LOCUS       NM_025910               2159 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus ribosomal oxygenase 2 (Riox2), mRNA.
ACCESSION   NM_025910
VERSION     NM_025910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Zhou,L., Zhao,X., Sun,J., Zou,K., Huang,X., Yu,L., Wu,M., Wang,Y.,
            Li,X. and Yi,W.
  TITLE     Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation
            to regulate neural stem/progenitor cell identity
  JOURNAL   Nat Commun 15 (1), 10227 (2024)
   PUBMED   39587091
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Lian,S.L., Mihi,B., Koyanagi,M., Nakayama,T. and Bix,M.
  TITLE     A SNP uncoupling Mina expression from the TGFbeta signaling pathway
  JOURNAL   Immun Inflamm Dis 6 (1), 58-71 (2018)
   PUBMED   28967702
  REMARK    GeneRIF: results demonstrate the TGFbeta signaling pathway plays a
            critical role in regulating Mina expression and SNP rs4191790
            controls heritable variation in Mina expression level, raising
            important questions regarding the evolution of an allele that
            uncouples Mina expression from the TGFbeta signaling pathway.
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Thakur,C., Wolfarth,M., Sun,J., Zhang,Y., Lu,Y., Battelli,L.,
            Porter,D.W. and Chen,F.
  TITLE     Oncoprotein mdig contributes to silica-induced pulmonary fibrosis
            by altering balance between Th17 and Treg T cells
  JOURNAL   Oncotarget 6 (6), 3722-3736 (2015)
   PUBMED   25669985
  REMARK    GeneRIF: Results suggest that mdig may contribute to silica-induced
            lung fibrosis by altering the balance between Th17 and Treg cells.
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Pillai,M.R., Lian,S. and Bix,M.
  TITLE     Mina: a Th2 response regulator meets TGFbeta
  JOURNAL   Curr Opin Immunol 31, 38-43 (2014)
   PUBMED   25282476
  REMARK    GeneRIF: Mina: a Th2 response regulator meets TGFbeta.
            Review article
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   Lian,S., Potula,H.H., Pillai,M.R., Van Stry,M., Koyanagi,M.,
            Chung,L., Watanabe,M. and Bix,M.
  TITLE     Transcriptional activation of Mina by Sp1/3 factors
  JOURNAL   PLoS One 8 (12), e80638 (2013)
   PUBMED   24324617
  REMARK    GeneRIF: Sp1/3 transcription factors trigger Mina expression
            through additive activity targeted to a cluster of four Sp1/3
            binding sites forming the P1 promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2159)
  AUTHORS   Yosef,N., Shalek,A.K., Gaublomme,J.T., Jin,H., Lee,Y., Awasthi,A.,
            Wu,C., Karwacz,K., Xiao,S., Jorgolli,M., Gennert,D., Satija,R.,
            Shakya,A., Lu,D.Y., Trombetta,J.J., Pillai,M.R., Ratcliffe,P.J.,
            Coleman,M.L., Bix,M., Tantin,D., Park,H., Kuchroo,V.K. and Regev,A.
  TITLE     Dynamic regulatory network controlling TH17 cell differentiation
  JOURNAL   Nature 496 (7446), 461-468 (2013)
   PUBMED   23467089
REFERENCE   7  (bases 1 to 2159)
  AUTHORS   Mori,T., Okamoto,K., Tanaka,Y., Teye,K., Umata,T., Ohneda,K.,
            Tokuyama,K., Okabe,M. and Tsuneoka,M.
  TITLE     Ablation of Mina53 in mice reduces allergic response in the airways
  JOURNAL   Cell Struct Funct 38 (2), 155-167 (2013)
   PUBMED   23748603
  REMARK    GeneRIF: Mina53 plays a role in the allergic response to inhaled
            allergens, possibly through controlling IL-4 production.
REFERENCE   8  (bases 1 to 2159)
  AUTHORS   Okamoto,M., Van Stry,M., Chung,L., Koyanagi,M., Sun,X., Suzuki,Y.,
            Ohara,O., Kitamura,H., Hijikata,A., Kubo,M. and Bix,M.
  TITLE     Mina, an Il4 repressor, controls T helper type 2 bias
  JOURNAL   Nat Immunol 10 (8), 872-879 (2009)
   PUBMED   19561615
  REMARK    GeneRIF: Mina specifically bound to and repressed the Il4 promoter.
            Mina overexpression in transgenic mice impaired Il4 expression,
            whereas its knockdown in primary CD4(+) T cells led to Il4
            derepression.
REFERENCE   9  (bases 1 to 2159)
  AUTHORS   Tsuneoka,M., Nishimune,Y., Ohta,K., Teye,K., Tanaka,H., Soejima,M.,
            Iida,H., Inokuchi,T., Kimura,H. and Koda,Y.
  TITLE     Expression of Mina53, a product of a Myc target gene in mouse
            testis
  JOURNAL   Int J Androl 29 (2), 323-330 (2006)
   PUBMED   16533354
  REMARK    GeneRIF: Mina53 is prominently expressed in proliferating,
            undifferentiated spermatogonia, and plays a role in cell
            proliferation from the spermatogonial stage to the meiotic prophase
            in spermatogenesis, but not in meiotic divisions per se.
REFERENCE   10 (bases 1 to 2159)
  AUTHORS   Tsuneoka,M., Koda,Y., Soejima,M., Teye,K. and Kimura,H.
  TITLE     A novel myc target gene, mina53, that is involved in cell
            proliferation
  JOURNAL   J Biol Chem 277 (38), 35450-35459 (2002)
   PUBMED   12091391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY345199.1, AK007810.1 and AC154854.2.
            
            On Aug 21, 2009 this sequence version replaced NM_025910.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025109.1, AK031671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               BY345199.1         1-119
            120-1985            AK007810.1         90-1955
            1986-2159           AC154854.2         184805-184978
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..2159
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="ribosomal oxygenase 2"
                     /db_xref="GeneID:67014"
                     /db_xref="MGI:MGI:1914264"
     exon            1..171
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            172..631
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1597
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /EC_number="1.14.11.79"
                     /note="histone lysine demethylase MINA; bifunctional
                     lysine-specific demethylase and histidyl-hydroxylase MINA;
                     MYC-induced nuclear antigen; myc induced nuclear antigen"
                     /codon_start=1
                     /product="ribosomal oxygenase 2"
                     /protein_id="NP_080186.3"
                     /db_xref="CCDS:CCDS28257.1"
                     /db_xref="GeneID:67014"
                     /db_xref="MGI:MGI:1914264"
                     /translation="MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFES
                     LISPIKVETFFKEFWEQKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNV
                     CRSISGKKKVLNKDGRAHFLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGS
                     LVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIG
                     TPTHDFLLKPGDLLYFPRGTIHQAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFV
                     FDIAKEDVALRSGMPRRMLLNVETPADVTRKLSGFLRTLADQLEGREELLSSDMKKDF
                     VKHRLPPFFEGNGTETMDPGKQLPRLDNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVY
                     IYHSLKNVRQMHMIGEEEESEIFGLRFPLSHVDALKQIWCGSPIRVKDLKLDTDEEKE
                     NLALSLWSESLIQVL"
     exon            632..751
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            752..880
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            881..984
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1087
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1259
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1348
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1438
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..2159
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="hexamer: CATAAA"
     polyA_site      1874
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="major polyA site"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="hexamer: ATTAAA"
     regulatory      1963..1968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="hexamer: AATAAA"
     polyA_site      1968
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
     polyA_site      1995
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
                     /note="hexamer: AATAAA"
     polyA_site      2056
                     /gene="Riox2"
                     /gene_synonym="1810047J07Rik; 2410057H13Rik;
                     3830408E23Rik; Mina"
ORIGIN      
        1 gtgggcgggg ccgcgtctcg ggagcccgcc ctggacgtga ccacgccgtc gcgcccttcc
       61 atgccttagc tgggtcaact tgcggaagac acgcaacagg ccgtgccggt gcagcgcgtg
      121 ggacgcgggt caggctgaga agtgcagctc tggagggctg gggcctaact ggtttgcatt
      181 tcctccctac tcgtgaacaa tgccaaagaa agtgcagccc acaggggatg agaacgaaga
      241 agcgtctgtt ccttgcaagc gggtgaagga ggagctgcct gaaacgcttt ctgtattaaa
      301 ctttgacagc cccagtagtt tcttcgaaag tttaatctca cccatcaaag tagagacttt
      361 tttcaaggaa ttctgggaac aaaagcccct tctcatccag agggatgacc ctgtactggc
      421 caaatattac cagtctctgt tcagcctctc agatctgaag agactctgca agaaaggagt
      481 gtactatgga agagacgtga atgtctgccg gagcatcagt gggaagaaga aggttttaaa
      541 taaggacggc agagcacatt ttcttcagct gagaaaagat tttgatcaga agagggcaac
      601 aattcagttt caccaacctc agagatataa ggatgagctg tggcggatcc aggaaaagct
      661 ggaatgttac tttgggtcct tagtaggctc gaatgtgtac atgactcctg caggatctca
      721 gggcctccct ccacattatg atgatgttga ggtttttatc ctgcagctgg agggaacgaa
      781 acactggcgc ctgtactccc caactgtgcc cctggcacac gagtacagtg tggaatctga
      841 ggaccggatc ggcacaccga cacacgactt cctgctgaag cctggagatt tgttgtactt
      901 tcccagaggg accattcatc aggcagaaac tccttcaggc ctggcctact ctattcacct
      961 gactattagc acctaccaga acaattcatg gggagactgc cttttggatt ccatttcggg
     1021 gttcgtattt gacattgcaa aggaagatgt ggcattaagg agtggaatgc cccggcggat
     1081 gctcctgaat gtggaaaccc cagctgatgt aacaaggaag ttgagtggct ttctgaggac
     1141 tcttgcagac cagctcgagg gcagagaaga gctgctgtca tcagatatga agaaggactt
     1201 cgtcaagcac agactccctc ctttcttcga gggaaatgga acggagacga tggacccagg
     1261 taaacagttg ccaaggttgg acaacataat aagactgcag ttcaaagatc acattgtcct
     1321 cacagtaggg ccagataaga atccatttga tgaagctcaa caaaaggtgg tttacatcta
     1381 tcattctctg aagaatgtga ggcagatgca catgatagga gaagaggagg aatccgagat
     1441 tttcggtctt cgctttcctt tatcacatgt ggatgctctg aagcaaatct ggtgcgggtc
     1501 accaattcgt gttaaggacc tgaaacttga cacagatgaa gaaaaggaga acctggcact
     1561 gtctctctgg tcggagtctt taatccaagt actctagtgc ctttatgcag agaattgttg
     1621 attttctcta tacatacatt cagtgagcgg ggagggggct tggcgctctg gttagtactg
     1681 tgggtggagg tgtagtgacc tagaggagca aggagaagaa gctggttcat gtccttgtgg
     1741 acacgagagg aaaaccagga aattattagg catcccagac tctgataaaa cgatacttcg
     1801 gacaagttta ttcaatgcag tgttgtagaa aaggcacaac tgcagtacac atgtcataaa
     1861 gattatgtca gtaacctggc tcgtcttgct tctttggaag aaataactcc tttaaagagc
     1921 atcactggct ccgaaaatac tttctaacaa ttaaaactta ggaataaagt tggatttttt
     1981 tctttacaat gaaaatatac atatctttga gcatacatga cccctttccc cattaaaata
     2041 aacatgtttc gtgtaatact gccacaccca taagaggtac ccagcatctg tgcccgtgca
     2101 gagctctcag acgctgcttg gaagatgaca gaagagccag agattggaaa aaaaaaaaa
//
