LOCUS       NM_138952               2702 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus receptor (TNFRSF)-interacting serine-threonine kinase
            2 (Ripk2), transcript variant 1, mRNA.
ACCESSION   NM_138952
VERSION     NM_138952.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2702)
  AUTHORS   Lu,K., Li,Y. and Xiao,H.
  TITLE     LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive
            Disorder Model via RIP2 Expression through ROS-NOD2 Induction
  JOURNAL   Altern Ther Health Med 30 (8), 202-207 (2024)
   PUBMED   38064597
  REMARK    GeneRIF: LACC1 Promoted Nerve Injury in an Anesthesia-Induced
            Cognitive Disorder Model via RIP2 Expression through ROS-NOD2
            Induction.
REFERENCE   2  (bases 1 to 2702)
  AUTHORS   Larochelle,J., Howell,J.A., Yang,C., Liu,L., Gunraj,R.E.,
            Stansbury,S.M., de Oliveira,A.C.P., Baksh,S. and
            Candelario-Jalil,E.
  TITLE     Pharmacological inhibition of receptor-interacting protein kinase 2
            (RIPK2) elicits neuroprotective effects following experimental
            ischemic stroke
  JOURNAL   Exp Neurol 377, 114812 (2024)
   PUBMED   38729551
  REMARK    GeneRIF: Pharmacological inhibition of receptor-interacting protein
            kinase 2 (RIPK2) elicits neuroprotective effects following
            experimental ischemic stroke.
REFERENCE   3  (bases 1 to 2702)
  AUTHORS   Larochelle,J., Tishko,R.J., Yang,C., Ge,Y., Phan,L.T., Gunraj,R.E.,
            Stansbury,S.M., Liu,L., Mohamadzadeh,M., Khoshbouei,H. and
            Candelario-Jalil,E.
  TITLE     Receptor-interacting protein kinase 2 (RIPK2) profoundly
            contributes to post-stroke neuroinflammation and behavioral
            deficits with microglia as unique perpetrators
  JOURNAL   J Neuroinflammation 20 (1), 221 (2023)
   PUBMED   37777791
  REMARK    GeneRIF: Receptor-interacting protein kinase 2 (RIPK2) profoundly
            contributes to post-stroke neuroinflammation and behavioral
            deficits with microglia as unique perpetrators.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2702)
  AUTHORS   Le,L., Shan,H., Lin,Y., Xia,W., Ma,X., Jiang,C., Shi,Z. and Xu,Y.
  TITLE     The Ubiquitination of RIPK2 is Mediated by Peli3 and Negatively
            Regulates the Onset of Infectious Osteomyelitis
  JOURNAL   Jpn J Infect Dis 76 (4), 240-245 (2023)
   PUBMED   37121674
  REMARK    GeneRIF: The Ubiquitination of RIPK2 is Mediated by Peli3 and
            Negatively Regulates the Onset of Infectious Osteomyelitis.
REFERENCE   5  (bases 1 to 2702)
  AUTHORS   Chen,Y., Wan,Y., Shan,H., Lin,Y., Xia,W., Yin,F., Jiang,C. and
            Shi,Z.
  TITLE     Ubiquitin-Specific Peptidase 8 Is Critical for the Onset of
            Infectious Osteomyelitis by Targeting RIPK2 Ubiquitination
  JOURNAL   Jpn J Infect Dis 76 (3), 197-203 (2023)
   PUBMED   36858599
  REMARK    GeneRIF: Ubiquitin-Specific Peptidase 8 Is Critical for the Onset
            of Infectious Osteomyelitis by Targeting RIPK2 Ubiquitination.
REFERENCE   6  (bases 1 to 2702)
  AUTHORS   Humphries,F., Yang,S., Wang,B. and Moynagh,P.N.
  TITLE     RIP kinases: key decision makers in cell death and innate immunity
  JOURNAL   Cell Death Differ 22 (2), 225-236 (2015)
   PUBMED   25146926
  REMARK    Review article
REFERENCE   7  (bases 1 to 2702)
  AUTHORS   Chin,A.I., Dempsey,P.W., Bruhn,K., Miller,J.F., Xu,Y. and Cheng,G.
  TITLE     Involvement of receptor-interacting protein 2 in innate and
            adaptive immune responses
  JOURNAL   Nature 416 (6877), 190-194 (2002)
   PUBMED   11894097
REFERENCE   8  (bases 1 to 2702)
  AUTHORS   Inohara,N., del Peso,L., Koseki,T., Chen,S. and Nunez,G.
  TITLE     RICK, a novel protein kinase containing a caspase recruitment
            domain, interacts with CLARP and regulates CD95-mediated apoptosis
  JOURNAL   J Biol Chem 273 (20), 12296-12300 (1998)
   PUBMED   9575181
  REMARK    Erratum:[J Biol Chem 1998 Jul 17;273(29):18675]
REFERENCE   9  (bases 1 to 2702)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 2702)
  AUTHORS   Corradi,A., Croci,L., Stayton,C.L., Gulisano,M., Boncinelli,E. and
            Consalez,G.G.
  TITLE     cDNA sequence, map, and expression of the murine homolog of GTBP, a
            DNA mismatch repair gene
  JOURNAL   Genomics 36 (2), 288-295 (1996)
   PUBMED   8812455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC058088.1 and AL807379.17.
            
            On Jul 28, 2016 this sequence version replaced NM_138952.3.
            
            Summary: This gene encodes a member of the receptor-interacting
            protein family of serine/threonine protein kinases. The encoded
            protein contains a C-terminal caspase activation and recruitment
            domain, and is a component of signaling complexes in both the
            innate and adaptive immune pathways. It is a potent activator of
            nuclear factor kappa B and inducer of apoptosis in response to
            various stimuli. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159593.1, BC069878.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BC058088.1         1-145
            146-420             AL807379.17        137120-137394       c
            421-574             AL807379.17        132173-132326       c
            575-730             AL807379.17        128931-129086       c
            731-888             AL807379.17        125813-125970       c
            889-938             AL807379.17        113101-113150       c
            939-1100            AL807379.17        111970-112131       c
            1101-1186           AL807379.17        106673-106758       c
            1187-1273           AL807379.17        102919-103005       c
            1274-1367           AL807379.17        101517-101610       c
            1368-1529           AL807379.17        98321-98482         c
            1530-2046           AL807379.17        97271-97787         c
            2047-2702           BC058088.1         2171-2826
FEATURES             Location/Qualifiers
     source          1..2702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.7 cM"
     gene            1..2702
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /note="receptor (TNFRSF)-interacting serine-threonine
                     kinase 2"
                     /db_xref="GeneID:192656"
                     /db_xref="MGI:MGI:1891456"
     exon            1..420
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..574
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..730
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..888
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..938
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1100
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1186
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1273
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1367
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1529
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..2680
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /note="hexamer: AGTAAA"
     polyA_site      2046
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /note="major polyA site"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2678
                     /gene="Ripk2"
                     /gene_synonym="2210420D18Rik; CARD3; CARDIAK; CCK;
                     D4Bwg0615e; RICK; RIP2"
ORIGIN      
        1 aggggtagga ggcaggggct gaggagttgg tgaaggtagg agcccgccca gggagggccg
       61 gcggagggag gagcccgccg agtccaggag gagggaggag gacggtccac cccggcgcgg
      121 ccgcagaccc gacgggctcc ctggcacagc tgaccgggcc ggaactgcag cggccacgcg
      181 ggaatgggcc gccccgggac ctagcgccgc ggccagggtc gggcggagcc gccgcgcagc
      241 cggagccatg aacggggacg ccatctgcag cgcgctaccc cccatcccgt accacaagct
      301 cgccgacctg cactacctca gccggggcgc ctctggcacg gtctcgtcgg cacgacacgc
      361 agactggcgc gtgcgggtgg cagtgaagca cctacacatc cacacgccgc tgctcgacag
      421 tgaaagaaat gatatcttac gagaagccga aatattacat aaagcaagat ttagttacat
      481 tcttccaatt ttgggaattt gcaatgagcc tgaatttttg ggcatagtta ctgaatacat
      541 gccaaatgga tcattaaatg agcttctaca cagaaaaact gaatatcctg atattgcatg
      601 gccattgaga ttccgcatcc tgcatgaaat tgctcttggt gtaaattatc tgcacaatat
      661 gaacccccct ctgcttcatc atgacctaaa gactcagaat atcttgttgg ataatgaatt
      721 tcatgttaag attgcagatt ttggtttatc aaaatggcgc atgatgtcac tctctcaatc
      781 acgaagttac aaatctgcac ccgaaggagg aacaatcatc tatatgccac ctgagaacta
      841 tgagccagga cagaaatcaa gggccagtgt gaagcatgat atatacagct atgcagttat
      901 catgtgggaa gtgttatcca gaaaacagcc ttttgaagag gtcaccaatc ctttgcagat
      961 catgtacagt gtgtcccagg gacatcgacc tgacaccagt gaggagaatt tgccatttga
     1021 tatacctcat cgaggtctca tgatctctct aatacagagt ggatgggcgc aaaacccaga
     1081 tgaaagacca tcctttttga aatgcttaat agaacttgaa ccagttctga gaacatttga
     1141 agacataact ttccttgagg ctgttattca gctaaagaaa gcaaagatac agagttcctc
     1201 aagtactatt cacttatgtg ataagaaaat ggatttatcg ctaaacatac ctgcaaatca
     1261 tcccccacag gaggaatcgt gtggatcctc tctgctctct agaaacactg gttctcctgg
     1321 accctccaga tccctatcag ctcctcaaga caagggattt ttatctggag cacctcaaga
     1381 ctgctcttcg ttgaaggcac accactgtcc tggaaaccac agctgggatg gtatcgtttc
     1441 tgtaccacca ggggcagcct tctgtgatcg cagggcctcc tcgtgttcct tggctgtaat
     1501 aagtccattc ttggttgaga aaggttcaga gcgcccacca attggtatag cccaacagtg
     1561 gatccagagt aagagggaag ccattgtgag ccagatgact gaagcctgcc ttaaccaatc
     1621 gctggacgcc cttctgtctc gtgacctgat catgaaggag gactatgaac tcattagcac
     1681 caaacctaca aggacctcaa aagtcagaca gctgctagat acgtctgaca tccaaggaga
     1741 agagtttgcc aaagttgtag tgcagaagtt gaaagataac aagcagctgg ggctgcagcc
     1801 ttacccagaa gtacctgtgc tttccaaagc accgccttca aatttccctc agaataaaag
     1861 cttgtaaggg ggccttcttt gggaggaagt cagtttacaa atggttattt atatttctgt
     1921 tacctgtata atatttgtat agaaaacatg agagtattag acgcttcact gaaggttgat
     1981 ggaagagtct cttcccatga cgttgcagta tttttttaaa ttaatataag taaaaagttt
     2041 gctttatgct gtgtagttca gtttttacgt cagtttcact acttgaactt tttatgtgat
     2101 aattacattt ttctagtatg taacagtgcc ttaaagtggc ctttgtttct gatggaagac
     2161 actttcacac tcaccttctc tgcggattcc tcattattcg tctagagtgc agtttgactt
     2221 tacatagcag tgattcaggc tccccatttg ccaatcccaa gttcagatct ccaaagagtt
     2281 actcggtttt aagtttgact tacaaattct ttagcaggtg gtctcaagga atgtagagta
     2341 tataaagaag cgggggagaa aaaattaaca ctggccagcc gtggacctct gcttaacttt
     2401 tgcctcctgt ctgtctccag agcgagcagc ccattgtgca tcctgctgca gcctgcttcc
     2461 ggctcctgtt ttaagcatat gcgggttggg tagaagccga cctttactta gctattttct
     2521 ttgtaaaaca ccatggtttt tgaactgaag gcaggtacac tcctccacac agctaactcc
     2581 gttcaatcac cgcatgtcgg ccacgcctct ctgtgtttga ttttccaaga ttgctcttat
     2641 caacttgacg agaaacaata aaaaggcaat acagtgtgca aaaaaaaaaa aaaaaaaaaa
     2701 aa
//
