LOCUS       NM_019955               1899 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus receptor-interacting serine-threonine kinase 3
            (Ripk3), transcript variant 1, mRNA.
ACCESSION   NM_019955
VERSION     NM_019955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1899)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 1899)
  AUTHORS   Hanggi,K., Li,J., Gangadharan,A., Liu,X., Celias,D.P.,
            Osunmakinde,O., Keske,A., Davis,J., Ahmad,F., Giron,A.,
            Anadon,C.M., Gardner,A., DeNardo,D.G., Shaw,T.I., Beg,A.A., Yu,X.
            and Ruffell,B.
  TITLE     Interleukin-1alpha release during necrotic-like cell death
            generates myeloid-driven immunosuppression that restricts
            anti-tumor immunity
  JOURNAL   Cancer Cell 42 (12), 2015-2031 (2024)
   PUBMED   39577420
REFERENCE   3  (bases 1 to 1899)
  AUTHORS   Sun,Y., Ji,L., Liu,W., Sun,J., Liu,P., Wang,X., Liu,X. and Xu,X.
  TITLE     Influenza virus infection activates TAK1 to suppress
            RIPK3-independent apoptosis and RIPK1-dependent necroptosis
  JOURNAL   Cell Commun Signal 22 (1), 372 (2024)
   PUBMED   39044278
  REMARK    GeneRIF: Influenza virus infection activates TAK1 to suppress
            RIPK3-independent apoptosis and RIPK1-dependent necroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1899)
  AUTHORS   Mannion,J., Gifford,V., Bellenie,B., Fernando,W., Ramos Garcia,L.,
            Wilson,R., John,S.W., Udainiya,S., Patin,E.C., Tiu,C., Smith,A.,
            Goicoechea,M., Craxton,A., Moraes de Vasconcelos,N., Guppy,N.,
            Cheung,K.J., Cundy,N.J., Pierrat,O., Brennan,A., Roumeliotis,T.I.,
            Benstead-Hume,G., Alexander,J., Muirhead,G., Layzell,S., Lyu,W.,
            Roulstone,V., Allen,M., Baldock,H., Legrand,A., Gabel,F.,
            Serrano-Aparicio,N., Starling,C., Guo,H., Upton,J., Gyrd-Hansen,M.,
            MacFarlane,M., Seddon,B., Raynaud,F., Roxanis,I., Harrington,K.,
            Haider,S., Choudhary,J.S., Hoelder,S., Tenev,T. and Meier,P.
  TITLE     A RIPK1-specific PROTAC degrader achieves potent antitumor activity
            by enhancing immunogenic cell death
  JOURNAL   Immunity 57 (7), 1514-1532 (2024)
   PUBMED   38788712
REFERENCE   5  (bases 1 to 1899)
  AUTHORS   Gitlin,A.D., Maltzman,A., Kanno,Y., Heger,K., Reja,R.,
            Schubert,A.F., Wierciszewski,L.J., Pantua,H., Kapadia,S.B.,
            Harris,S.F., Webster,J.D., Newton,K. and Dixit,V.M.
  TITLE     N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB
            kinase family to limit Toll-like receptor signaling and
            inflammation
  JOURNAL   Immunity 57 (5), 973-986 (2024)
   PUBMED   38697117
REFERENCE   6  (bases 1 to 1899)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1899)
  AUTHORS   Li,M., Feng,S. and Wu,M.
  TITLE     Multiple roles for nuclear localization signal (NLS, aa 442-472) of
            receptor interacting protein 3 (RIP3)
  JOURNAL   Biochem Biophys Res Commun 372 (4), 850-855 (2008)
   PUBMED   18533105
REFERENCE   8  (bases 1 to 1899)
  AUTHORS   Meylan,E., Burns,K., Hofmann,K., Blancheteau,V., Martinon,F.,
            Kelliher,M. and Tschopp,J.
  TITLE     RIP1 is an essential mediator of Toll-like receptor 3-induced
            NF-kappa B activation
  JOURNAL   Nat Immunol 5 (5), 503-507 (2004)
   PUBMED   15064760
REFERENCE   9  (bases 1 to 1899)
  AUTHORS   Newton,K., Sun,X. and Dixit,V.M.
  TITLE     Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the
            B-cell and T-cell receptors, tumor necrosis factor receptor 1, and
            Toll-like receptors 2 and 4
  JOURNAL   Mol Cell Biol 24 (4), 1464-1469 (2004)
   PUBMED   14749364
  REMARK    GeneRIF: RIP3 is not an essential modulator of NF-kappa B signaling
            downstream of several receptor systems
REFERENCE   10 (bases 1 to 1899)
  AUTHORS   Pazdernik,N.J., Donner,D.B., Goebl,M.G. and Harrington,M.A.
  TITLE     Mouse receptor interacting protein 3 does not contain a
            caspase-recruiting or a death domain but induces apoptosis and
            activates NF-kappaB
  JOURNAL   Mol Cell Biol 19 (10), 6500-6508 (1999)
   PUBMED   10490590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012177.1, BY209344.1, AC098877.3, AA270784.1 and BF658559.1.
            
            On Aug 19, 2009 this sequence version replaced NM_019955.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029210.1, AF178953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AK012177.1         1-241
            242-385             BY209344.1         203-346
            386-782             AK012177.1         369-765
            783-820             AC098877.3         103129-103166       c
            821-966             AK012177.1         802-947
            967-1490            AA270784.1         57-580
            1491-1882           AK012177.1         1464-1855
            1883-1899           BF658559.1         309-325
FEATURES             Location/Qualifiers
     source          1..1899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1899
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /note="receptor-interacting serine-threonine kinase 3"
                     /db_xref="GeneID:56532"
                     /db_xref="MGI:MGI:2154952"
     exon            1..241
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1682
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     receptor-interacting serine/threonine-protein kinase 3;
                     RIP-like protein kinase 3; RIP-3; mRIP3; receptor
                     interacting protein 3"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 3 isoform 1"
                     /protein_id="NP_064339.2"
                     /db_xref="CCDS:CCDS27131.1"
                     /db_xref="GeneID:56532"
                     /db_xref="MGI:MGI:2154952"
                     /translation="MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTW
                     NHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGS
                     LAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLA
                     DFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGILVWA
                     VLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSE
                     NRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNLSAREPSQRGTEMDC
                     PRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVAGTPQIPHT
                     LPFRGTTPGPVFTETPGPHPQRNQGDGRHGTPWYPWTPPNPMTGPPALVFNNCSEVQI
                     GNYNSLVAPPRTTASSSAKYDQAQFGRGRGWQPFHK"
     exon            242..385
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..695
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..853
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..900
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1068
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1136
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1469
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1527
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1884
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /note="hexamer: AATAAA"
     polyA_site      1884
                     /gene="Ripk3"
                     /gene_synonym="2610528K09Rik; Rip3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctctt atttgaaagg gaagttgtga agtcgctcat tcaaagtccg ggggagcgac
       61 ctgggaagcg gaattcgggg cctgaacctc cgtgccttga cctactgatt gttccctttg
      121 cagaccctgc cttcctctca gtccacactc cgagccgtag acgtcgggtt tccagctccg
      181 tctgtgcaca cataactcca ggaagccgct agctcccgac gatgtcttct gtcaagttat
      241 ggcctactgg tgcgtcagcg gttcctctgg tgagccgtga agaactgaag aagctggagt
      301 ttgtgggtaa aggagggttc ggagtcgtgt tccgggcaca ccacagaaca tggaaccatg
      361 atgtagcagt caagatcgtg aactcgaaga agatatcctg ggaggtgaag gctatggtta
      421 atcttcgtaa tgagaacgtt ctgctcctgc tgggggtcac tgaggacctc cagtgggact
      481 tcgtgtccgg gcaggctctg gtgacaagat tcatggagaa tggctccctc gcagggctgc
      541 tgcaacccga gtgccctcgg ccctggccac tcctctgtcg cctgctgcag gaagtggtgc
      601 tggggatgtg ctacctacac agcttgaacc ctccgctcct gcaccgggac ctcaagccct
      661 ctaacattct gctggatcca gagctccacg ccaagctagc agattttggc ctgtccacgt
      721 ttcagggagg gtcccagtca gggtcaggat caggatcagg atccagggac tctgggggca
      781 ccctagcgta cttggaccca gagctgttat ttgatgtcaa cctgaaggct tctaaagcga
      841 gtgatgtcta cagctttggg atcctcgtgt gggcagtgct ggctggcaga gaagctgagt
      901 tggtagacaa gacttcacta atccgggaaa cagtgtgtga caggcagagt cgtcctccac
      961 tgacagagct gcctccaggt agccctgaga ctcccggctt ggaaaaactg aaggagttaa
     1021 tgattcattg ctggggttcc cagtccgaaa acaggccatc cttccaggac tgcgaaccaa
     1081 aaaccaatga agtttacaat ctggtaaagg acaaggtaga tgctgctgtc tccgaggtaa
     1141 agcattatct gtctcagcac agaagcagcg gcagaaactt gtctgccaga gagccaagcc
     1201 aaagaggcac agaaatggat tgcccgaggg aaaccatggt ttctaaaatg ctggaccgcc
     1261 tgcatttgga ggaaccctcc ggaccagttc ctggaaaatg tcctgagagg caagcacagg
     1321 acacatcagt tgggcctgcc acaccagcaa ggacatcttc tgaccccgtg gctggcactc
     1381 ctcagattcc acatacttta cccttcagag gcacaacacc tgggccagtc tttactgaga
     1441 ctcccggtcc tcacccccaa aggaatcagg gagatggaag acacggcact ccttggtatc
     1501 cctggacccc accgaatcca atgacagggc caccggctct cgtcttcaac aactgttctg
     1561 aagtgcagat tgggaactac aactccttgg tagcaccacc aagaactact gcctcaagtt
     1621 cggccaagta tgaccaagca cagttcggca ggggtagggg ctggcagccc ttccacaagt
     1681 agacttcaga gaatcactgc aagagcctga agtgtgccat tcagcgtggc aataaaaagc
     1741 acgttttaag caacctggac tggctaagac agtccttgcc acttcctgaa gctcacaaca
     1801 ttctgtgagg acagttggac ctacacccaa actgactctt gacccatctc cttaaagtca
     1861 ataaacatag catgttaact gtgaaaaaaa aaaaaaaaa
//
