgtgggcct gcagggaaag gatgcctggt tgcctctgca
     1801 ctatgctgcc tggcagggcc accttcccat tgttaagctg ctagccaagc agcctggggt
     1861 gagtgtgaat gcccagacac tagacgggag gacacccctg cacctggctg ctcagagggg
     1921 gcattaccgt gtggctcgca ttctcattga cctgtgctct gatgttaaca tctgcagcct
     1981 acaggcacag acacctctgc atgttgctgc agagactgga cacactagta ctgccaggct
     2041 actcttgcat cgtggtgctg gcaaggaggc tttgacctca gagggctata ctgccttgca
     2101 cctggcagcc cagaatggac acctggctac tgtcaagctg ctcatagagg agaaggctga
     2161 tgtgatggct cggggtcccc tgaatcagac agcactgcac ctggctgctg cccgtggaca
     2221 ctcagaggtg gtagaagagc tggtcagtgc tgacctcatt gacctgtctg atgagcaggg
     2281 cctcagcgca ctgcacctgg ctgctcaggg caggcattca cagactgtgg agacactgct
     2341 caaacatgga gcacacatca acttgcagag tctcaagttc caaggaggcc agagctctgc
     2401 tgccacgttg ctccgacgca gcaagaccta gcttgccacc acaaaaccag ggctccgtgt
     2461 aggcttctgg accatccttg tttcctcatg gggacagaat ggtcctggga cactgctcac
     2521 cctgttggtg gcctgcccat acactgacca agcagaggct aatggacaag gcaggagtag
     2581 ctgtcttggg gcacagtagc caaagtgtct gatgtcagat gggactaggt tggtgtcatg
     2641 tcactgtggt attgattggc tgctgatgca ggccttttat gacaaagcct atacaagaat
     2701 gtctcctctg tccatagagc aagccatttc tgcttgcttg gagcatgaca tcttcagtag
     2761 agatgtggga agggcagtgt cctttgtctt ctcattgtga tgggcagagt agctgtctct
     2821 gaaggcatag tgggttctta atatatgagt gacatggtag ctttgcttga gacctgtgag
     2881 gatctggctg ctggagtcta gaaagggagt gattataaag ccacagggtt ggtcctaaca
     2941 ctggacagcc ttgccaacat gaaactgctg tttcatttgg tattttggtt ttggttttta
     3001 gttttgatgt ctaggtcacc atgcctcgtt cccccgattt ccctgctgag ttctcagcta
     3061 aaatgtcaga gccatatata taaaagttac cggaaatttt tttgtaaatg ggttttatac
     3121 taaaagttgt ttagtcaaac agtttgctct ttcaggctct cttggtgaag tgatggtttg
     3181 ggccaagggc tttgctgact tgccctttag caacttctgc tatgttccag ttacagtaga
     3241 tgaatgtggg cagaggtggc cattggagat tgttgtactc tgaggagtca gattcgatag
     3301 ccttttgttg taccttcccc atttctgttc tgaacactgt cactgtagag atgacctgtg
     3361 tgcaaacatg ctatagcatg gtatgtgaca cagaatgata ttaatgtact gtgtactttg
     3421 acatgaatca tggacaggat actctttcat gacaggaagt agtggagctg gctatgtttt
     3481 aatatgcctc aatttgtctt cactgcttcc ctctcttgtg taaaacacgg ggaccatagg
     3541 agatctgttt tatgtcaata aaggactccg cctacttttg gaa
//
