LOCUS       NM_001359997            4759 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus receptor (TNFRSF)-interacting serine-threonine kinase
            1 (Ripk1), transcript variant 2, mRNA.
ACCESSION   NM_001359997 XM_006516607
VERSION     NM_001359997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4759)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 4759)
  AUTHORS   Zhang,T., Fu,W., Zhang,H., Li,J., Xing,B., Cai,Y., Zhang,M.,
            Liu,X., Qi,C., Qian,L., Hu,X., Zhu,H., Yang,S., Zhang,M., Liu,J.,
            Li,G., Li,Y., Xiang,R., Qi,Z., Hu,J., Li,Y., Zou,C., Wang,Q.,
            Jin,X., Pang,R., Li,P., Liu,J., Zhang,Y., Wang,Z., Zhu,Z.J.,
            Shan,B. and Yuan,J.
  TITLE     Spermidine mediates acetylhypusination of RIPK1 to suppress
            diabetes onset and progression
  JOURNAL   Nat Cell Biol 26 (12), 2099-2114 (2024)
   PUBMED   39511379
REFERENCE   3  (bases 1 to 4759)
  AUTHORS   Zhou,H., Gong,H., Liu,H., Jing,G., Xia,Y., Wang,Y., Wu,D., Yang,C.,
            Zuo,J., Wang,Y., Wu,X. and Song,X.
  TITLE     Erbin alleviates sepsis-induced cardiomyopathy by inhibiting
            RIPK1-dependent necroptosis through activating PKA/CREB pathway
  JOURNAL   Cell Signal 123, 111374 (2024)
   PUBMED   39216682
  REMARK    GeneRIF: Erbin alleviates sepsis-induced cardiomyopathy by
            inhibiting RIPK1-dependent necroptosis through activating PKA/CREB
            pathway.
REFERENCE   4  (bases 1 to 4759)
  AUTHORS   Jetton,D., Muendlein,H.I., Connolly,W.M., Magri,Z., Smirnova,I.,
            Batorsky,R., Mecsas,J., Degterev,A. and Poltorak,A.
  TITLE     Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis
            to control Yersinia infection
  JOURNAL   Cell Rep 43 (8), 114641 (2024)
   PUBMED   39154339
  REMARK    GeneRIF: Non-canonical autophosphorylation of RIPK1 drives timely
            pyroptosis to control Yersinia infection.
REFERENCE   5  (bases 1 to 4759)
  AUTHORS   Jin,X., Zhang,Y., Zhou,Y., Luo,Y., Han,X., Gao,Y., Yu,H., Duan,Y.,
            Shi,L., Wu,Y. and Li,Y.
  TITLE     Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial
            Necroptosis by Activation of RIPK1 Acetylation
  JOURNAL   Circ Arrhythm Electrophysiol 17 (7), e012452 (2024)
   PUBMED   39012929
  REMARK    GeneRIF: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing
            Atrial Necroptosis by Activation of RIPK1 Acetylation.
REFERENCE   6  (bases 1 to 4759)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   7  (bases 1 to 4759)
  AUTHORS   Melnick,M., Chen,H., Zhou,Y. and Jaskoll,T.
  TITLE     Embryonic mouse submandibular salivary gland morphogenesis and the
            TNF/TNF-R1 signal transduction pathway
  JOURNAL   Anat Rec 262 (3), 318-330 (2001)
   PUBMED   11241200
REFERENCE   8  (bases 1 to 4759)
  AUTHORS   Hofmann,K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   9  (bases 1 to 4759)
  AUTHORS   Kelliher,M.A., Grimm,S., Ishida,Y., Kuo,F., Stanger,B.Z. and
            Leder,P.
  TITLE     The death domain kinase RIP mediates the TNF-induced NF-kappaB
            signal
  JOURNAL   Immunity 8 (3), 297-303 (1998)
   PUBMED   9529147
REFERENCE   10 (bases 1 to 4759)
  AUTHORS   Stanger,B.Z., Leder,P., Lee,T.H., Kim,E. and Seed,B.
  TITLE     RIP: a novel protein containing a death domain that interacts with
            Fas/APO-1 (CD95) in yeast and causes cell death
  JOURNAL   Cell 81 (4), 513-523 (1995)
   PUBMED   7538908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161117.4.
            
            On Jan 24, 2018 this sequence version replaced XM_006516607.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156803.1, BC058162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AC161117.4         146192-146535       c
            345-564             AC161117.4         139078-139297       c
            565-721             AC161117.4         138197-138353       c
            722-859             AC161117.4         135511-135648       c
            860-1091            AC161117.4         133541-133772       c
            1092-1241           AC161117.4         131752-131901       c
            1242-1318           AC161117.4         127441-127517       c
            1319-1409           AC161117.4         122066-122156       c
            1410-1943           AC161117.4         120647-121180       c
            1944-2084           AC161117.4         118718-118858       c
            2085-4759           AC161117.4         113728-116402       c
FEATURES             Location/Qualifiers
     source          1..4759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.01 cM"
     gene            1..4759
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="receptor (TNFRSF)-interacting serine-threonine
                     kinase 1"
                     /db_xref="GeneID:19766"
                     /db_xref="MGI:MGI:108212"
     exon            1..344
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..564
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..2371
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /EC_number="2.7.11.1"
                     /note="cell death protein RIP; receptor-interacting
                     protein 1; serine/threonine-protein kinase RIP"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_001346926.1"
                     /db_xref="CCDS:CCDS26443.1"
                     /db_xref="GeneID:19766"
                     /db_xref="MGI:MGI:108212"
                     /translation="MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVIL
                     KKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMH
                     VLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVA
                     SFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIV
                     LWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDR
                     PTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRS
                     NSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEK
                     QTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQ
                     LSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPY
                     FSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTS
                     LTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMRE
                     GTKGATVGKLAQALHQCCRIDLLNHLIRASQS"
     exon            565..721
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..859
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1091
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1241
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1318
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1409
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1943
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2084
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..4759
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3246..3251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="hexamer: AATAAA"
     polyA_site      3272
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="major polyA site"
     regulatory      3774..3779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="hexamer: AATAAA"
     polyA_site      4759
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacaggg gcggccgcag cctagcacca ccccagtagt ccttagagga ggaccagcgg
       61 cccccggaac ggcctcggga gcgcgggtgt cggtgccgct cacctcccgg gagtccagcg
      121 gcggtgcgga cccgcggagg tgcgagctgg acgcggcggg aggcggcagg ctgtggggga
      181 cctgcgagtg gctgggcgcc acttcagcac cgaactccga ccggtcctcg tcagggccca
      241 gggccgtccc ggccgggcag ccacggcgag gcgccgctcc tgacgtccac cgcccgtcct
      301 tcctcaccta ggccggggta cttggccgcg ggaaggcctc tgaggacaca gcactaagca
      361 agaaccaaaa gtggtgtgtt ggagattctg agcaatcaaa atgcaaccag acatgtcctt
      421 ggacaatatt aagatggcat ccagtgacct gctggagaag acagacctag acagcggagg
      481 cttcgggaag gtgtccttgt gttaccacag aagccatgga tttgtcatcc tgaaaaaagt
      541 atacacaggg cccaaccgcg ctgagtacaa tgaggttctc ttggaagagg ggaagatgat
      601 gcacagactg agacacagtc gagtggtgaa gctactgggc atcatcatag aagaagggaa
      661 ctattcgctg gtgatggagt acatggagaa gggcaacctg atgcacgtgc taaagaccca
      721 gatagatgtc ccactttcat tgaaaggaag gataatcgtg gaggccatag aaggcatgtg
      781 ctacttacat gacaaaggtg tgatacacaa ggacctgaag cctgagaata tcctcgttga
      841 tcgtgacttt cacattaaga tagccgatct tggtgtggct tcctttaaga catggagcaa
      901 actgactaag gagaaagaca acaagcagaa agaagtgagc agcaccacta agaagaacaa
      961 tggtggtacc ctttactaca tggcacccga acacctgaat gacatcaatg caaagcccac
     1021 ggagaagtcg gacgtgtaca gctttggcat tgtcctttgg gcaatatttg caaaaaagga
     1081 gccctatgag aatgtcatct gtactgagca gttcgtgatc tgcataaaat ctgggaacag
     1141 gccaaatgta gaggaaatcc ttgagtactg tccaagggag atcatcagcc tcatggagcg
     1201 gtgctggcag gcgatcccag aagacaggcc aacatttctt ggcattgaag aagaatttag
     1261 gcctttttac ttaagtcatt ttgaagaata tgtagaagag gatgtggcaa gtttaaagaa
     1321 agagtatcca gatcaaagcc cagtgctgca gagaatgttt tcactgcagc atgactgtgt
     1381 acccttacct ccgagcaggt caaattcaga acaacctgga tcgctgcaca gttcccaggg
     1441 gctccagatg ggtcctgtgg aggagtcctg gttttcttcc tccccagagt acccacagga
     1501 cgagaatgat cgcagtgtgc aggctaagct gcaagaggaa gccagctatc atgcttttgg
     1561 aatatttgca gagaaacaga caaaaccgca gccaaggcag aatgaggctt acaacagaga
     1621 ggaggaaagg aaacgaaggg tctctcatga cccctttgca cagcagagag ctcgtgagaa
     1681 tattaagagt gcaggagcaa gaggtcattc tgatcccagc acaacgagtc gtggaattgc
     1741 agtgcaacag ctgtcatggc cagccaccca aacagtttgg aacaatggat tgtataatca
     1801 gcatggattt ggaactacag gtacaggagt ttggtatccg ccaaatctaa gccaaatgta
     1861 tagtacttat aaaactccag tgccagagac caacataccg ggaagcacac ccaccatgcc
     1921 atacttctct gggccagtag cagatgacct cataaaatat actatattca atagttctgg
     1981 tattcagatt ggaaaccaca attatatgga tgttggactg aattcacaac caccaaacaa
     2041 tacttgcaaa gaagagtcga cttccagaca ccaagccatc tttgataaca ccactagtct
     2101 gactgatgaa cacctgaacc ctatcaggga aaacctggga aggcagtgga aaaactgtgc
     2161 ccgcaagctg ggcttcactg agtctcagat cgatgaaatc gaccatgact atgaaagaga
     2221 tggactgaaa gagaaagttt accaaatgct tcagaagtgg ctgatgcggg aaggcaccaa
     2281 aggggccaca gtgggaaagt tggcccaggc acttcaccaa tgttgcagga tagacctgct
     2341 gaaccacttg attcgtgcca gccagagcta agcctgggca ggctctggca gtgggaagca
     2401 aactatttgt ctggtgcaca aaccccgttt gcccactagc cttcagaact ctatctcagc
     2461 atgagctctg catttgagca cacagggtca tgcagtttgg aactggtgga tgggaagaga
     2521 aatctgaagc ccacagtgat tcttcagaac atgcaagcat aaagaccgct gaatgaatgg
     2581 tcggtccatg accagtagga ggaaaaaaat taaaaataca gtgtattgag ttttcaaagg
     2641 gagagaagat gttgggggaa ggtggccttc gttcagcttg tgtcatagtc atcacttagg
     2701 ttatttgctc agtttcctgt ggtttcattg ggtaagggga aaacaaacaa aaaacattca
     2761 aagaatgtaa aatcagctag cttcccgctt catggactgt gagtcagaaa agttctgctc
     2821 aaatgccttc tatgagccac ggctcttcta aaaactatag gatctgttaa cttgagcatc
     2881 caatgctgta ctgtcacctt aagctttaag aatcatgtgt aattctagtc tatcaaatta
     2941 tcaattagtg agagattttt aaggagtgct aaggagaaaa aggtgcaggg cagagagaga
     3001 tcttcaggta ctggctgtca ttgcagctca ggtactggct gtcattgcag agctgctgct
     3061 ggttctggct gctgtaaaaa gtctactttt aagtttctaa agtttctcta ccattctggc
     3121 gcttcatgca gtttcccacc ctgtgagccc cacagaggga acagatgtgc aggaaacact
     3181 gatcgggaaa taccatctcc tcctctctgg atatgactgg tgccttagca ctgttccctg
     3241 tgcccaataa actgtttcct cagttttctc cagtgtgctg tacaaatatg tttcttctgt
     3301 gtgccaccaa tcaagaaagg acagcttcag agtcatcttg tgcctttagg aagcccatat
     3361 tgcaacctac aagtgagtga aggagctagg gtagaagact gaagccgcct acaccagcca
     3421 cagtcactgt taggatgggc tgcacagccg ctttggcctt gttggccatt ctggcactca
     3481 ttggcacttc atcctccttt gttgggctat cctgtactca gtaggatatt tgggaacatt
     3541 cctggcctcc atctgcaaga tgccaacagt acaagtcaac ctcacaacac ccaccaggtg
     3601 tgagaaaaat aactagatat tgctacatgt tctttggagg gactctcctg taacgttatt
     3661 tcccccatcc ccagacaagg tttctcagtt ctcgctgtcc tggaactcac tttgtagacc
     3721 agattggtct cccaattcag agatctgcct gcctctgcct cctgagtgct gggaataaag
     3781 gcatgtgcca ccaccaccca gcttcctgct gtaagtttat atgccttact tctcctgtca
     3841 cacaggctag gccatcatta acagcatgga acatgcacag tggaagggaa ttggagcagg
     3901 gaaggttcca ggctttcctg aaggagcctg catagtcttt aaaaaatgtt ttctttttaa
     3961 cttctaatgc tgttttaaga agacagaatt agaaactgct tctagtggag ttttaaggag
     4021 aataaaatag caagggaggc cagagctggt tttggaattg cagtagcaat cagggtccta
     4081 gtattaaaat catgtctgtt agtgttcagt aggggaagac ttgtgtgtcc actgctgaag
     4141 ataggtgctt cagatccagg cctggattgt gaccacagac tttcagatct tttccaggct
     4201 caccactgac agccagacaa tggcttggca cctcgagttg tggctgagcc tgtatgagtt
     4261 gaaggatggt cagtagatga agccgtttac tctcatggtg tgtgcccttg tacaagagat
     4321 ctgggcgcgt gacacaaagc cagtcattga caggctagac ccaaagacct ttaagcactc
     4381 ccatttgctt ccgctgtatc acaataactg atgactttgt agtcagtggt acctgctccg
     4441 aacaagtacg tggagtgtgg gagtccctct gggagcccag cgtggaatta gaacacctct
     4501 ttaaagccac ctcctaagcc gagcagaatg cagtggactg gggtacaagt cagacctgag
     4561 tgtcattgtc cacatcatgg aaaaacaaga tggccaccag aacactgaag gcctgaggag
     4621 actaaccctg ttcccagaac tcagagttct gtttggttct gtttttaata agataacctt
     4681 tctttaatgt atacatatgc atatacatat atatttgtac tttaaataca gagtactgaa
     4741 taaaatttat gtgactata
//
