LOCUS       NM_023633               2346 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ribosomal oxygenase 1 (Riox1), mRNA.
ACCESSION   NM_023633
VERSION     NM_023633.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Xiao,Y., Li,J., Liao,X., He,Y., He,T., Yang,C., Jiang,L.,
            Jeon,S.M., Lee,J.H., Chen,Y., Liu,R. and Chen,Q.
  TITLE     RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA
            repair
  JOURNAL   Bone Res 10 (1), 19 (2022)
   PUBMED   35210392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Zhang,L., Chen,Q., Chen,Z., Wang,Y., Gamboa,J.L., Ikizler,T.A.,
            Garibotto,G. and Mitch,W.E.
  TITLE     Mechanisms Regulating Muscle Protein Synthesis in CKD
  JOURNAL   J Am Soc Nephrol 31 (11), 2573-2587 (2020)
   PUBMED   32764136
  REMARK    GeneRIF: Mechanisms Regulating Muscle Protein Synthesis in CKD.
            Erratum:[J Am Soc Nephrol. 2021 Feb;32(2):521. doi:
            10.1681/ASN.2020111609.. PMID: 33514643]
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Chen,Q., Sinha,K., Deng,J.M., Yasuda,H., Krahe,R., Behringer,R.R.
            and de Crombrugghe,B.
  TITLE     Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes
            Bone Formation
  JOURNAL   J Bone Miner Res 30 (9), 1608-1617 (2015)
   PUBMED   25736226
  REMARK    GeneRIF: NO66 regulates bone formation, at least in part, via
            regulating the number of bone-forming cells and expression of
            multiple genes that are critical for these processes
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Chen,Q., Zhang,L., de Crombrugghe,B. and Krahe,R.
  TITLE     Mesenchyme-specific overexpression of nucleolar protein 66 in mice
            inhibits skeletal growth and bone formation
  JOURNAL   FASEB J 29 (6), 2555-2565 (2015)
   PUBMED   25746793
  REMARK    GeneRIF: Data indicate that mesenchymal overexpression of nucleolar
            protein 66 (NO66) inhibits skeletal cell proliferation.
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Sinha,K.M., Yasuda,H., Zhou,X. and deCrombrugghe,B.
  TITLE     Osterix and NO66 histone demethylase control the chromatin of
            Osterix target genes during osteoblast differentiation
  JOURNAL   J Bone Miner Res 29 (4), 855-865 (2014)
   PUBMED   24115157
  REMARK    GeneRIF: propose that Osx is a molecular switch for the formation
            of an active chromatin state during osteoblast differentiation,
            whereas NO66 helps gene repression through histone demethylation
            and/or formation of a repressor complex
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Sinha,K.M. and Zhou,X.
  TITLE     Genetic and molecular control of osterix in skeletal formation
  JOURNAL   J Cell Biochem 114 (5), 975-984 (2013)
   PUBMED   23225263
  REMARK    Review article
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Sinha,K.M., Yasuda,H., Coombes,M.M., Dent,S.Y. and de
            Crombrugghe,B.
  TITLE     Regulation of the osteoblast-specific transcription factor Osterix
            by NO66, a Jumonji family histone demethylase
  JOURNAL   EMBO J 29 (1), 68-79 (2010)
   PUBMED   19927124
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   Eilbracht,J., Reichenzeller,M., Hergt,M., Schnolzer,M., Heid,H.,
            Stohr,M., Franke,W.W. and Schmidt-Zachmann,M.S.
  TITLE     NO66, a highly conserved dual location protein in the nucleolus and
            in a special type of synchronously replicating chromatin
  JOURNAL   Mol Biol Cell 15 (4), 1816-1832 (2004)
   PUBMED   14742713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133183.3 and BC059809.1.
            
            On Sep 10, 2009 this sequence version replaced NM_023633.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC138094.1, AB041553.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC133183.3         114200-114248       c
            50-2342             BC059809.1         1-2293
            2343-2346           AC133183.3         111903-111906       c
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.97 cM"
     gene            1..2346
                     /gene="Riox1"
                     /gene_synonym="2410016O06Rik; MAPJD; NO66"
                     /note="ribosomal oxygenase 1"
                     /db_xref="GeneID:71952"
                     /db_xref="MGI:MGI:1919202"
     exon            1..2346
                     /gene="Riox1"
                     /gene_synonym="2410016O06Rik; MAPJD; NO66"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1896
                     /gene="Riox1"
                     /gene_synonym="2410016O06Rik; MAPJD; NO66"
                     /EC_number="1.14.11.27"
                     /EC_number="1.14.11.79"
                     /note="lysine-specific demethylase NO66; nucleolar protein
                     66; myc associated protein with JmjC domain; histone
                     lysine demethylase NO66; bifunctional lysine-specific
                     demethylase and histidyl-hydroxylase NO66"
                     /codon_start=1
                     /product="ribosomal oxygenase 1"
                     /protein_id="NP_076122.2"
                     /db_xref="CCDS:CCDS26033.1"
                     /db_xref="GeneID:71952"
                     /db_xref="MGI:MGI:1919202"
                     /translation="MDELPNGNGAALLKRGRGRRRRHPQSQPRGASVLALPLRPRKIR
                     RHRKSAAASRVAALRARALRSEDSDSKVAVASVRGKRKRPAELLEASRSAEPRPVSAR
                     PRSASATLPSRVEGWAALSRNLGTAAPPPPGSHADEPGRPRASPLQQVLTELNGIPSS
                     RRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDRSYYEGLFSTADLDSMLRYEDV
                     QFGQHLDAARYVDGRRETLNPPGRALPAAAWSLYRAGCSLRLLCPQAFSPTVWQFLAV
                     LQEQFGSMAGSNVYLTPPDSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALT
                     SSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGD
                     FLEAVLPLAVQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARL
                     GHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPVRWEAGEPVNVGAQLTTET
                     QVHMLQDGVARLVGEGGRLFLYHTVENSRVYHLEEPKCLEIHPQQADAMELLLRSYPE
                     FVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVPS"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riox1"
                     /gene_synonym="2410016O06Rik; MAPJD; NO66"
                     /note="hexamer: ATTAAA"
     polyA_site      2344
                     /gene="Riox1"
                     /gene_synonym="2410016O06Rik; MAPJD; NO66"
                     /note="major polyA site"
ORIGIN      
        1 ctacccaggg aatgccgaag gactcgcccc cttcccagaa agcaccacgg ccgcggaagc
       61 gtgggacccg ccggccgccc cgctatggac gagctaccga atggcaacgg tgcggcgctg
      121 ctgaagcgcg ggcgggggag gcgccggcgg cacccgcagt cgcagccccg cggcgcgtcg
      181 gtcttggccc tgcccttgcg gccccggaag atccgaaggc accggaaaag tgcggcggcg
      241 tcccgcgtgg ccgcgctgag agctcgcgcg ctccggagcg aggactcgga ctcgaaagtg
      301 gcggtggcct cggttcgggg caagcggaag aggccggcag agctgctgga ggcctcgcgg
      361 tcggcggagc cgcggccggt gtcagcgcgc ccgaggtcgg cttcggcgac gctgccgagc
      421 cgcgtggagg gatgggctgc gctctcccgg aacctgggga cggccgctcc gccgccgccg
      481 ggctcgcacg cggatgagcc ggggcgaccc cgggcttcgc cgctgcagca ggtactgacg
      541 gagctgaacg gcatccccag cagccggagg cgcgccgccc gcctcttcga gtggctcctg
      601 gcgcccctgc ctccggacca cttctaccgg cggctgtggg agcgggaggc ggtgctggtg
      661 cggcggcagg accgcagcta ctacgagggt ctcttctcca ccgccgacct ggactcgatg
      721 ctgcgctacg aggacgtgca attcgggcag catctggacg ccgcgcgcta cgtcgatgga
      781 cggcgggaga ccttgaaccc gccgggccgc gcgcttcccg ccgccgcgtg gtccttgtac
      841 cgagccggct gctccttgcg cctcctgtgc ccgcaagcct tctcgcccac cgtgtggcag
      901 tttctggccg tgctccagga gcagtttggc agcatggcgg gctccaacgt ctacctcacg
      961 cccccggact cgcagggctt tgctcctcac tacgatgaca tcgaggcttt cgtgttgcag
     1021 ctggaaggtc ggaaactctg gcgcgtctac cgaccgcggg acccgagtga ggagttggcc
     1081 ctgacatcta gtcccaactt cagccaggag gaccttggtg agcctgtgct gcaaacggta
     1141 ctggaacctg gagacctgct ctattttcct cggggcttca ttcaccaagc tgaatgtcag
     1201 gatggagtcc actccctaca cctcaccttg tccacctacc agcgcaatac atggggtgac
     1261 ttcctggagg ctgtactgcc tctggcagtg caagcggcca tagaggagaa cgtggagttc
     1321 cgcagaggct tgccccgaga cttcatggat tacatggggg cccagcattc cgactctaag
     1381 gatcctagaa ggacagcttt catggaaaag gtgcgggtct tggttgctcg cctgggacac
     1441 tttgctcctg tcgatgctgt ggctgaccag agagcaaaag acttcattca cgattccctg
     1501 ccccctgtgt tgaccgatag ggaacgggct ctaagtgttc acgggctccc agttcgctgg
     1561 gaggctggag aacccgtcaa tgtgggggcc cagctgacaa ctgaaaccca agtccacatg
     1621 cttcaggacg gcgtagctcg gctggtggga gagggaggcc gattgttcct gtatcacacg
     1681 gtggaaaact ctcgagttta tcacctagag gaacccaagt gcttagaaat ccacccccag
     1741 caagccgacg ccatggaact cttgcttcgc tcctacccgg agtttgtgag agtgggggac
     1801 ttgccatgtg acagtgtgga agaccagctc tccttggcaa ccatgttata tgataagggg
     1861 ctgctactca ccaagacacc tctagttccg agttagtttt ttgaggatgg ctggaaagag
     1921 tgccgttgcg actctccact accgttgcct ctctttttaa agaggtcggg ttcttacctt
     1981 gctaagcatc agtatggttg tgcttacctt taggattttt tcagtgtcgc agacttcagg
     2041 ctggagaaga acctttttac ctaggtgtaa aagtaaacac aggaattgaa gctgaggggg
     2101 aaagttcgtg gcagaagtgg ccctgacccc tgtcctttca gagcaccagc ttcattccct
     2161 acagtgtcca gtgtaccggg tagcattggc tgggccattc tgctggagac attgggggtt
     2221 ttatatggaa gttgcttcct tgggttctat ttcatcagtt tgcggggctg agctggggtc
     2281 agtgtgctgc gcgttaagtt tgtatgaacg tcagatttat taaaaaaaaa agtgccaaag
     2341 accatc
//
